Manchester City and Liverpool will put their epic Premier League title race on hold for a few days, as they have the small matter of the Champions League semi-finals to think about.
City are hoping to go one better than last year after losing in the final to Chelsea. Standing in their way in the last four are Real Madrid, who eliminated the holders in the quarter-finals and boast a striker in Karim Benzema who has 12 goals in nine Champions League appearances this season.
Also facing LaLiga opposition are Liverpool, though Villarreal are unlikely to be a team they expected to meet at this stage of the competition.
Led by a knockout football specialist in Unai Emery, Villarreal cannot be taken lightly by the Reds, even with Emery's men historically struggling in games in England.
Ahead of the first legs, Stats Perform digs into some of the best Opta numbers around the two semi-final ties.
Manchester City v Real Madrid
Madrid might just be beginning to feel it is their year after progressing from remarkable knockout ties against Paris Saint-Germain and Chelsea.
However, the omens are against them ahead of their first leg with City. Los Blancos haven't won on any of their previous three trips to face Manchester City in European competition (two draws, one defeat), with the most recent two coming in the knockout stages of the Champions League – a 0-0 draw in the 2015-16 semi-final first leg and a 2-1 loss in the 2019-20 last-16 second leg.
Pep Guardiola won't need any additional motivation as he looks to finally end his wait for a Champions League triumph with City, and the Barcelona legend can complete a historic hat-trick by overseeing an elimination of Madrid.
Indeed, Guardiola has eliminated Madrid from the knockout stages of the Champions League on two previous occasions, beating them 3-1 on aggregate in the 2010-11 semi-finals with Barcelona and 4-2 on aggregate in the 2019-20 last-16 with City. He is looking to become the first manager to eliminate Madrid from the competition on three occasions.
Madrid won away from home in the first leg at Chelsea in the quarter-finals, their only victory in their last six away games against English teams in the Champions League. No team has ever beaten two different English sides away from home in the knockout stages in a single Champions League campaign.
Champions League history between the two managers, however, is with Madrid's Carlo Ancelotti. He and Guardiola have faced each other six times, with the City boss claiming four wins to Ancelotti's two.
However, all four of Guardiola's wins came with City against Ancelotti's Everton, while the Italian saw his Madrid side beat Guardiola's Bayern Munich in both legs of the 2013-14 Champions League semi-finals, claiming a 5-0 aggregate triumph. Such a one-sided tie is unlikely this time around.
Liverpool v Villarreal
Villarreal are arguably the story of the 2021-22 Champions League, having sensationally knocked out Juventus and Bayern Munich to reach this stage.
However, games in England have historically been a problem for the Yellow Submarine. Since a 2-1 victory over Everton back in August 2005, Villarreal haven't managed to win any of their last eight away games in England in all competitions (three draws, five defeats), tasting defeat to Manchester United at Old Trafford in the group stages earlier this season.
Despite Villarreal's well-organised defensive set-up, a high-scoring game could well be in the offing. During his managerial career, Villarreal boss Emery has faced Liverpool five times (once with Sevilla and four times with Arsenal), with those matches producing 26 goals (5.2 per game on average), and both teams netting in each.
Liverpool will be the clear favourites to do the majority of that goalscoring. Of the 12 sides to have reached the semi-finals of the European Cup/Champions League on at least five occasions, only Benfica (seven wins from eight) and Milan (10/12) have a higher ratio of progressing to the final than Liverpool (82%), who have managed to reach the final on nine of their previous 11 semi-final appearances.
Although Liverpool possess serious depth in attack with Diogo Jota and Luis Diaz playing significant roles, Mohamed Salah is still the obvious candidate to be their talisman.
Only in 2017-18 (10) has Salah scored more Champions League goals in a single campaign than the eight he has scored this season, moving his tally for the club onto 33. The Egyptian is just three behind both Didier Drogba (Chelsea) and Sergio Aguero (Man City) for the most goals netted in the competition for an English side (both 36).
Yet Emery's track record in Europe should have Liverpool fans nervous that he could be the man to dash their quadruple dreams.
The only European meeting between Emery and Liverpool was the 2016 Europa League final, in which Emery's Sevilla side beat Klopp's Reds 3-1. On top of that, since the start of the 2009-10 season, the year of the inaugural UEFA Europa League campaign, Emery has progressed from 84 per cent of his Europa League/Champions League knockout ties (31/37).
That is second-best ratio of any manager to have taken charge of at least 10 ties, after only Zinedine Zidane (14/16 – 88%).