Diego Simeone is keeping his fingers crossed that Antoine Griezmann's injury is not too serious after the striker hobbled off in Thursday's 5-0 Copa del Rey win over Rayo Majadahonda.

The France international – who scored his side's fourth after being introduced as a substitute – sustained a thigh injury in last month's derby defeat to Real Madrid before testing positive for COVID-19 last week.

Simeone did not reveal the nature of Griezmann's injury but said he hopes the France international, who left the pitch visibly upset, is not sidelined for long.

"The doctors will inform better than me," he told a media conference. "He is a very important player for us and it is a shame that he was injured again.

"We hope he does not have much time out."

Simeone fielded a strong starting XI for the game, which was played at the Wanda Metropolitano despite Majadahonda being drawn as the home team, and they never looked like they would suffer an upset after Matheus Cunha's early opener.

Renan Lodi and Luis Suarez made it three before the interval, while Griezmann and fellow substitute Joao Felix rounded off the scoring in the second half.

After scoring against Granada in LaLiga before the mid-season break, Joao Felix has now scored in consecutive away games in all competitions for just the second time ever after doing so against Real Mallorca and Lokomotiv Moscow in October 2019.

Simeone was full of praise for the Portugal international and wants to see more of the same from him in the coming weeks.

"It was an extraordinary performance in the second half," the Atleti boss added.

"He has come out with great enthusiasm and everything he has tried has turned out well for him. I'm very happy for him and I'm sure it will be good for us if he continues at this level."

After four defeats in a row before the mid-season break, Atleti have started 2022 with back-to-back wins.

Simeone has been pleased with his side's attitude since their return to action and he does not want them to let up.

"The side has a lot of desire to do things well," he said. "The players have great intensity from minute one to get out of the moment of difficulty that the team was going through.

"Achieving consistency in the league is the most difficult thing and it is what we are trying to do."

Atleti are next in action on Sunday when they visit Villarreal in LaLiga.

Atletico Madrid cruised into the last 16 of the Copa del Rey thanks to a 5-0 rout of Rayo Majadahonda on Thursday.

Diego Simeone fielded a strong starting XI for the game, which was played at the Wanda Metropolitano despite Majadahonda being drawn as the home team, and they never looked like they would suffer an upset after Matheus Cunha's early opener.

Renan Lodi and Luis Suarez then made it three before the interval as the Colchoneros threatened to run riot.

Substitute Griezmann – who later hobbled off with an injury – added a fourth after a fine move, before Joao Felix wrapped up the scoring with a sumptuous finish. 

Atleti's relentless early pressure told after 17 minutes when Matheus Cunha fired home after Yannick Carrasco had blocked an attempted clearance.

Lodi then opened his account for the season nine minutes later, superbly firing into Alvaro Fernandez's top-left corner from 15 yards after being picked out by Thomas Lemar.

Suarez, who had earlier been denied by Fernandez, added a third four minutes before the interval, the Uruguay international slotting home Marcos Llorente's low cross from 12 yards.

Simeone's men started the second half at a sluggish pace, but they added a fourth in the 67th minute when Griezmann slammed the ball into the roof of Fernandez's roof after combining superbly with fellow substitute Angel Correa. 

Joao Felix added further gloss to the scoreline with 11 minutes remaining, cutting in from the left and whipping the ball into the top corner. 

What does it mean? Griezmann injury mars routine win

Given the strength of Simeone's starting XI it was little surprise to see Atleti blow their less illustrious opponents away with consummate ease.

The only blot on their copybook was the injury to Griezmann, who was visibly upset as he walked down the tunnel.

Suarez endures

Suarez's typically composed finish was his first Copa del Rey goal for Atleti and his 20th overall. Since his arrival in Spain ahead of the 2014-15 season, only Lionel Messi (27) has scored more goals in the competition.

Giralt's game cut short

Majadahonda goalkeeper Gorka Giralt was cruelly denied the chance to test himself against some of Spanish football's biggest names after suffering a hand injury inside the first minute. The 26-year-old cut a despondent figure as he walked off the pitch to be replaced by Fernandez.

What's next?

Fourth-placed Atleti return to LaLiga action on Sunday when they visit Villarreal, who sit four places and four points beneath them.