Top overall seed Alabama were ousted from the NCAA tournament Sweet 16 after an upset 71-64 loss to San Diego State on Friday.

The Crimson Tide were well below their best in a sloppy performance with 14 turnovers, shooting three-of-27 from beyond the arc.

SDSU's Darrion Trammell scored 21 points as San Diego progressed to the Elite Eight for the first time.

Trammell led the way offensively for the Aztecs, while Nathan Mensah had eight rebounds and five blocks, while Lamont Butler had three steals, four rebounds and four assists.

For Alabama, top-five NBA Draft prospect  Brandon Miller scored nine points with 11 rebounds but committed six turnovers and shot three-of-19 from the field, including one-of-10 from three-point range.

Crimson Tide guard Mark Sears scored 16 points with 10 rebounds but shot none-of-five from beyond the arc.

"Everybody is really disappointed in the loss," Alabama coach Nate Oats said. "It ended too soon."

Midwest regional top seed Houston were also eliminated in the Sweet 16 on Friday after losing 89-75 to Miami.

Hurricanes guard Nijel Pack led the way with 26 points including seven-of-10 three-pointers as Miami made 11 of their first 22 attempts from beyond the arc.

Miami will take on Midwest second seed Texas in the Elite Eight after the Longhorns won ___ over the Xavier Musketeers, with Tyrese Hunter scoring a team-high __ points with __-of-__ three-pointers.

South regional six seed Creighton defeated Princeton 86-75 to set up a Elite Eight meeting with SDSU, after Ryan Kalkbrenner and Baylor Scheierman scored 22 and 21 points respectively.

The first massive upset of the NCAA Tournament arrived on Thursday as the 15-seed Princeton Tigers knocked out the two-seed Arizona Wildcats 59-55.

Incredibly, the undersized Tigers won despite shooting only four-of-25 (16 per cent) from three-point range, getting it done on the defensive end as they held Arizona to 24 points in the second half.

Despite the loss, it was still a strong showing from the game's top NBA prospect as Arizona's six-foot-11 Lithuanian junior Azuolas Tubelis posted 22 points (nine-of-20 shooting), five rebounds, four steals and a block.

In a full-circle moment, Princeton head coach Mitch Henderson was drenched during post-game celebrations. The victory came 27 years after he played in the Tigers' last great March Madness upset, knocking off four-seed UCLA in the 1996 tournament.

But Arizona were not the only big favourite to fall, as the four-seed Virginia Cavaliers were stunned late in a 68-67 defeat at the hands of the 13-seed Furman Paladins.

Virginia led by four with just 12 seconds remaining, but after two Furman free throws, fifth-year senior Kihei Clark inexplicably tried to launch a full-court pass while being trapped in the backcourt. The pass was intercepted, allowing Garrett Hein to set up J.P. Pegues for the game-winning three with two seconds on the clock.

Things were less dramatic for the one seeds in action, as freshman star and likely NBA lottery pick Gradey Dick led the Kansas Jayhawks to a 96-68 drubbing of the Howard Bison.

Dick, 19, had 19 points (seven-of-13 shooting) with 11 rebounds, five assists and three steals as Kansas kept their foot on the pedal right to the end, using the blowout as an opportunity for some live practice against competitive opposition.

It was a different strategy for the Alabama Crimson Tide, with none of their starters playing more than 21 minutes, including top-three NBA draft hopeful Brandon Miller as he finished scoreless on five shots.

The Houston Cougars completed the one seed clean sweep as they were made to work for a 63-52 win against the Northern Kentucky Norse, with top prospect Jarace Walker putting together 16 points (six-of-eight shooting), six rebounds and two blocks.