Mercedes reserve driver Nyck de Vries is set to make his Formula One debut in Monza, filling in for Williams' Alex Albon after he was ruled out of contention.

Albon travelled to a local hospital for treatment for appendicitis on Saturday and it was announced he would not race in the Italian Grand Prix.

Instead, De Vries will drive for Williams in his place in an opportunity for him to impress ahead of a potential spot on the grid in 2023.

"Williams Racing can confirm that, after feeling unwell this morning and seeking medical advice from the FIA and local hospital, Alex Albon is now undergoing treatment for appendicitis," the team's statement said.

"Following on from this, we can confirm that the team's reserve driver Nyck de Vries will drive in place of Alex for the remainder of the Italian Grand Prix weekend.

"Alex is in good spirits and the team wishes him a speedy recovery."

De Vries had already been involved in the week's events at Monza, driving for Aston Martin in the first free practice session, and has said he feels he deserves an opportunity to drive next season.

"Obviously, it's a dream and I think I would deserve a chance, but ultimately it's not up to me to decide a driver line-up," he told reporters.

Mercedes team principal Toto Wolff has also previously backed De Vries for a seat in 2023, though conceded he is unable to help and the team may have to let him go with George Russell and Lewis Hamilton on their books.

"If we are not able to provide him [De Vries] with an interesting Formula One project, in a way we need to let him go," he told Sky Sports during the French Grand Prix weekend.

"He's looking at various options - sportscars and maybe Formula E, but you must never give up on the opportunity that one day a Formula One door can open. He has been very good and I can't really help him."

Alpine, Williams, Haas, Alfa Romeo and AlphaTauri are all yet to confirm their full driver line-up for 2023, leaving five spots on the grid.

The first domino in the Formula One driver market has fallen with Aston Martin's confirmation that Fernando Alonso will be driving for the team in 2023.

Sebastian Vettel's retirement announcement ahead of the Hungarian Grand Prix was always going to lead to movement on the grid but Alonso's move from Alpine is a significant statement of intent from the Silverstone-based team.

Alpine are currently vying for the best of the rest tag in 2022, alongside McLaren, while it has been a year to forget so far for Aston Martin – but they still boast one of the most recognisable brands on the grid and Alonso is a stellar acquisition.

There will be further movement, with a number of teams yet to confirm their full driver line-up for the 2023 season – with Alpine, Haas, Alfa Romeo, AlphaTauri having one spot open, while Williams have not confirmed either driver.

That leaves six seats up for grabs as it stands, with some of the outcomes easier to analyse than others – Alonso's departure from Alpine solves their headache as it leaves a slot open for reserve driver Oscar Piastri.

The Australian was already heavily tipped to take a seat on the grid for 2023 but, with Esteban Ocon and Alonso at Alpine, just where that spot would open was up for debate, with a Williams move touted, but it should now be a fairly easy decision.

For Williams, it could result in the continuation of their partnership with Mercedes. With Alex Albon expected to retain his seat, a replacement for Nicolas Latifi is on the agenda and the leading option may now be Nyck de Vries.

Toto Wolff had already conceded that De Vries, who is on their young driver programme, could be let go in order for him to open avenues in F1, but a seat becoming available at Williams would be perfect for all parties – potentially lining-up De Vries as Lewis Hamilton's long-term successor.

Another option for Williams is Jamie Chadwick, who has dominated the W series and has her eyes set on a seat in F1, though she has expressed doubt as to whether women can cope with the physical demands of the series.

Seats at Haas, Alfa Romeo and AlphaTauri are harder to assess but Mick Schumacher could play a pivotal role for the trio. Yet to be confirmed by Haas for 2023, the young Ferrari driver could make a sidewards move to continue his F1 career.

Given AlphaTauri's relationship with Red Bull, Alfa Romeo seems the more likely option for Schumacher if he was to depart Haas and an opportunity to drive alongside Valtteri Bottas could aid his development – though Alfa Romeo have a young talent of their own waiting in the wings in the form of Theo Pourchaire.

Felipe Drugovich, the runaway leader in F2 this season, and American Logan Sargeant are alternative options within the young driver ranks, while both have additional appeal due to their respective nationalities, Brazil and the United States, both of which are areas of growth for F1.

The break period in the F1 season is usually the time where teams line everything up for the next year, so the next few weeks before the season resumes in Belgium are likely to be extremely busy – and there could be some surprises in store.

Lewis Hamilton will step aside for the first practice session at the French Grand Prix this week to give Nyck de Vries his opportunity for Mercedes.

The Silver Arrows have confirmed that Dutchman De Vries will get his opportunity to get behind the wheel of the W13 at the Circuit Paul Ricard on Friday.

It is a mandatory Formula One ruling that rookie drivers get two practice sessions per season.

Mercedes tweeted on Friday: "This weekend @nyckdevries will be taking the wheel of W13 for FP1.

"Lewis has chosen this weekend to fulfil the first of two young driver sessions required by all teams this season. George [Russell] has selected one later in the year."

Hamilton secured three consecutive third-placed finishes before the mid-season break.

Mercedes boss Toto Wolff is hopeful the team can make further strides ahead of round 12 in France.

He said: "Third and fourth in Austria was a satisfying result for the whole team, particularly given the position we were in on Friday evening.

"The team worked miracles to have two complete race cars ready for the Sprint and Grand Prix. Twenty-seven points on Sunday were a good reward for that effort.

"We scored three podiums in the first seven races, and we have now achieved four in the last four. I'm pleased with the momentum we are building, and it reflects the mammoth effort of the team.

"Our understanding of the W13 is growing with every lap and it's encouraging to see that reflected in our development and results.

"While we were quicker in Austria, we still weren't quick enough to challenge at the front. We need to keep chasing those final few tenths and bringing new developments to the cars, including this weekend in France.

"Paul Ricard is a very different track and challenge. It has smooth tarmac and a wide range of corner types, along with long straights. The aim will be to make further inroads on the gap to the front and hopefully be back on the podium.

"Nyck is replacing Lewis in first practice this weekend, as part of the allocated sessions for young drivers this year. So, we're looking forward to seeing how he gets on."