Nick Foles will start for the Indianapolis Colts against the Los Angeles Chargers on Monday as Matt Ryan is benched for a second time this season.

Former Atlanta Falcons quarterback Ryan led the Colts through the first seven games, but was demoted after the 19-10 defeat to the Tennessee Titans in October with the team 3-3-1.

Sam Ehlinger started in his place but lost both games before Ryan was given the nod for the 25-20 road victory over the Oakland Raiders in Week 10, the first game under new head coach Jeff Saturday after Frank Reich was fired.

Indianapolis have gone 0-4 since that win though, including a stunning 39-36 defeat to the Minnesota Vikings on Saturday having led 33-0 at half-time.

The second-half collapse was the biggest in NFL history, with the Vikings scoring 29 unanswered points from 36-7 down to send the game to overtime, before Greg Joseph kicked a field goal to condemn the Colts to a dramatic loss.

That is likely to be Ryan's final game of the season and potentially his time in Indianapolis is over,

Foles won Super Bowl LII with the Philadelphia Eagles, toppling Tom Brady and the New England Patriots in a Super Bowl MVP-winning performance.

He has played for the Colts' AFC South rival Jacksonville Jaguars since then as well as the Chicago Bears, and gets another chance to start at the age of 33.

With Indianapolis 4-9-1 and likely to be officially ruled out of playoff contention this weekend, Saturday believes the change at quarterback is necessary.

"It's never an easy decision," Saturday told reporters. "[I] think the world of Matt, he’s a pro’s pro.

"It's not been the season he expected, nor the Colts as a whole.

"[I] just didn't feel we made enough plays offensively. This is not all on Matt.

"Ultimately I feel like Nick will give us a better chance to go win these last three games."