The San Francisco 49ers punched their ticket to the postseason as Ambry Thomas' overtime interception clinched a dramatic comeback win over the Los Angeles Rams.

San Francisco went into the Week 18 clash knowing a win would see them reach the playoffs for the second time in three seasons. A loss would allow the New Orleans Saints, who cruised past the Atlanta Falcons, to sneak in and claim the final Wild Card berth.

The latter outcome looked the more likely when the Rams surged to a 17-0 lead and, even though the Niners got a field goal before half-time, San Francisco still faced an uphill battle.

However, Deebo Samuel scored a touchdown on the ground and then threw another to Jauan Jennings on a trick play to tie things up.

A juggling interception of Jimmy Garoppolo by Jalen Ramsey in the endzone followed by a Matthew Stafford strike to Cooper Kupp put the Rams in a seemingly commanding position at 24-17.

However, Garoppolo - playing with a torn ligament in his right thumb - led a five-play, 88-yard drive that finished with him connecting with Jennings, forced overtime at SoFi Stadium.

The 49ers won the coin toss and a 12-play, 69-yard drive on which Jennings featured heavily set up a Robbie Gould field goal to give San Francisco the lead for the first time.

And it was an advantage they held as Stafford's deep shot for Odell Beckham Jr. was plucked out of the air by rookie cornerback Thomas to set up a mouth-watering Wild Card matchup with the Niners' historic rivals the Dallas Cowboys.

For Los Angeles, it is a sixth successive defeat to the 49ers, though they still won the NFC West after the Seattle Seahawks beat the Arizona Cardinals, whom the Rams will host in the opening round of the playoffs.

The Arizona Cardinals continued their excellent road form as they edged the Dallas Cowboys 25-22 in a potential-playoff preview with Kyler Murray leading the way on Sunday.

The Cardinals improved their season record to 11-5 and their road record to 8-1, snapping a three-game skid, with Texas-born Murray throwing two touchdowns as he completed 26 of 38 attempts for 263 yards.

The Cowboys had trailed 22-7 at the final charge but stormed back into contention as Dak Prescott threw three TD passes for the game but Murray expertly managed the clock late.

Murray found Antoine Wesley for two TDs including a spectacular catch in the third quarter, while Jonathan Ward made a remarkable helmet catch on a fake punt.

The Cowboys lost Michael Gallup to injury upon his second-quarter receiving touchdown and did not return, not helping their cause.

Prescott, who completed 24 of 38 passes for 226 yards along with 20 rushing yards, found Cedrick Wilson and Amari Cooper for final-quarter TDs to tighten the game but he also had a costly fumble at 22-14.

Chargers snap skid as Williams scores 101-yard return

The Los Angeles Chargers snapped a two-game skid with a 34-13 victory over the Denver Broncos to boost their Wild Card hopes as they improve to a 9-7 record.

Chargers quarterback Justin Herbert threw 22 of 31 passes for 237 yards with two touchdowns, breaking the franchise record for single-season touchdown passes at 35.

Andre Williams scored a 101-yard kickoff return touchdown in the fourth quarter, while Austin Ekeler returned to LA's line-up and was important, with 17 carries for 58 yards and a touchdown, along with three receptions for 54 yards.

Lance leads 49ers to key win in Wild Card race

Trey Lance stepped in for the injured Jimmy Garoppolo and provided two touchdown passes as the San Francisco 49ers won 23-7 over the Houston Texans.

Lance completed 16 of 23 passes for 249 yards with the two TDs and an interception to help the 49ers improve to 9-7 in the NFC Wild Card pursuit.

Deebo Samuel and Elijah Mitchell scored the touchdowns as the 49ers scored 20 second-half points to secure the win.

The New Orleans Saints do not know where they will open the NFL regular season, but they are doing all they can to stay focused after Hurricane Ida ravaged the city on Sunday. 

Ida made landfall on the Louisiana coast as a powerful Category 4 storm, 16 years to the day after Hurricane Katrina devastated the region. 

The entire city of New Orleans lost power on Sunday but Gayle Benson, who owns the Saints and the NBA's Pelicans, said in a statement Monday that her teams' facilities suffered only superficial damage.

The Saints relocated operations to the Dallas area over the weekend at the invitation of the Cowboys, and head coach Sean Payton said they will remain there at least through Wednesday. 

They are scheduled to host the Green Bay Packers in the regular-season opener on September 12, but Payton told reporters all options are on the table if playing at home is not feasible. 

"Obviously we’ll have a plan B," he said. "And, you know, there are a lot of other things probably from a priority standpoint that are more important for our city.

"But that all being said, we fully anticipate starting the regular season with Green Bay and then the question would be where that game's at."

Speaking to reporters before practice on Monday, Payton noted his team's concern over their homes and belongings left behind. 

"Left behind are obviously apartments, condominiums, homes. Those are all physical things. Nonetheless, they're still home for so many people," Payton said. "I think to some degree that going out and being able to practice today is going to be good for everyone, because from afar, there’s only so much you can do."

The Saints cancelled their final pre-season game, which was to be played at the Superdome against the Arizona Cardinals on Saturday.

NFL rules mandate teams give players this weekend off from practice, and Payton indicated he did not expect the Saints to be back at their home facility when work resumes next Monday. 

Benson said the Federal Emergency Management Agency has accepted the Saints' offer to use their facilities and will stage assistance efforts out of the NFL and NBA teams' practice facility in suburban Metairie. 

Benson also said she will donate $1million to a relief fund that will help the region recover from the storm. 

"Our team is safe and focussed on preparing for, and winning, the first regular game against the Green Bay Packers," Benson said. "We look forward to returning to New Orleans to continue those preparations as soon as our government leaders say it is safe to do so.

"Fortunately, the Caesars Superdome received only minor damage and will be prepared to host games as soon as the city's infrastructure will allow."

Drew Brees is a "legend" who will be sorely missed after announcing his retirement, fellow New Orleans favourite Zion Williamson said. 

Brees called time on his glittering 20-year NFL career on Sunday, with glowing tributes pouring in for the quarterback. 

And Pelicans star Williamson, fresh from a 135-115 win over the Los Angeles Clippers, praised someone whose welcoming words have stuck with him. 

Williamson was the top pick in the 2019 NBA Draft and received a special message from Brees, who has had a lasting impact on the 20-year-old.

"He's a legend in the game, I think everybody knows that he's a legend," said Williamson, who is 22 years Brees' junior. 

"He gave his heart and soul to the game. I know a lot of people are sad to see him go. 

"Drew told me I think the truest thing anybody has ever told me, my first game in New Orleans – you love your city, they'll love you right back. 

"Whenever new people come and visit, that's the same thing I tell them. That's the kind of influence he's had on me." 

Brees is a 13-time Pro Bowler and was MVP in the Saints' Super Bowl win over the Indianapolis Colts in February 2010. 

The 42-year-old retires as the all-time leader in passing completions (7,142) and passing yards (80,358).

Drew Brees has called time on his remarkable NFL career, announcing his retirement after 20 seasons.