Queensland emerged victorious in a pulsating series finale to reclaim the State of Origin shield in a thrilling 22-12 win over New South Wales in Brisbane on Wednesday.

The Maroons looked to be in danger of slipping to a fourth series defeat in the last five in their own backyard, after the Blues handed them a blowout defeat in Perth for Origin II following a narrow win in Sydney in Origin I.

But in one of the modern great deciders in series history, Billy Slater's wounded hosts held on in the final quarter of a bruising encounter to win at Suncorp Stadium in Origin III.

Both teams lost players to injury straight out of the gate, with New South Wales' Cameron Murray and Queensland duo Selwyn Cobbo and Lindsay Collins all forced off with head injuries in the first five minutes.

Despite being down two men, the Maroons still struck first through Valentine Holmes' tackle-busting dart out wide in the 12th minute, though the Penrith Panthers half-back combo of Nathan Cleary and Jarome Luai promptly combined for a Blues response six minutes later

Debutant Jacob Saifiti steamrollered through after repeat sets for the visitors to hand them the lead nine out from the break, but Queensland reduced the deficit to two heading into the interval after Kurt Capewell leapt onto a sublime Harry Grant grubber.

An ill-tempered start to the second half saw Dane Gagai and Matt Burton both sin-binned for a dust-up, before Ben Hunt helped quell a Blues resurgence with a superb 40-20, setting the stage for a chain of repeat sets eventually finished by Kalyn Ponga.

Grant looked to have potentially sealed the deal for the Maroons with a dozen minutes left on the clock, only for the bunker to chalk it off - but when Hunt picked off a last-gasp Cleary chip to go the length of the field with two minutes to go, the release of emotion around Brisbane ensured this would be remembered as one of the all-time series encounters.

New South Wales pulled level in the State of Origin series with an impressive 44-12 win against Queensland in Perth on Sunday.

After a dramatic defeat in Origin I in Sydney, it was imperative that the Blues bounced back, and they got the first points on the board from the boot of Nathan Cleary with a 12th-minute penalty.

The Maroons crossed for the first try of the night in the 23rd minute when Felise Kaufusi ran onto a well-timed Kalyn Ponga pass, though the Blues responded immediately as Cleary executed a smart kick to his left straight into the hands of Matt Burton, who went over.

Queensland came right back though as Ponga again created an opening with a quick run and delayed pass to Valentine Holmes, who handed off to Cameron Munster, the player of the match in Origin I, and he raced through to score.

The game turned when Kaufusi was sent to the sin bin for repeated infringements just before half-time, and it made an immediate difference as a swift move out to the left ended with Burton moving the ball on to Brian To'o, who sped to the corner, with Cleary adding the extras to make it 14-12 to the Blues at the break.

Brad Fittler's men began the second half in equally dominant fashion as the Blues took the game away from their tiring opponents, with Daniel Tupou and Jarome Luai adding further tries before the hour.

The floodgates opened as Cleary claimed two tries of his own to take the game away from Queensland, with Angus Crichton adding another before the end, sealing a dominant win to set up Origin III at Suncorp Stadium on July 13.

Queensland survived a late rally from New South Wales to claim a tense 16-10 victory in this year's State of Origin opener in Sydney.

New South Wales went into Origin I having won three of the last four series, and Jack Wighton crashed over in the 14th minute at Accor Stadium to give them a 4-0 lead.

But the Blues could not build on that advantage and the Maroons overturned it in the 34th minute when Dane Gagai pounced on Selwyn Cobbo's grubber kick and Valentine Holmes added the extras.

Junior Paulo looked to have quickly restored the Blues' lead, only for Cameron Murray to be penalised for obstruction and Queensland took control after the restart.

Daly Cherry-Evans side-stepped his way over as first receiver from the scrum eight minutes into the second half and Kalyn Ponga fed Holmes for Queensland's third try five minutes later.

Murray gave New South Wales hope nine minutes from time, but Queensland held on with a great defensive effort led by Man of the Match Cameron Munster, who helped secure the win for former Melbourne Storm and Maroons team-mate Billy Slater in his first Origin game as head coach.

The NRL has moved the final match of the State of Origin series to the Gold Coast due to coronavirus restrictions in Newcastle.

It means New South Wales Blues – who lead the series 2-0 after rampant victories in the opening two games – have the chance to win three State of Origin matches in Queensland to complete what would be an unprecedented clean sweep.

Game one of the series was scheduled to be played in Melbourne, only for COVID-19 restrictions to force a switch to Townsville.

While game two took place as planned in Brisbane, game three – which is next week – was moved from Sydney's Stadium Australia to Newcastle's McDonald Jones Stadium.

However, with Sydney and the surrounding areas in lockdown, New South Wales' regional government advised that a major event with a crowd would not feasible. 

Gold Coast has been selected as a low-risk option, with both teams located close to the Cbus Stadium, which will be able to welcome a capacity crowd of around 27,000.

Though it means all three matches will have been held in Queensland, Blues coach Brad Fittler is unfazed.

"It's disappointing that we can't play at Newcastle and play in front of a NSW crowd," Fittler said. "But we will play anywhere, anytime."

The Blues thrashed the Maroons 50-6 in game one, before winning game two 26-0.