Jenson Button will enter three NASCAR Cup Series races in 2023, debuting at Circuit of the Americas on March 26.
Button won the 2009 Formula One world championship with Brawn, later driving for Mercedes before leaving the series in 2017.
The Briton has since tried his hand at rival series but had not until now raced in NASCAR.
Button will drive Rick Ware Racing's No. 15 Ford Mustang in three races, following up his Austin, Texas bow with entries in the inaugural Chicago Street Race on July 2 and at the Indianapolis Motor Speedway Road Course on August 13.
"Obviously, racing a Cup car is very different than what I'm used to," Button said.
"It's a lot heavier, with a lot less power and, basically, no downforce. It's got a sequential gearbox where you need to blip the throttle, so there's lots of stuff to learn in a very short space of time.
"But I just get excited about that new challenge, and when I throw myself into something, I am 100 per cent in.
"I'm not just doing it for fun in some one-off. I want to be competitive, and I know that to be competitive, it's going to take a bit of time. That's why doing these three races works very well this season."