Shohei Ohtani has been hailed as the "most physically gifted baseball player ever" by Boston Red Sox pitcher Matt Barnes after inspiring the Los Angeles Angels to a dramatic victory at Fenway Park.

Two-way star Ohtani hit a two-out, two-run drive in the ninth inning of Sunday's MLB showdown as the Angels beat the Red Sox 6-5 in the series finale to snap a four-game losing run.

Ohtani entered the frame in the final inning along with Mike Trout and, after the latter hit a bloop single to keep the game alive, Ohtani smashed a home run off Barnes for his second homer of the series.

In doing so, Ohtani denied Barnes his 10th save of the season - only four others currently have more than nine - and the Red Sox closer was impressed by what he saw.

"I personally think he's the most physically gifted baseball player that we've ever seen," Barnes said in his post-game interview. "I don't know that you're ever going to see someone who can throw 100-101 (mph) and hit the ball 600 feet. 

"He's a special player and incredibly talented. Hopefully, he stays healthy and has a long career."

Ohtani now has 12 homers this season, which is the joint-most in MLB alongside Mitch Haniger, Aaron Judge and Ronald Acuna Jr.

After his inspired display against the Red Sox, the 26-year-old's RBI count stands at 29 - the joint-12th best in the division - and his batting average .262.

"Coming off a losing streak and the first two games of the series, the way we lost, it wasn't a good way to lose," Ohtani said through a translator.

"So, it was huge for us and the team to come up with this. We showed that we can beat any team."