Carlos Alcaraz, a 17-year-old wildcard, will face Rafael Nadal in the second round of the Madrid Open, with the top seeds set to get their campaigns underway on Tuesday and Wednesday.

Alcaraz, featuring in an ATP Masters 1000 event for just the second time, was in impressive form as he saw off France's Adrian Mannarino 6-4 6-0.

The teenager, who will face Nadal on his 18th birthday on Wednesday, fired 19 winners as he took the initiative against his more experienced opponent and his reward is significant.

He became the tournament's youngest ever match winner, beating the record set by Nadal.

"For me, [to] play against Rafa is a dream come true," Alcaraz said as he readies himself to go up against the 20-time grand slam winner.

"Since I was a kid, I wished to play a match against Rafa and now I will be able to here [on] the Centre Court of La Caja Magica in Madrid. It is a really special match against Rafa."

He told Tennis Channel: "It's the best present for my birthday."

The biggest casualty of the day was 13th seed Grigor Dimitrov, who lost 3-6 6-3 7-6 (7-5) to Lloyd Harris early on, the South African now 4-0 against top-20 opponents this year.

Two qualifiers in Pablo Andujar and Marcos Giron played out a remarkable encounter that lasted three hours and 21 minutes.

The first set alone clocked in at just over an hour and a half, but eventually Giron came through the gruelling clash 6-7 (8-10) 7-6 (7-4) 7-5 to set up a meeting with third seed Dominic Thiem.

Fabio Fognini defeated Carlos Taberner 7-6 (7-4) 2-6 6-3 for the right to face eighth seed and Italian countryman Matteo Berrettini.

Diego Schwartzman, the seventh seed, awaits Aslan Karatsev after he beat Ugo Humbert in straight sets in what was the Russian's debut appearance at the tournament.

Dan Evans and John Isner were among the other players to secure progress on Monday.

Denis Shapovalov relished feeling much better on court as he impressively bounced back from two consecutive defeats to win at the Madrid Open.

The number 11 seed brushed aside the challenge of Dusan Lajovic on Sunday, winning 6-1 6-3 in the first round.

Shapovalov had suffered disappointment on Thursday when he was knocked out in the second round of the Estoril Open, an event where he was the number one seed.

He has not reached the quarter-finals in his previous two ATP Tour events but won 90 per cent of his first-serve points against Lajovic, hitting 21 winners to his opponent's five.

"Just definitely felt a lot better - I felt very good on the court," Shapovalov said after a 63-minute win in which he did not lose serve. 

"I'm just happy to get the first win.

"Not much can change in the span of a couple of days, but Madrid is a place where I have had a lot of success, from back in juniors to making semis here in the Masters [1000 event] and finals of Davis Cup.

"It's just a place where it kind of feels like home to me and I just feel so comfortable." 

Shapovalov will face Alexander Bublik – who saw off Marton Fucsovics in straight sets – in round two.

Tommy Paul, meanwhile, will play Andrey Rublev after defeating Pedro Martinez.

In the only match of the day to go the distance, Australian Alex de Minaur battled back to triumph 4-6 7-5 6-1 against Jaume Munar.

He will play either Lloyd Harris or Grigor Dimitrov, who are scheduled to do battle on Monday.

Naomi Osaka suffered a shock second-round exit to Karolina Muchova at the Madrid Open, but there was no such trouble for Simona Halep as she held off Zheng Saisai.

Second seed Osaka was playing just her second match on clay since the 2019 French Open due to injury issues and became the latest big name to fall at the hands of Muchova.

The world number 20, who had already defeated two top-five players this season, prevailed 6-4 3-6 6-1 in a time of one hour and 49 minutes in the Spanish capital.

Osaka has now lost two of her last three matches, having been eliminated from the Miami Open quarter-finals by Maria Sakkari at the end of March.

"I think today for me it was quite different from the last time I lost in Miami, and I actually think I played much better here, so I'm very happy about that," Osaka said.

"I think what I can take away from this is that I tried my best throughout the entire match. I think tennis-wise, I felt I was too defensive in the first set.

"I wouldn't say I’m happy that I lost, but I think I learned a lot. So that's all I can hope for."

Two-time champion Halep has yet to drop a set in this year's tournament after seeing off unseeded opponent Zheng 6-0 6-4.

Halep took nine games in a row at the start of the match but, like in her opening-round win over Sara Sorribes Tormo, she had to hold off a late surge from her opponent to advance.

Next up for Halep is a last-16 showdown with Elise Mertens, who beat Elena Rybakina 7-6 (7-4) 7-5 in the last of Sunday's matches.

Fifth seed Aryna Sabalenka safely advanced earlier in the day thanks to a 6-3 6-3 win against Daria Kasatkina, while Sakkari beat Anett Kontaveit 6-3 6-1.

Sabalenka was on course to face Victoria Azarenka for a place in the quarter-finals, but the Belarussian withdrew from her match with Jessica Pegula because of a back injury.

Elsewhere, Jennifer Brady, who knocked out fellow American Venus Williams in the first round, eased past Jelena Ostapenko 6-2 6-1.

Brady faces a tricky test in the next round with Anastasia Pavlyuchenkova, who defeated sixth seed Karolina Pliskova 6-0 7-5, seeking another scalp.

Ash Barty overcame Tamara Zidansek and her own disjointed performance to reach the third round of the Madrid Open on Saturday.

The Australian triumphed 6-4 1-6 6-3 after nearly two hours on court to extend her winning streak on clay to 13 matches.

Barty will face reigning French Open champion Iga Swiatek in the next round, the 19-year-old having eased past Laura Siegemund 6-3 6-3 in a contest where she failed to take 10 match points before getting over the line.

Barty endured a more troubled contest with Zidansek, landing just 51 per cent of her first serves.

Zidansek lost the opener after a wayward forehand at 4-4 but was authoritative in the second as she won a set against a top-10 player for the first time.

However, a series of errors early in the decider allowed world number one Barty to open up a lead she did not relinquish. Barty was champion at Roland Garros in 2019 but skipped last year's Paris grand slam, so the clash with Swiatek will pit together the two most recent French Open winners.

"[It was] a really tough match," Barty said after edging out Zidansek. "I felt my margins were a little bit off. I made a lot of errors. I think I was missing in the right way, but still just a foot or two here or there makes a big difference. I felt like there were probably too many loose ones for me today.

"I don't think there was a lot in it by any means. We had a lot of close games in the first set, early in the second set. In the third, as well, there were a lot of close games. I think the response early in the third was good. I was a bit more aggressive, was able to bring the match back on my terms."

Petra Kvitova set up a meeting with Veronika Kudermetova – who knocked out defending champion Kiki Bertens – after overcoming long-time rival Angelique Kerber 6-4 7-5.

Kerber got the opening break in each set, only to drop serve in the next game, with Kvitova ultimately rewarded for powerful hitting as she ended the contest with 33 winners to her opponent's 14.

"I served very well, especially in the important points," said Kvitova, who leads the head-to-head record 8-6. "I think we really played very well. She even served very well, as well. It was tough to attack her serve."

Fifteenth seed Johanna Konta suffered a straight-sets loss to Anastasija Sevastova, while Ons Jabeur fought back to beat Sloane Stephens.

Naomi Osaka quickly adapted to playing again on clay as she was among the seeds to triumph in Friday's action at the Madrid Open.

Osaka had not featured on the red dirt since a third-round exit at the 2019 French Open, missing out on competing on the surface last year due to injury.

This year's Australian Open champion stumbled out of the blocks against Misaki Doi, quickly falling 3-0 behind in the opener, but recovered from the early setback to prevail in straight sets.

The second seed hit 26 winners in a 7-5 6-2 triumph over her compatriot, who has now lost all three of their meetings on the WTA Tour.

"You obviously want to play well against a player that's from the same country," Osaka said.

"I never really know what to expect because I feel like she always plays better when I play against her, so it's a bit tough to manage controlling my emotions. But I think I was able to do it pretty well."

Simona Halep also won in her opener at the event, the third seed racing through the first set before holding off a fightback from Sara Sorribes Tormo in the second.

Halep – who needed 83 minutes to clinch a 6-0 7-5 victory – has been crowned champion twice in Madrid, the first time coming in 2016 before she returned a year later to successfully defend the title.

Aryna Sabalenka wasted little time in seeing off the challenge of Vera Zvonareva, the fifth seed producing 37 winners in a 6-1 6-2 win, her first ever in the event.

Maria Sakkari found the going much tougher before eventually ousting Amanda Anisimova, losing the first seven games in a row before rallying for a 0-6 6-1 6-4 triumph.

Daria Kasatkina was also pushed in her opener, with a 4-6 6-4 7-6 (7-1) win over Irina-Camelia Begu taking just over three hours.

Karolina Pliskova had to go the distance after falling a set behind against Coco Gauff, while two-time finalist Victoria Azarenka came out on top in a deciding set against Ekaterina Alexandrova.

In the final match on a busy day, Jennifer Brady won 6-2 6-4 in an all-American clash with Venus Williams.