Rory McIlroy and Bryson DeChambeau were among the big names whose preparation for the 2022 Masters took a blow at the Valero Texas Open on Friday.
In the last week before the first major of the year, McIlroy, DeChambeau, Jason Day and Rickie Fowler all missed the cut.
With the cut line at one under par, McIlroy's second-round 73 left him one over, while DeChambeau was way off the pace at five over following his 76.
DeChambeau has not long returned from injury, finishing bottom of his group at last week's WGC-Dell Technologies Match Play, losing two of his three matches and tying the other.
When he started with a triple-bogey on Friday, it became clear the 2020 U.S. Open champion would not be continuing into the weekend in Texas.
Meanwhile, McIlroy had been in encouraging form a month ago, but his performances have gradually declined to the point an Augusta challenge again seems unlikely.
The Masters remains the only major McIlroy is yet to win.
While the big names faltered, world number 547 Kevin Chappell excelled, finishing his second round in a tie for second place, two shots behind leader Ryan Palmer.
Once a contender on the PGA Tour, Chappell's only win came at this event five years ago.
"I just feel at ease around this place," he said after shooting a 65. "My soul and this golf course get along. I really enjoy being here.
"I'm excited about where my game is because I don't think I've played great yet.
"It's not like the ball is coming out of the middle of the clubface every time and flying where I'm looking, but I've been able to scramble and get the ball in the hole."