Indianapolis Colts running back Jonathan Taylor has been placed on injured reserve, ending his season due to a right ankle injury.

Taylor suffered the injury on the Colts’ first possession of the game on a 13-yard reception in Saturday's 39-36 loss to the Minnesota Vikings.

Last season's NFL leading rusher's campaign is over as players must a minimum of four games on injured reserve, with the 4-9-1 Colts out of playoffs contention.

Taylor has battled ankle soreness all this year and has missed three games this season due to ankle issues.

Taylor entered Week 15 ranked 11th in the league with 861 rushing yards in 10 games. His 86.1 rushing yards per game this season ranks fourth in the NFL.

Indianapolis Colts running back Jonathan Taylor exited Saturday’s game against the Minnesota Vikings with a right ankle injury and was ruled out for the rest of the contest.

Taylor suffered the injury on the Colts’ first possession of the game on a 13-yard reception.

The leading rusher in the NFL last season, Taylor has battled ankle soreness all this year and has missed three games this season due to ankle issues.

Taylor entered Week 15 ranked 11th in the league with 861 rushing yards in 10 games. His 86.1 rushing yards per game this season ranks fourth in the NFL.

The injury left Zack Moss and Deon Jackson to handle duties in the backfield as the Colts looked to avoid a seventh loss in their last eight games.

Jonathan Taylor has been ruled out for the Indianapolis Colts' Week 9 clash with the New England Patriots, head coach Frank Reich announced on Friday.

The running back is out with an ankle injury and is one of four absentees against the Patriots, along with cornerback Tony Brown (hamstring), quarterback Matt Ryan (shoulder) and linebacker Grant Stuard (pectoral).

Deon Jackson filled in for Taylor in his previous absences in Weeks 5 and 6, rushing 25 times for 104 yards and a touchdown, as well as catching 14 passes for 108 yards in those two games.

He faces fresh competition in the backfield, however, following the arrival of Zack Moss – who was acquired in a trade with the Buffalo Bills on Tuesday that saw Nyheim Hines depart, with the Colts also earning a conditional sixth-round pick for the 2023 NFL Draft.

Moss had limited opportunities on the ground in Buffalo, recording 17 carries for 91 yards, and has not played since Week 5.

The Colts are on a two-game losing streak and sit 3-4 on the season, second in the AFC South behind the 5-2 Tennessee Titans.

The Indianapolis Colts have ruled running-back Jonathan Taylor out of contention for Thursday's clash against the Denver Broncos due to an ankle injury.

Taylor suffered a twisted ankle in Sunday's defeat to the Tennessee Titans but was hopeful that he would be able to feature in the opening game of Week 5.

"I definitely do plan to play, but if you can't go you can't go. That's why you have to get as much treatment as you can," he said on Tuesday.

However, the Colts announced on Wednesday that Taylor was among four players officially listed as out for the meeting in Denver, alongside safety Julian Blackmon (ankle), linebacker Shaquille Leonard (concussion/nose/back) and defensive end Tyquan Lewis.

Nyheim Hines is likely set to see increased usage on the ground in Taylor's absence, having largely been an aerial presence for the Colts this season – just 11 of his 124 yards in 2022 coming from rushing plays.

The Colts stand 1-2-1 for the season ahead of facing the Broncos, who they boast a 7-3 record against from their last 10 meetings.

Russell Wilson and Jonathan Taylor are both hopeful of being able to feature in Thursday's clash between the Denver Broncos and the Indianapolis Colts.

Broncos quarterback Wilson has been listed as 'limited' for team training at the start of the week with a shoulder injury but is "super confident" he will be able to take to the field against the Colts.

"I'm doing good, hanging in there. You get banged up a couple times here and there," he said.

Asked whether he feels he will be able to take to the field against the Colts, he added: "Yeah, I'm super confident."

Wilson has begun his Broncos career with a 61.1 per cent completion percentage, the lowest of his NFL career, throwing for 980 yards and four touchdowns.

Meanwhile, Colts running back Taylor was not as resolute with his fitness, having suffered a badly twisted ankle in Sunday's defeat to the Tennessee Titans.

"I definitely do plan to play, but if you can't go you can't go. That's why you have to get as much treatment as you can," he said on Tuesday.

Taylor has rushed for 328 yards in the opening four games of the season, scoring one touchdown, while adding 44 receiving yards.

Both sides have fallen beneath expectations at the start of the season, the Broncos 2-2 while the Colts are 1-2-1.

Jonathan Taylor's knee injury is reportedly not thought to be serious, though the Indianapolis Colts' star is a doubt for their clash with the Denver Broncos on Thursday.

Taylor was injured as the Colts' uneven start to the season continued with a 24-17 defeat to AFC South rivals the Tennessee Titans on Sunday.

The defeat dropped the Colts to 1-2-1, with Indianapolis once again struggling to justify considerable offseason hype.

An extended absence for Taylor, who last year led the NFL with 1,811 rushing yards and 18 touchdowns on the ground, would deal another substantial blow to the Colts' hopes of returning to the postseason.

NFL Media's Ian Rapoport calmed fears of Taylor being out for the long term, but pointed out that the tight turnround could make it difficult for him to feature in Week 5.

The Colts are only half a game back in the AFC South race, but another defeat to a conference opponent in the Broncos would leave them in a potentially much more significant hole.

For Taylor's part, he was unsure whether he would be healthy to feature in Denver.

He told reporters of his ankle injury: "It just tweaked up a little bit, but I'm feeling good now.

"It was a lot of commotion going on. Things just happen so fast on the field. It's crazy."

Asked about his status for the meeting with the Broncos, Taylor replied: "I'm not sure yet, but we'll see how things are tomorrow [Monday] morning."