Simona Halep eased to victory over compatriot Elena-Gabriela Ruse on home soil in Romania to advance through to the last 16 of the Transylvania Open.

Ruse won her first WTA title at the Hamburg European Open in July and reached the final of the Palermo Ladies Open later that month, but she was second best against Halep.

The top seed produced a commanding performance as she held serve throughout and broke her opponent twice in both sets to progress 6-1 6-2 in a time of 73 minutes.

Halep, who departed at the quarter-final stage of the Kremlin Cup last week, is on course to meet US Open winner Emma Raducanu in the semi-finals in Cluj.

Anett Kontaveit also prevailed on Wednesday with a straight-sets win of her own, the second seed seeing off Aleksandra Krunic 6-3 7-5.

The 25-year-old, seeking her third WTA 500 indoor trophy in the space of two months, made the most of some Krunic errors to set up a last-16 tie with Alison Van Uytvanck.

Anhelina Kalinina earlier beat Anna-Lena Friedsam 6-2 6-2 to become the first player to book their place in the quarter-finals.

At the Courmayeur Open in Italy, top seed Dayana Yastremska required three sets to overcome Kateryna Kozlova 6-1 3-6 7-5.

Clara Tauson and Ann Li also avoided upsets as they beat Giulia Gatto-Monticone and Kamilla Rakhimova respectively.

Daria Kasatkina suffered a first-round defeat against Anhelina Kalinina in the Kremlin Cup, while Jaqueline Cristian stunned Tamara Zidansek at the Tenerife Open.

World number 28 Kasatkina, who has won four WTA Tour titles, fell on home soil to Kalinina as the Ukrainian triumphed 6-2 6-3 on Monday.

Ajla Tomljanovic cruised past Liudmilla Samsonova in similar fashion, claiming a 6-2 6-4 victory in Moscow to set up a last-16 clash with top seed Aryna Sabalenka, who is ranked second in the world.

Anna Kalinskaya joins Tomljanovic in the next round as she defeated Dayana Yastremska 7-6 (7-5) 6-4 on home soil and the Russian will now face French and US Open semi-finalist Maria Sakkari.

Lesia Tsurenko had no issues against China's Qinwen Zheng as she won 6-4 6-3, while American Bernarda Pera beat Aleksandra Krunic 7-6 (7-3) 6-3 to seal her second-round berth.

Meanwhile, number two seed Zidansek, who sits 33rd in the world rankings, crashed out in Tenerife as world number 108 Jaqueline Cristian succeeded 7-5 4-6 6-1.

Zhang Shuai was the sixth favourite in Spain but she lost to fellow Chinese star Wang Xinyu 6-2 6-1, with Anna Karolina Schmiedlova also defeating Kaja Juvan 4-6 6-1 6-4 and Irina-Camelia Begu overcoming Marta Kostyuk 6-4 6-4.

Dayana Yastremska says she is "astonished" after the world number 29 was provisionally suspended for failing an out-of-competition doping test.

The International Tennis Federation (ITF) on Thursday revealed Yastremska was charged on December 22, having tested positive for mesterolone metabolite in a sample taken on November 24.

Ukrainian Yastremska, who reached a career-high 21st in the rankings 12 months ago, says she is not guilty of any wrongdoing and will do all in her powers to clear her name.

The 20-year-old posted on Twitter: "I firmly state that I have never used any performance-enhancing drugs or any prohibited substances.

"I am astonished and under shock, particularly given that two weeks prior to this test - on 9 November 2020 - I tested negative at the WTA event in Linz. After this last tournament of the year, I stopped practising to rest prior to the start of the new season.

"Only a very low concentration of mesterolone metabolite was detected in my urine. Given that low concentration and given my negative test two weeks earlier, I have received scientific advice that the result is consistent with some form of contamination event.

"Besides, I have been informed that this substance is meant for use as medication by men and that women are advised not to use it due to the adverse effects it causes."

Yastremska said she was "resolutely determined to do everything to clear my name".

Rising star Yastremska has three WTA singles titles to her name.

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