Barry Bonds missed out again on baseball's Hall of Fame as David Ortiz was elected in his first year on the ballot.

For a 10th year, the vote of the Baseball Writers' Association of America (BBWAA) did not give sufficient backing to San Francisco Giants great Bonds, the player with the most home runs in Major League history (762).

Bonds will no longer feature on future BBWAA ballots, but he could still reach the Hall of Fame through a different route.

Players required votes from 75 per cent of the baseball writers, and Ortiz got there after securing 77.9 per cent support. That amounted to a vote of approval on 307 of the 394 ballots, but Bonds could only draw 66 per cent (260 votes).

Boston Red Sox great Ortiz, a Dominican-American who struck 541 home runs across his MLB career, began his career with the Minnesota Twins but came to the fore in Boston where he spent 14 seasons from 2003 to 2016.

Now 46, Ortiz was a 10-time All-Star and three-time World Series winner during his Red Sox career. Players are eligible for Hall of Fame nomination after five years in retirement.

Popularly known as 'Big Papi', Ortiz's election was praised by Bonds, who wrote on Instagram: "CONGRATULATIONS Big Papi on your induction into the Hall of Fame! Well deserved…I love you my brother."

Joining Bonds in missing out during a 10th year of eligibility were Roger Clemens (65.2 per cent), Curt Schilling (58.6 per cent) and Sammy Sosa (18.5 per cent).

They and Bonds could yet secure Hall of Fame status via the Today's Game Era Committee, which will meet in December to consider players who have made an impact on the sport since 1988.

Ortiz will be joined in being officially inducted in Cooperstown this July by six selections from the Golden Days and Early Baseball Era committees. They are Jim Kaat and Tony Oliva, along with the late Bud Fowler, Gil Hodges, Minnie Minoso and Buck O'Neil.

Bonds was a seven-time National League MVP in a career that spanned 1986 to 2007, beginning at the Pittsburgh Pirates before he moved on to San Francisco from 1993. He experienced controversy surrounding performance-enhancing drugs allegations, but Bonds has always insisted he did not knowingly use any such substances.

The San Francisco Giants expressed disappointment at Bonds missing out, posting on Twitter: "We remain hopeful that he will gain election into the National Baseball Hall of Fame through the next phase of the voting process."

Alex Rodriguez and David Ortiz are among the newcomers on the ballot for the Baseball Hall of Fame's Class of 2022, which was announced Monday by the Hall.

Their arrival coupled with 2022 being the last year on the ballot for Barry Bonds and Roger Clemens guarantees questions about how the game should grapple with the legacy of performance-enhancing drugs will remain at the forefront for another election cycle.

Ten-year members of the Baseball Writers' Association of America (BBWAA) can vote for up to 10 of the 30 players on this year's ballot, and a candidate must receive at least 75 per cent of the votes to be elected. Results will be announced on January 25. 

The BBWAA did not elect anyone last year, with Curt Schilling coming the closest at 71.1 per cent followed by Bonds (61.8) and Clemens (61.6). 

All three will be in their 10th and final year on the writers' ballot, along with Sammy Sosa. 

Bonds, Clemens and Sosa have seen their candidacies stall thanks in part to long-standing rumours of PED use, and Rodriguez and Ortiz could face similar hurdles. 

Unlike the others, Rodriguez was suspended for violating MLB's drug policy, missing the entire 2014 season, while Ortiz reportedly was among the players who tested positive during unofficial survey testing in 2003. 

Voters will have to weigh that against their impressive on-field accomplishments. Rodriguez is one of the best hitters the game has ever seen, a three-time American League MVP and 14-time All-Star whose 696 home runs and 2,086 RBIs rank fourth in baseball history. 

Ortiz was a 10-time All-Star who led the Boston Red Sox to three World Series titles after a decades-long drought for the franchise and remains one of the most beloved figures of his era. 

Other first-time players on the 2022 ballot include longtime first baseman Mark Teixeira, 2007 National League MVP Jimmy Rollins, 2006 AL MVP Justin Morneau, 2007 NL Cy Young Award winner Jake Peavy and the man who won that award the next two seasons, Tim Lincecum. 

Closers Joe Nathan and Jonathan Papelbon, catcher A.J. Pierzynski, speedy outfielder Carl Crawford and slugger Prince Fielder also are on the ballot for the first time.

Players must get at least five per cent of the vote each year to remain on the ballot for the following election. 

Other holdovers from previous ballots back this year include Scott Rolen (52.9 per cent last year), Omar Vizquel (49.1), Billy Wagner (46.4), Todd Helton (44.9) and Gary Sheffield (40.6). 

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