Danilo D'Ambrosio suffered a strain to the medial collateral ligament in his left knee against Sampdoria on Wednesday, Inter have confirmed.

Defender D'Ambrosio was introduced as an 81st-minute substitute against Samp and was on the end of a strong challenge from Mehdi Leris deep into stoppage time.

The 32-year-old's leg appeared to buckle under the tackle and he was left in clear pain, although medical staff were able to help the player to his feet to walk off the pitch in the final moments of the 2-1 defeat – Inter's first in nine matches.

A statement on Thursday detailed the nature of the injury after medical tests.

"His condition will be reassessed next week," the Nerazzurri said.

Wednesday's match was D'Ambrosio's 11th appearance of the season, of which only four have been starts. He has scored three goals from defence but contributed to just a single clean sheet.

The Golden State Warriors are not overly concerned by Stephen Curry's ankle issue in the defeat to the Los Angeles Clippers as the superstar point guard is confident it will not prove a major setback.

Curry's outstanding run of form was checked in Wednesday's 108-101 reverse at Chase Center.

The two-time NBA MVP had scored a career-high 62 points against the Portland Trail Blazers and then added another 30 versus the Sacramento Kings in the Warriors' past two games.

Yet Curry contributed only 13 points against the Clippers, bringing his season average down to 29.6, and shot one-of-six from beyond the arc.

More concerningly, Curry was not able to finish the game as he complained of an ankle problem in the fourth quarter and exited with just over a minute remaining.

But head coach Steve Kerr had positive news for Golden State fans, who have already seen Klay Thompson condemned to another long-term lay-off after the team's 2019-20 season was wrecked by injury woes.

"He did tweak it. He told me it's not serious," Kerr said on Wednesday. "He'll come in tomorrow and get treatment and we'll check it out.

"The good news is Steph does not think it's anything too serious."

The Warriors had led earlier in the fourth quarter despite Curry's failure to make an impact, with each of their five starters finishing with a negative plus/minus.

Kerr's second unit instead led the way, as Eric Paschall scored 19 points in 20 minutes, but the Golden State coach paid tribute to the Clippers' defensive effort.

"There was not a ton of rhythm or flow," he said. "We played a team that's going to be – at full strength, like they were tonight – one of the best defensive teams in the league, with a ton of length.

"They did a really good job. I thought they played an excellent defensive game. They hounded Steph and we couldn't find a rhythm."

Kerr reserved praise for his own defense, too, describing Draymond Green as "the best defensive player in the world" after he weighed in with six defensive rebounds and two steals.

And the coach suggested this was a key reason for a slow start to the game, although he was asked if the riot on Capitol Hill earlier in the day had also contributed.

"There was a strange energy in the air at the beginning of the game and that may have been a factor," Kerr said, having addressed the issue at length prior to tip-off.

Bradley Beal insisted "I don't give a damn" after tying a franchise points record for the Washington Wizards in their defeat to the Philadelphia 76ers.

Beal's career-high 60 points on Wednesday could not prevent a 141-136 loss at Wells Fargo Center as the Wizards slipped to 2-6 for the season.

The 27-year-old was 20-of-35 on shooting, including seven-of-10 from three-point range, as he equalled Gilbert Arenas' franchise best against the Los Angeles Lakers back in 2006.

Still, the two-time All Star took little pride in recording a personal best in another loss.

"I'm p***** off," Beal said. "I'm mad. I don't count [them]. Any of my career highs, they've been in losses. So I don't give a damn. You can throw it right out the window with the other two or three I've had.

"I just want to win. Sometimes you might be able to score 40, 50, 60, whatever the case may be, but I just want to win, whatever that looks like. We came up a little bit short."

Beal's spectacular 57 points in the first 36 minutes proved futile as Philadelphia closed out a high-scoring contest, making 61.7 per cent from the field throughout.

Washington tied the scores at 119 each after having trailed by 10 at the start of the fourth quarter, but Joel Embiid led the 76ers to a strong finish, sinking a three-point jumper from 28 feet.

"I think they got stops and made more plays than we did down the stretch," Beal said when asked what made the difference late on. "I think Embiid hit a tough three... they were making a lot of shots. They hit a lot of tough shots.

"They shot 60 per cent from the field and 62 per cent from three. You can't win a game like that."

For Embiid, it was all part of the service.

"They pay me to take over the game," he said after making 38 points, eight rebounds and five assists. "They pay me to dominate. That's my job.

"I always give credit to my teammates. [But] I finished."

Kai Havertz was dubbed the 'Crown Prince of German football' while at Bayer Leverkusen but the Bundesliga club have a new star now: Florian Wirtz.  

While his former club colleague has struggled so far to make an impact at Chelsea, Wirtz - the latest young gem to come through at Leverkusen - is dazzling for Peter Bosz's team, who remain ensconced in the top four despite defeats either side of the mid-season break in Germany's top flight. 

The 17-year-old did not wait long to suggest he could be the heir apparent, either. Having made his debut in May 2020, he became the youngest goalscorer in Bundesliga history the following month, finding the net in a 4-2 defeat to Bayern Munich after coming on as a substitute. Youssoufa Moukoko has since snatched that record away.

This season, Wirtz has gone from the periphery to centre stage, scoring twice and providing four assists in 13 appearances. His transition from promising talent to first-team regular has been swift, leading to comparisons to Havertz, the playmaker who swapped the BayArena for Stamford Bridge.

However, for Bosz, while both players have huge potential, the duo differ in so many ways.

"I never compare players with each other because that is impossible. There is no player like the other," Bosz told Stats Perform News. "You can't compare them. That's not possible.

"I also won't do that with Florian Wirtz, because he has his own style. He is different from Kai Havertz, who is more of a striker. Florian Wirtz, as far as I am concerned, is a midfielder, so you can't compare them.

"Also, you can't compare them physically; Kai is 1.92metres (6ft 3in), Florian is shorter. One is left-footed, the other one right-footed. They both have their own style. But both of them are very good. Both are very talented. Both have a huge career ahead of them.

"And Florian is only 17 years old. What he has shown though in the Bundesliga already is something special."

Wirtz has been a part of a Leverkusen squad that has impressed so far in this campaign, both at home and abroad. 

Despite a first defeat to Bayern Munich before the mid-season pause in Germany, Leverkusen gathered 28 points from their opening 13 league games. Only three times have they managed to collect more points across the same period - and on each of those occasions they went on to finish in the top four.

In the Europa League, Die Werkself finished top of Group C to qualify for the last 32 in style, winning five of their six round-robin fixtures. Having reached the quarter-final stage of the competition last year, when they lost 2-1 to Inter, hopes are high they can go further this time around. 

But while there has been much to please Bosz and Leverkusen's supporters so far, the Dutch coach insists there is still plenty more to come from his squad.

"Everyone still has some space to improve," he said, insisting no player has reached a nine out of 10 yet. "The difference to last year is that we are very consistent now.

"We deliver stable performances. It means that we concede less goals. We stand more compact on the pitch.  

"But we have also lost important players. Kai Havertz went to Chelsea, Kevin Volland to Monaco. I think that our team spirit has improved. This is the biggest step ahead." 

Despite Havertz no longer being around, Leverkusen have been excellent going forward, with champions Bayern the only team to score more in the Bundesliga so far. Their attacking intent has not come at a considerable cost defensively either - only second-placed RB Leipzig have conceded fewer goals.

The emergence of Wirtz has been one of the factors in helping Leverkusen continue to progress as a club, even with those key departures in the previous transfer window.

"He's a very talented young player. He has a lot more to improve. But, you know, he's only 17," Leverkusen winger Leon Bailey told Stats Perform News about his talented young team-mate.

"He's still learning. But he has a lot of qualities that a lot of older players don't have yet. And that's something you can see clearly, and this is something that's special. 

"And I think, as the years go by, he will only get better. There is a lot more to come from him, as he understands more and get a lot more experience.  

"I would say he's very smart. He has a lot of quality when he's on the ball. And he has a great passing ability."

Bailey's assessment is backed up by Wirtz's output, with no Leverkusen player having created more chances from open play than his tally of 23. While his passing accuracy is perhaps lower than might be hoped for at 73 per cent, his touches in the opposing box (31) and passes into the final third (55) are examples of his forward thinking when in possession. 

Those risks have reaped their rewards this term too, considering his six goal contributions so far. Bosz clearly has faith in him, as only goalkeeper Lukas Hradecky and Moussa Diaby have played more minutes in the Bundesliga so far. 

Any suggestion of becoming the new Havertz may be wide of the mark, but the future looks bright for Wirtz, the latest jewel to emerge at Leverkusen. 

The Boston Celtics edged the Miami Heat in the NBA on Wednesday, while the Milwaukee Bucks claimed their third straight win.

In a rematch of last season's Eastern Conference finals, the Celtics overcame the Heat 107-105 in Miami.

Jayson Tatum (27 points) and Jaylen Brown (21 points and 12 rebounds) led the Celtics (6-3) to their win.

But Payton Pritchard (six points) made the decisive lay-up with 0.2 seconds remaining to secure the win.

The teams kneeled in protest ahead of the clash, in response to a riot on Capitol Hill and after no charges were brought against the police officer who shot and seriously injured Jacob Blake, a black man, in Kenosha in August last year.

Meanwhile, the Bucks made it three straight wins by easing past the Detroit Pistons 130-115.

Giannis Antetokounmpo guided Milwaukee into a 5-3 record with 25 points, eight rebounds and four assists.

Hayward heroic, Beal brilliance not enough for Wizards

Gordon Hayward scored a career-high 44 points to see the Charlotte Hornets past the Atlanta Hawks 102-94.

Bradley Beal equalled a Washington Wizards record, but it was not enough. Beal tied the franchise record with 60 points in a 141-136 loss to the Philadelphia 76ers.

Joel Embiid once again inspired the 76ers, scoring 38 points to go with eight rebounds and five assists as they improved to 7-1.

A 35-point haul from Malcolm Brogdon helped the Indiana Pacers beat the Houston Rockets 114-107.

Curry cools off

After 92 points in the previous two games, Stephen Curry cooled off. He went five-of-17 from the field for 13 points in 35 minutes as the Golden State Warriors fell to the Los Angeles Clippers 108-101.

Beal ties record

Beal was in spectacular form for the Wizards. He equalled Gilbert Arenas' record of 60 points for the Wizards against the Los Angeles Lakers in 2006.

Wednesday's results

Indiana Pacers 114-107 Houston Rockets
Orlando Magic 105-94 Cleveland Cavaliers
Philadelphia 76ers 141-136 Washington Wizards
Charlotte Hornets 102-94 Atlanta Hawks
Boston Celtics 107-105 Miami Heat
New York Knicks 112-100 Utah Jazz
Milwaukee Bucks 130-115 Detroit Pistons
Oklahoma City Thunder 111-110 New Orleans Pelicans
Phoenix Suns 123-115 Toronto Raptors
Los Angeles Clippers 108-101 Golden State Warriors
Sacramento Kings 128-124 Chicago Bulls

76ers at Nets

The 76ers will look to continue their good start to the season when they take on the Brooklyn Nets (4-4). The Nets will again be without star Kevin Durant, who is in quarantine.

Pep Guardiola said John Stones had proven he belongs at Manchester City after a derby win over United in the EFL Cup semi-finals.

Stones scored his first City goal since November 2017 and Fernandinho sealed a 2-0 win at Old Trafford on Wednesday as the three-time defending champions booked a spot in the final against Tottenham.

The City defender, who was relieved to see the flag raised after the ball bounced off him and into his own net during the semi-final, has been in good form this season, and his six possessions gained against United were the equal best for his side.

City manager Guardiola was full of praise for Stones, who had appeared on the outer at the club before beginning to impress.

"He came back and he made another outstanding performance – but the most important thing is he can do something he hasn't been able to do – play four, five, six games in a row. This is important," he told a news conference.

"He had to handle [Marcus] Rashford, who is dangerous and clever, and the quality of his passes to Joao [Cancelo] were outstanding. All the team, Fernandinho, our captain, what a performance again. He read the game incredibly well, he moved the team. Outstanding.

"All the players – [Ilkay] Gundogan, Raheem [Sterling], Phil [Foden] ... all the team."

Guardiola added: "All credit [to Stones]. Football is a long career – it is up and down, sometimes bad moments. He was out longer than we expected but he came back and he absolutely belongs here.

"We can help him but when someone plays like this, it's credit to him. Hopefully he can continue in this way."

Bradley Beal equalled the Washington Wizards' franchise record with 60 points in a loss to the Philadelphia 76ers on Wednesday.

Beal exploded for 60 points on 20-of-35 shooting, including seven-of-10 from three-point range, in a 141-136 loss to the 76ers.

The guard equalled Gilbert Arenas' record of 60 points for the Wizards against the Los Angeles Lakers in 2006.

Russell Westbrook was the Wizards' next highest scorer with 20.

But Washington slipped to 2-6 after Joel Embiid (38 points) and Seth Curry (28) led the way for the 76ers (7-1).

Barcelona coach Ronald Koeman believes Lionel Messi is slowly getting back to his best after a brace against Athletic Bilbao.

Messi scored twice, to go with Pedri's goal, at San Mames on Wednesday as Barca recorded a 3-2 victory.

The star has been involved in 10 goals in his past 10 games in all competitions, netting eight and assisting two.

And Koeman feels Messi, who has netted 12 times in 20 appearances this season, is improving.

"Since the first day that I arrived at the club I think Lionel Messi has given everything," he told a news conference.

"I haven’t been surprised by his quality because he's obviously been showing how good he is for years. It's possibly true that he's been less effective than normal which is why there could have been doubts but he's doing a lot better now, he feels comfortable at the moment and he feels up for the challenge.

"That's how I feel. But I think Messi is the one who can answer that best."

Pedri cancelled out Inaki Williams' opener before Messi's double, and Barca moved into third in LaLiga despite Iker Muniain's late goal.

Koeman also praised Ousmane Dembele, who along with Pedri and Antoine Griezmann had a game-high three key passes.

"I think everything starts with the player himself. If the player feels comfortable and feels physically fit he can play well," he said.

"I don't think there's ever been any question about his quality, at least in my opinion, but there have been doubts about his ability to stay fit. At the moment he seems fully fit and I have to think about the programme of games ahead and when we can give him a rest because he hasn't played regularly for quite some time.

"He has to learn how to manage his game time as well. But in terms of the football he can play we know what he can give to the team. He's very good going forward, he attacks with the ball and those are good qualities for us."

Barca, who are seven points behind league leaders Atletico Madrid and have played two more games, visit Granada on Saturday.

Ronald Koeman believes Barcelona demonstrated they are on the right track by overcoming an early setback to win 3-2 at Athletic Bilbao.

Inaki Williams raced clear to put the hosts, who had Marcelino in charge for the first time, in front inside three minutes of Wednesday's LaLiga clash.

However, Barca responded impressively, goals from Pedri and Lionel Messi putting them in front by the break before the latter increased their lead just after the hour mark.

Koeman had to endure a nervy finish after Iker Muniain's 90th-minute finish, but promised his squad will "fight until the last match" in LaLiga after moving up to third in the table.

"The final result is a bit short because we have been superior in many phases," Koeman said, having now recorded three away wins on the spin in LaLiga for the first time in his reign.

"They made it 1-0 and we did not have the defensive coordination, but then we controlled [the game].

"I am happy with the result and with how we have achieved it. We have deserved it. Winning because of our game and our opportunities.

"The teamwork has been phenomenal. We will fight until the last match. There is distance [to go], but we are on the right track." 

Messi will understandably dominate the agenda having scored twice, but Koeman was also quick to praise the performance of Pedri, who completed over 90 per cent of his attempted passes.

The teenage midfielder scored the equaliser, heading in Frenkie de Jong's cutback cross with goalkeeper Unai Simon out of position, while it was his backheeled pass that set up Messi to make it 2-1.

"Pedri is showing despite his youth that he is very mature," the Dutchman said in his post-match interview.

"Messi has always shown his desire but today also with goals. It is very important."

Messi's long-term future at Camp Nou may be unclear but his recent form has shown no lack of commitment to the cause; he has been involved in 10 goals in his last 10 games in all competitions.

Barca are next in action on Saturday, when they visit Granada.

Copious injuries, late positive COVID-19 tests and a suspension; a highly anticipated clash between Serie A leaders Milan and defending champions Juventus at San Siro on Wednesday threatened to seriously underwhelm.

There was no Alvaro Morata for the Juve, while full-backs Alex Sandro and Juan Cuadrado were forced to sit out after returning positive coronavirus results.

Milan were without star striker Zlatan Ibrahimovic and their midfield was decimated by the absences of Sandro Tonali (suspension), Ismael Bennacer (injury) and Rade Krunic (coronavirus). The dire situation forced Stefano Pioli to start right-back Davide Calabria alongside Franck Kessie in the central pivot.

Yet despite the difficulties faced by both teams, a thriller was served up in Milan, and Federico Chiesa took centre stage as Milan's unbeaten streak in Serie A was ended at 27 by a 3-1 loss to Juve.

ACT ONE

The last time Milan held a superior position to Juve heading into a meeting of the sides was in November 2015, and on that occasion the Bianconeri emerged triumphant thanks to a goal from Paulo Dybala.

While the Argentina international, who has been struggling for consistency and dealing with a fever, was not the man to open the scoring on this occasion, he still played a pivotal role.

After drifting across the pitch to offer support to Chiesa, he held up a pass from the winger before returning it by dragging the ball back behind his standing leg and flicking it around Alessio Romagnoli.

It was weighted perfectly for Chiesa's dart into the box, which was not tracked adequately by Theo Hernandez, and he drilled a shot across Gianluigi Donnarumma into the bottom-left corner.

ACT TWO

A thoroughly entertaining first half saw Juve control possession but Milan get more shots away. There were 21 in total during the opening 45 minutes, 12 for the Rossoneri and nine for Juve, a number only two Serie A games this season have exceeded (Sassuolo v Cagliari – 22, Cagliari v Napoli – 23).

Wojciech Szczesny kept out Samu Castillejo, Rafael Leao and Hakan Calhanoglu, as well as stopping Aaron Ramsey from scoring what would have been an incredible own goal, before he was finally beaten by the unlikely source of Calabria.

Juve did not appear happy the goal was allowed to stand, with Calhanoglu putting in a contentious challenge on Adrien Rabiot to launch the counter-attack from which Leao fed Calabria to guide a fine finish into the top-right corner.

It ensured Milan found the back of the net for a 36th consecutive Serie A game – a run only bettered by Juve (43 in 2014 and 44 in 2017) – with Leao involved in an eighth goal in 12 league appearances this season, one more than he managed across the entirety of the previous campaign.

ACT THREE

Unsurprisingly the game was far less open after the interval, but Chiesa was able to separate the teams once more.

Again it was Dybala leading the supporting cast, spotting his team-mate in space on the right and drilling a pass across for him to attack Hernandez once more.

Just as in the first half, Chiesa's feet proved too quick as he shifted the ball to his left and threaded a curling shot between Hernandez and Romagnoli and into the bottom-left corner. It was his sixth goal involvement (three scored, three assisted) against Milan in Serie A, which is more than he has managed against any other side.

The 23-year-old is proving himself to be a man for the big occasion. Since the start of last season, he has been thoroughly impressive against the best teams in the league. In that time, he has had a hand in three goals against Milan (two scored, one assisted) and Atalanta (two scored, one assisted) and also scored in meetings with Inter, Napoli and Lazio.

THE UNDERSTUDIES

While Cristiano Ronaldo was arguably the quietest of Juve's forward-thinking players, Chiesa made way for Dejan Kulusevski a minute after his goal, as Weston McKennie entered for Dybala.

The pair combined to put the game to bed in the 76th minute, McKennie sweeping in after a fine run down the right from Kulusevski.

The sole consolation for the Rossoneri was that they remained top of the league due to Inter's defeat to Sampdoria earlier on Tuesday, but Chiesa's blockbuster display proved Juve will not be content with solely being extras in the title race this season.

Federico Chiesa scored a brilliant brace as Juventus ended Milan's unbeaten start to the season and clinched a crucial 3-1 victory that moves the Serie A champions up to fourth in the table.

Andrea Pirlo's men produced a scintillating attacking display to become the first team to beat leaders Milan in the league in 28 matches and did so without leading scorer Alvaro Morata.

Ably assisted by Paulo Dybala on both occasions, Chiesa scored with confident finishes in either half and Milan's waves of attacking pressure found Juventus goalkeeper Wojciech Szczesny in fine form before Davide Calabria found the net.

The Bianconeri, who added a third through substitute Weston McKennie, will hope this was a turning point in a tumultuous season, having played with the guile and poise they have lacked for so much of it, while Milan will reflect on a missed opportunity to extend their lead at the top to four points after Inter lost to Sampdoria.

Juventus' high press overwhelmed Milan early on and Paulo Dybala tested Gianluigi Donnarumma from six yards before Chiesa crashed a thunderous shot onto the post.

With 18 minutes played the Old Lady's superb start paid dividends, Dybala's smart back-heel sending Chiesa into the area and the Fiorentina loanee sent a low shot bouncing into the far corner of Donnarumma's net from 12 yards.

Juve had Szczesny to thank for keeping them ahead with a string of saves but he was powerless to stop Calabria's shot from finding the top corner after the lively Rafael Leao teed him up – although Juventus claimed Adrien Rabiot was fouled in the build-up.

Szczesny got down well to save Diogo Dalot's powerful 20-yard shot as Milan came out firing after the interval but Juve weathered the storm before Aaron Ramsey missed a golden chance to give them the lead, shooting wide from close range with just Donnarumma to beat.

Just after the hour mark, Chiesa struck again, Dybala picking him out on the edge of the box where he bent a superb left-footed shot into the far corner.

Chiesa then left the field with an injury and was replaced by McKennie, who swept home Juventus' third in the 76th minute after a jinking run through Milan's defence by fellow substitute Dejan Kulusevski.

What does it mean? The fightback is on

Juventus have now won three of their last four Serie A matches and are playing with real verve.

Having had such a short pre-season with his side, Pirlo has been playing catch-up but his expansive, fast-attacking style of play seems to be finally bearing fruit as his players cut out defensive errors.

Dybala at his best

Dybala's two assists were as incisive and spectacular as Chiesa's finishes and the Argentina international also won six duels to help Juventus stay on top.

Leao rues missed chances

Milan could have been ahead at half-time had Leao made more of the clear-cut chances that fell to him and, despite his assist for Calabria's goal, he will remember this game for his three unsuccessful shots at goal.

Key Opta Facts

- Juventus have won 14 of their last 16 Serie A games against AC Milan (L2).
- AC Milan are enjoying the third-longest streak of Serie A consecutive matches with a goal: 36. In the history of the competition, the only two longer streaks have both been by Juventus: 43 in 2014 and 44 in 2017.
- Federico Chiesa has been involved in six Serie A goals against AC Milan (3 goals, 3 assists).
- Prior to Wednesday, the last time a player twice assisted the same Juve team-mate was in February 2018 against Sassuolo (Federico Bernardeschi to Gonzalo Higuain).

What's next?

Milan are at home against struggling Torino on Saturday, and Juventus entertain in-form Sassuolo a day later.

Paris Saint-Germain failed to get off to a winning start under Mauricio Pochettino as they were held to a 1-1 draw by Saint-Etienne in Ligue 1.

Thomas Tuchel oversaw a 4-0 defeat of Strasbourg in PSG's final game of 2020, although it was not enough for the German to keep his job as the defending champions sat third.

And Pochettino was unable to mastermind a victory to kickstart his reign as a rather lethargic PSG struggled to build on Moise Kean's 22nd-minute equaliser.

That goal cancelled out Romain Hamouma's opener, but PSG were ultimately fortunate Saint-Etienne did not snatch a first win over the capital club since 2012, their point enough to move second but three points behind Lyon.

Both goalkeepers were called into action inside the opening 10 minutes as Keylor Navas denied Harold Moukoudi at one end before Moise Kean tested Jessy Moulin at the other.

Yet Pochettino's tenure had its first setback 19 minutes in when PSG played themselves into trouble, Idrissa Gueye's slip pounced on by Denis Bouanga, with Hamouma supplying a neat finish over Navas.

PSG hit back inside three minutes, however, as Marco Verratti played in Kean to slam in the first goal of the Pochettino era on the turn.

Mathieu Debuchy's low strike forced Navas into a smart stop before half-time, and PSG's goalkeeper came to their rescue again in the second period, blocking Bouanga's path to goal.

Navas was beaten with 20 minutes remaining, but the crossbar kept out Bouanga's header.

Kean snatched at a good chance as PSG sparked back into life, yet Angel Di Maria's low strike – well saved by Moulin – was the only shot on target the visitors managed in the second half as Pochettino was forced to settle for a point.

John Stones ended his long goal drought as holders Manchester City secured a 2-0 derby win over Manchester United to set up an EFL Cup final showdown with Tottenham.

Stones has been outstanding at the heart of the City defence since forcing his way back into the side this season and he scored his first City goal in 1,162 days at Old Trafford on Wednesday.

The in-form centre-back had earlier put the ball in his own net early on but Marcus Rashford was offside, summing up how his fortunes have changed.

United were unable to respond following Stones' goal early in the second half and Fernandinho doubled City's lead seven minutes from time with an excellent finish.

Pep Guardiola's side were worthy winners, dumping their neighbours out at the same stage they did 12 months ago as they aim to win the competition for a fourth consecutive season.

Diego Simeone hinted at the idea he could leave Atletico Madrid at the end of the season after their awful Copa del Rey defeat to third-tier Cornella.

Simeone's LaLiga leaders exited the Copa on Wednesday, losing 1-0 to a goal from former Atletico B defender Adrian Jimenez.

Ricard Sanchez was sent off as Atleti slumped to a shock reverse swiftly described by the Spanish media as a "disaster" among the very worst of Simeone's 502 games in charge of the club.

The long-time coach named a strong side, including record signing Joao Felix, but saw his team remarkably unable to register a single shot on target.

Copa failings are a familiar story by now, though, with the Rojiblancos losing to Cultural Leonesa last season. Meanwhile, they have not beaten a fellow LaLiga outfit in the competition since seeing off Elche in January 2017.

Simeone recognised Atleti are struggling in one-off knockout matches - also losing in last season's Champions League to RB Leipzig - but added the surprising qualifier that it would be an issue to consider only if he was still at the helm next year.

"[Cornella] played better," he said. "In the whole game, what they wanted was always done better than what we wanted.

"They took advantage of the set-piece situations and immediately found the goal.

"The boys tried to compete in the best way. In the first half, we had more chances, and in the second, it was rockier. It got difficult after the red card.

"This competition has not given us satisfaction in recent years but solutions will have to be found if we are here next year."

Saul Niguez, captain on the night, identified the same problem as he added: "We apologise to the fans. We never throw away competitions, but in these single-game editions we are not doing well."

Given Atleti's struggles, the decision to replace Joao Felix with 18-year-old debutant Mario Soriano 15 minutes from time prompted some discussion.

But the Portugal international mustered only one shot, which was blocked, prior to his withdrawal and failed to create a single chance - unlike his replacement.

Joao Felix epitomised the visitors' display as he completed just 13 of his 21 attempted passes and lost possession 13 times, winning none of his three aerial duels.

The change still appeared a big call, yet Simeone explained his star forward was struggling with an ankle injury.

"He was hurt," Simeone said. "We looked for a fresher guy. He had a bruised ankle and we wanted to find a guy in good condition."

Atletico Madrid were the victims of a Copa del Rey giant-killing for a second successive season as Diego Simeone's side went down 1-0 to Cornella.

LaLiga leaders Atleti lost 2-1 to Cultural Leonesa in the round of 32 last season, and slumped out to Segunda B opposition on Wednesday.

The 10-time Copa winners fell behind to Adrian Jimenez's sensational flick seven minutes into the second-round tie in Catalonia.

Saul Niguez hit the woodwork and Lucas Torreira went close with a free-kick, but Ricard Sanchez's second booking compounded Atleti's issues as minnows Cornella claimed a famous triumph.

Sanchez was fortunate not to concede a penalty for handball in the opening minutes, before Jose Gimenez, making his 200th Atleti appearance, scythed down Raul Prieto.

With Gimenez, who was booked for his troubles, off the pitch receiving treatment, Cornella added insult to injury, with Agus Medina's cross flicked home expertly by Jimenez.

Atleti seemed set to restore parity shortly after the 20-minute mark, yet Angel Correa saw two efforts blocked either side of Saul hitting the crossbar.

Though Atleti were seeing over 60 per cent possession, they would have been 2-0 down heading into the break if not for Miguel San Roman's save from Pablo Fernandez.

Vitolo got in behind Cornella's backline early in the second half, only for an errant offside flag to deny him a chance to equalise.

Torreira's curling free-kick was inches away from levelling proceedings, though Atleti were then fortunate that Eloy Gila flicked over from close range at the other end.

Sanchez's frustrating night was made worse when he was deemed to have kicked out at Cornella goalkeeper Ramon Juan – the full-back seeing red just 11 minutes after receiving his first booking as Atleti's comeback efforts proved futile.