Zlatan Ibrahimovic feels Milan have become "fragile" and is seeking an instant response to Saturday's 3-0 thrashing against Atalanta when they take on fierce rivals Inter next.

Previously unbeaten in 27 league matches stretching back into the 2019-20 season, Milan have now lost two of their last four games - they also went down 3-1 to Juventus earlier this month. 

Goals from Cristian Romero, Josip Ilicic and Duvan Zapata condemned Stefano Pioli's side to their latest defeat, but they are still top at the midway point of the season as closest challengers Inter could only manage a 0-0 draw with Udinese. 

However, Ibrahimovic accepts being winter champions will count for little unless Milan regain some consistency and end their decade-long wait for Scudetto success. 

"We lost two games after more than 30 matches that we didn't lose," he told Sky Sport Italia.  

"The team is a bit fragile because when certain players are missing, we lack a bit of experience. They are replaced by young players, but this is no excuse.  

"We make many sacrifices; we work and we are first for a reason.

"But being top at this stage does not matter. We are halfway through the championship, so far we have done well but still nothing this is the most difficult period because there are so many games and now we just have to continue." 

Asked if Tuesday's Coppa Italia quarter-final with Inter has now taken on even more importance, Ibrahimovic said: "We have to redeem ourselves after this defeat.  

"We have the chance to do it in a few days and then against Inter. That will be a good match." 

Milan's club-record run of scoring in 38 successive league games was ended in Saturday's loss at San Siro, a game in which the Rossoneri managed only two shots on target. 

Ibrahimovic was unable to test Pierluigi Gollini with any of his five efforts, while his 36 touches of the ball were the fewest by any home player to take part in the entire game. 

The veteran striker, who has 12 goals in nine league outings this term, admitted afterwards that he felt isolated up front. 

"In the first half I was too alone in attack," he said. "I didn't have anyone close to support me, but it could also be because of the pressure from Atalanta that put us in trouble.  

"Today many things were missing, it was not our day. Now the important thing is to recover and think about the next match to redeem ourselves."

Roma head coach Paulo Fonseca said the club will discuss the error made in the Coppa Italia upset against Spezia after the club used six substitutes.

Spezia shocked Roma 4-2 after extra time in the Italian capital, where Fonseca's side capitulated and sensationally made one substitution too many in the last 16 on Tuesday.

Roma would have been eliminated by default even if they won at home to Spezia after Fonseca introduced Ibanez for Pedro in extra time, having already made five changes to his line-up.

Fonseca's Roma believed they could use six substitutes – an additional change in extra time as seen in cup competitions – but that was not the case in the Coppa Italia.

Asked about the mistake at Stadio Olimpico, under-fire boss Fonseca – who oversaw a humiliating 3-0 derby loss to Lazio in Serie A on Friday – said post-match: "If there is an issue, we have time to discuss that internally. If there is."

Fonseca was looking to bolster his defence after centre-back Gianluca Mancini was shown a second yellow card in the 91st minute, and goalkeeper Pau Lopez saw red just seconds later.

With Roma down to nine men, Spezia capitalised on their numerical advantage as Riccardo Saponara and Daniele Verde struck in extra time.

Roma had rallied from 2-0 down inside 15 minutes to force extra time via Lorenzo Pellegrini's 43rd-minute penalty and Henrikh Mkhitaryan's fine finish with 17 minutes remaining.

Hosts Roma conceded two goals during the first 15 minutes of play, in all competitions, for the first time since January 2020 as they were eliminated in the Coppa Italia round of 16 for just the third time in the last 20 seasons – twice against Spezia.

It was also the first time since 2015-16 that Roma played extra time in the Coppa Italia.

"We had a bad start to the game; the penalty, and then another moment that's hard to really understand," Fonseca said. "But the team responded, they played well, they created chances and it could have been a different result.

"We missed so many chances and so then, with two men sent off, it all became much harder."

"It's a tough moment. We wanted to go further in the cup, but I can't say anything bad about the attitude of the players. We have to now focus on the next game," Fonseca continued.

Pressure is mounting on Fonseca, who was appointed in 2019, but the Portuguese tactician said: "My future has been up for discussion ever since I got here. I am encouraged by the position we have in the league right now – it's where we want to be – and I have confidence in my team. But when we don't win I am always being discussed. I have to stay focused on my job."

Roma – winless in three matches across all competitions having conceded nine goals – are fourth in Serie A, nine points behind leaders Milan through 18 games.

Hamza Rafia scored the winner on his debut as Juventus needed extra time to beat Genoa 3-2 and reach the quarter-finals of the Coppa Italia.

A much-changed Juve side were a cut above Serie A strugglers Genoa in the first half at Allianz Stadium on Wednesday, but made hard work of setting up a last-eight tie against Sassuolo or SPAL.

Dejan Kulusevski was outstanding in the opening 45 minutes, scoring inside two minutes and laying on a second goal for Alvaro Morata.

Lennart Czyborra pulled a goal back from out of the blue in an otherwise one-sided first half and Filippo Melegoni later equalised, but 21-year-old Tunisia international Rafia came off the bench to settle the tie late in the first half of extra time.

Romelu Lukaku hopes Inter are learning as they continue to struggle to perform consistently over 90 minutes despite sitting second in Serie A and reaching the quarter-finals of the Coppa Italia.

Lukaku headed an extra-time winner to see off Fiorentina 2-1 in the Coppa on Wednesday, his 119th-minute goal settling a tie in which Inter had led at half-time through Arturo Vidal's penalty.

A dominant first 45 minutes had seen the Nerazzurri attempt eight shots to Fiorentina's one, while having 56.6 per cent of the possession.

But Christian Kouame equalised after 57 minutes, prior to Lukaku's introduction as a substitute, as the Viola outshot their visitors nine to six in the second period.

For Inter, it was a second successive match in which they lost the initiative, even if Lukaku's goal this time meant they advanced to face Milan in the last eight.

At Roma on Sunday, despite trailing at half-time, quickfire goals from Milan Skriniar and Achraf Hakimi had Antonio Conte's men in front before they conceded a late leveller.

Ahead of the Roma game, Conte had bemoaned Inter's inability to make fast starts, having led at the interval just four times in Serie A this term.

But Lukaku is now concerned by his team's displays from half-time onwards, a period in which they have scored an impressive 30 goals and conceded just 12 in the league.

"I don't know why it happens," Lukaku told Rai Sport. "We already said it after the draw against Roma that it shouldn't happen, but it happened, even if we still won this time.

"We are young, we must learn from these things, but we want to improve."

Having booked the meeting with Milan, a fixture he was reluctant to immediately discuss, Lukaku acknowledged there were still positives.

"We are happy to have won a difficult match against a great coach [Fiorentina's Cesare Prandelli]," he said. "We are happy and we want to continue like this."

Turning focus back to Serie A, Inter face champions Juventus next on Sunday, with the Derby d'Italia rivals determined to win to keep the pressure on leaders Milan.

"I expect a tactical match between two teams who are doing good things," Lukaku added. "Juventus are a big team. We want to prepare well for this match."

Substitute Romelu Lukaku rescued Inter with a 119th-minute winner to knock Fiorentina out of the Coppa Italia with a 2-1 win for the second season running.

Lukaku started from the bench ahead of Sunday's Derby d'Italia against Juventus but was called for in the second half after Christian Kouame had cancelled out Arturo Vidal's penalty opener.

There was no immediate impact as the Nerazzurri sought to get their season back on track, having taken just a point from their prior two Serie A matches.

Yet Lukaku made his mark deep into extra time at the Artemio Franchi, powering a header past Pietro Terracciano to book Inter's place in the quarter-finals.

Stefano Pioli was glad to see Zlatan Ibrahimovic get another 45 minutes under his belt in Milan's penalty shoot-out win over Torino.

Ibrahimovic, 39, made his return from injury off the bench against the same opponent in Serie A on Saturday, but started and played 45 minutes three days later as Milan reached the Coppa Italia quarter-finals with a 5-4 penalty shoot-out victory.

Milan head coach Pioli was happy to see the forward, who has scored 10 goals in seven Serie A matches this season, get more game time after being out for seven weeks.

"We wanted to give him a longer time compared to the previous championship game. We preferred to let him play from the beginning due to his characteristics," he said, via Sky Sport.

"This time will be used to improve his condition in view of the next championship match."

The clash at San Siro finished 0-0 before Hakan Calhanoglu scored the decisive penalty in the shoot-out after Ciprian Tatarusanu had denied Tomas Rincon.

It meant Milan reached the Coppa Italia quarter-finals for the 12th consecutive season.

"I am lucky to have a team that knows how to fight, knows how to play, knows how to grit its teeth in a difficult match even for the qualities of our opponents," Pioli said.

"For the many occasions we had, we could have avoided even reaching penalties, but we went beyond physical and mental fatigue and this is a desired qualification."

Milan, who are three points clear atop the Serie A table, visit Cagliari on Monday.

Milan booked a place in the quarter-finals of the Coppa Italia with a penalty shoot-out victory over Torino at San Siro following a goalless draw after extra time.

The Serie A leaders eased to a 2-0 win when the sides met in the league on Saturday but found it a lot tougher to break down their opponents - 28 points worse off in the league - in Tuesday's cup tie.

Zlatan Ibrahimovic squandered the best early opening on his first start since November 22 and Milan then dominated the second half, twice hitting the post and having a penalty shout turned down.

Neither side could find a way through in the additional 30 minutes, but it was the hosts who prevailed on spot-kicks to set up a tie with Fiorentina or Inter - Hakan Calhanoglu scoring the decisive penalty after Ciprian Tatarusanu had denied Tomas Rincon.

Paulo Dybala could be out for almost three weeks after suffering a knee injury against Sassuolo on Sunday, Juventus have confirmed.

The Argentina international was replaced by Dejan Kulusevski in the 43rd minute of Juve's 3-1 Serie A win at the Allianz Stadium.

The club confirmed on Monday he has suffered a "low-grade lesion of the medial collateral ligament" in his left knee and will be out of action for "approximately 15-20 days".

The 27-year-old looks certain to miss the Coppa Italia clash with Genoa on Wednesday, the Supercoppa Italiana against Napoli next week and Serie A games versus Inter and Bologna. He could also miss another league game against Sampdoria on January 30.

Juve's only Serie A defeat this season came when Dybala was not in the side. Their win ratio without him is 40 per cent compared to 63.6 per when he features.

When going back to the start of the 2019-20 campaign, Juve have lost as many times in the 10 league games without Dybala (four) as they have in the 44 in which he has taken part – their win percentage sliding from 72.7 to 30 in his absence.

Juve also confirmed Weston McKennie and Federico Chiesa underwent tests on Monday, which revealed neither player is suffering from a serious injury.