Furious Nigeria supporters stormed the pitch at the National Stadium in Lagos after rivals Ghana sealed a World Cup spot at the expense of the Super Eagles.
Arsenal's Thomas Partey opened the scoring in the 10th minute for Ghana, before William Troost-Ekong levelled from the penalty spot for the hosts midway through the first half.
Nigeria could not find a crucial second goal, however, with Otto Addo's Ghana side holding on for the 1-1 draw, to progress to Qatar 2022 via away goals after a 0-0 draw in the first leg.
The result sparked ugly scenes inside the stadium, with videos on social media showing supporters leaving their seats and smashing equipment at the side of the pitch.
There was heartbreak for Mohamed Salah and Egypt after they suffered another dramatic penalty shoot-out defeat to Senegal.
Hosts Senegan recovered from a 1-0 first-leg deficit to beat Egypt by the same margin at the Abdoulaye Wade Stadium, before Salah, with dozens of laser pens seemingly pointing at his face, fired Egypt's first penalty of the shoot-out over the bar.
Mostafa Mohamed later failed with the visitors' fourth kick, allowing Salah’s Liverpool team-mate Sadio Mane to slam his penalty past Mohamed El Shenawy and seal Senegal's progress, in a repeat of February's Africa Cup of Nations final triumph.
"We try our best but today was not enough," he wrote. "To all my players and my staff, [I give] my recognition and humble thank you.
"You will be always in my heart. It was my privilege to work and be helped by such dedicated and capable professionals and wonderful friends."
There was stunning late drama in Bilda as Karl Toko Ekambi scored late in extra time to seal a 2-1 win for visitors Cameroon against Algeria, the Indomitable Lions progressing to Qatar via away goals after a 2-2 aggregate draw.
Algeria thought they had sealed a place at the World Cup when Ahmed Touba cancelled out Eric Maxim Choupo-Moting's opener with two minutes remaining in extra time, but there was just enough time left for Ekambi to seal the most dramatic of victories.
Morocco also booked their place in Friday's World Cup draw with an emphatic 4-1 win over Democratic Republic of Congo. A brace from Azzedine Ounahi, as well as goals from Tarik Tissoudali and Achraf Hakimi, sealed a 5-2 aggregate win over DR Congo, who scored a late consolation through Ben Malango.
Meanwhile, a 0-0 draw for Tunisia against Mali was enough to see the former seal their own place in Qatar after they managed a 1-0 win in the first leg.