Eduardo Escobar and Edwin Diaz came up big as the New York Mets beat their cross-town rival Yankees in what could be a potential World Series rehearsal on Tuesday, emerging with a 6-3 win.

Kicking off a highly anticipated Subway Series, with 2015 being the last time the two teams lead their respective divisions, the Mets made the big plays amid a charged atmosphere in Queens.

Back-to-back home runs from Anthony Rizzo and Aaron Judge put the Yankees up 2-0 in a thrilling first inning, with the Mets rallying back with four runs in their opening frame, including Escobar's huge two-run, two-out shot off Jordan Montgomery.

Before extending their lead to 6-3 in the eighth inning, Diaz came in to close for the Mets, striking out four and giving up a solitary hit for his 22nd save out of 25.

Running away with the American League at one point, the Yankees now only lead the Houston Astros by two games on 66-32, while the Mets moved to 60-37 and within five of the National League-leading Los Angeles Dodgers.

Springer slam propels Blue Jays

Though his team trail the Yankees by 11.5 games in the AL East, George Springer hit the seventh grand slam of his career, as the Toronto Blue Jays claimed a 10-3 win over the St Louis Cardinals.

The Cardinals were without Paul Goldschmidt and Nolan Arenado, whose unvaccinated status prohibits them from entering Canadian soil, with Alejandro Kirk hitting his 12th homer of the year.

It was not enough against the Blue Jays, who notched up a tie-breaking five-run sixth inning via Springer's slam and Matt Chapman's RBI single, to extend their winning streak to seven games.

Pinder punches second slam of the night in A's win

The Houston Astros were not able to capitalise on the Yankees' defeat and edge closer in the AL standings, with the Oakland Athletics earning a 5-3 win.

The best and worst records in the AL West faced off and the latter reeled off a four-run third inning to get the eventual win, with Chad Pinder slugging a grand slam of his own off Luis Garcia.

The A's are now one game away from a shock three-game series sweep against the Astros, who remain stuck on 64-34.