The Los Angeles Chargers' ability to challenge for the NFC West will be put to the test when they take on the Cincinnati Bengals in Week 13. 

Los Angeles have won three straight games since a defeat to the NFC-leading Arizona Cardinals and can ill afford a slip-up against a Bengals side that are challenging in the AFC North. 

The Kansas City Chiefs have finally hit their stride but face a tough test when the Denver Broncos visit Arrowhead Stadium, while Monday sees a battle for supremacy in the AFC East between the New England Patriots and the Buffalo Bills. 

We've run down some of the standout stats from the biggest games in Week 13. 

Los Angeles Chargers (6-5) @ Cincinnati Bengals (7-4) 

The Bengals will be hopeful of avenging their 16-13 loss to the Chargers in Week 1 – their second straight defeat to Los Angeles. However, Cincinnati won their four other meetings since the 2010 season and are riding high after a resounding 41-10 victory over the Pittsburgh Steelers last time out. 

It was only the third time the Bengals beat the Steelers by 30 points or more, with the last occurrence being all the way back in September 1989. 

An early kick-off on the east coast will be tough for the Chargers to navigate, particularly after a 28-13 loss to the Denver Broncos in Week 12. They had three rushing first downs against the Broncos, making it the fourth game in which they have had that many or fewer this season – the third most in the NFL. 

They may continue to rely on quarterback Justin Herbert to help them get points on the board. His 438 passing attempts this season places him third in the NFL, behind only Tom Brady (457) and Patrick Mahomes (449). 

The Chargers defense will need to keep a close watch on Joe Mixon, though. The running back had a career-high 165 rushing yards and 11 first downs in Week 12. 

Denver Broncos (6-5) at Kansas City Chiefs (7-4)  

Not only have the Chiefs won four straight after a 3-4 start, but they've also come out on top in 11 straight meetings with the Broncos – a run that stretches back to Week 10 of 2015. One more victory will make it the longest winning streak against a single opponent in the team's history. 

The game will have big implications on the playoff hopes of both sides, while the Broncos could move off the bottom of the AFC West and replace the Chiefs at the summit with a victory. 

Kansas City will hope Mahomes can restore the levels of production seen previously. He did not have a rushing or throwing touchdown in the 19-9 win over the Dallas Cowboys last time out, his second such game in his past five outings. In the 51 games before this run, he had a TD in 50 of them. 

He has still led an offense that has had 30 drives with 10 or more plays this season – the most in the NFL. Though the Chiefs' ability to get the ball out of their opponents' hands (they have allowed the fifth fewest drives with 10 or more plays this season) could be counteracted by Teddy Bridgewater's excellence under pressure. 

Bridgewater has a league-best completion percentage (77.6) to go with seven TD passes and no interceptions when facing the blitz this season. 

New England Patriots (8-4) at Buffalo Bills (7-4) 

The Bills dethroned the Pats in the AFC East in 2020 and could do with a home win to boost their chances of retaining the crown this year. 

New England fell to a 24-21 loss to the Bills on their last trip to Buffalo but are 15-2 across their previous 17 visits. They are also head into Monday's matchup on the back of a six-game winning streak. 

The game appears set to be played in frigid conditions and some stingy defenses may make for tepid action too – the Bills (182) and Patriots (190) are ranked first and second respectively for fewest points allowed this season. The Bills have allowed just 182 points while the Patriots have given up 190. 

Mac Jones threw for a career-high 310 yards in last week's win against the Tennessee Titans, but Buffalo made it 21 straight games in which they have had at least 300 yards of offense when the defeated the New Orleans Saints 31-6 on Thanksgiving. 

Stefon Diggs has been key for the Bills. He had 74 receiving yards against the Saints – his ninth game with at least 60 this season, behind only Cooper Kupp (11) and Justin Jefferson (10). 

Elsewhere... 

The Cardinals (9-2) are up against the Chicago Bears (4-7) at Soldier Field on their return from their bye week. The road team has won each of the last five meetings between these teams dating back to Chicago’s 20-point comeback on Monday Night Football in Arizona in Week 6, 2006. 

The New York Giants (4-7) will be hoping to stop the Miami Dolphins (5-7) make it five wins on the bounce. The Dolphins are the only team in the NFL this season to have had both a four-game winning streak and a four-game losing streak. 

Tom Brady leads the league in passing attempts (457), completions (309) and touchdowns (30) this season and will be hoping to steer the Tampa Bay Buccaneers (8-3) to victory at the Atlanta Falcons (5-6) 

The Seahawks (3-8) have lost eight games in a season for the first time since 2011, ending a franchise-record run of nine years with seven or fewer losses. However, they will no doubt be up for a grudge match against the San Francisco 49ers (6-5).