Tua Tagovailoa threw three interceptions before leaving with a concussion and James Cook had three touchdowns as the Buffalo Bills rolled to a 31-10 rout of the Miami Dolphins on Thursday night.

Tagovailoa, who has a history of dealing with head injuries, collided with Bills defensive back Demar Hamlin in the third quarter on a fourth-down keeper and hit the back of his head against the turf.

He remained down for about two minutes before getting to his feet and walking to the sideline. Tagovailoa made his way to the tunnel not long afterward, looking into the stands, appeared to smile and departed for the Dolphins' locker room.

The Dolphins needed almost no time before announcing it was a concussion.

Tagovailoa positioned himself for a big pay bump with an injury-free and productive 2023. He threw for 29 touchdowns and a league-best 4,624 yards.

Cook caught a 17-yard touchdown pass from Josh Allen and scored on runs of 1 and 49 yards in the first half, flipping into the end zone when he gave the Bills a 24-7 lead.

Allen, playing with a glove on his left non-throwing hand after hurting it in Buffalo's opener, completed 13 of 19 passes for 139 yards. He's 12-2 against the Dolphins and the Bills are 14-2 against Miami since coach Sean McDermott’s first year as head coach in 2017.

Miami’s star receiver Tyreek Hill was held to three catches for 24 yards during a week in which he dominated national headlines. Hill was pulled from his sports car by Miami-Dade County police officers, pushed face-first onto a street and handcuffed during a traffic stop outside the Dolphins’ home stadium hours before their season opener.