The New York Jets have had a nightmare start to their preseason with second-year quarterback Zach Wilson limping out of Friday's 24-21 win over the Philadelphia Eagles.

Wilson suffered a right knee injury in the first quarter, buckling without contact as he scrambled out of the pocket trying to outrun a tackler.

The 23-year-old Jets QB fell, got up limping, before dropping to the turf again and exiting for the locker room.

Wilson had thrown an interception on the Jets' fifth play, finishing the game completing three of five passes for 23 yards.

The injury concern is to the same knee that he sustained a PCL sprain last season, causing him to miss four games.

Jets head coach Robert Saleh revealed Wilson would have an MRI on Saturday to determine the extent of the injury but said his ACL was "supposed to be intact".

The Jets have high hopes for their 2021 NFL Draft second pick, building their roster around him this offseason, having bolstered their offensive ranks with tight ends C.J. Uzomah and Tyler Conklin and drafting wide receiver Garrett Wilson and running back Breece Hall.

Wilson had a difficult rookie season with a 3-10 record, completing 213 of 383 attempts for nine touchdowns and 2,334 yards with 11 interceptions for a 55.6 completion rate.

There were other injury worries from Friday's preseason games with Atlanta Falcons wide receiver Drake London hurting his right knee in their 27-23 win over the Detroit Lions.

San Francisco 49ers running back Elijah Mitchell watched on in their clash with the Green Bay Packers after suffering a hamstring injury during their camp.

Cincinnati Bengals quarterback Brandon Allen, covering for Joe Burrow who is recovering from an appendectomy, was ruled out due to a concussion in their 36-23 loss to the Arizona Cardinals.