Jarren Duran hit a tiebreaking two-run homer in the fifth inning and the American League scored five unanswered runs to defeat the National League 5-3 in the All-Star Game on Tuesday night in Arlington, Texas.

Shohei Ohtani staked the National League to a 3-0 lead with a three-run homer in the third inning off Tanner Houck, but the American League answered in the bottom half with three runs of its own.

Juan Soto doubled home a pair of runs and scored on pinch-hitter David Fry’s hit one out later.

Hunter Greene opened the bottom of the fifth by getting the first two outs, but Anthony Santander singled and Duran sent an 0-1 pitch 413 feet into the right-center field seats to give the AL a 5-3 lead.

Duran was named All-Star Game MVP.

Mason Miller struck out two in a perfect inning to earn the win and Cole Ragans, Seth Lugo and Kirby Yates each worked one scoreless inning before Emmanuel Clase fanned two in the ninth for the save.

Paul Skenes, 22, became the fifth rookie to start an All-Star Game and pitched a hitless first inning. His 11 big league games are the fewest for an All-Star.

The AL has won 10 of the last 11 All-Star Games and improved to 48-44-2 all-time in the Midsummer Classic.

Elias Diaz belted a two-run homer in the eighth inning and the National League snapped a nine-game losing streak to the American League with a 3-2 win in the MLB All-Star Game on Tuesday.  

With the National League trailing 2-1, Nick Castellanos led off the eighth with a walk against Felix Bautista and moved to second on a wild pitch before Diaz deposited a 2-2 offering over the wall in left field.

It was the first All-Star at-bat for Diaz, the Colorado Rockies catcher who was named MVP.

The NL won the All-Star Game for the first time since an 8-0 victory in 2012.

Yandy Diaz opened the scoring for the AL with a second-inning home run off Mitch Keller and the NL tied it in the fourth on Luis Arraez’s RBI single.

Bo Bichette’s sacrifice fly in the sixth scored Salvador Perez and put the AL back on top.

Craig Kimbrel walked two in the ninth but struck out Jose Ramirez to end it.

Toronto Blue Jays closer Jordan Romano left in the seventh inning due to back tightness.

Despite the American League's (AL) 3-2 win in the MLB All-Star Game on Tuesday, Clayton Kershaw relished pitching the opening inning, conceding it "meant a lot" to him.

After nine All-Star selections and six appearances, the three-time National League (NL) Cy Young Award winner visibly savoured the moment as he approached the mound.

After the Los Angeles Dodgers won the World Series in 2020, Kershaw had effectively achieved everything could as a pitcher in baseball today, but had never started in an All-Star Game.

Achieving it in front of his home fans at Dodger Stadium on Tuesday, the usually measured 34-year-old could not hide his excitement. 

"It was actually a lot of fun today to be out there, and the crowd was awesome," Kershaw said after his opening inning. "I can’t say enough good things about Dodger fans, people in LA in general, just how much these last few days, how much they wanted me to do this. It meant a lot to me.

"I tried to take a minute at the beginning to take it all in and look around, which I usually never do. Being here at Dodger Stadium, a place where I’ve been now for 15 years, and to get to do something like this with the best in the world, is really fun.

"And it was also really personal for me and my family, everybody. I’m excited it’s over."

Leading off for the AL, Shohei Ohtani was able to claim a single off Kershaw's first pitch, but the Dodgers' starter caught him trying to steal second, before striking out Aaron Judge.

Paul Goldschmidt gave the NL a 2-0 lead in the opening frame after Mookie Betts drove Ronald Acuna Jr. in, crushing a solo home run up the middle off Shane McClanahan.

The AL team were able to claim the lead with a three-run fourth via Giancarlo Stanton's two-run shot, before Byron Buxton followed up with a solo homer of his own.

Coming in to pinch hit in what could be his final at-bat in an All-Star game, Albert Pujols sent a ball deep into left-field off Paul Blackburn in the bottom of the fourth, but Andrew Benintendi eventually made the catch with the crowd at Dodgers Stadium seemingly willing his hit over the wall.

The AL bullpen started to take over proceedings after Alek Manoah came onto the mound, keeping the NL without a hit between the second and fifth innings.

Emmanuel Clase spectacularly closed for the AL's ninth consecutive win in what was a dominant pitching display.

Vladimir Guerrero Jr homered like his father 15 years ago as he won the MVP with the American League defeating the National League 5-2 in MLB's annual All-Star Game in Denver on Tuesday.

The American League extended their winning run to eight in a row, with Guerrero's home run marking the 200th in All-Star history.

Shohei Ohtani started on the mound for the American League All-Star team, sending down a shutout innings with no hits, tossing down the fastest pitch of the game at 100.2 mph.

Ohtani went 1-2-3, taking out Fernando Tatis, Max Muncy and Nolan Arenado.

The Japanese two-way star, who led off as the designater hitter, was zero-and-two at-bat but earned praise from American League manager Kevin Cash.

"We're all in awe of his ability to do that," Cash said about Ohtani's two-way game. "He came in hyped up on this stage.

"He gets warmed up to get take the at-bat, he was sitting in his chair to catch his breath.

"The way he's handled everything makes it more special, watching him interact with his teammates and handle the media, it's pretty remarkable."

Guerrero Jr's 468-feet home run meant the Guerreros joined the Bonds and Griffeys as father-sons who have homered in All-Star games.

The 22-year-old Toronto Blue Jays slugger went one-from-three, with two RBI along with his solo home run in the third inning and becomes the youngest MVP in history.

"It means the world to me," Guerrero Jr said. "I just want to say thank you to my dad. This is for you."

J.T. Realmuto got the National League on the board with a solo home run in the fifth inning, while Ohtani's Los Angeles Angels team-mate Jared Walsh made a crucial diving catch at left from a Kris Bryant fly ball to round out the win.