Stefon Diggs feels the Buffalo Bills might be "blinking a little bit" after their defeat to the Minnesota Vikings in the game of the year so far.

The Bills led 27-10 in the third quarter and still appeared set to prevail leading 27-23 late in the fourth with the Vikings seemingly on their last chance on fourth-and-18.

However, Justin Jefferson's remarkable one-handed grab, which immediately entered the discussion around the best catches of all-time, set in motion a chaotic and incredible finish.

Despite that catch, Buffalo looked to have clinched the game when they stopped Minnesota on the Bills' one-yard line, but Josh Allen fumbled the snap on the subsequent series, Eric Kendricks recovering to put the Vikings ahead with 41 seconds left.

Allen led the Bills down the field for a game-tying field goal that forced overtime, in which the Vikings took the lead on a field goal after once again failing to convert from inside the Buffalo five-yard line following another Jefferson-inspired drive.

That gave Allen the chance to win it for Buffalo with a touchdown, but he paid the price for a poor decision as the Bills quarterback was intercepted in the endzone by Patrick Peterson and Minnesota clung on for a 33-30 success.

Buffalo's second successive defeat dropped them to 6-3, meaning the Bills are now third in the AFC East behind the Miami Dolphins and New York Jets.

It is a surprising downturn for a team that has long since been seen as Super Bowl favourites, and one Diggs put down to the Bills not following their mantra. 

"We've got to continue to play sharp," said Diggs. "I mean, I feel like we're coming out in the first half, minds sharp, getting after it, and then we somewhat hit a little lull and then kind of got to get back in the groove.

"It seemed like when we've got to get in the groove, it's always crunch time. And we always manage to kind of figure it out and make a way, but it'll save us if we don't take that lull, don't take that little gasp of air.

"[Defensive end] Von [Miller] always say don't blink and I feel like we might be blinking a little bit, especially when we come out trying to figure it out... This game has its ebbs and flows along with the season. I mean, we can’t ride a rollercoaster, so chin up."

Asked to explain what he meant by blinking, Diggs pointed the finger at himself for a false start in the fourth quarter.

"No, I mean, if you look at the score, the score was still tight," Diggs added. "When I think about a lull I feel like it's more so not being as sharp. For example like me jumping offsides like s*** like that.

"That's more so like a lull, not so much about the other team because like I said every week the other team will give you their best shot and they’re always going to give us that. More so looking inward than anything."

Justin Jefferson's critical fourth-quarter catch in the Minnesota Vikings' thrilling Week 10 win over the Buffalo Bills will go down as one of the best of all-time, but for the All-Pro wideout it was simply a case of him meeting expectations he has held since childhood.

Jefferson's astonishing one-handed grab on fourth-and-18 with the Bills ahead 27-23 kept the Vikings' hopes alive in an instant classic, the 23-year-old arcing his body backwards and leaping to rip the ball away from Cam Lewis for a 32-yard reception.

Despite driving down to the Buffalo one-yard line, Minnesota failed to get across the goal-line, but the Vikings were handed a reprieve when Bills quarterback Josh Allen fumbled the snap after the turnover on downs, Eric Kendricks recovering to put the visitors ahead with 41 seconds left.

Allen led the Bills down the field for a game-tying field goal that forced overtime, in which the Vikings took the lead on a field goal after once again failing to convert from inside the Buffalo five-yard line following another Jefferson-inspired drive. That gave Allen the chance to win it for Buffalo with a touchdown, but he was intercepted in the endzone by Patrick Peterson as Minnesota clung on for a remarkable 33-30 success.

In a game of so many dramatic moments, it is the image of Jefferson wresting the ball from Lewis in mid-air while falling backwards that will be the defining one.

Yet the Vikings star appeared to see nothing extraordinary about his pivotal play.

"Before we left the huddle," Jefferson told Peter King for Football Morning in America.

"Kirk [Cousins] said to me, 'Hey, I might just throw this up to you.' Kirk knew. We just needed to make something happen.

"I felt how close [Lewis] was. I knew it was going to be a battle for the ball. On plays like that, I don't remember exactly what happened. But I'm going up, I'm going to fight for the ball.

"That's my ball. Since ninth grade, those are the balls I think I should catch. I'm just happy Kirk trusted me and put the ball up for me to catch."

Jefferson finished with 193 yards and a touchdown on 10 catches. It marked his 20th career game with at least 100 receiving yards and saw him surpass Odell Beckham Jr. (19) and Randy Moss (19) for the most such games by a player in his first three seasons in NFL history.

He has yet to play in a postseason game, but with his latest heroics helping the Vikings improve to 8-1, that appears destined to change.

Aaron Rodgers was delighted to "knock back" the negative voice in his head by leading the Green Bay Packers to an overtime comeback win over the Dallas Cowboys.

The Packers went into the game, which saw Rodgers go against former head coach Mike McCarthy, on a five-game losing streak that dropped them to 3-6.

Green Bay last week scored only nine points in a defeat to the Detroit Lions, with many viewing that as the final nail in their coffin.

Rodgers agreed that loss was a low point, but felt the Packers could only go in one direction from there.

He ensured they went on an upward trajectory, throwing three touchdown passes to rookie receiver Christian Watson as the Packers fought back from 28-14 down in the fourth quarter to see off the Cowboys 31-28.

"Last week was definitely a low, rock-bottomish for sure," Rodgers said. "Not in a depressive, isolationism way but more disappointment. And I felt like that was the bottom and it was only up from there.

"I think a lot of the battles that we face are between I and I, between the person that can go out there and dominate and knows that they can, and the little voice in your head that tries to knock you out of that confident perch around you.

"I'm happy that I knocked that voice back into hell and had a good performance today."

The Packers' win over the 6-3 Cowboys and the coach in McCarthy who led them to glory in Super Bowl XLV in the 2010 season keeps them alive in the NFC playoff picture.

They are 4-6, two games back in the loss column of the 5-4 San Francisco 49ers, who would be the seventh and final seed in the conference if the season ended today.

And Rodgers is hopeful it could be the start of a remarkable turnaround in their fortunes.

"That was a turning point for us, hopefully a turning point that leads us to go on a streak," Rodgers said of the fourth-quarter fightback.

"But that [trailing 28-14] was a chance for guys to [go], 'Ah, it's not our season, 3-7, what are we doing in the offseason, it's not gonna be our year.'

"It just felt like energetically something was gonna go our way, and we stuck together in the fourth."

Amid all the furore around his appointment as interim head coach, Jeff Saturday may have been the coolest man in the building as he guided the Indianapolis Colts to a 25-20 road win over the Las Vegas Raiders.

In his first game as a head coach above the high school level, Saturday tasted a victory that will have gone some way to silencing his critics.

Saturday's lack of experience made the former Pro Bowl center unlikely candidate, with others among the Colts coaching staff seen as having more valid claims, but owner Jim Irsay had little hesitation in turning to the 47-year-old to replace the fired Frank Reich. 

Despite all the controversy surrounding him, Saturday remained cool, calm and collected.

"In all honesty and in all truth, I felt very at peace," he said, before diverting all the praise to his players.

"I told the guys just all three phases was an incredible team effort. These guys have been through it.

"I told the staff, the coaches, the players, [about] the fortitude that they presented and the way they played. They laid it all out there and I just could not be more appreciative of those guys and the way they played.

"Everybody from offense, defense and, obviously, on special teams, these guys, they rallied and it's a special moment for all of those guys and I tipped my hat to all of them. It's just an honour to be a part of it."

"I just kept telling them, man, just keep pushing through and I said it's going to come down to the last play. It always does in the NFL. And who goes hardest, the longest ultimately wins.

"We made a couple plays there at the end that were spectacular."

In a surprising move, Saturday opted to return the starting quarterback role to veteran Matt Ryan, pivoting away from second-year youngster Sam Ehlinger.

Ryan was serviceable, completing 21 of 28 passes for 222 yards and no turnovers, but they relied on their running game to get the job done.

"I wanted to talk to the staff on Friday afternoon, but I knew what I was going to do," Saturday said of his call to bring Ryan back in. 

"I knew everybody was with it and I felt like Matt gave us the best chance to win. I had the conversation with Sam, who was a true pro, and I have so much respect for that young man and the way that he's conducting himself and the type of team-mate he is."

The Los Angeles Rams are unclear on the severity of the ankle injury that forced Cooper Kupp out of Sunday's 27-17 loss to the Arizona Cardinals, but head coach Sean McVay says "it didn’t look good".

Kupp clutched his right ankle when he landed awkwardly trying to catch a fourth-quarter John Wolford pass and was checked by the Rams medical staff before walking to the locker room.

The Rams wide receiver, who also hurt his right ankle late in their Week 8 game but played the following week, did not speak to media afterwards.

"I don't have anything right now," McVay told reporters. "I just know it didn't look good, it didn't sound good."

Kupp, who won last year's Super Bowl MVP, has been the Rams' key offensive player this season. The wide receiver has 72 receptions for 813 yards with six touchdowns, with one rushing TD from nine carries this season.

The Rams' latest loss left the Super Bowl LVI champions with a 3-6 record, sitting last in the NFC West after three straight losses.

Kupp enjoyed an historic 2021 season, becoming the fourth player in NFL history to lead the league in receptions, receiving yards and receiving touchdowns in the same season, alongside Jerry Rice, Sterling Sharpe and Steve Smith Sr.

The 29-year-old had 145 receptions for 1,947 yards and 16 touchdowns in the 2021 regular season, before adding 33 receptions for 478 yards and six touchdowns in the postseason.

The San Francisco 49ers had a dominant second half to end the Los Angeles Chargers' dominance over them with a 22-16 victory at Levi's Stadium on Sunday.

The Niners' running game came to the fore in the second half, taking the lead for the first time with 7:54 remaining in the fourth quarter after Christian McCaffrey's touchdown.

San Francisco went 12-0 in the second half, turning around a 16-10 half-time deficit, ending the Chargers' five-game streak against them. The win means San Francisco claimed back-to-back victories to improve to 5-4, while the Chargers dip to 5-4 having lost two of their past three games.

The Niners enjoyed more possession, rushing for 157 yards compared to the Chargers' 51, with Elijah Mitchell (89 yards on 18 carries) and Deebo Samuel (27 yards on four carries) contributing well on their returns from injury.

Niners quarterback Jimmy Garoppolo completed 15 of 23 passes for 197 yards with no touchdowns or interceptions, although he ran in a TD late in the first half.

Garoppolo linked up with Brandon Aiyuk, who had six receptions for 84 yards, on a 24-yard pass leading to McCaffrey's decisive rushing two-yard TD.

The Chargers scored on the opening drive of the game when QB Justin Herbert pinpointed DeAndre Carter on a 32-yard deep left pass.

In the final two minutes, a one-handed Josh Palmer could not reel in a desperate fourth-down pass from Herbert, who finished the game on 21-of-35 passing for 196 yards with one TD and one interception, before Robbie Gould made it a six-point game with a 20-yard field goal.

Miami Dolphins edge rusher Emmanuel Ogbah will miss the remainder of the season after tearing his triceps in Sunday’s game against the Cleveland Browns, according to multiple reports.

Ogbah exited in the second quarter with what was initially termed an elbow injury, and did not return to Miami’s 39-17 win.

The injury ends a disappointing campaign for Ogbah, whom the Dolphins re-signed to a four-year, $65million contract in March. The seven-year veteran managed just one sack and 11 tackles in nine games.

Ogbah was coming off back-to-back nine-sack seasons and ranked second among Dolphins players with 12 passes defensed in 2021.

Miami did address a need for pass-rush help at the recent trade deadline by acquiring outside linebacker Bradley Chubb from the Denver Broncos on November 1. The Dolphins signed the impending free agent to a five-year, $110m extension shortly after the trade.

The Dolphins also have 2021 first-round pick Jaelan Phillips and veteran Melvin Ingram available as edge rushers.

Las Vegas Raiders quarterback Derek Carr was on the verge of tears as he faced the media following his side's third consecutive loss, dropping their record to a borderline unsalvageable 2-7.

The Raiders were favourites at home against the Indianapolis Colts on Sunday after the visitors named a new interim head coach and offensive playcaller during the week, but an explosive performance from running back Jonathan Taylor carried the Colts to a 25-20 win.

Las Vegas committed no turnovers, but struggled to move the ball, averaging just 3.2 yards per carry on 24 attempts, while the Colts had 207 rushing yards from 30 attempts, buoyed by a 66-yard touchdown scamper from Taylor.

Speaking to reporters after the game, Carr had to pause several times to gather himself as he tried to explain how it does not feel to him that every member of the team is giving their all.

"I can't speak for everybody – I know where I stand, I love the silver and black, and I'm going to give it everything I can every time I'm out there," he said. 

"I love [head coach] Josh [McDaniels], I love our coaches. They've had nothing but success – way more than I've ever had. 

"I'm sorry for being emotional, I'm just p***** off about some of the things that a lot of us try and do just to practise, and what we put our bodies through just to sleep at night.

"For that to be the result of all that effort, it p***** me off, it p***** a lot of guys off. It's hard… I wish everybody in that room felt the same way about this place.

"As a leader, that p***** me off, if I'm being honest."

He said there was a players' meeting immediately after the loss where leaders addressed their concerns "man-to-man".

"We had our leaders address it man-to-man just now," he said. "It was good, it needed to be done, it needed to be said, and I think for me, I'm always going to just show the way.

"I'm going to show the way, show them what it looks like, show them how hard it is. In the huddle in the second quarter I told them 'this is going to be hard, but we're going to come back and win this game, I believe it'.

"It's going to be hard, though. It's not going to be easy, you've got to do the hard things. Josh always preaches 'do the hard things right'.

"I'm not perfect, I'm never going to be perfect, but the love I have for this place and the effort I give is going to be second-to-none every time.

"I think the emotion of just nine years of stuff hit me today, for how much I really love this place. It's not going to change anything, I'm going to come out here and fight and compete next week, and that's what I'm going to do."

When asked if he believes the coaching staff needs to take accountability for their six losses by one-possession margins – including three blown leads of at least 17 points – Carr refused to point the finger.

"We all take accountability, and the NFL, it's one-score games all the time," he said. "So this team has to learn how to finish those.

"There's been so many of them – six, right? You flip all of those, and everyone is feeling good about it, and I'd feel great about everything.

"That just isn't the case, but it's on all of us. But for me, I'm going to speak for myself and I'm going to come in, take my coaching from Josh, and he'll be hard on me like he always is.

"And I'm thankful for it, we'll keep going forward, and all that. I think if everyone takes that mindset, that's when you get better."

The Raiders travel to take on the Denver Broncos in Week 11, needing a win to keep their slim playoff chances alive.

Green Bay Packers rookie Christian Watson was the star of the show in his side's 31-28 comeback win in overtime against the Dallas Cowboys on Sunday.

With no career receiving touchdowns coming into the contest, the second-round draft pick got one on the board in the first quarter, reeling in a deep ball for a 58-yard touchdown in response to CeeDee Lamb's opening score.

A 12-yard rush from Aaron Jones would give the Packers a lead, before Dalton Schultz tied things up with the fourth touchdown of the first frame.

Second-quarter scores to Cowboys running back Tony Pollard and a second for Lamb gave their side a 28-14 lead at halftime, but Dallas would not score the rest of the way.

Watson brought it back to a one-possession game with his second touchdown to begin the fourth quarter, and he struck again with 2:29 remaining in regulation to tie the game and force overtime.

After the Cowboys failed to convert a fourth down in the extra period, the Packers marched downfield and set-up a game-winning 28-yard field goal for Mason Crosby.

With Packers quarterback Aaron Rodgers desperate for a new go-to option, Watson was targeting on eight of his 20 passes for a whopping 40 per cent target share. For reference, Cooper Kupp of the Los Angeles Rams leads the league with a 31.7 per cent target share entering Week 10.

Watson caught four of his eight targets for 107 yards and three touchdowns, while to all other receivers Rodgers completed 10 passes for 117 yards and no scores.

Saturday gets his first Sunday win

In his first game as a head coach above the high school level, Indianapolis Colts legend Jeff Saturday led his team to a 25-20 road win against the Las Vegas Raiders.

In a surprising move that was not announced pre-game, interim coach Saturday opted to return the starting quarterback role to veteran Matt Ryan, pivoting away from second-year youngster Sam Ehlinger.

Ryan was serviceable, completing 21 of 28 passes for 222 yards and no turnovers, but they relied on their running game to get the job done.

Star running back Jonathan Taylor was the Colts' workhorse, carrying 22 times for 147 yards and two scores, highlighted by a 66-yard touchdown run to take the lead in the third quarter.

Josh Allen threw an overtime interception as the Justin Jefferson-inspired Minnesota Vikings fought back to prevail 33-30 in the game of the NFL season so far.

Minnesota looked set to fall short in the biggest test of their credentials as contenders to date when Greg Joseph missed an extra point after a C.J. Ham touchdown to leave the Vikings trailing 27-23 in the fourth quarter.

Yet an already engrossing contest to that point served as merely a prelude to an inexplicable finale that ensured this game will go down as an all-time classic.

The Vikings' hopes looked to be over when they faced fourth and 18 on their own 27-yard line with two minutes remaining, only for Jefferson to produce an astonishing show of athleticism to leap and bend backwards to snatch a desperation throw away from the clutches of Bills defender Cam Lewis and keep the drive alive.

Six plays later, after two more completions to Jefferson, the Vikings had fourth down at the Bills' one-yard line. Dalvin Cook's drop of a Kirk Cousins pass looked to have sealed the game for Buffalo, but the Bills were flagged for offside. The Vikings did not take their second chance, though, with Cousins stopped short on a quarterback sneak.

Incredibly, however, the Bills likewise could not execute a quarterback sneak from their own goal-line, Allen fumbling the snap into the hands of Minnesota linebacker Eric Kendricks for a go-ahead touchdown.

Allen still had 36 seconds to force overtime and, with the help of a hugely controversial diving catch from Gabe Davis, he did just that, setting up Tyler Bass for a game-tying 29-yard field goal.

The Vikings won the coin toss and, though they again failed to find the endzone after a stunning 24-yard throw from Cousins to Jefferson put Minnesota on the Buffalo two-yard line, the boot of Joseph gave them the lead.

Minnesota's profligacy meant Allen had the chance to win the game with a touchdown, but having driven the Bills to the Vikings' 20-yard line, Allen threw his fourth red-zone interception in two games to Patrick Peterson as Kevin O'Connell's visitors held on to triumph and move to 8-1. A second straight loss drops the Bills to 6-3.

Chiefs in cruise control

While the Bills, their primary AFC rivals, lost the game of the year, the Kansas City Chiefs enjoyed a much calmer afternoon, easing past the Jacksonville Jaguars 27-17 thanks to a four-touchdown day for Patrick Mahomes.

They now have the lead of the AFC at 7-2, with the Miami Dolphins their closest challengers at 7-3 as a 39-17 win over the Cleveland Browns moved Mike McDaniel's team to the top of the AFC East ahead of the Bills, who are now third in their division. The Tennessee Titans are 6-3 after a 17-10 defeat of the Denver Broncos.

Fields heroics not enough for Bears

Justin Fields is emerging as one of the best young quarterbacks in the NFL over recent weeks, and he delivered another scintillating showing for the Chicago Bears versus the Detroit Lions.

Fields threw for 167 yards and two touchdowns and rushed for 147 yards and another two scores, including an incredible 67-yard scamper in the fourth quarter. However, a missed extra point gave the Lions a chance to win with a touchdown, and Jamaal Williams clinched it for Detroit with a one-yard run that sealed a 31-30 triumph.

The Bears made unwanted history in defeat, becoming the first NFL team ever to score at least 29 points in three consecutive games and lose all three.

The Tampa Bay Buccaneers strengthened their grip on first place in the NFC South as they survived a fourth-quarter fightback from the Seattle Seahawks to prevail 21-16 in Munich.

Tampa Bay went into the NFL's first regular-season game in Germany having got back on track with a last-gasp 16-13 win over the Los Angeles Rams and on top in their division despite an underwhelming 4-5 record.

For three-and-a-half quarters, there was little sub-par about the Buccaneers' performance at the Allianz Arena, where they led 21-3 with under nine minutes remaining.

Geno Smith threw touchdowns to Tyler Lockett and Marquise Goodwin to cut their advantage to 21-16, but Tom Brady delivered a clock-killing final drive to seal the game for the Bucs, who improve to 5-5, a game ahead of the 4-6 Atlanta Falcons with a tie-breaking head-to-head win in the NFC South. The Seahawks drop to 6-4.

After a scoreless first quarter, the Bucs took the lead at the end of a 13-play drive, Brady connecting over the middle with Julio Jones, who galloped into the endzone for a 31-yard touchdown.

While Smith and the Seahawks' offense continued to struggle, Brady looked increasingly comfortable and led another 13-play drive that was capped by a Leonard Fournette rushing touchdown to put Tampa Bay up 14-0.

Seattle responded in the third quarter with a 55-yard field goal but did not look like stopping the Bucs' offense until a remarkable trick play saw Fournette intercepted by Tariq Woolen while trying to throw to Brady.

But Smith fumbled in the red zone on the subsequent drive and Brady's four-yard touchdown pass to Chris Godwin seemingly put the game beyond doubt.

Smith connected with Lockett to give Seattle hope that was furthered by Goodwin's diving touchdown grab after a Cody Barton interception.

However, the Bucs gained three first downs on the final drive to end any prospect of a turnaround in Bavaria.

The Seattle Seahawks are keen on signing quarterback Geno Smith for next season after his stellar campaign so far.

Arriving as part of a trade deal with the Denver Broncos that saw franchise QB Russell Wilson depart after nine years in the Pacific Northwest, Smith edged fellow new arrival Drew Lock to a starting berth and has excelled in 2022.

A campaign that began with a surprise win against the Broncos has seen Seattle stand 6-3 for the year and top of the NFC West ahead of Sunday's game against the Tampa Bay Buccaneers in Munich.

Smith has been a major part of the Seahawks' success, completing 73.1 per cent of his passes and throwing for 2,199 yards, with the NFL Network's Ian Rapoport stating Seattle are keen to secure him to a new contract.

An offer is yet to be made to Smith, who is a free agent in 2023, but discussions are set to take place following the conclusion of the season – which may be later than was initially expected given the team's surprise playoff push.

Victory against the Bucs on Sunday would extend the Seahawks' win streak to five, with only the Philadelphia Eagles (eight) and Minnesota Vikings (six) on a longer run.

The Buffalo Bills are giving quarterback Josh Allen every chance to prove his fitness to play in Sunday's clash against fellow division leaders Minnesota Vikings despite an elbow concern.

Allen was listed as questionable for the game on the injury report, while the Bills opted not to elevate third-string QB Matt Barkley to the active roster.

The MVP candidate, who has led Buffalo's offense with 2,403 passing yards for 19 touchdowns along with 392 rushing yards and four other scores on the ground this season, was limited at Friday practice having picked up the elbow injury late in Sunday's loss to the New York Jets.

Allen has only participated in one day of practice this week, having sat out on Wednesday and Thursday but Bills head coach Sean McDermott remained bullish.

"We are literally in an hour-to-hour situation here just looking at how he's going to progress through the day," McDermott told reporters on Friday.

"As he goes through these different tests, medically, making sure that he's able to check the boxes in a progression to where we can see if we can proceed through the course of the day here."

ESPN has reported that Allen's specific concern is an ulnar collateral ligament, related to nerves, in his right elbow. Allen missed four games in the 2018 season with a similar injury to the same arm.

Case Keenum is Allen's back-up QB and he has spoken about being prepared to play if required this week.

"At the end of the day, Josh needs to be Josh, if he's able to play," McDermott added. "And if Case plays, then Case needs to be Case and run the offense."

The Bills are 6-2 and atop the AFC East division, while the Vikings are 7-1 and clear on top of the NFC North on the back of a six-game winning run.

Buffalo lost to the Kansas City Chiefs 42-36 in overtime in the divisional playoffs last season.

The San Francisco 49ers are getting healthy at the right time as they bid to kick-start a second-half surge towards the postseason and get a rare win over the Los Angeles Chargers on Sunday.

San Francisco had their bye in Week 9, having got to 4-4 in emphatic fashion a week earlier, routing the Los Angeles Rams 31-14 at SoFi Stadium.

They return home to Levi's Stadium to face the Chargers in primetime and, while they have beaten the Rams eight times in a row in the regular season, they have not had such fortune against the other Los Angeles team in the NFL.

Indeed, the Chargers are looking to win their sixth straight game against the 49ers, which would make them the first team to do so since the Seattle Seahawks (who nine games from 2014 to 2018).

However, the two teams have not met since Los Angeles' home win in Week 4 of the 2018 season.

The 49ers, who have once again battled the injury bug in a recurring theme of head coach Kyle Shanahan's tenure, are set to get eight players back from absences.

Versatile star wide receiver Deebo Samuel (hamstring), Jauan Jennings (hamstring), fullback Kyle Juszczyk (finger) and linebacker Dre Greenlaw (calf) are all set to return after missing the win over the Rams.

Running back Elijah Mitchell, linebacker Azeez Al-Shaair, backup tackle Colton McKivitz and defensive end Jordan Willis will also make their comebacks from injuries that saw them placed on the injured reserve list.

Mitchell has not played since injuring his knee in Week 1, and it is his and Samuel's infusion back into the lineup that will be most intriguing to watch from an offensive standpoint for San Francisco.

Neither Samuel nor Mitchell has had the chance to play with 49ers running back Christian McCaffrey, whom San Francisco acquired in a blockbuster trade with the Carolina Panthers last month.

In his second game against the Rams, McCaffrey threw for, rushed for and caught a touchdown. He was the first player to do so in the same game since the Chargers' LaDainian Tomlinson completed the feat in Week 6 of the 2005 season and only the fourth since the 1970 merger.

Adding Samuel, whose ability to excel as a receiver and a running back propelled the Niners to the NFC Championship Game last season, and 2021 leading rusher Mitchell into the mix alongside another dual running and receiving threat in McCaffrey opens an array of options for Shanahan, especially against a Charger run defense allowing the most yards play (5.7) on the ground in the NFL.

In contrast to the 49ers' improving injury report, the Chargers will again be without top wide receivers Keenan Allen and Mike Williams, while right tackle Trey Pipkins is out with a knee injury. Practice squad lineman Foster Sarell could get the nod in his stead ahead of much-maligned backup Storm Norton.

Despite losing left tackle Rashawn Slater to a torn ACL earlier in the season, the Chargers' offensive line has held up well. Quarterback Justin Herbert was not sacked in the win over the Atlanta Falcons in Week 9, and the Chargers have allowed the fewest sacks in the league this season (10). They have not given up 10 or fewer sacks through eight games since the 2008 season (also 10).

That could change against a fearsome 49ers defensive front. The Niners are third in the NFL with a sack rate of 8.9 per cent, though they are once again missing their best interior pass rusher, Arik Armstead, with a foot injury.

The lack of receiving weapons and injuries up front would appear to put Herbert and the 5-3 Chargers in a tough spot. However, the 49ers will be wary of Herbert's ability to overcome adversity, as he has continued to thrive even as the Chargers have failed to deliver since he entered the league in 2020.

Through 40 career starts, Herbert has accounted for 90 touchdowns (82 passing, 8 rushing). Only Patrick Mahomes (107), Dan Marino (95) and Kurt Warner (91) accounted for more scores in their first 40 starts.

The midpoint of the NFL season is tougher to discern following the move to a 17-game campaign but, with Week 10 off and running, it's fair to say we are into the second half.

It is in these final nine weeks when the games will become increasingly important and the onus will be on the game's best to deliver and make sure their respective teams are in position to reach the postseason.

The performances in this half of the campaign will have a significant influence on the end of year awards and on the identity of players named to the All-Pro team.

But which players are most deserving of the latter honour following the opening half of the season?

Stats Perform dug deep into its advanced metrics to help fill out its All-Pro team at the midway point of the year.

Quarterback: Patrick Mahomes - Kansas City Chiefs

Mahomes is second in the NFL in Efficiency Versus Expected in expected passing situations among quarterbacks. He trails Josh Allen, however, having produced 36 completions of at least 20 yards compared to 30 for Allen. He has also been the more accurate quarterback, posting a well-thrown percentage of 82.7 compared to 82.2 for Allen.

Running Back: Tony Pollard - Dallas Cowboys

Among running backs with at least 50 designed runs, Pollard leads the NFL in yards per carry (6.25), is second in yards after contact per attempt (2.94) and first in yards per carry when there is a disruption by a defender (5.27). Pollard is also sixth in yards before contact per rush (3.46).

Wide Receiver: Tyreek Hill - Miami Dolphins

Hill is third in big-play rate among wide receivers with at least 50 targets. His rate of 39.5 per cent trails only Amari Cooper (40.4) and team-mate Jaylen Waddle (39.7). In terms of registering a burn, which is when a receiver wins his matchup on a play where he is targeted, he leads all qualifying wideouts with 5.0 burn yards per route and is on pace to finish with over 2,000 receiving yards.

Wide Receiver: Stefon Diggs - Buffalo Bills

Diggs leads the NFL in open percentage against man coverage, winning 74.42 per cent of his matchups and reaffirming his status as one of the NFL's elite route-runners.

Slot Receiver: Justin Jefferson - Minnesota Vikings

No receiver with at least 25 targets from the slot is averaging more burn yards per route (5.0) or burn yards per target (16.32) than Jefferson.

Tight End: Mark Andrews - Baltimore Ravens

When he has been healthy, no tight end has done a better job of creating separation than Andrews, who leads all players at his position (min. 25 targets) in burn rate (78.1 per cent), big play rate (39 per cent) and burn yards per route (3.7).

Left Tackle: Laremy Tunsil - Houston Texans

The Texans' struggles are nothing to do with Tunsil, who leads all linemen with a pass block win rate of 94.64 per cent and all left tackles with a pressure rate allowed of 1.5 per cent.

Left Guard: Landon Dickerson - Philadelphia Eagles

With the Eagles' Jason Kelce succession plan in place at center, Dickerson can focus on playing guard, which he is doing outstandingly. He leads all left guards with a pressure rate of 3.3 per cent and his stunt-adjusted pass block win rate of 88.69 per cent is second among all guards.

Center: Creed Humphrey - Kansas City Chiefs

Humphrey's pass-block win rate of 87.96 per cent is second to Rodney Hudson of the Arizona Cardinals (90). However, Humphrey has played 253 pass block snaps compared to Hudson's 107. Humphrey has a double-team adjusted run-block win rate of 76.36 per cent, Hudson's is just 53.33.

Right Guard: Wyatt Teller - Cleveland Browns

An outstanding run-blocking guard with a win rate of 80 per cent in that area of the game, Teller's pass-block win rate of 90.74 per cent trails just Tunsil among all offensive linemen.

Right Tackle: Tristan Wirfs - Tampa Bay Buccaneers

The problems on the Bucs' offensive line are on the interior, not at tackle, where Wirfs has been exemplary. Wirfs has allowed three pressures in 277 pass-blocking snaps and is third in adjusted win rate (90.56 per cent) among linemen behind Tunsil and Teller.

Edge Rusher: Myles Garrett - Cleveland Browns

Garrett's pressure rate of 29.7 per cent is tied for the best among all edge rushers, while his pass-rush win rate is a phenomenal 68.3 per cent. Winning 48 of his 70 rushes, no edge defender can match him for disruption this season.

Interior Defensive Line: Aaron Donald - Los Angeles Rams

The Rams' hopes of retaining the Lombardi Trophy look to be hanging by a thread, but Donald is still Donald and once again playing at a ridiculously high level. Only two players (Derrick Brown and D.J Jones) have a higher run disruption rate among defensive tackles than Donald (40.5 per cent) while Quinnen Williams is the sole interior defensive lineman with a better pressure rate than his 24.2 per cent. No defender, however, can match Donald's remarkable pass-rush win rate of 73.66 per cent.

Interior Defensive Line: Quinnen Williams - New York Jets

The two players closest to Donald's level both reside in New York. Dexter Lawrence of the Giants has a better pass-rush win rate (72.8 per cent) than Williams (70.5 per cent) but Williams has been the slightly superior all-round defender, winning his run defense matchup 62.5 per cent of the time, adjusted for double-teams, compared to 54.67 per cent for Lawrence.

Edge Rusher: Von Miller - Buffalo Bills

Miller has been worth the extremely lofty price of admission for the Bills so far this season, posting a pass-block win rate of 57.33 and winning 62.96 per cent of his run defense matchups.

You may be screaming 'where is Micah Parsons?!' about the absence of the man seen as the Defensive Player of the Year frontrunner. Parsons is fourth in pressure rate among edge rushers (28.3 per cent), but 16 of his pressures have been unblocked, illustrating a role in the Dallas defense in which he often takes advantage of stunts as the looper. 

Athleticism and quickness creates a tougher situation for the linemen who are being gamed, but it also relies on the penetrator half of the stunt to pick two defenders. In other words, he's creating pressure because a different lineman is blowing a hole through the protection, giving Parsons a free rush on the QB.

In terms of traditional pass rushing, Parsons' impact has not quite been significant enough to make the cut.

Linebacker: Fred Warner - San Francisco 49ers

Warner remains the gold standard for coverage linebackers, allowing a combined open percentage across man and zone of just 15.49 that is second only to Pittsburgh Steelers safety Minkah Fitzpatrick (13.95 per cent). Warner has also displayed improvement as a blitzer in 2022, his pressure rate of 43.8 per cent second among inside linebackers with at least 20 pass rushes.

Linebacker: Demario Davis - New Orleans Saints

At 33, Davis continues to demonstrate impressive longevity. His combined open percentage allowed of 17.64 trails only Warner among linebackers with at least 100 total plays, while he has also won 23.21 per cent of his run defense opportunities, well above the average of 17.72 for the position.

Nickel Cornerback: Bryce Callahan - Los Angeles Chargers

While the Chargers' run defense has continually struggled, their play in the defensive backfield has been impressive, with Callahan a clear standout. He has lost just six of his 74 coverage matchups across man and zone for a combined open percentage of 17.57 that is the best among corners with at least 50 matchups.

Cornerback: Patrick Surtain II - Denver Broncos

In his second year in the NFL, Surtain already has an extremely strong claim for being considered the best corner in the league. He is third in combined open percentage (21) and his burn rate of 28.9 per cent is first among corners with at least 25 targets.

Cornerback: Darius Slay - Philadelphia Eagles

Second behind Callahan for open percentage (20.21), Slay is once again thriving as part of an Eagles defense that is continually taking the ball away. He has eight pass breakups and three interceptions this season to go along with his superb coverage numbers.

Safety: Derwin James - Los Angeles Chargers

The flexibility of James has been critical to the aforementioned success in the secondary for the Chargers. His burn rate allowed of 35.7 per cent is the third-best for his position while James has also proven an asset rushing the passer, registering three sacks.

Safety: Talanoa Hufanga - San Francisco 49ers

You can't watch a 49ers game without Hufanga being compared to Troy Polamalu. He has unquestionably earned such plaudits, though, giving up the second-fewest burn yards per target (5.68) among safeties and recording the best big-play rate (8.0 per cent). With three interceptions, six pass breakups, five tackles for loss, four stuffs and a sack, he is setting the standard for splash plays at safety.