Wing Alex Cuthbert and centre Johnny Williams will make their first appearances of Wales’ World Cup warm-up schedule against South Africa on Saturday.

Williams partners Mason Grady in midfield, while there are also starts for the likes of scrum-half Kieran Hardy and hooker Elliot Dee.

Flanker Jac Morgan will captain Wales for the second time in three games, suggesting he is a firm favourite to skipper Wales at the World Cup.

Taine Basham, meanwhile, is among the replacements for the Springboks’ Principality Stadium visit.

Basham failed a head injury assessment following a shoulder-led tackle to his head by England captain Owen Farrell at Twickenham last weekend.

Farrell was sent off, but in a decision that sent shockwaves throughout the rugby world his red card was overturned by a disciplinary panel.

The Welsh Rugby Union said that Basham “was not a confirmed concussion following completion of all three stages of the head injury assessment (HIA) protocol”.

Alex Cuthbert will miss Wales' two remaining Six Nations games due to a foot injury.

The wing came off the bench during defeats to Ireland and Scotland.

Cuthbert was ruled out of the 20-10 loss to England at the Principality Stadium last time out after doing damage to his foot.

The 32-year-old Ospreys flyer will play no part in a trip to face Italy at Stadio Olimpico on Saturday or Wales' final match of the tournament against France at Parc des Princes on March 18.

Louis Rees-Zammit and Josh Adams started on the wings in the defeat to England in Cardiff, the former scoring the only try for Warren Gatland's side.

Wales are bottom of the table without a point from three matches, facing a battle to avoid the Wooden Spoon.

Wales wing Alex Cuthbert has been ruled out of this weekend's series decider against South Africa with a shoulder injury.

The 32-year-old was forced off the field 17 minutes into the visitors' 13-12 victory in Bloemfontein on Saturday, which levelled the three-match series at 1-1.

Wales confirmed on Monday that Cuthbert will play no part in the third and final Test, with no replacement being called up.

Josh Adams, who replaced Cuthbert and scored Wales' late try, is now expected to start the crunch clash in Cape Town.

Captain Dan Biggar and prop Dillon Lewis suffered shoulder and arm injuries respectively in the second Test, but they have not yet been ruled out.

South Africa confirmed earlier on Monday that centre Andre Esterhuizen, who started for the much-changed hosts last time out, will play no part after breaking his hand.

Manu Tuilagi and captain Courtney Lawes will make their returns from injury in England's Six Nations showdown with Wales at Twickenham, while forward Taulupe Faletau will make his first appearance since last year's competition for the visitors on Saturday.

Both sides have posted a win and a loss in their two games so far to trail early leaders France in the table.

England bounced back from a 20-17 loss to Scotland by thrashing Italy 33-0 last time out, while Wales beat Scotland 20-17 after opening their title defence with a 29-7 defeat in Ireland.

Lawes returns from a concussion-enforced layoff which has kept him out of action since January, and regains the captaincy he held against South Africa last Autumn, replacing stand-in Tom Curry in the role.

Tuilagi also makes a welcome return from injury, but Ben Youngs will have to wait to win a record 115th cap after being named on the bench, as Eddie Jones makes four changes to the team which impressed in Rome, with Luke Cowan-Dickie and Kyle Sinckler also coming in.

Looking ahead to the match, Jones told England Rugby that he was content with his side's preparation, and was excited ahead of the showdown.

"We've prepared very well for this game, the squad have really come together on and off the pitch," said Jones. 

"Wales are a good, tough side and Six Nations champions, and it will make for an exciting Test match in front of a full Twickenham crowd.

"We've got a talented, young, hungry squad who have trained with real intensity this week. We're ready to go at them and can't wait to play in front of our supporters again."