The Chicago Bulls will have to make do without Zach LaVine and Alex Caruso in their do-or-die Eastern Conference playoffs Game 5 showdown with the Milwaukee Bucks.

Needing a victory to keep the series alive, the Bulls confirmed LaVine and Caruso will play no part at Fiserv Forum on Wednesday.

All-Star LaVine misses out a day after he entered the NBA's health and safety protocol, having revealed he was feeling unwell before a practice session.

Fellow guard Caruso took a blow to his face in the second quarter of an emphatic 119-95 Game 4 defeat on Sunday and is going through concussion protocols.

LaVine had led the Bulls with 24 points, 13 assists and five rebounds in a loss that left them trailing the series 3-1.

A depleted Chicago were already missing Lonzo Ball (knee) and Matt Thomas (leg).

Grayson Allen has been handed a one-game suspension for a foul on Alex Caruso that resulted in the Chicago Bulls guard fracturing his wrist. 

Caruso was ruled out for six to eight weeks after landing awkwardly following "unnecessary and excessive contact" from Allen during the Milwaukee Bucks' 94-90 win over the Bulls. 

Allen was adjudged to have committed a Flagrant 2 foul and he was ejected from the game following the hard foul on the Chicago star as he drove to the rim in the third quarter. 

An NBA statement read: "Milwaukee Bucks guard Grayson Allen has been suspended one game without pay for having made unnecessary and excessive contact against Chicago Bulls guard Alex Caruso, resulting in substantial injury to Caruso. 

"Allen will serve his suspension on Wednesday, January 26 when the Bucks face the [Cleveland] Cavaliers at Rocket Mortgage Fieldhouse in Cleveland, OH." 

The Bulls were already without starting guard Lonzo Ball, who is out for up to two months with a knee injury. 

Caruso has averaged 8.4 points, 3.9 assists and 3.9 rebounds in 27.7 minutes for the Bulls this season.

The Chicago Bulls have announced that guard Alex Caruso will miss six to eight weeks due to a wrist injury sustained in a controversial moment in Friday's 94-90 loss to the Milwaukee Bucks.

Caruso will undergo surgery early next week for a fractured right wrist, having been fouled by Milwaukee's Grayson Allen, who was subsequently ejected.

The former Lakers guard joins Lonzo Ball on the sidelines for the 28-16 Bulls, who have lost five of their past six games.

Caruso's agent Greg Lawrence called Allen's foul, deemed flagrant 2 by the officials, a "cheap shot" given the significant injury it had caused. Bulls head coach Billy Donovan had labelled Allen's act as "dangerous" after the game.

The 27-year-old guard played out the game but admitted his wrist continued to bother him, impacting his shooting.

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