Second seed Stefanos Tsitsipas was bundled out of the Miami Open in straight sets during Tuesday's fourth round by 2022 US Open semi-finalist Karen Khachanov.

The Russian 14th seed prevailed 7-6 (7-4) 6-4 over Tsitsipas in one hour and 34 minutes, powering 25 winners and making only nine unforced errors, compared to the Greek's 14.

Khachanov's triumph ended a winless 0-6 head-to-head record against Tsitsipas, while it also snapped his own 23-match losing streak against top-10 opponents.

The Russian, who also made this year's Australian Open semi-finals, has qualified for four of his six tour-level events this year.

Khachanov will take on 25th seed Francisco Cerundolo in the quarter-finals, with the Argentinian fighting back to get past Lorenzo Sonego 3-6 6-3 6-2 in just over two hours.

Defending champion and top seed Carlos Alcaraz had less trouble against Tommy Paul, cruising into the quarter-finals with a 6-4 6-4 victory.

Alcaraz won the winners' count 24-9, setting up a quarter-final clash with ninth seed Taylor Fritz, as the Spanish 19-year-old chases a rare Sunshine Double, having won last week's Indian Wells Open.

Fritz progressed after getting past seventh seed Holger Rune 6-3 6-4 in 86 minutes, sending down eight aces and 22 winners for the match.

Fourth seed Daniil Medvedev played late into the evening after a lengthy rain delay in Miami, but made light work of Quinten Halys 6-4 6-2, triumphing just past 1:30am local time.

Medvedev, who is into his third straight Miami quarter-final, will face American qualifier Christopher Eubanks in the last eight after he got past Frenchman Adrian Mannarino 7-6 (7-2) 7-6 (7-5) in another rain-delayed contest.

Italian 10th seed Jannik Sinner knocked off sixth seed Andrey Rublev 6-2 6-4, advancing to face Emil Ruusuvuori after he beat Botic van de Zandschulp 4-6 6-4 7-5.

Three of the top seeds in the Miami Open field were eliminated on Monday as Felix Auger-Aliassime, Hubert Hurkacz and Frances Tiafoe were all sent packing.

Fifth seed Auger-Aliassime was taken out 6-2 7-5 in one of the biggest wins of Francisco Cerundolo's career, with the Argentine avenging recent losses to the Canadian at both the Australian Open and the Indian Wells Open.

Adrian Mannarino's 7-6 (7-5) 7-6 (7-0) victory over eighth seed Hurkacz was arguably an even bigger upset, as it snapped his streak of nine consecutive losses against top-10 opponents at Masters 1000 events.

The 34-year-old Frenchman absorbed 20 aces from Hurkacz and still came out on top, limiting his own unforced errors to 13 for the match.

A third upset of the day saw unseeded Italian Lorenzo Sonego play a near faultless match to eliminate 12th seed Tiafoe, finishing the contest with 22 winners and only two unforced errors, while not facing a single break point in the brief 68-minute battle.

There was no drama for Daniil Medvedev as the fourth seed received a walkover against Alex Molcan, and he will face France's Quentin Halys in the fourth round after his 7-6 (7-2) 6-3 triumph over Mackenzie McDonald.

Two seed Stefanos Tsitsipas almost joined the long list of seeded victims, but he prevailed 6-3 4-6 6-4 against Christian Garin in the day's only three-setter.

The Greek star will meet Russian 14th seed Karen Khachanov in the fourth round after his comfortable 6-2 6-4 result over Jiri Lehecka, while unseeded American Christopher Eubanks finished the day's play with a 6-3 7-6 (9-7) defeat of Gregoire Barrere.

Lorenzo Musetti won his opening match at the Argentina Open in comfortable fashion, defeating hometown hero Pedro Cachin 6-2 6-3 on Thursday.

World number 20 Musetti is still just 20 years old, making him the third-youngest player inside the top-40. The only younger players are 19-year-olds Carlos Alcaraz (world number two) and Holger Rune (world number nine).

The talented Italian has two ATP Tour titles to his name, but none outside of Europe, and he will hope to change that after he advanced to the quarter-finals in Buenos Aires.

Musetti will play Peru's Juan Pablo Varillas next after he prevailed 6-4 6-4 against former world number three Dominic Thiem.

Fifth seed Francisco Cerundolo did his part to set up an all-Argentine quarter-final clash after dominating Jaume Munar 6-2 6-1, but compatriot Diego Schwartzman could not hold up his end of the deal, falling 6-1 6-3 to Spain's Bernabe Zapata Miralles.

Meanwhile, world number seven Taylor Fritz made a winning start to his Delray Beach Open campaign, defeating Ecuador's Emilio Gomez 6-4 6-3.

Fritz will play France's Adrian Mannarino in the quarter-final after the 34-year-old veteran eliminated 24-year-old American J.J. Wolf 7-5 6-2.

Second seed Tommy Paul was too strong for Denis Kudla in a 6-3 6-4 triumph, and he will play Radu Albot for a place in the semi-final after the Romanian emerged the 6-4 6-4 victor against Australia's Aleksandar Vukic.

Marcos Giron survived a scare against qualifier Alex Rybakov in the opening round of the Dallas Open on Tuesday, escaping with a 6-4 6-7 (1-7) 6-1 victory.

One of the top seeds in action, Giron is ranked over 300 spots higher than Rybakov, but the underdog put up a serious fight and held up well in all key indicators.

Rybakov had 29 winners with only 17 unforced errors, and he had just two double faults to go with seven aces, but Giron was better in both categories. His talent shone through with 34 winners and 16 unforced errors, while he also had 10 aces and no double faults.

Also in Dallas, French eighth seed Adrian Mannarino secured a 7-6 (8-6) 6-2 win against Steve Johnson, and he will now face Australia's Jordan Thompson following his 6-1 7-5 triumph over Denis Kudla.

Meanwhile, at the Cordoba Open, Argentina's Federico Coria was the top seed to advance after defeating Brazil's Thiago Monteiro 6-7 (5-7) 6-1 6-2.

There was less success for hometown seventh seed Pedro Martinez, who was eliminated 7-6 (7-3) 2-6 6-0 by Chile's Cristian Garin, while Federico Delbonis beat Alejandro Tabilo 6-7 (8-10) 6-2 7-6 (8-6) to earn a shot at second seed Francisco Cerundolo.

David Goffin got off the mark with his first victory of 2023 with a straight-sets win over fifth seed Alexander Bublik in round one of the Auckland Open.

The Belgian lost both matches at the inaugural United Cup last week, but he saw off Bublik 6-3 6-4 in 74 minutes to reach the last 16 in New Zealand.

Another seeded player fell at the first hurdle on Monday as Adrian Mannarino lost 6-4 7-6 (7-4) to J.J. Wolf.

Richard Gasquet advanced with a 6-3 6-1 win over wild card Kiranpal Pannu, while Jenson Brooksby beat Fabio Fognini 6-7 (2-7) 6-1 6-3 and will now face Diego Schwartzman.

At the Adelaide International 2, fifth seed Dan Evans suffered a 7-5 7-5 defeat to Mackenzie McDonald.

Fellow seeds Alejandro Davidovich Fokina and Miomir Kecmanovic overcame Brandon Nakashima and Kyle Edmund respectively.

Wins for Hubert Hurkacz and Magda Linette saw Poland advance to the City Finals of the United Cup in Australia on Tuesday.

Hurkacz made it through a tough encounter against Stan Wawrinka 7-6 (7-5) 6-4 to give Poland a 2-1 lead in their Group B tie with Switzerland in Brisbane, before Linette came from behind to beat Jil Teichmann 5-7 6-4 6-1 to clinch it.

Poland will face Italy in the Brisbane final, whose 5-0 whitewash of Norway included Matteo Berrettini sealing victory with a 6-4 6-4 win over Casper Ruud.

In Perth, Croatia advanced to the City Finals after a dramatic day that saw Caroline Garcia get France on the board with a straight sets win against Petra Martic, before Adrian Mannarino came from a set down against Borna Gojo to serve for the match as he looked to bring his country level at 2-2.

However, Gojo broke back in a tense encounter before winning a deciding tie-break to send Croatia through to face Greece, who sealed a 4-1 win against Belgium.

Stefanos Sakellaridis recovered from going a set behind to beat Zizou Bergs, before Maria Sakkari overcame Elise Mertens 6-1 7-5, with Sakkari and Stefanos Tsitsipas adding some gloss to the score with a mixed doubles success against Kirsten Flipkens and Michael Geerts. 

Spain and Australia were unable to progress but the hosts at least had the consolation of securing a victory thanks to wins for Jason Kubler against Albert Ramos-Vinolas, and the mixed doubles duo of John Peers and Sam Stosur against Jessica Bouzas Maneiro and David Vega Hernandez.

The USA had already secured their Finals berth against Great Britain in Sydney, but were ruthless as they finished off their tie against Germany to win 5-0.

After Jessica Pegula beat Laura Siegemund 6-3 6-2, Frances Tiafoe also defeated Oscar Otte in straight sets, before the American duo combined to beat Siegemund and Daniel Altmaier 6-7 (5-7) 6-4 10-7 to complete a clean sweep.

World number nine Andrey Rublev comfortably beat qualifier Laslo Djere 6-4 6-3 to secure his place in the second round of the Astana Open.

The fifth seed found a crucial break of serve when leading the opener 5-4 to take the first set in Kazakhstan, before winning the next three games to put himself in the ascendancy in the second.

And despite a desperate last stand to stay in the match from Djere, Rublev held serve three times with relative ease to finish off his Serbian opponent.

Eighth seed Felix Auger-Aliassime served 14 aces to Roberto Bautista-Agut's two in their first-round match, but it was the Spaniard who advanced with a 6-4 7-6 (8-6) success.

Meanwhile, world number 10 Hubert Hurkacz overcame Francisco Cerundolo in straight sets.

Adrian Mannarino, the runner-up in Astana in 2020, came from a set down to beat Stan Wawrinka – playing as a wildcard – 1-6 6-2 6-3, and qualifier Zhizhen Zhang romped to victory with a superb third set to seal a 4-6 6-4 6-1 comeback win of his own over Aslan Karatsev.

At the Tokyo Open, fourth seed Frances Tiafoe cruised into the second round with a 6-3 6-4 triumph over Yasutaka Uchiyama, one of three Japanese players who crashed out at the first-round stage of their home tournament.

Uchiyama's countrymen Taro Daniel and Shintaro Mochizuki also tasted defeat at the hands of Bernabe Zapata Miralles and Brandon Nakashima, respectively.

Adrian Mannarino won the second ATP Tour title of his career when he defeated Laslo Djere 7-6 (7-1) 6-4 in the final of the Winston-Salem Open on Saturday.

Mannarino, 34, entered the match with a 1-9 record from his 10 career final appearances, but capped off his incredible week with his fifth consecutive straight-sets win.

On his way to the decider, Mannarino eliminated ninth seed Emil Ruusuvuori, eighth seed Albert Ramos-Vinolas, fourth seed Maxime Cressy and second seed Botic van de Zandschulp.

Against Djere, Mannarino stuck to what he had done all week, which was limiting his own errors and taking advantage of his opponent's mistakes.

The Frenchman committed 12 less unforced errors (29-to-17), while also controlling the game with his serve, winning 78 per cent (49-of-63) of his service points compared to 63 per cent (45-of-71) for Djere.

It was actually the Serbian who secured the first break of the match, but it would also be his last break of the match as Mannarino tightened the screws, not allowing a single break point opportunity in the second set.

With the win, and the 250 ranking points, Mannarino will rise 20 places up to 45th in the world.

It will be an all-unseeded final at the Winston-Salem Open after Adrian Mannarino eliminated Botic van de Zandschulp 6-0 6-4 in the semi-final.

Van de Zandschulp, the tournament's second seed, was the last seeded entrant remaining in the draw.

In a dominant first set, Mannarino won 80 per cent (12-of-15) of his service points to not allow his Dutch opponent any openings, and he took advantage of some sloppy play.

Van de Zandschulp committed four double faults and 16 unforced errors in the opening set, while Mannarino had no double faults and only one unforced error as the 34-year-old played a veteran's game and allowed his opponent to beat himself.

Overall, Van de Zandschulp committed 20 more unforced errors and five more double faults in the loss.

Mannarino will play Serbia's Laslo Djere in the final, with a chance to win his second career ATP Tour title. His sole title came at the Netherlands' Rosmalen Championships back in 2019. He has a career record of 1-9 in finals.

Djere made it through after yet another grinding affair, defeating Switzerland's Marc-Andrea Huesler 7-6 (7-3) 7-6 (7-5) in two hours and 20 minutes.

All five of his wins this week have required over two hours of court time, with this being his first straight sets result.

In a match that saw each player secure one break of serve, Djere was just slightly better throughout, winning 52 per cent (98-of-189) of the total points, while building a 37-24 advantage in the winners category and serving 10 aces to Huesler's four.

Botic van de Zandschulp is the only seeded player remaining at the Winston-Salem Open, advancing to the semi-final after winning a pair of tiebreakers against Benjamin Bonzi 7-6 (8-6) 7-6 (7-1).

Van de Zandschulp, the second seed, is yet to lose a set in the tournament after straight sets wins against Tallon Griekspoor and Jaume Munar, and he used his dominant serve to get the job done against France's Bonzi.

The Dutchman had 15 aces while Bonzi had three, and he posted 50 winners to Bonzi's 24 in a terrific exhibition of power tennis.

Van de Zandschulp, 26, will face Adrian Mannarino in the semi-final as the 34-year-old seeks his second career ATP Tour title, beating Maxime Cressy 6-4 7-6 (7-3).

Fourth seed Cressy was Mannarino's third consecutive seeded scalp, having also defeated ninth seed Emil Ruusuvuori and eighth seed Albert Ramos-Vinolas to make it this far.

Cressy's 10 double faults and 26 unforced errors shot himself in the foot, as the veteran Mannarino played a clean match, posting two double faults and eight unforced errors.

Serbia's Laslo Djere has taken the scenic route to the semi-final, winning his fourth three-set match of the week as he edged past Richard Gasquet 6-4 3-6 7-6 (8-6) in two hours and 43 minutes.

It comes after a three-hour-11-minute marathon against Jason Kubler in the previous round, and a two-hour-50-minute war of attrition against Joao Sousa prior to that.

Djere will hope to have some more gas in the tank when he meets Switzerland's Marc-Andrea Huesler in the semi-final after he upset 13th seed Jack Draper 6-4 6-4.

Former world number one Andy Murray was left frustrated after physically fading on his way to a first-round exit at the Citi Open with a 7-6 (10-8) 4-6 6-1 loss to Mikael Ymer on Tuesday.

The three-time Grand Slam winner failed to convert four set points in the first set before the Swede triumphed in two hours and 50 minutes.

The match was full of momentum swings, with the 35-year-old capitalising on Ymer's own physical issues, appearing to cramp in the second set, to level it up after winning five of the final six games of the set.

But 23-year-old Ymer regained his composure and physical state to race away with the third set for victory, rounding out 37 winners for the match, leaving Murray frustrated.

"It was disappointing obviously," Murray told reporters. "I thought there was some good tennis in the first set. After that, both of us were struggling a bit physically. The level of the tennis was not great.

 "Obviously [I] had chances in the first set to close that out. I had set point at 6-5, then... three in the tie-break and didn't get it.

"I think he seemed like maybe he was cramping a little bit in the second set, but recovered absolutely fine after the break at the end of the [second] set.

"Went off to change and cool off a little bit, and he recovered well for the third, whereas I didn't really. Yeah, just frustrating."

The first-round exit comes after Murray lost in the Hall of Fame Open quarter-finals in Newport to Alexander Bublik when he cramped up in hot and humid conditions.

"Struggled a little bit the past two tournaments with that," he said. "I need to have a little look at that with my team and maybe see why that is, make a few changes."

French veteran Adrian Mannarino took care of Bradley Klahn 6-2 6-4, while Jack Draper beat Stefan Kozlov 7-5 6-2 to set up a second-round date with top seed Andrey Rublev.

World number 112 Benoit Paire also triumphed in the first round on Tuesday, getting past Peter Gojowczyk 7-5 6-4.

Kyle Edmund, Jack Draper, Borna Gojo, Dominik Koepfer, J.J Wolf and Denis Kudla also were victorious, with Alexei Popyrin progressing after a walkover against Wu Tung-lin.

The top seeds were all victorious in Thursday's action at the Atlanta Open, with John Isner prevailing 7-6 (10-8) 4-6 7-6 (7-3) in an all-American showdown against Ben Shelton to close the day's play.

Isner, 37, relied as he usually does on his trusty serve to get the job done in tiebreakers, winning the match despite not breaking Shelton's serve a single time.

The second seed won 85 per cent (60-of-71) of his successful first serves, while Shelton was similarly stout, converting 83 per cent (50-of-60).

Isner will meet fellow American Jenson Brooksby in the quarter-finals after he came back from an early break to defeat Mackenzie McDonald 6-3 6-4.

The biggest differentiating factor between the two players was Brooksby's effectiveness off his second serve, winning 61 per cent (14-of-23) of those opportunities compared to just 22 per cent (four-of-18) from McDonald.

Fourth seed Alex de Minaur defeated fellow Australian James Duckworth 6-4 6-4 in a competitive match, but De Minaur simply created more chances for himself, with five break point opportunities while Duckworth had two.

De Minaur will play France's Adrian Mannarino after he defeated American Andres Martin 7-5 6-3.

Mannarino's main advantage was with his return game, securing four breaks of serve while dropping his own serve only once.

Daniil Medvedev is one match away from winning his first title of 2022 after beating Adrian Mannarino in straight sets to reach the Rosmalen Grass Court Championships final.

Defending champion Mannarino had won eight matches in a row at the ATP 250 event, which was last held in 2019, but he fell 7-5 7-5 to Medvedev in a match lasting a little under two hours.

Top seed Medvedev, whose most recent appearance in a final came at the Australian Open in January, will now face home favourite Tim van Rijthoven on Sunday.

"Adrian plays good, and some games in this match I was like: okay, I can't do anything," said Medvedev, who will reclaim top spot in the ATP rankings next week.

"I had to just continue playing my tennis. He was unbelievable sometimes, missing sometimes, so I just continued my game, and it managed to work today."

Medvedev was far from his best against flat-hitting Mannarino, with the first set featuring five breaks of serve, but the 26-year-old did enough to edge in front.

After wasting a chance to serve out the match in the 10th game of the second set, Medvedev edged a mammoth 11th game and avoided any sort of scare to advance through.

The Russian will next face a different sort of test against Van Rijthoven after the Dutch wildcard stunned second seed Felix Auger-Aliassime earlier on Saturday.

Van Rijthoven, who had not won a match at tour level until his opening-round win over Matthew Ebden, prevailed 6-3 1-6 7-6 (7-5) in a thrilling semi-final.

After sharing the first two sets, Van Rijthoven wasted six break-point opportunities in the decider, but he held his nerve in the tie-break to keep his dream run going.

He is the first Dutchman to reach the final in 's-Hertogenbosch since Raemon Sluiter in 2009.

Adrian Mannarino dumped sixth seed Aslan Karatsev out of the Lyon Open with a straight-sets victory on day one.

Mannarino secured a 7-6 (9-7) 6-4 win on Sunday to reach the second round in his homeland.

The Frenchman roared back from 5-1 down in the first set and rocked Karatsev further by winning the tie-break.

Mannarino then claimed the only break of the second set to advance at the expense of the Russian.

Holger Rune will be his opponent in round two following the Dane's 7-6 (7-4) 7-6 (7-3) defeat of Arthur Rinderknech.

Francisco Cerundolo will do battle with top seed Cameron Norrie in the second round after the Argentine saw off James Duckworth 6-2 3-6 6-3.

There were just two matches in the first round of the Geneva Open, with Tallon Griekspoor and Kamil Majchrzak progressing at the expense of seeds Tommy Paul (6) and Alexander Bublik (8) respectively. 

Rafael Nadal overcame a marathon first-set tiebreaker to move into the Australian Open quarter-finals with a straight-sets win over French veteran Adrian Mannarino on Sunday.

Nadal continued on his search for a record-breaking 21st grand slam title with the 7-6 (16-14) 6-2 6-2 victory at Rod Laver Arena.

The Spaniard will take on either third seed Alexander Zverev or Canadian 14th seed Denis Shapovalov in the last eight on Tuesday. The win marks Nadal's 14th appearance in the Australian Open quarters.

Nadal has only dropped one set in his first four matches at the Australian Open but the opening set against Mannarino was epic, with the sixth seed edging his opponent after 80 minutes.

The 2009 Australian Open winner trailed 3-0 in the tie-break but fought back to level it up, eventually taking the set 16-14 with his seventh set point.

Nadal assumed complete control from that set on, dominating the second and third to win in two hours and 40 minutes.

The 35-year-old was powerful, sending down 16-7 aces, while he won 88 percent on his first serve across the match. Nadal only offered up two break points for the match.

DATA SLAM: Nadal on the right track

Nadal has dropped 38 games across his four matches at the Australian Open, making light work of Mannarino in the latter two sets which collectively took as long as the first.

The Spaniard won in Melbourne in 2009 but lost finals in 2012, 2014, 2017 and 2019, yet without Novak Djokovic and Roger Federer at this year's event it looms as his best chance for years to lift the title and he seems in good health and form. 

WINNERS/UNFORCED ERRORS

Nadal – 42/22

Mannarino – 37/34

ACES/DOUBLE FAULTS

Nadal – 16/6

Mannarino 7/4

BREAK POINTS WON

Nadal – 5/17

Mannarino – 1/2