Alexander Zverev has accused Stefanos Tsitsipas of behaving like a junior and disrespecting his opponents by taking such long bathroom breaks during matches.

Andy Murray was furious when Tsitsipas was off court for around eight minutes ahead of the final set in their thrilling first-round match at the US Open on Monday.

Tsitsipas also required a medical timeout for a foot problem during a pulsating contest that the world number three won 2-6 7-6 (9-7) 3-6 6-3 6-4 at Flushing Meadows.

Murray said he had lost respect for the 23-year-old, who defended his lengthy spell off court and stated he had played by the rules.

The Brit was in no mood to back down on Tuesday, however, as he tweeted: "Fact of the day. It takes Stefanos Tsitsipas twice as long to go the bathroom as it takes Jeff Bezos to fly into space. Interesting."

Zverev appeared to accuse Tsitsipas of communicating with his father and coach, Apostolos, when he took a break during their semi-final showdown at the Western and Southern Open in Cincinnati this month.

Tsitsipas responded by denying having ever used his phone during such a situation, describing the accusation as "absolutely ridiculous."

However, world number four Zverev had Tsitsipas in his sights once again after beating Sam Querrey 6-4 7-5 6-2 in New York.

The German said: "It's happening every match. It's not normal. It happened to me in the French Open, to Novak at the finals [of the] French Open. I think Hamburg against [Filip] Krajinovic he was complaining, against me in Cincinnati was ridiculous, and now here again. I think players are catching up with that.

"He's the number three player in the world. I do not believe he needs to do that, because if you're top three in the world, you're one of the best in the sport.

"These kind of things happen at junior events, at Futures, at Challengers maybe, but not when you're top three in the world.

"You're allowed to do that but it's like an unwritten rule with players. I have been breaking rackets, I go insane sometimes and all that but one thing I'm very proud of, and I'll keep for the rest of my career, is I win and I lose by playing tennis on the tennis court."

Zverev reiterated his grievance with Tsitsipas having taken such a lengthy break during their meeting in Cincinnati.

"I didn't ask that question in Cincinnati, which I was very surprised at, because I was going to answer that very truthfully and honestly," he said.

"He's gone for 10-plus minutes. His dad is texting on the phone. He comes out and all of a sudden his tactic completely changed. It's just not me but everybody saw it. The whole game plan changes.

"I'm like, either it's a very magical place he goes to or there is communication there. But I also don't want to disrespect him. He is a great player, he is number three in the world for a reason. He's winning tournaments and playing incredible tennis this year for a reason, so it's not only that.

"But I do believe, and Andy said it as well, there is some level of respect that everybody needs to have between players.

"I feel like sometimes - or he might just go to the toilet. We don't know that, that's also possible. But it just happens too often, I would say."

Andy Murray has doubled down on his criticism of Stefanos Tsitsipas by joking that his US Open conqueror's bathroom breaks take twice as long as Jeff Bezos' trips to space.

World number three Tsitsipas beat Murray 2-6 7-6 (9-7) 3-6 6-3 6-4 in a thrilling five-set battle in the opening round at Flushing Meadows on Monday.

The opening-day showdown was overshadowed by Tsitsipas' controversial bathroom break ahead of the decisive fifth set – the Greek star spending around eight minutes off court, much to the frustration of Murray.

Tsitsipas also required a medical timeout for an apparent foot problem after losing the third set to 2012 champion Murray, who was far from impressed following almost five hours of action.

Speaking after the match, Murray – who failed to progress beyond the first round of the US Open for the first time in 15 appearances – said he had lost respect for Tsitsipas and suggested his opponent had deliberately attempted to disrupt his flow. 

Tsitsipas defended his lengthy break, insisting he had played by the rules and that he would speak to Murray face-to-face should the Briton wish to take the issue further.

Rather than resolving the matter, however, Murray aimed another dig at Tsitsipas with a sarcastic message on his personal Twitter account on Tuesday, comparing the stoppage to the 10 minutes and 10 seconds it took billionaire Bezos to fly to space last month.

"Fact of the day. It takes Stefanos Tsitipas (sic) twice as long to go the bathroom as it takes Jeff Bazos (sic) to fly into space. Interesting," he posted.

With the win over Murray, Tsitsipas became the 10th active player to defeat all four members of the 'Big Four' – Murray, Novak Djokovic, Rafael Nadal and Roger Federer.

Tsitsipas will meet world number 44 Adrian Mannarino in the second round on Wednesday.

Defending US Open champion Naomi Osaka passed her opening-round test, producing a powerful performance against Marie Bouzkova 6-4 6-1 on Monday.

All eyes were on Osaka following a difficult couple of months due to mental health concerns as a result of "long bouts of depression" since winning the 2018 US Open.

Osaka withdrew from May's French Open having won her first-round match, after she was fined and threatened with further punishment – and possible expulsion from the grand slam – for skipping obligatory media duties.

The Japanese star subsequently pulled out of Wimbledon before returning for the Olympic Games, though she suffered a surprise loss on home soil in Tokyo and was reduced to tears during a news conference in Cincinnati.

But as fans returned to Flushing Meadows for the first time in two years after the 2020 event was played behind closed doors due to the coronavirus pandemic, Osaka looked comfortable under the Arthur Ashe Stadium lights with the likes of former heavyweight champion Mike Tyson and Hollywood star Alec Baldwin in the crowd.

Bouzkova kept pace with Osaka in the opening set, not overawed by the occasion, but she came unstuck on serve in the 10th game.

While fending off one set point, Bouzkova was unable to save another, slicing a backhand into the net as Osaka closed out the set on her opponent's racquet.

With a set under her belt having reeled off 21 winners in the opener, Osaka stepped it up a gear – winning seven consecutive games before Bouzkova avoided a bagel.

Bouzkova continued to battle but it only delayed the inevitable as Osaka continued her quest for a fourth US Open crown and fifth slam title.

Data slam: Osaka on track to follow in Serena's footsteps

The 23-year-old needed one hour, 33 minutes to book her spot in the next round. Osaka is looking to become the first woman to win consecutive titles at Flushing Meadows since 23-time major champion Serena Williams claimed three in a row from 2012 to 2014.

Osaka is the only woman to win at least one major title over the past four seasons, claiming the Australian Open in 2019 and 2021, as well as the US Open in 2018 and last year.

WINNERS/UNFORCED ERRORS

Osaka – 34/23
Bouzkova – 10/8

ACES/DOUBLE FAULTS

Osaka – 4/1
Bouzkova – 2/2

BREAK POINTS WON

Osaka – 3/6
Bouzkova – 0/8

Andy Murray said he has lost respect for Stefanos Tsitsipas in a scathing criticism of the world number three's excessively long bathroom break at the US Open.

Tsitsipas rallied past three-time grand slam champion Murray 2-6 7-6 (9-7) 3-6 6-3 6-4 in a thrilling five-set battle in the opening round of the major at Flushing Meadows on Monday.

Murray's career has been devastated by injuries – the 34-year-old underwent hip resurfacing in 2019 but he has continued to be plagued by fitness problems – however he turned back the clock in a heroic display on Arthur Ashe Stadium, where the former world number one led two sets to one before Tsitsipas' comeback.

But the opening-day showdown was overshadowed by Tsitsipas' controversial bathroom break at the end of the fourth set – the Greek star spent around eight minutes off court, much to the frustration of Murray.

Tsitsipas also required a medical timeout for an apparent foot problem after losing the third set to 2012 champion Murray, who was far from impressed following almost five hours of action.

"It can't be a coincidence that it's happening at those moments. I don't believe it [Tsitsipas' foot] was causing him any issue at all," said world number 112 Murray after failing to progress beyond the first round of the US Open for the first time in 15 appearances.

"The match went on for another two-and-a-bit hours after that. He was fine, moving great I thought. It's just disappointing because I feel it influenced the outcome of the match. I'm not saying I necessarily win that match [without Tsitsipas' delays], for sure, but it had influence on what was happening after those breaks.

"I rate him a lot. I think he's a brilliant player. I think he's great for the game. But I have zero time for that stuff at all, and I lost respect for him."

"If people don't care enough about it to change, that's fine," Murray said of players taking long breaks.

"Look, I'll speak to my team about it. I'll listen to what, I don't know, fans, players and everything are saying about it. Maybe I'm being unreasonable. Maybe I'm overreacting to something because I lost the match.

"But yeah, right now sitting here I feel like it's nonsense and they need to make a change because it's not good for the sport, it's not good for TV, it's not good for fans. I don't think it's a good look for the players either.

"I'm sitting in here after a match like that against one of the best players in the world, and rather than talking about how fantastic he is, how good he is for the game, how great it was for me that I was able to put on a performance like that after everything that's gone on the last four years – I'm sitting in here talking about bathroom breaks and medical timeouts and delays in matches.

"That's rubbish, I don't think that that's right. I said I don't want to do press tonight because I know I'm going to sit here and it's going to seem like I'm just smashing him. Yeah, that's annoying for me because sounds like sour grapes because you've lost a match and everything.

"I would have said the same thing if I'd won, I promise. It was nonsense, and he knows it."

Stefanos Tsitsipas was able to breathe a sigh of relief on Arthur Ashe Stadium after the third seed rallied past former world number one Andy Murray 2-6 7-6 (9-7) 3-6 6-3 6-4 in a thrilling five-set battle.

French Open runner-up Tsitsipas and 2012 champion Murray was one of the standout matches in the opening round at Flushing Meadows and the near-five-hour showdown did not disappoint as the latter turned back the clock in New York on Monday.

Murray's career has been devastated by injuries – the 34-year-old underwent hip resurfacing in 2019 but he has continued to be plagued by fitness problems.

However Murray, who only had one pair of shoes, soaking wet with sweat, took a positive approach from the start and earned a surprise two-sets-to-one lead against the slam hopeful.

Murray, though, was made to rue his inability to capitalise on two set points at 6-4 in the second-set tie-break – leaving the door open for world number three Tsitsipas.

Tsitsipas held his nerve as the prospect of a first-round boilover beckoned, but it was not without controversy after the Greek star took his time in the bathroom between the fourth and fifth seeds, frustrating Murray.

It is the first time in 15 US Open appearances world number 112 Murray lost in the opening round in New York.

"It is not easy," Tsitsipas – who celebrated his ATP Tour-leading 49th victory of the year – said in his on-court interview. "I had to make lots of sacrifices to come back.

"I think the atmosphere was great today, with a lot of positive tennis. The New York crowd is known to be one of the best crowds in the world.

"The fact we are able to compete out here with an electric crowd today is something we have been waiting for."

Tsitsipas, who will meet Adrian Mannarino in the second round, added: "I hope I am able to keep my game at the same level as I managed today.

"Hopefully I will be back here on this court."

Novak Djokovic is a strong favourite to become only the third man to complete a calendar Grand Slam and make history at the US Open.

Djokovic has won all three majors this year and can complete a 2021 clean sweep at Flushing Meadows.

The irrepressible world number one would also go beyond Roger Federer and Rafael Nadal – both absent due to injury – with 21 grand slam singles titles if he triumphs in New York.

There will be no elusive record-equalling 24th major singles crown for Serena Williams, who has not recovered from the hamstring injury she suffered at Wimbledon.

With Ash Barty and Naomi Osaka the leading contenders to take the women's singles title, Stats Perform use Opta data to preview the final grand slam of the year.

WHAT A DIFFERENCE A YEAR MAKES FOR DOMINANT DJOKOVIC

Djokovic was thrown out of the US Open last year after accidentally hitting a line judge in the throat with a tennis ball.

The 34-year-old arrived in New York in far better spirits than when he left last September, having taken on all comers this year.

Djokovic missed out on a Golden Slam when he failed to win Olympic gold in Tokyo, but he could join Don Budge (1938) and Rod Laver (1962 and 1969) as the only men to win all four majors in the same year.

Maureen Connolly (1953), Margaret Court (970) and Steffi Graf (1988) are the only women to achieve the incredible feat.

BARTY TO GO BACK-TO-BACK?

Barty became the first Australian woman to win a Wimbledon singles title for 41 years in July.

Not since Williams in 2012 has a player claimed back-to-back women's singles major crowns in the same year, but Barty could take some stopping.

She could become the ninth woman in the Open Era to win Wimbledon and the US Open in the same season. 

Margaret Court, Billie Jean King, Chris Evert, Martina Navratilova, Steffi Graf, Martina Hingis, Venus Williams and Serena Williams can boast that achievement.

OSAKA BACK TO DEFEND TITLE

Japanese sensation Osaka won her third grand slam title at Flushing Meadows last September and went on to add a fourth at the Australian Open this year.

Osaka returns to grand slam action for the first time since withdrawing from the French Open, citing struggles with her mental health.

The world number three could be the first woman to win consecutive titles at Flushing Meadows since Serena Williams claimed three in a row from 2012 to 2014.

Osaka is the only woman to win at least one major title over the past four seasons, winning the Australian Open in 2019 and 2021, as well as the US Open in 2018 and last year.

ZVEREV BIDS TO BANISH PAINFUL MEMORIES

Alexander Zverev was beaten by Dominic Thiem in his maiden grand slam final in New York last year after the German had been two sets up.

He will not have to face Thiem this time around as the defending champion is sidelined due to injury.

Zverev was the only player to serve 100 or more aces during the tournament last year, firing down 131 but also racking up more double faults (64) than anyone else.

The world number four won his fourth title of the year in Cincinnati last week but Djokovic is undoubtedly the man to beat at Flushing Meadows.

Novak Djokovic has history in his sights as he begins his US Open quest; after three grand slam titles in 2021, a fourth beckons at Flushing Meadows.

Rod Laver was the last man to achieve a sweep of the Australian Open, French Open, Wimbledon and US Open singles in the same year, all the way back in 1969.

Steffi Graf won all four on the women's side in 1988, and it seemed a knock-in that Serena Williams would do likewise in 2015 when she headed to the US Open with three majors already bagged.

But winning any title at that level is never easy, and Williams famously came unstuck when she faced Roberta Vinci in the semi-finals.

Djokovic will be mindful that what seems an inevitability to the outside world remains very much still only a possibility. After his US Open tribulations last year, and a recent jolt at the Olympics, he will know anything can happen.

Here, Stats Perform looks at how Djokovic's situation at Flushing Meadows carries most of the hallmarks of Serena's own position as she headed into the tournament six years ago.

IT'S ALL ABOUT THE SLAMS

It was not always this way, but Djokovic has reached the point in his career when he can choose targets, decide which records he wants to break, and throw everything at those goals.

At the start of the year in Australia, he savoured triumphing at Melbourne Park for a ninth time and pointed to how Roger Federer, Rafael Nadal, Williams and Margaret Court had achieved so much.

"They've made history already," Djokovic said. "They made a tremendous mark in our sport. I'm trying to build that and develop that myself in a very unique, authentic way that is suitable to me.

"Whether I think about winning more slams and breaking records, of course. Of course, I do. And most of my attention and my energy from this day forward, until I retire from tennis, is going to be directed in majors, trying to win more major trophies."

It had very clear echoes of Williams in 2015, also in Australia, setting out her own ambitions for the year and specifically targeting the French Open and Wimbledon.

"Those are the two I really have my eye on, because I would like to do better at those. And I know I can do better," she said.

Williams set her heart and mind on that twin challenge and won both.

"I definitely am not going to play as much this year, and I'm just going to go for everything when I do play," said Williams.

BUILDING UP

When Williams reached New York in August 2015, she had delivered a 48-2 win-loss record for the season, landing each of the majors alongside the Miami Open and the Western and Southern Open. Petra Kvitova in Madrid and Belinda Bencic in Toronto had been the only two players to get the better of the 33-year-old Williams.

Djokovic has a 38-5 record for the year, albeit it has the feel of a more dominant year for the 34-year-old Serbian. Two of those losses came at the Olympics, in a semi-final and bronze medal match, and the other three came in his first three events on clay, losing to Dan Evans in Monte Carlo, Aslan Karatsev in Belgrade and Nadal in Rome.

When it mattered on clay, though, Djokovic majorly turned up in Paris, gutsily beating Lorenzo Musetti from two sets down in the fourth round, ending Nadal's streak of four Roland Garros titles by sinking the Spaniard in the semi-finals, and then leaving Stefanos Tsitsipas devastated in the final, with another fightback after dropping the first two sets.

Wimbledon followed, and Djokovic by then was openly targeting a Golden Slam – each major and the Olympic title.

Much like with Williams and her loss to Bencic in the Toronto semi-finals six years ago, however, Djokovic showed he was fallible as history beckoned. From a set up, he lost to Alexander Zverev at Tokyo 2020, a blow that was compounded by missing out on bronze when Pablo Carreno Busta sprang another shock.

HISTORY CAN BE A FIERCE OPPONENT

Williams and Djokovic have won non-calendar Grand Slams before, winning four in succession spanning two seasons.

Williams first achieved that from the French Open in 2002 to the Australian Open in 2003, and in 2015 she was aiming for five slams in a row at the US Open, having begun her dominant streak at her home grand slam the previous year.

She won the first set of the semi-final against Vinci, the world number 43, but was then second best to the Italian, with Williams saying her conqueror "played literally out of her mind".

But the disappointment was stark, underlined by Williams' terse response to the question of how disappointed she felt by the result.

"I don't want to talk about how disappointing it is for me," she said. "If you have any other questions, I'm open for that."

The four-in-a-row feat has only been performed once by Djokovic, from Wimbledon in 2015 to the French Open in 2016. Had he not been disqualified during the US Open last year for carelessly hitting a ball that struck a line judge, he would most likely currently be on a four-slam streak.

Those who win the first three slams of the year often do complete the set, but there are four instances of singles players falling one short by failing in the year's last major.

Before Williams, the most recent case was Martina Navratilova in 1984, when the imperious left-hander headed to the Australian Open – then played at the end of the year rather than the start – in pursuit of the Grand Slam. She lost to Helena Sukova in the semi-finals, and said: "If I'd have won, I'd have done it all. If I lost I had to start from scratch. Both are hard to cope with."

Navratilova had won 74 consecutive matches until that loss and ended the season with a 78-2 record.

In the men's game, Jack Crawford (1933) and Lew Hoad (1956) also fell short, both losing in finals of the US National Championships, the tournament that became the US Open. Don Budge (1938) and Laver (1962 and 1969) are the only men to have won a calendar Grand Slam in singles.

The weight of expectation is immense for Djokovic as he pursues what would be his crowning glory, not only sealing the Grand Slam but reaching 21 majors, one ahead of Nadal and Federer and into the outright lead in the men's game. The prospect cannot be ignored, and it will be a heavy burden to carry over the coming fortnight.

As Djokovic said on Friday: "I would be lying if I said that’s not something that I’m thinking about or that my attention is not going that way.

"I’m very motivated to play my best tennis. But I have to hit one ball at a time, as they say, try to be in the moment, have a guiding star in a way, a dream to win a slam here."

Novak Djokovic said claiming an elusive calendar Grand Slam would be the greatest achievement of his illustrious career.

Djokovic can become the first man since Rod Laver in 1969 to complete the slam sweep if he wins the US Open, having already conquered the Australian Open, French Open and Wimbledon in 2021.

The world number one would be just the third man to win all four majors in the same year after Don Budge was the first to do so in in 1938 before Laver in 1962 and 1969.

Djokovic could also move clear of rivals Roger Federer and Rafael Nadal, who will both miss the Flushing Meadows tournament due to injury, for the most men's grand slam titles in history – the trio are level on 20.

Preparing for his first-round match against Holger Rune in New York, Djokovic – who missed out on a Golden Slam when he failed to win Olympic gold in Tokyo – told reporters: "I'm very inspired to play my best tennis here.

"I don't want to say it's now or never for me because I think I'm going to have more opportunities in my life to win Slams. I don't know if I'm going to be having more opportunities to win calendar Slams.

"That's why it's a very unique opportunity. At the same time, I don't need to put any additional pressure to what I already have, which is pretty big from my own self and from of course people around me.

"But I thrive under pressure, as well. I've done that many times in my career. Pressure is a privilege, it truly is. This is what you work for day-in, day-out, all your life, to put yourself in a unique position to win Grand Slams and to make history. At the end of the day, I'm a big tennis fan, [a] fan of history. I admire this sport. I love it. I have this chance, and I'm going to try to use it."

A three-time US Open champion, the 34-year-old Djokovic owns a 75-12 record at the slam in the United States.

It will be Djokovic's first time back at Flushing Meadows since he was sensationally defaulted from last year's US Open after hitting a linesperson with the ball during his fourth-round match against Pablo Carreno Busta.

"Obviously I know how big of an opportunity is in front of me here in New York, where historically I've played really well over the years. It's probably the most entertaining tennis court that we have. [The] crowd will be back [in the] stadium," Djokovic said.

"I can't wait. Honestly I'm very motivated to play my best tennis. But I have to hit one ball at a time, try to be in the moment, have a guiding star in a way, a dream to win a Slam here, which would obviously complete the calendar Slam.

"I'm hugely inspired and motivated by that, no doubt. But at the same time, I know how to balance things out mentally, with lots of expectations around. My participation here, without Rafa and Roger participating, I feel it. I know there are a lot of people who are going to be watching my matches and expecting me to do well and fight for a Slam."

Defending US Open champion Naomi Osaka believes she could have better handled her decision not to participate in media conferences at the French Open.

Osaka withdrew from the French Open having won her first-round match, after she was fined and threatened with further punishment – and possible expulsion from the grand slam – for skipping obligatory media duties.

The four-time grand slam champion had confirmed before Roland Garros that she would not be taking part in post-match news conferences, suggesting her mental health was not helped by having to attend the mandatory interviews.

Osaka, the world number three, stated she has had "long bouts of depression" since winning the 2018 US Open title.

The 23-year-old subsequently pulled out of Wimbledon, but returned as one of Japan's great hopes for the Tokyo Olympics.

However, she suffered a surprise defeat to Marketa Vondrousova, while her preparation for Flushing Meadows also took a hit with a last-16 loss to Jil Teichmann in Cincinnati earlier this month.

Reflecting on her decision in Paris, Osaka, who won her second US Open title in 2020, told reporters: "I feel there's a lot of things that I did wrong in that moment.

"But I'm also the type of person that's very in the moment.

"I think there's a lot of things that I learned to do better. Of course, I don't feel the same situation will happen again.

"Whatever I feel, I'll say it or do it. I don't necessarily think that's a bad thing.

"I would say, maybe think it through a bit more, in the way that I didn't know how big of a deal it would become."

A few days prior to her defeat to Teichmann, Osaka broke down in tears during her first news conference since she pulled out of Roland Garros.

Yet the Queens-raised star was more composed during her media duties on Friday, as she aims to cap off what has been a difficult 2021.

"I think the biggest memory that comes back to me is being a little kid, running around the entire site," said Osaka, who will take on Marie Bouzkova to get her title defence started.

"I don't know if that may be the reason why I play so well here, but there's definitely a lot of nostalgia.

"I know I haven't played that many matches. But actually I feel pretty happy with how I'm playing."

Stefanos Tsitsipas faces Andy Murray and Ash Barty will take on 2010 finalist Vera Zvonareva in the first round of the US Open.

French Open runner-up Tsitsipas and 2012 champion Murray is one of the standout matches in the opening round at Flushing Meadows.

Top seed Novak Djokovic will start his quest for a calendar Grand Slam against a qualifier in New York and could face a repeat of the Wimbledon final versus Matteo Berrettini in the last eight.

World number one Djokovic, a strong favourite for a record 21st major title with Rafael Nadal and Roger Federer absent due to injury, could do battle with Alexander Zverev at the semi-final stage.

Daniil Medvedev, the second seed, is in the bottom half with Tsitsipas, who he could come up against in the semi-final. Medvedev's first test will come against Frenchman Richard Gasquet.

Barty could come up against Iga Swiatek in the last eight and Karolina Pliskova if she makes it through to the semi-finals.

Simona Halep's encounter with Camila Giorgi is a mouthwatering first-round match, while defending champion Naomi Osaka returns to grand slam action against former US Open junior champion Marie Bouzkova.

Angelique Kerber could be a tough fourth round opponent for Osaka. Close friends Madison Keys and Sloane Stephens meet in another eye-catching first-round match.

There will be no Serena or Venus Williams at the final major of the year due to injuries.

Top seed Elina Svitolina had no trouble booking her spot in the Chicago Women's Open quarter-finals on the same day Venus Williams and Sofia Kenin pulled out of the US Open.

Svitolina made light work of Fiona Ferro on Wednesday, cruising to a 6-4 6-4 victory at the WTA 250 tournament.

The Ukrainian star and bronze medallist at the 2020 Olympic Games in Tokyo will face seventh seed Kristina Mladenovic in the quarters.

Marketa Vondrousova – the fifth seed, ninth seed Alize Cornet, Tereza Martincova and Rebecca Peterson also moved through from the round of 16.

At Tennis in the Land, second seed Anett Kontaveit secured a quarter-final berth by topping Caroline Garcia 6-3 6-3 in Cleveland.

Meanwhile, Williams and Kenin withdrew from next week's US Open at Flushing Meadows.

Williams – a two-time US Open champion – will not compete in New York due to a persistent leg injury, joining sister Serena in sitting out the year's final grand slam.

"It's super, super, super disappointing," Williams said in a video via her Twitter and Instagram accounts. "I'm having some issues with my leg all this summer, and just couldn't work through it.

"I tried my best here in Chicago [at the WTA 250 Chicago Women's Open], but I just was unable to figure out the equation. And there's been so many times where I've been able to figure it out, even not in the best of my health, but this time, I just couldn't make any miracles work."

Kenin – the 2020 Australian Open champion – withdrew after testing positive for coronavirus.

"Fortunately I am vaccinated and thus my symptoms have been fairly mild," Kenin tweeted. "However I have continued to test positive and thus will not be able to compete at the US Open next week."

"I plan to spend the next several weeks getting healthy and preparing to play well this fall. Thank you all for supporting me. I want to wish all the players the best of luck in New York."

Patrick Mouratoglou says Serena Williams' "heartbreaking" withdrawal from the US Open was the "only possible decision" for the American.

Williams on Wednesday revealed she will not play in her home grand slam due to injury.

The 23-time major champion has not played on the WTA Tour since suffering a torn hamstring at Wimbledon in June and she has not fully recovered.

Mouratoglou, Williams' coach, stated that pulling out of the final slam of the year was the only option for the six-time US Open singles champion.

He tweeted: "Since she had to pull out from Wimbledon, @serenawilliams has been fully committed to her recovery and we've done everything we could so that she could compete at the @usopen. But her body isn't ready. It is heartbreaking, but this is the only possible decision."

Williams posted on Instagram earlier in the day: "After careful consideration and following the advice of my doctors and medical team, I have decided to withdraw from the US Open to allow my body to heal completely from a torn hamstring,

"New York is one of the most exciting cities in the world and one of my favourite places to play – I'll miss seeing the fans but will be cheering everyone on from afar. Thank you for your continued support and love. I’ll see you soon."

Williams, who turns 40 next month, is the latest high-profile withdrawal from the tournament after Roger Federer and Rafael Nadal pulled out through injury

It will be the first time since 1997 that the US Open will be played without Williams, Federer or Nadal.

Serena Williams has withdrawn from the US Open after failing to fully recover from a torn hamstring.

The 23-time grand slam champion, who won six of those titles at Flushing Meadows, has not played on the WTA Tour since sustaining the injury at Wimbledon in June.

She skipped last week's Western and Southern Open in the hope of being ready in time for the her home major in New York, but has now taken the decision to pull out of the event.

"After careful consideration and following the advice of my doctors and medical team, I have decided to withdraw from the US Open to allow my body to heal completely from a torn hamstring," Williams posted on her Instagram account on Wednesday.

"New York is one of the most exciting cities in the world and one of my favourite places to play – I'll miss seeing the fans but will be cheering everyone on from afar. Thank you for your continued support and love. I’ll see you soon."