Joel Embiid suffered a thumb injury as he led the Philadelphia 76ers to a road win at the Toronto Raptors but is confident it will not impact him in Game 4.

The 76ers took a 3-0 lead in the first-round series with Wednesday's 104-101 overtime victory, which was sealed by Embiid's turnaround three-pointer with 0.8 seconds remaining.

This two-game road trip was expected to be tricky for the 76ers, who are missing Matisse Thybulle, as he is not fully vaccinated.

But the Raptors have been without star rookie Scottie Barnes and now face the prospect of being swept when the series continues on Saturday.

Embiid is certainly hoping that will be the case, confirming he will again have a big role to play despite emerging after Game 3 with his right thumb in a brace.

"I think I might have twisted it, so we are going to see what's going on tomorrow," Embiid said before being asked if he would be kept on the sideline.

"No," he replied. "No chance, no."

As an MVP candidate and the biggest threat to the Raptors, Embiid was the centre of attention for the Scotiabank Arena crowd.

The 76ers center was jeered throughout in his first playoff game in Canada since an awful six-for-18 shooting performance in Game 7 of the 2019 Eastern Conference semi-finals, when it was Kawhi Leonard's turn to score a dramatic winner for the Raptors.

But Embiid said: "It felt great. Obviously we know what happened a couple of years ago. It just felt great.

"I just knew that coming in here tonight, it was going to be a tough place. Obviously, it's always a tough place to play, especially in the playoffs. They've got great fans, they're loud.

"I know coming into Toronto I was definitely going to be the bad guy for quite some time. So I just wanted to come out and let the game come to me. It felt great, but the job is not done."

The 21 points Embiid scored in Game 7 three years ago were actually his most on the road in that series, averaging just 15.5 per cent and 34.0 per cent shooting in playoff games at Scotiabank Arena prior to Wednesday's visit.

The 28-year-old finished with 33 points, on 12-for-20 shooting, and 13 rebounds this time but insisted "revenge" was not on his mind.

"It's just the first round to me," Embiid said. "Honestly, I haven't really thought about what happened three years ago.

"Obviously, the shot makes me feel good about what kind of happened. But during this whole series, I haven't really thought about coming in here and trying to get my revenge.

"I think I'm more focused about trying to win the whole thing, one game at a time, and trying to do whatever's necessary to get us there."

Giannis Antetokounmpo says being without Khris Middleton for any length of time would be a "tremendous loss" for the Milwaukee Bucks.

Middleton sprained the medial collateral ligament in his left knee during the fourth quarter of the Bucks' 114-110 loss to the Chicago Bulls on Wednesday.

Head coach Mike Budenholzer confirmed Middleton will undergo an MRI scan on Thursday to determine his status for the rest of the first-round playoff series, which is level at 1-1.

At the very least, the 30-year-old faces a race against time to be ready for Game 3 on Friday, and Antetokounmpo acknowledged that would be a huge blow for his side.

"We need this guy. When he asks for a sub, you know that it's bothering him because he doesn't leave the game," Antetokounmpo said.

"You expect him to get up and walk it off and get back to the game, but you see he was limping and limping and you're thinking like, 'Oh, I hope it's not bad, I hope it's not bad."

Middleton had scored 18 points and provided eight assists before leaving the game and has averaged 20.1 points, 5.4 rebounds and 5.4 assists this season.

He averaged at least 21.5 points in the past four playoff series and had 24 points, 6.3 rebounds and 5.3 assists per game in the NBA Finals.

"We have a job to do here," Antetokounmpo added. "Khris is one of the best players on the team, if he's not able to be with us, it's going to be a tremendous loss for us."

Antetokounmpo led the scoring for the Bucks with 33 points, but that was not enough as the Bulls – inspired by 41-point DeMar DeRozan – levelled up the series.

The Bucks also lost Bobby Portis in the first quarter after being caught in the face by an elbow from Tristan Thompson, but Budenholzer is optimistic he can make a swift return.

"We anticipate he should be fine with some time and that he should be good," Budenholzer said.

DeRozan's career playoff-high scoring return ensured the Bulls beat the third-seeded Bucks for just a second time in 19 meetings.

"No matter what you did in the regular season, this is a brand new start and new mindset," DeRozan said. 

"You could see it in all the guys. It doesn't matter if we'd lost 20 times to those guys. This is an opportunity for us to compete. We've got to take advantage of it."

Kevin Durant accepts it is down to him to step up and rescue the Brooklyn Nets' playoff series after struggling once again as his side fell 2-0 down to the Boston Celtics.

The 12-time NBA All-Star went zero-of-10 from the field in the second half, which is the most field attempts without a make in any half during his career.

While Durant did manage to score 12 points in the second half, it was not enough as the Celtics overturned a 17-point deficit to prevail 114-107 on Wednesday.

He is now 13-for-40 from the field in the series, having also struggled in the Nets' 115-114 loss in Game 1.

"It's on me to just finish it and figure it out," Durant said when asked about his latest underwhelming display. 

"I'm not expecting my team-mates or the defense to give me anything. I've just got to go out there and play."

Despite being targeted by multiple players, Durant still led the scoring with 27 points at TD Garden as he finished 18-of-20 from the free throw line.

Rather than complain about opposition tactics, though, the 33-year-old hopes to find a solution in time for Game 3 in Brooklyn on Saturday.

"They're playing two, three guys off me sometimes on me when I'm off the ball," Durant said. "They're mucking up actions when I run off stuff.

"I see [Al] Horford leaving his man to come over and hit me sometimes. Two or three guys hit me wherever I go. And that's just the nature of the beast in the playoffs. 

"I feel like I got a couple good shots there in the fourth that just didn't go down, but I see a few of their guys around me every time I get the ball.

"So I got to be more patient, but also play fast sometimes, too."

Kyrie Irving, who added 10 points for the Nets, believes the blame should be shared on the back of successive defeats.

"We're going against the No. 1 team in defense in the league. They've proven it, so it's not going to be easy, but it can be done," he said.

"I've got to get [Durant] to his spots and make the game a lot easier, and I believe I can do that with the assistance of the coaches and having a game plan to attack this defense."

The Boston Celtics overturned a 17-point deficit to go 2-0 up over the Brooklyn Nets in their playoff series, winning 114-107 on Wednesday.

The Nets' lack of off-ball movement eventually told against the NBA's best defensive team, as Kevin Durant scored 12 points in the second half but went zero-of-10 from the open floor and the Nets went 11-of-36 collectively.

Kyrie Irving shot one-of-seven after the main break and the Nets' iso-ball provided such a net loss, the second-half collapse came despite the Nets holding advantages in team rebounding, fast-break points and points off turnovers for the game.

Derrick White was the only Celtic not to score in double digits as Ime Udoka went with the eight-man rotation. Even with the relatively low 27 assists for the team, the Celtics still had a +11 margin over the Nets in that category.

Jayson Tatum was the only player on the floor with a double-double, putting up 19 points, 10 assists and six rebounds as the Celtics protected home court.

Sixers inch closer to series sweep

The Philadelphia 76ers took a commanding 3-0 lead in their series with the Toronto Raptors, claiming a 104-101 win in overtime on the road.

After protecting home court, the Sixers also fought their way back from a 17-point deficit to take a huge step towards claiming the first-round series.

With the game tied at 101, Joel Embiid scored the game-winning basket with 0.8 seconds remaining, evading Precious Achiuwa and receiving the inbound to bury a turnaround three-pointer off the catch.

The MVP candidate finished with 33 points on 12-of-20 shooting and 12 rebounds, while James Harden and Tyrese Maxey contributed 19 points each.

It was yet another poor shooting night for Fred VanVleet and Gary Trent Jr, combining for 36 points but off 12-of-32 shooting from the floor, with VanVleet's two-of-10 from beyond the arc particularly damaging.

Bulls split series in Milwaukee

The Chicago Bulls have managed to split the opening two games and can potentially gain home-court advantage in the series after their 114-109 win over the Milwaukee Bucks.

There was a sense the Bulls could take at least one game from Milwaukee after the opener, which saw them almost claim the win despite a horrible shooting night from Nikola Vucevic, DeMar DeRozan and Zach LaVine.

After a combined 21-of-71 in Game 1, the three Bulls bounced back with a combined 33-of-62 from the floor, while Alex Caruso gave them a reference point with primary ball-handling duties.

The Bucks just could not stop DeRozan getting to his mid-range spots and the five-time All-Star finished with 41 points. Caruso did a bit of everything on both ends with nine points and 10 assists as well as two blocks and two steals.

While Giannis Antetokounmpo put up 33 points, Milwaukee ultimately could not work their way back from a poor first half that opened up an 18-point deficit.