Inter Miami had their six-match unbeaten streak snapped by New York Red Bulls, who cruised to a 4-0 victory in MLS.
Former Manchester United utility Phil Neville – current head coach of the franchise co-owned by ex-Red Devils team-mate David Beckham – had overseen a club-first run of three consecutive victories.
Inter Miami were also in the midst of their best undefeated run in the team's young existence, having kept four straight clean sheets for the first time in their history.
However, 10-man Inter Miami crashed back down to earth at the hands of the visiting Red Bulls on Friday.
Patryk Klimala opened the scoring in the 18th minute before Red Bulls team-mate Omir Fernandez doubled the lead just past the half-hour mark at DRV PNK Stadium, where Inter Miami defender Nicolas Figal was sent off following a second yellow card prior to the interval.
The Red Bulls had collected just six points over their last 10 matches (W1 D3 L6) following a 2-1 loss to Columbus Crew on Tuesday – the fewest points New York have collected in any 10-game span since totalling just four points (W1 D1 L8) in June-August 2009.
But the Red Bulls emerged victorious after Fabio sealed the points with a second-half brace.
Inter Miami are eighth in the Eastern Conference, a point outside the play-off positions, while the 11th-placed Red Bulls are six points further back.
On Friday, Beckham increased his stake at Inter Miami, with the former United, England and Real Madrid winger "more committed than ever" to the MLS club.
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