Lee Carsley wants the England players at his disposal to "make the most of the situation" after nine others dropped out through injury.
Everton defender Jarrad Branthwaite on Wednesday became latest player to withdraw from the Nations League games with Greece and Republic of Ireland.
Trent Alexander-Arnold, Cole Palmer, Phil Foden, Jack Grealish, Bukayo Saka, Declan Rice, Aaron Ramsdale and Levi Colwill have also dropped out.
England captain Harry Kane has admitted to being unhappy with the large number of withdrawals for interim boss Carsley's final two games in charge.
However, Carsley attempted to put a positive spin on the situation when speaking at his pre-match press conference on Wednesday ahead of facing Greece.
"The focus all camp has been on the players that are here and it's important that we make the most of the situation," he told reporters.
"With the amount of players that have pulled out, it gives other players an opportunity to be here.
"We're really looking forward to the game and it's going to be a tough test for us and the focus has been purely on the players that are here.
"With the amount of pull-outs we've had in the window, historically it's been like that in the past - November has always been a challenging window.
"But the culture that Gareth [Southgate], Steve [Holland] and the rest of the lads created has made it a really positive environment and the players that are here thoroughly deserve to be here."
Grealish was one of the first players to withdraw from the squad, having been called up despite not playing for club side Manchester City since 20 October.
City boss Pep Guardiola questioned England's decision to include Grealish in their squad as he recovers from injury, but Carsley insisted he was justified in doing so.
"The medical teams are constantly talking throughout squad selection, regardless of whether there are games or not," Carsley said.
"We are constantly getting updates. The medical departments have brilliant communication between club and country.
"It was always the case we were going to get the players who were potentially going to miss out in to the assessed. Jack was one of them. He was assessed and sent back and it was as clear as that."
England trail Group B2 leaders Greece by three points with two rounds of fixtures to play, having lost the reverse fixture 2-1 at Wembley last month.
The Three Lions have won on all four of their previous trips to face Greece, doing so by an aggregate score of 9-1 - only against Luxembourg (5/5) do they hold a better 100% win rate away from home.
However, Greece are on the longest active winning run of any European nation in all competitions (five games) and could win six consecutive matches for the first time November 2013.
Carsley, who will step aside for Thomas Tuchel after next week's home match with Republic of Ireland, said: "We're expecting a tough game against Greece and it’s one we have to win.
"But we're really looking forward to it, we've had a good week's training, the players are in good spirits and it's going to be a sell out with a great atmosphere.
"We've had to wait four or five weeks for this, but this next window is so important to us, not just tomorrow but Republic of Ireland as well, so it's a great challenge for us."
Michel urges Girona to rise to the occasion against out-of-form Madrid
Girona boss Michel has urged his players to prove themselves against "one of the best teams in the world" when they face Real Madrid in LaLiga on Saturday.
Michel's side, who finished third in the Spanish top-flight last season, have failed to replicate that form, currently occupying eighth place after 15 games of their campaign.
Girona come into the clash with Carlo Ancelotti's side on the back of a shock defeat to fourth-tier side Logrones in the Copa del Rey in midweek.
They have also failed to win any of their last three games in all competitions, scoring just two goals, which both came in a 2-2 draw with Villarreal in their last league match.
Though Girona have not lost any of their last four games in LaLiga (W3 D1), which is their longest unbeaten run in the competition this season, Michel highlighted his side's attack as an issue so far this term.
"We are a better team in defence than last year. However, we need to improve in attack, to finish plays," Michel told reporters.
"When you go down you have to get up as soon as possible and that day is tomorrow."
But Madrid have been in a slump of their own, losing four of their last seven games across all competitions, including a midweek defeat to Athletic Bilbao that saw their longest unbeaten run away from home in LaLiga come to an end (W13 D8).
Despite their recent form, Michel was under no illusions about the task at hand for his players, insisting his side must play a "perfect" game to get a result on Saturday.
"Tomorrow I expect what it is, the Champions League and LaLiga winners. A great team with great players," he added.
"We are playing against one of the best teams in the world, and we have to play a perfect game.
"There is no need to motivate the players for a game against Real Madrid."
And looking at recent meetings between the two sides, the odds are stacked against Michel's side.
Madrid have won their last two meetings with Girona in LaLiga, keeping clean sheets in both, and can make it three wins in a row against the Catalan side for the first time in the top-flight.
Michel has also struggled against Los Blancos in LaLiga. He has lost two of his four league meetings with Carlo Ancelotti (W1 D1).
Only against Diego Simeone (W1 L4) has he suffered more defeats as Girona boss in the competition (also two against Imanol Alguacil, Manuel Pellegrini and Quique Setien).
Al-Ittihad 2-1 Al-Nassr: Bergwijn nets last-gasp winner for leaders
Steven Bergwijn's last-gasp winner earned Al-Ittihad a huge victory in their quest for the Saudi Pro League title, beating Al-Nassr 2-1 at King Abdullah Sports City on Friday.
Karim Benzema had given the hosts a 55th-minute lead before Cristiano Ronaldo levelled two minutes later, but Bergwijn struck the decisive blow in second half stoppage time.
In a tepid opening 45 minutes, clear-cut chances were hard to come by, with Bergwijn and Benzema going closest for the hosts, but unable to trouble Bento.
However, Al-Ittihad got themselves in front shortly after the break when Muhannad Al Shanqiti picked out Benzema, with the Frenchman on hand to tuck the ball home.
But the hosts' joy was short-lived after Angelo saw his effort cleared off the line by Danilo Pereira, before the Brazilian laid the ball back to Ronaldo to level the scoring.
With the game looking to end all square, Al-Ittihad stole the three points at the death as Bergwijn cut inside before curling a right-footed effort into the far-left corner.
The result moved Al-Ittihad three points clear at the summit, though Al-Hilal can go level with them with a win over Al-Raed on Saturday. Al-Nassr, meanwhile, stayed in fourth.
Data Debrief: Bergwijn bursts Ronaldo's bubble
Al-Ittihad have often been second best in their encounters with Al-Nassr, but they earned an impressive victory against Ronaldo's side, though it may not have been deserved.
They managed an expected goals (xG) total of just 0.66 from their 11 shots compared to Al-Nassr's 1.2 from the same number of attempts.
Benzema also ended his goal drought against Al-Nassr, having failed to score against them in his previous game against them. The former Madrid striker ended the game with a team-high xG of 0.36, while also having more shots (seven) and touches in the opposition box (four) than any of his team-mates.
Al-Ittihad have now won their last nine league matches, their second-longest streak in the competition after 10 wins between October 2021 and February 2022, while also triumphing in their eighth-straight home match in the Pro League.
Neuer and Gnabry out of Bayern's clash with Heidenheim
Manuel Neuer and Serge Gnabry will be absent when Bayern Munich take on Heidenheim in the Bundesliga.
Bundesliga leaders Bayern, who lost to Bayer Leverkusen in the DFB-Pokal in midweek, were already without top scorer Harry Kane.
Now two of his team-mates have joined him on the treatment table.
Neuer, who was sent off against Leverkusen, has an issue with his ribs, while Vincent Kompany did not specify Gnabry's injury.
"Manuel Neuer has discomfort with his ribs. It also looks like Serge Gnabry won't be involved either. Aleksandar Pavlovic is available," Kompany told reporters.
"Pavlo is available. There's no limit on how long he can play. He's not played for a while, but he's available."
Kompany did, though, provide a positive update on Kane.
"Things are looking good. I don't want to give a timeline and put our medical team under pressure. It could well be that he plays again this year. But everything needs to go perfectly," Kompany said of Kane.
Bayern are firmly in control in the Bundesliga and are unbeaten after 12 games with 30 points, four more than second-placed Eintracht Frankfurt.
They will fancy their chances of maintaining that unbeaten streak when they take on relegation-threatened Heidenheim, who have lost their last four league games.
However, Kompany warned against complacency.
"They're playing in Europe. It's always tough to be competitive in both competitions. What Heidenheim have done over the last 20 years is good," Kompany said.
"They're a very solid club. They won't panic now. We don't differentiate in how we prepare. It'll be another important game for us."
Heidenheim won their last Bundesliga game against Bayern 3-2 – they became the first promoted team in the league's history to come from two goals down to beat the Bavarians.
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