Saul Niguez scored the only goal of the game as Atletico Madrid responded to their Copa del Rey elimination with an unconvincing 1-0 victory over Osasuna that maintained their grip on LaLiga's top four.
Diego Simeone's side suffered a 3-1 extra-time loss to Real Madrid in the Copa quarter-finals on Thursday and were far from their best three days later at El Sadar.
Jan Oblak had to keep Osasuna at bay in the second half, before substitute Saul's calm 74th-minute finish proved the difference as Atletico recorded a much-needed triumph.
Victory moved Atletico three points clear of Villarreal and Real Betis in fifth and sixth respectively, while Simeone's side trail Real Sociedad – who play Real Madrid later on Sunday – by four.
An offside flag rendered Oblak's impressive 23rd-minute save against Chimy Avila redundant before Jose Gimenez headed over a presentable chance from Antoine Griezmann's in-swinging corner at the other end.
Aitor Fernandez repelled Griezmann from close range after a scramble inside the area, though neither side impressed during an otherwise drab first half.
Griezmann forced another smart Fernandez stop with a low drive immediately after the interval, while Avila headed David Garcia's deep right-wing cross narrowly over.
Oblak expertly denied Moi Gomez's back-post half-volley just past the hour, and that save proved pivotal when Saul raced onto Rodrigo De Paul's throughball to find the bottom-right corner and secure victory.
Tottenham 3-0 Qarabag: Postecoglou's side win Europa League opener despite early red card
Ten-man Tottenham recovered from an early setback to start their Europa League campaign with a commanding 3-0 victory over Qarabag.
Despite Radu Dragusin's early red card, goals from Brennan Johnson, Pape Sarr and Dominic Solanke helped Ange Postecoglou's side to a third straight win in all competitions.
Just seven minutes had elapsed when the hosts were reduced to 10 men as last-man Dragusin dragged down Juninho after he was caught in possession.
However, Spurs responded brilliantly to take the lead just five minutes later, with Solanke stealing possession and feeding Johnson, who applied a neat first-time finish.
The hosts survived a scare before the break when Juninho steered wide from Elvin Cafarquliyev's cross but doubled their advantage seven minutes after the restart when Mateusz Kochalski helped a corner into the path of Sarr, who instinctively volleyed home.
Qarabag squandered a great opportunity to halve the deficit just before the hour mark when Toral Bayramov's penalty hit the crossbar after Yves Bissouma tripped Cafarquliyev.
Tottenham capitalised in the 68th minute as Kochalski parried Son's shot into Solanke's path and he put the game beyond the visitors, who were denied a consolation later on when Juninho's header was disallowed for offside.
Data Debrief: Spurs soar despite Dragusin's historic early bath
It had the potential to be a difficult night for Tottenham when Dragusin was shown a straight red card - Spurs' earliest in a major European match.
The defender also became the first Tottenham player to be sent off on his European debut.
Spurs recovered to take control of the contest, though they survived a scare when Bayramov hit the bar with Qarabag's first missed penalty in the Europa League after six consecutive successful kicks.
Napoli 5-0 Palermo: Five-star hosts cruise into Coppa Italia last 16
Cyril Ngonge scored twice in an electrifying performance, as Napoli breezed into the Coppa Italia last 16 with a crushing 5-0 win over Serie B Palermo on Thursday.
Ngonge struck first in the seventh minute with a left-footed drive that bounced in front of Salvatore Sirigu before squirming under his body into the net, leaving the goalkeeper shaking his head in disbelief.
Sirigu was at fault again five minutes later when Ngonge lashed another left-footer from a difficult angle, the ball flying across the face of the goal before nestling in the side netting to make it 2-0.
Palermo gave the hosts a scare as Matteo Brunori struck the post 29 minutes in, but Napoli were too big, too strong and too quick for their second-tier visitors, with Juan Jesus nodding home from a corner to make it 3-0 just before the break.
The visitors' hopes of a comeback were shattered when they were reduced to 10 men just before the hour mark. Aljosa Vasic was given a straight red card for dangerous play after catching Billy Gilmour in the face.
David Neres slotted home the fourth in the 70th minute, pressing to help win the ball back before coolly knocking into the net.
Scott McTominay then came off the bench to score with his first touch, rifling home a pass from fellow substitute Romelu Lukaku seven minutes later to complete the rout.
Data Debrief: A perfect performance
Conte's first game in charge was in the first round of this competition, and the Partenopei edged their way through with a penalty shootout win over Modena.
It was a totally different performance this time around though. They had 16 shots, seven of which were on target, accumulating just 1.55 expected goals.
Ngonge's part was perhaps the most impressive - he scored with both of his shots, with those chances equalling just 0.09 xG, though he just could not snatch a hat-trick in the second half to round off a brilliant game.
KC, JC, Excelsior all score heavily in Manning Cup wins
Kingston College, Jamaica College and Excelsior High all scored massive wins in ISSA/Digicel Manning Cup action on Wednesday.
KC hit seven past Meadowbrook High at Meadowbrook to remain atop Zone C with 13 points from five games.
Elsewhere in Zone C, Campion College dispatched Penwood 2-0 to draw level on 10 points with their opponents who are in second place on goal difference.
Jose Marti Technical edged Cumberland High 2-1 in the St. Catherine derby in the day’s other Zone C clash.
Zone F action saw leaders Jamaica College defeat Bridgeport High 9-0 with Giovanni Taylor bagging four goals as the standout performer. Excelsior High hammered Pembroke Hall 11-0 in the other game from the zone.
In Zone D, Vauxhall High grabbed a late equalizer to secure a 1-1 draw against Camperdown High to remain unbeaten this season.
STATHS displayed a vintage performance as they held firm to secure their third win of the season with a 1-0 victory versus Haile Selassie and remain top of the zone with 10 points from their four outings.
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