Premier League managers are already feeling the strain amid cascading numbers of COVID-19 cases and mid-season injuries. Now many top bosses stand to lose stars to the Africa Cup of Nations.

Africa's greatest football show – now commonly known as AFCON – gets under way on Sunday in Cameroon.

Although the 2019 edition was held in June and July, it has historically been a January-into-February tournament and has returned to that place on the calendar.

A host of Premier League big names are hoping to make an impact during the four-week tournament, which falls slap-bang in the middle of European club campaigns, causing a major clash of competitions.

Premier League clubs certainly cannot complain of a lack of fair warning. It was June 2020 when African football chiefs decided the 2021 edition of the tournament would have to be pushed back by 12 months to a January 2022 start, in the hope the coronavirus crisis would have eased.

Here, Stats Perform takes a look at which teams from the English top flight might feel its impact the most.

Can Reds cling on in title battle?

If Liverpool lose no further ground on leaders Manchester City by the time their stars return from AFCON, then Jurgen Klopp would surely settle for that.

The 2019-20 Premier League champions have taken two points from a possible nine to leave the title as effectively City's to lose, and now Klopp is going to have to get by without Mohamed Salah, Sadio Mane and Naby Keita.

Egyptian striker Salah is the Premier League's leader in goals (16) and assists (9, level with Trent Alexander Arnold) so far this season. He has taken 80 shots in 20 games (38 of these have hit the target), played 12 throughballs and created 40 chances from open play: in each of those categories he is at the top of the Premier League charts for players defined by Opta as forwards.

How do you cope without such a contribution? Having Mane on hand would help, but Mane will be turning out for Senegal, a team who, like Salah's Egypt, are firmly in the mix as serious trophy contenders. Don't expect either back at the end of the group stage.

Mane has eight Premier League goals this term, including the opener at Chelsea recently. That goal return puts Mane joint-second among African scorers in the Premier League this season, level with Watford's Emmanuel Dennis, who is not in Nigeria's squad.

Mane has played 19 throughballs and has made 23 tackles to boot, which is the seventh highest number of tackles by a forward in the league this season, a rarely mentioned attribute of his game. He does not always tackle with his elbow, either.

Keita will presumably be less of a miss, with the Guinean's Anfield contribution remaining underwhelming, but Liverpool have been so hard hit by absentees recently that to lose anybody for up to five weeks is an inconvenience.

They are at least assured of Joel Matip's presence this month. The centre-back last played for Cameroon in 2015 and has retired from international duty. That is bad news for the AFCON hosts but helps Liverpool, given Matip remains a sturdy presence, with a duel success of 69.47 per cent this season ranking him third among Premier League defenders with 10 or more appearances, and a passing accuracy of 88.89 per cent putting him eighth in that metric.

Liverpool only have two league games inked in between now and the end of AFCON, against Brentford and Crystal Palace, but the Reds also have two postponed fixtures to be slipped in somewhere along the line.

Wintertime Blues?

Pep Guardiola's Manchester City hold a 10-point lead over second-placed Chelsea, with Liverpool a point further back but possessing a game in hand on the top two. Reigning champions City have won 11 straight Premier League games and the Citizens have the resources to be able to cope with the short-term loss of Riyad Mahrez, who will captain Algeria.

Mahrez's six goals and four assists this season have come at a startling rate. Given the depth in City's squad, he does not always start, so to appreciate his contribution it is worth looking at his numbers per 90 minutes on the pitch.

The former Leicester City forward is averaging 0.64 goals and 0.43 assists per 90 minutes – impressively close to Salah's return of 0.81 and 0.45 in those categories – and is one of only four Premier League players with 10 or more appearances to average at least 1.00 goal involvements per 90 (Michael Olise 1.43, Salah 1.26, Roberto Firmino 1.24, Mahrez 1.07).

The Blues of Chelsea may have concerns over the absence of goalkeeper Edouard Mendy, given the Senegalese's stabilising influence at the back. His save percentage of 77.14 has only been beaten this season in the league by Wolves' Jose Sa (80.82) and Arsenal's Aaron Ramsdale (77.46).

Spaniard Kepa Arrizabalaga struggled in the early stages of his Chelsea career and is now the undoubted understudy.

Yet Kepa's form when given an opportunity this season has not given such cause for concern. The former Athletic Bilbao goalkeeper has been chiefly used in cup action, and he has achieved a remarkable save percentage of 81.48, suggesting that for a short run of games, he could be a perfectly able deputy.

Can an exodus to Africa affect the race for Europe?

Will fourth-placed Arsenal miss Pierre-Emerick Aubameyang? It seems unlikely now, given he was dropped and stripped of the captaincy after a disciplinary breach before heading off to join Gabon. He has not played for a month. The Gunners won five games in a row without him, including four in the league, before being unlucky to lose to Manchester City.

Cold facts tell us Arsenal have a points average of 1.9 per Premier League game when Aubameyang has started games this season, and 1.5 when he has been either a substitute or out of the team, but those figures may not be significant given the momentum Mikel Arteta's players have built in the recent absence of the 32-year-old. His continuing exile from the first team seems unlikely to cause much consternation.

For manager Arteta to lose Thomas Partey (Ghana) at this point is a blow though, with the former Atletico Madrid player having been excellent in the 2-1 defeat to City, having been slowly building up to such a performance. He had more touches, won more duels, made more tackles and played more successful passes than any other Arsenal player.

Arsenal have a big derby at Tottenham coming up on January 16, and they might feel Partey's absence that day, particularly given Spurs, who currently sit sixth, are sending no current first-teamers away to AFCON.

Splitting the north London rivals for now are West Ham, in fifth, and it will surely have hurt David Moyes to wave off Said Benrahma for a month of Algeria duty. The playmaker has five goals and four assists in the league this season, as well as making 83 ball recoveries and creating 21 chances in open play. That makes him one of only 13 players in the competition to top both 80 recoveries and 20 open-play chances created, and one of only five Premier League stars to tick both boxes and score at least five times. Crystal Palace's Wilfried Zaha, away with Ivory Coast, is another member of that small group.

Seventh-placed Manchester United will lose Eric Bailly to Ivory Coast too. But with Phil Jones back in the first team, will Bailly be missed? The former Villarreal centre-back has played just 217 minutes in the Premier League this season. United youth prospect Hannibal Mejbri is also away, in his case with Tunisia.

Further into mid-table, Wolves must find an alternative to the excellent Romain Saiss (tackle success rate 72.73 per cent) on the left side of their defence, after he joined up with Morocco. Brighton and Hove Albion powerhouse Yves Bissouma has the highest tackle success rate among midfielders to have made more than 40 such challenges in the Premier League this season (50 attempted, 35 won: 70 per cent hit rate) and he will line up for Mali after ending an international exile.

Leicester City sent away striker Kelechi Iheanacho (2 goals, 4 assists this season) for Nigeria service at a bad time for the Foxes, given injured Jamie Vardy faces several weeks out of action.

Palace are firmly in favour of players heading away to represent their countries, but the Eagles never particularly like to be without Zaha (5 goals, 1 assist, 86 dribbles). Since his return from Manchester United in August 2014, Palace have averaged 1.2 points and a 32.9 per cent win percentage with Zaha in their starting line-up, and 0.9 points and a 24.5 win percentage when he has not been in that matchday XI. The loss of Cheikhou Kouyate (80.56 per cent success rate from 36 tackles) to Senegal duty may also diminish the sturdiness of Patrick Vieira's Eagles spine.

Can Clarets cope without Cornet?

The relegation scrap seems more likely to be affected by transfer market activity than departures to AFCON.

Newcastle United and Norwich City, the league's bottom two, are sending nobody away, while fourth-bottom Watford have kept Dennis (8 goals, 5 assists) and it remains to be seen what happens to Ismaila Sarr (5 goals), who has been absent with injury of late but has headed for checks with Senegal doctors.

Burnley, who sit 18th, are seemingly the team to watch carefully here. Maxwel Cornet, now away with Ivory Coast, has scored six Premier League goals from just 10 shots on target, and Sean Dyche must find a way to make the Clarets impactful without the former Lyon man.

The Premier League has confirmed rearranged dates for three fixtures that were postponed over the festive period.

In total, 18 matches were postponed over Christmas as rising coronavirus cases at clubs across the league led to large-scale disruption.

The issues have continued into the new year, with the first leg of the EFL Cup semi-final between Liverpool and Arsenal having to be pushed back, while the Reds' FA Cup clash with Shrewsbury Town this weekend is also in doubt.

Three top-flight games were rearranged last week, with Southampton versus Brentford, Everton versus Leicester City and West Ham versus Norwich City to be played on January 11 and 12.

Now, three more games have been confirmed to be taking place the following week, including fixtures for Manchester United and Tottenham.

Brentford host United on January 19, while Leicester and Spurs face each other in the day's other fixture.

January 18 sees Burnley host Watford and Chelsea visit Brighton and Hove Albion.

The latter game was set to take place in February, but has had to be moved forward due to the Blues' participation in the FIFA Club World Cup. The teams drew 1-1 at Stamford Bridge on December 29.

Arsenal's match with Burnley that was planned for Saturday, January 22 has now been pushed back to January 23, with the Gunners set to play Liverpool in the rearranged EFL Cup fixture on January 20.

Aaron Ramsey has not had the best of times since moving to Juventus.

The Wales midfielder joined Juve from Arsenal in 2019 on a four-year deal.

Ramsey has only managed 70 appearances in an injury hit two and a half years with Juventus.

TOP STORY – RAMSEY TO LEAVE JUVENTUS IN JANUARY

Aaron Ramsey is set to exit Juventus in the January transfer window, reports Sky Sports.

Italian transfer supremo Gianluca Di Marzio claimed that Ramsey is likely to return to the Premier League, having already turned down an offer from Burnley .

Newcastle United have been linked with Ramsey, along with Everton.

ROUND-UP

- Bayern Munich will consider swapping Kingsley Coman with Barcelona winger Ousmane Dembele in the off-season, reports L'Equipe. Coman's contract expires in 2023 and negotiations on a new deal have stalled.

- Sky Sports have reported that Newcastle are contemplating a bid for Lucas Digne. The full-back is set to leave Everton this month after a falling out with Rafael Benitez, though supposedly prefers a move to London, with Chelsea and West Ham also said to be interested.

- Everton, meanwhile, hold an interest in Newcastle midfielder Sean Longstaff and have already made a bid, according to the Daily Mail and Sky Sports.

- Paris Saint-Germain may look to sign Lyon's Lucas Paqueta next off-season, so say L'Equipe.

- Manchester United are determined to secure Wolves' Portuguese midfielder Ruben Neves in January, according to The Sun.

- Lazio have opened talks with Liverpool on a deal for Belgium international forward Divock Origi, claims LazioNews24.

- According to Sky Sports, five Premier League clubs have held talks with Barcelona's Philippe Coutinho.

The first heavyweight tussle of the new year in the Premier League did not disappoint as Chelsea and Liverpool played out an entertaining 2-2 draw at Stamford Bridge.

The Blues were held at home for the fifth time in six league games, a run that includes three straight draws in the top flight for the first time since February 2016.

But Thomas Tuchel's side can be happy with a point after recovering from two goals down as they extended their unbeaten run against the Reds in the league to four matches.

While there was nothing to separate the sides sitting second and third, Brentford, Brighton and Hove Albion and Leeds United were all victorious on Sunday.

Here, Stats Perform unpacks the pick of the Opta data from another eventful day in the Premier League.

Sadio Mane opened the scoring in a Premier League game for the 37th time since joining Liverpool in 2016-17 – only Tottenham's Harry Kane (40) has done so on more occasions.

However, some will argue that Mane was fortunate to be on the field at that point after catching Cesar Azpilicueta with his elbow after just six seconds.

Mane was instead issued a yellow card with 15 seconds on the clock, making it the earliest booking in a Premier League game since Opta started recording such data in 2006-07, nine seconds faster than the previous quickest caution for Scott McTominay against Newcastle United in December 2019.

Mohamed Salah went on to double Liverpool's lead with his fourth league goal against Chelsea, which is the joint-most any player has scored against the Blues after playing for them, along with Manchester City's Kevin De Bruyne.

Chelsea responded brilliantly with two goals in the space of 245 seconds through a Mateo Kovacic stunner and Christian Pulisic's well-taken strike, ensuring they remain a point above their opponents having played a game more.

This was the fourth occasion in this season's Premier League that a side has failed to win a game in which they have led by two goals, with Liverpool accounting for two of those occasions, having also drawn 2-2 with Brighton in October.

Leeds United 3-1 Burnley: More Maxwell magic not enough

Leeds scored three times in a Premier League game for the first time this season on their way to ending a four-game run without a victory, putting distance between themselves and Burnley in the final relegation spot.

Previously with just one win to their name in the competition since the end of October, Jack Harrison squeezed home for Leeds to open the scoring at Elland Road before Maxwell Cornet equalised through Burnley's first direct free-kick goal since Boxing Day 2017.

That was Cornet's sixth Premier League goal in 10 appearances, the most by an African player in their first 10 games since Pierre-Emerick Aubameyang for Arsenal in April 2018 (also six).

Stuart Dallas restored Leeds' advantage on his 250th appearance for the club in all competitions, becoming the first United player to reach that tally since Lucas Radebe in November 2003.

The much-needed victory was sealed by Daniel James in added time, meaning Leeds are unbeaten in 10 Premier League games against sides starting the day in the relegation zone (W8, D2) since returning to the top flight last season.

As for Burnley, they have now won just one of their last 20 Premier League matches and are winless in 11 on their travels, their worst such run on the road since 17 without a victory between August 2016 and April 2017.

Everton 2-3 Brighton and Hove Albion: Mac Allister inspires soaring Seagulls

The highest-scoring game of the day in the Premier League took place at Goodison Park, where Everton suffered defeat in their opening league game of a calendar year for the fifth year running, their worst such streak since a run of seven between 1957 and 1963.

Brighton's opening goal via Alexis Mac Allister after two minutes and 43 seconds was the Seagulls' fastest-ever away from home in the competition, and their third-fastest overall.

Dan Burn doubled the visitors' lead on Merseyside, shortly before the returning Dominic Calvert-Lewin became the 22nd different player to miss a Premier League penalty for the Toffees – only Arsenal (23) have more.

Anthony Gordon scored his first senior goal to give Everton a bit of hope, only for Mac Allister to register for a second time as Brighton moved to 27 points after 19 games – their joint-best return at this stage of a top-flight campaign alongside 1981-82.

It was another afternoon to forget for Rafael Benitez, however, with Everton having now picked up only 19 points from 18 games, which is their worst return at this stage since accruing 17 from 18 matches in 2005-06.

Brentford 2-1 Aston Villa: Bees bounce back again

Comeback experts Brentford hit back to beat Villa late on thanks to goals from Yoane Wissa and Mads Roerslev after Danny Ings had opened the scoring in west London.

Only West Ham (12) and Everton (11) have won more points from losing positions in the Premier League this term than Brentford, who have now recovered nine points in total.

That is in complete contrast to a Villa side that have lost more games in the competition since the start of last season after scoring first than any other side (eight).

Ings has now opened the scoring in more different English top-flight games since the start of 2019-20 than any player (18), but that early strike was not enough for Steven Gerrard's men.

Wissa's equaliser was Brentford's first Premier League goal from outside the box and full-back Roerslev, who set up that strike, completed the turnaround to become the second Bees player to score and assist in the same game in the competition for the club after Ivan Toney.

Cashed-up Newcastle United are currently sitting last on the Premier League table, without a win with the season into December.

As a result, the Magpies are expected to be busy when the transfer window opens in January.

Newcastle are the only team yet to win a Premier League game this season.

TOP STORY – NEWCASTLE TARGET ENGLISH SEXTET

The Telegraph claims that Newcastle United have six English players on their January shortlist, including Manchester United's Jesse Lingard, Tottenham's Harry Winks, Chelsea's Ross Barkley and Atletico Madrid's Kieran Trippier.

According to the report, the club will hand over a blank cheque to manager Eddie Howe to land players who can make an instant impact.

Newcastle's owners are confident they can act swiftly in January despite their ongoing search for a sporting director. Burnley's James Tarkowski and Liverpool's Nat Phillips are also on their radar.

ROUND-UP

- The Mirror reports that Arsenal are tracking Everton's England international forward Dominic Calvert-Lewin with a view to an end-of-season move, as Alexandre Lacazette's replacement.

- Manchester United's veteran Uruguayan striker Edinson Cavani wants to join Barcelona next season claims The Times.

- Milan and Internazionale are both lining up bids for Manchester United's Brazilian full-back Alex Telles according to The Sun.

- The Sun claims that Chelsea loanee Saul Niguez is unhappy at the club and wants a switch in January after joining the Blues on loan from Atletico Madrid in August. However, Saul cannot join a third European club this season, complicating matters.

- Talks between Barcelona and Ousmane Dembele have failed to progress, putting in doubt his future at the club, reports Sport.

The race to sign Erling Haaland may have taken another turn.

Norway forward Haaland is a hot property being pursued by a host of top clubs, with Manchester United among them.

Borussia Dortmund retained his services at the start of this season but the race is expected to heat up in the off-season.

TOP STORY – UNITED HOPEFUL OF HAALAND EDGE

The Mirror reports that the imminent appointment of Ralf Rangnick at Manchester United can give them the edge in the race for Borussia Dortmund's Erling Haaland.

Rangnick and Haaland worked together previously at Salzburg and United believe that relationship can propel them to the front of the queue.

Manchester City, Real Madrid and Paris Saint-Germain are all in the race to sign the 21-year-old.

ROUND-UP

- PSG will not let head coach Mauricio Pochettino exit the club during the season amid links with Manchester United's vacant managerial role, reports Goal. The Argentine may be allowed to leave at the end of the season.

- Marca report that Real Madrid will not be signing Manchester United midfielder Paul Pogba in the off-season despite widespread speculation about a move.

- Sevilla are leading the race to sign Blackburn's Chile international Ben Brereton, according to The Sun. Rovers want £20m for his services.

- West Ham are set to launch a £7m bid to sign Burnley defender James Tarkowski,  report The Sun.

Chelsea boss Thomas Tuchel has revealed an infected wisdom tooth was the reason behind Mason Mount's recent absence as the midfielder eyes a return against Burnley.

Mount missed the last two matches, which came against Newcastle United in the Premier League and Malmo in the Champions League, through illness.

Tuchel has elaborated on what caused the problem and also discussed the England call-up Mount received despite his recent absence from the league leaders' team.

"It's a tricky one," Tuchel said when he was asked about Mount ahead of Saturday's home top-flight clash with Burnley on Saturday.

"Mason was ill but the reason was his wisdom tooth, this was the reason for the feeling [unwell], a bit of an infection. 

"Then he was back in training and lost a bit of weight as he couldn't eat properly. He takes medication and let's see. 

"He is in the squad for Saturday and can play some minutes, but we will need to wait for the reaction because it seems proper treatment has to be done."

Mount, who scored a hat-trick against Norwich City the last time he started a match on October 23, could join up with England at some stage in the international break.

But Tuchel was not sure whether it would be from the start or even at all, with matches against Albania and San Marino coming up in World Cup qualifying.

"If everything is okay [then he will join up], but we need a proper treatment, so it can be that he is out or he joins a bit later," added the German.

"We will always push and encourage him. We are proud when he is selected, he is proud. 

"So there is nothing going on behind closed doors to keep Mason here. There is something going on we need to take care about."

After 10 matches, Chelsea lead Liverpool by three points at the top of the table.

They face Burnley having won their last four Premier League games against them, scoring 12 and conceding twice in that run, but Tuchel is not expecting an easy ride.

Marcos Alonso has been added to the Chelsea injury list, while forwards Romelu Lukaku and Timo Werner remain out along with midfielder Mateo Kovacic.

Tuchel said: "Marcos injured himself in the very last minute of the Malmo match.

"He tried to come out for training but the stress is too high on the ankle. Nothing big but too painful at the moment.

"We know exactly what we'll get from Burnley, they have a clear identity, a manager that has been in charge many years. It will be a tough one."

Asked when Lukaku could return, Tuchel said: "We have the international break now and then we will be more clear. We will see what is going on during the second week of the international break."

And his stance on the football calendar was clear amid debate over the likes of Mount and Callum Hudson-Odoi, who has rejected a call-up for England's Under-21 team.

"There are too many international windows, too many competitions, too many games for the top players," he said. "That increases quantity and not quality. It's too much, simple as that."

Chelsea have scored 16 goals in their opening five home Premier League games this season (W4 L1), their joint-most at this stage of a Premier League season.

The Burnley clash will be the 30th league game for Tuchel at Chelsea and he has racked up 18 clean sheets over the course of his first 29. 

Jose Mourinho is the only Premier League manager to keep more than 18 in his first 30 games in charge in the competition (22).

Nuno Espirito Santo hailed the unity demonstrated by Tottenham in their 1-0 EFL Cup fourth-round win over Burnley. 

Lucas Moura's 68th-minute header proved the difference at Turf Moor as Spurs progressed to the quarter-finals of the competition for the third time in four seasons. 

The visitors were made to dig deep as Burnley pushed for an equaliser late on, but they held out for victory and a first clean sheet in 11 matches in all competitions. 

Nuno felt his players deserved credit for their application as they responded to Sunday's Premier League defeat at West Ham. 

"We did a good job controlling the way they play," he said. "We were much better in the second half in terms of mobility and dynamic.  

"The end of the match is about defending, sticking together. It's good for the team.  

"We know that games require suffering and require unity, so we must congratulate the players because they did a good job." 

One sour note saw Tottenham lose Bryan Gil to injury after just 25 minutes of the tie, with Nuno revealing they are still awaiting a full assessment of the damage. 

Last season, Spurs were runners-up to Manchester City, whose quest for a fifth straight EFL Cup triumph was ended by a penalty shoot-out defeat at West Ham on Wednesday. 

Nevertheless, Nuno was quick to play down his side's chances of going the extra step this year after booking their place alongside the likes of Liverpool, Chelsea and Leicester City in the quarter-final draw. 

"We cannot look much further," he added. "We came here to go through; we did it in a good way and with a good game.  

"Let's see the draw and wait for the next one. 

"There are still a lot of teams. Every team involved in the competition is an option, so let’s focus on ourselves." 

Lucas Moura scored the only goal as Tottenham beat Burnley 1-0 to progress to the EFL Cup quarter-finals.

The Brazilian settled the all-Premier League fourth-round clash in the 68th minute at Turf Moor, firmly planting home a header from Emerson Royal’s cross.

Victory means the 2021 finalists of this competition are through to the last eight for the third time in four years.

Nuno Espirito Santo's side also registered a first clean sheet in 11 attempts, and only a second away win in eight.

Tottenham had only lost once in their 14 previous meetings with Burnley and had a good chance after just three minutes.

Giovani Lo Celso played Harry Kane through on goal, but the England captain uncharacteristically dragged his effort wide.

Emerson came to Spurs' rescue at the other end 10 minutes later; the full-back importantly clearing Johann Gudmundsson’s deep cross with Dwight McNeil lurking.

Aiming to beat a Premier League opponent over 90 minutes for the first time in five attempts in this competition, Spurs turned up the pressure after the break.

Nick Pope produced brilliant reflexes to deny Lo Celso from Kane's through ball in the 65th minute.

However, the Burnley goalkeeper was powerless three minutes later as an unmarked Lucas – on as an early substitute for the injured Bryan Gil – headed in Emerson's cross from close range.

The hosts pushed for an equaliser late on with Ashley Barnes testing Pierluigi Gollini from distance.

However, Spurs held on and the Clarets' wait for a first quarter-final appearance since the 2008-09 season continues.

Defending champions Manchester City will travel to West Ham in the EFL Cup fourth round, while Arsenal host Leeds United.

Pep Guardiola's men are in search of an unprecedented fifth successive triumph in the competition and they will face Hammers, who beat City's rivals Manchester United 1-0 in round three on Wednesday.

Arsenal cruised to a 3-0 victory over League One AFC Wimbledon and they take on Leeds at the Emirates Stadium next after Marcelo Bielsa's side edged past Fulham on penalties.

There are five all-Premier League ties in total, with Leicester City pitted against Brighton and Hove Albion after being defeated at the weekend in the top flight by Graham Potter's men.

European champions Chelsea needed penalties to sneak past Aston Villa and they will host Southampton, who also required spot-kicks to defeat Sheffield United.

Burnley crushed Rochdale 4-1, but a much tougher task awaits them as they face Tottenham after their shoot-out triumph over Nuno Espirito Santo's former club Wolves, while Brentford meet Stoke City away from home in the next round.

Liverpool make the trip to Deepdale to do battle with Championship side Preston North End, who demolished Cheltenham Town 4-1 on Tuesday.

There will be at least one non-top-flight side in the last-eight stage as Sunderland face Queens Park Rangers after Mark Warburton's men upset Everton.

The fourth-round clashes are set to take place during the week commencing October 25.

EFL Cup draw:

Chelsea v Southampton

Arsenal v Leeds United

Stoke City v Brentford

West Ham v Manchester City

Leicester City v Brighton and Hove Albion

Burnley v Tottenham

Queens Park Rangers v Sunderland

Preston North End v Liverpool

Harvey Elliott has been handed a first Premier League start for Liverpool against Burnley, while captain Jordan Henderson returns to action for the Reds.

Henderson suffered a groin injury in the derby defeat to Everton at Anfield in February and has not featured for Jurgen Klopp's men since, though he was involved in England's Euro 2020 campaign.

Elliott became the youngest player to make an appearance in Premier League history in May 2019, making his debut for former club Fulham when aged 16 years and 30 days.

The 18-year-old now gets the chance from the outset after appearing twice as a substitute during the 2019-20 campaign for Liverpool, with Andy Robertson is also fit again to return to the bench.

The Scotland left-back suffered ankle ligament damage in a pre-season friendly with Athletic Bilbao and while Saturday's clash has come too soon to start again, it appears he could be ready for the Chelsea game next week.

Liverpool ran out 3-0 winners in their Premier League opener against Norwich City, in which Elliott tasted seven minutes of action off the bench, but they now host a Burnley side who ended their 68-game unbeaten home run last term.

Mohamed Salah netted once, his record-breaking fifth consecutive goal on the opening day of a Premier League campaign, as well as providing two assists against the Canaries.

A brace against the Clarets would see the Egypt forward reach 100 Premier League goals in 160 appearances. Only four players have ever achieved that feat in the competition before: Alan Shearer (124 games), Harry Kane (141), Sergio Aguero (147) and Thierry Henry (160).

Burnley, in contrast, got their campaign underway with a 2-1 loss at home to Brighton and Hove Albion. They could win consecutive away league matches at Anfield for the first time since 1894-95 and 1896-97.

England international Kieran Trippier has expressed his desire to return from Spain this off-season.

The Atletico Madrid full-back has spent two seasons in Spain, helping Diego Simeone's side win LaLiga in 2020-21.

A former Burnley and Tottenham defender, Trippier has been pursued by Manchester United who are yet to agree a fee with Atletico.

TOP STORY – ARSENAL ENTER TRIPPIER RACE

Arsenal have joined United in targeting Kieran Trippier, reports The Sun.

The Gunners see Trippier as Hector Bellerin's replacement, with the Spaniard having been linked with Inter as he aims to make a move away from north Lonndon.

Atletico are demanding €40million (£34million) for 30-year-old Trippier.

ROUND-UP

- The Sunday Mirror are reporting that Harry Kane will need to force through his transfer from Tottenham to Manchester City, after Spurs chairman Daniel Levy's claim the England captain is not for sale. City are reportedly prepared to wait and start the new season without a recognised striker.

- Inter are closing in on a deal for Atalanta's Colombian forward Duvan Zapata, with an offer of €30m on the table, reports Cesar Luis Merlo. Zapata is seen as a replacement for Romelu Lukaku, with the Belgium striker set to exit for Chelsea.

- Atalanta are ramping up their move to sign Chelsea forward Tammy Abraham as part of the three-club shuffle. Fabrizio Romano claims the Atalanta board will meet Chelsea in the next 48 hours, with a price tag of around €40m to be discussed.

- Paris Saint-Germain have held advanced talks with the agent of Napoli defender Kalidou Koulibaly about a move, reports Foot Mercato.

- Burnley are struggling to complete a move to sign RB Leipzig's Ademola Lookman on loan, according to The Sun.

The Premier League's big-money clubs are circling for Aston Villa's Jack Grealish.

The England midfielder is drawing interest from multiple suitors keen to lure him away from Villa Park.

Could a move be on the cards after the Euros? 

TOP STORY – BLUES WANT GREALISH

Chelsea are strong contenders to sign Jack Grealish from Aston Villa, Football Insider reports. 

The England international has also drawn interest from Manchester City, but the Blues' involvement could change the dynamic. 

Football Insider claims owner Roman Abramovich has approved the type of expenditures that would be necessary to land players like Grealish, and winning the Champions League will only loosen the reins on Chelsea's spending. 

ROUND-UP

- Kylian Mbappe wants to move on from Paris Saint-Germain, according to RMC Sport, which says the France international will depart on a free transfer when his contract expires next year if he does not move during this window. 

- Lionel Messi's long-anticipated new contract with Barcelona could be announced as soon as Thursday, according to Le 10 Sport. 

- If Man City are to complete a deal to land Harry Kane from Tottenham, they will need to do it without using Raheem Sterling in a swap deal. Sterling has no interested in joining Spurs as part of the reported £100million move for Kane, ESPN said. 

- Sergio Ramos plans to join PSG, AS reports, spurning interest from City and Manchester United. 

- Chelsea see Villarreal's Gerard Moreno as a fall-back option if they cannot sign Erling Haaland, according to Fichajes. 

- Milan are looking at Rafinha of PSG as a potential addition as Hakan Calhanoglu moves on, Calciomercato reports. 

- England defender James Tarkowski is drawing interest from Wolves and West Ham, the Telegraph reports, while the Mail says Leicester City also are eyeing the Burnley man. 

- Scott Parker is set to depart Fulham and become Bournemouth's new manager, The Athletic reports. 

Mason Greenwood scored twice as Manchester United left it late to beat Burnley 3-1 at Old Trafford and make it five Premier League wins in a row for the first time since January 2019.

United had failed to defeat Burnley at home in their last four attempts and could not find a way through in a goalless first half on Sunday that saw Chris Wood have an early goal ruled out.

It was the fourth league game running the Red Devils had failed to score in the first half but Greenwood fired in the opener three minutes into the second period.

James Tarkowski promptly equalised with his first goal of the season, though Greenwood popped up again six minutes from time and substitute Edinson Cavani wrapped up a win that moves United to within eight points of leaders Manchester City.

The Premier League made its comeback this weekend, and there was no shortage of drama on Sunday.

It was a tail of turnarounds throughout the four fixtures – three sides coming from behind to win while Newcastle United and Tottenham played out a topsy turvy 2-2 draw.

Manchester United needed a late goal to see off Brighton and Hove Albion, while Southampton and Aston Villa claimed victories.

United have now won 95 Premier League points after conceding first, seven more than any other team in the history of the competition and, using Opta data, we take a look at more of the best facts from across the day's matches.

Southampton 3-2 Burnley: Ings puts former club to the sword in thrilling fightback 

Southampton picked up their first Premier League home win since their opening game in 2021 as they came from two goals down to beat Burnley 3-2, ending a run of five league outings at St. Mary's without a victory (D1 L4).

The Saints had not won a league game that they had trailed in by two goals since March 2016, when they defeated Liverpool under Ronald Koeman, but Danny Ings inspired the turnaround against his former club.

Having teed up Stuart Armstrong's goal, Ings became just the fourth player in Premier League history to score in four successive appearances against sides he has previously played for in the competition, after Robbie Keane in 2004, Jermain Defoe in 2009 and Wilfried Bony in 2017.

It was Nathan Redmond who then dealt the decisive blow, volleying in from Theo Walcott's cross after Nick Pope had brilliantly denied Ings a second.

Redmond has been directly involved in five goals in his past two games for Southampton (three goals and two assists), as many direct goal involvements as he had registered in his previous 30 appearances in all competitions combined.

Chris Wood gave Burnley the lead from a VAR-awarded penalty – the 100th spot-kick taken in the top flight this season, and the 83rd to be converted. This is only the seventh Premier League campaign to see a century of penalties awarded.

Newcastle United 2-2 Tottenham: Kane double not enough as Spurs let another lead slip

Tottenham looked set to move into the top four as they led 2-1 at Newcastle – Harry Kane's double putting them ahead after Joelinton carried on his goalscoring form against Spurs; he has now netted a total of four Premier League goals in 62 appearances, with two of those coming in four matches versus the north London team.

Kane has been directly involved in 45 goals in all competitions this term, scoring 29 times and providing 16 assists, equalling his career-best tally from 2017-18 (41 goals and four assists).

He has also scored 84 goals in 120 away games in the Premier League for Spurs, the most goals any player has scored on the road for a single club in the competition, going past Wayne Rooney's 82 for Manchester United.

Yet his efforts were not enough – Joe Willock rescuing a point for relegation-battling Newcastle, who have drawn three consecutive Premier League games at St. James' Park for the first time since another three-game run spanning December 2017 and January 2018.

Tottenham have dropped four points from winning positions against Newcastle this season, their most in a campaign against a single side since also dropping four versus Arsenal and West Brom in 2015-16, while Spurs have now failed to win six Premier League games after leading at half-time, the most of any side in 2020-21.

Aston Villa 3-1 Fulham: History made at Villa Park before Cottagers collapse

Sunday's clash between Aston Villa and Fulham was the first game in Premier League history in which every player in the starting XI for both sides was born after the first ever Premier League game on August 15, 1992.

Despite Dean Smith saying he would be available, Jack Grealish was not in Villa's squad, and Fulham hit the front through Aleksandar Mitrovic, who – after 159 days and 23 games without a goal for club and country – has now scored six times in the past 12 days, five times for Serbia and once for the Cottagers.

Yet only Southampton (18) and Brighton (20) have dropped more points from winning positions in the Premier League this season than Fulham (16) after Scott Parker's third-bottom side suffered a collapse.

Trezeguet scored a rapid double – his two goals coming just 160 seconds apart. The Egypt international had previously attempted more shots without scoring than any other player in this season's Premier League (29).

Ollie Watkins helped himself to his first league goal in eight games, ending a run of 18 shots without a goal in the competition since netting versus Arsenal in February.

Manchester United 2-1 Brighton and Hove Albion: Matchwinner Greenwood in elite company

Only Wayne Rooney (15) and Marcus Rashford (13) have scored more Premier League goals as teenagers for United than Mason Greenwood (12), who struck late on to complete the turnaround at Old Trafford.

Former Red Devil Danny Welbeck opened the scoring in Sunday's final game – he became the first player to net as many as three Premier League goals against United after having appeared for the club in the competition.

The 2020-21 season is only the second to see two players who have previously appeared for Manchester United in the Premier League score against them (Wilfried Zaha and Welbeck), along with the 1997-98 campaign, when Dion Dublin and Mark Hughes did so.

But United have now won 25 points from losing positions this term, nine more than any other side, while Brighton remain winless at Old Trafford in 13 attempts in all competitions (D2 L11).

Rashford – who has only scored more league goals (five) against Leicester City than he has against the Seagulls – equalised after being teed up by Bruno Fernandes, who has been directly involved in five goals in three Premier League appearances against Brighton.