Argentina qualified for the 2022 World Cup in Qatar, despite playing out a goalless draw with CONMEBOL rivals Brazil.
Lionel Messi returned to the line-up but he was unable to inspire Argentina, who played out a stalemate against Qatar-bound Brazil in San Juan on Tuesday.
That underwhelming performance left Copa America champions Argentina waiting to discover their World Cup fate.
Argentina only had to wait less than an hour as 10-man Chile lost 2-0 at home to Ecuador, sealing La Albiceleste's qualification after Colombia and Uruguay also failed to win.
Lionel Scaloni's Argentina – riding a 27-game unbeaten streak – are second in the CONMEBOL standings with five matches remaining, six points behind leaders Brazil and six clear of third-placed Ecuador.
Argentina and Brazil have both played a game less following September's qualifier in Sao Paulo, which was sensationally abandoned after Scaloni's men left the field as Brazilian health officials tried to detain visiting players due to coronavirus regulations.
Having ended their 28-year wait for silverware via July's Copa America, Messi's Argentina will now look to conquer the World Cup.
Two-time champions Argentina – eliminated in the round of 16 at Russia 2018 – have not won the World Cup since Diego Maradona inspired the country to 1986 glory, though they reached the final in 2014.
Argentina and Brazil played out an underwhelming 0-0 draw as the Copa America champions missed the chance to secure World Cup qualification.
Meeting for the first time since September's fixture was sensationally abandoned in Sao Paulo after Argentina left the field as Brazilian health officials tried to detain visiting players, La Albiceleste had the opportunity to earn a trip to Qatar 2022 following Colombia's draw against Paraguay.
However, despite Lionel Messi's return to the starting XI on Tuesday, Argentina were unable to breach CONMEBOL leaders Brazil, who were already assured of a spot at next year's tournament.
Argentina could still qualify on Tuesday if Chile lose to Ecuador later on Tuesday.
Chances were few and far between after a cagey start between Argentina and Brazil in San Juan, where neither goalkeeper was really tested in the opening half as Neymar sat out for the Selecao due to a thigh injury.
However, there was a big moment involving Argentina defender Nicolas Otamendi and Brazil's Raphinha as the game came to life approaching half-time.
Raphinha went down in a heap and was left bleeding after coping a blow from Otamendi, but the former Manchester City centre-back escaped punishment.
Alisson almost gifted Argentina a chance to break the deadlock after failing to catch a cross but Brazil managed to clear their lines, while the Liverpool keeper took a boot to the face minutes before the interval.
Fred went close to making the breakthrough for Brazil on the hour – the ball fell to the Manchester United midfielder on the edge of the box and his volley hit the crossbar.
There was another opening for Brazil with 19 minutes remaining, but Vinicius Junior's effort was straight at Emiliano Martinez.
Neymar will miss his meeting with Lionel Messi after being ruled out of the CONMEBOL World Cup qualifier against Argentina due to an adductor injury, the Brazilian Football Confederation (CBF) announced.
Brazil – already assured of a Qatar 2022 berth – will meet Argentina in San Juan on Tuesday, with a win for Messi's men all but guaranteeing World Cup qualification.
After coming off the bench against Uruguay last time out, Messi will definitely play a part for Copa America champions Argentina, according to head coach Lionel Scaloni.
However, Brazil superstar and Paris Saint-Germain team-mate Neymar – who teed up Lucas Paqueta for the winning goal against Colombia – will not be involved because of a thigh injury.
"After training at the Palmeiras Football Academy this Monday morning, athlete Neymar Jr. complained of pain in the adductor region of his left thigh," the CBF said.
"Neymar Jr. reported insecurity with the situation and because there was not enough time to carry out complementary exams, the technical committee chose to preserve the player, who will not travel with the Brazilian team's delegation to San Juan, location of Tuesday's game against Argentina."
Brazil and Argentina will meet for the first time since September's World Cup qualifier was sensationally abandoned in Sao Paulo.
The top-of-the-table fixture was halted following an apparent breach of coronavirus regulations, Argentina naming three Premier League players in their starting line-up – Aston Villa goalkeeper Emiliano Martinez and Tottenham pair Cristian Romero and Giovani Lo Celso – amid travel restrictions.
Despite the rulings, Martinez, Romero and Lo Celso were all starters for Argentina, with Brazilian health officials quickly acting by entering the pitch shortly after the match had started.
A subsequent melee ensued, and the visitors eventually left the field and did not return, Brazil playing out a training fixture among one another.
Looking ahead to Tuesday's showdown, Brazil head coach Tite told reporters: "It is hard to get the dimension of it. I don’t know how it was from the Argentinian side of it. Everything that happened. I am sorry about the fact that the match didn't happen.
"But now we have all the facts and understand why it didn't happen. I have all this very clear: before football, health is more important, laws exist and the correction of the facts. All these happened. I don't know how they face this situation because it is very particular.
"I can say that Brazil v Argentina is a huge match. Historically, it is huge. A lot of quality on both sides. The two best campaigns, a lot of technical quality individually from both teams."
England captain Harry Kane has set a new record for Three Lions goals in a calendar year by netting his 13th of 2021 against San Marino.
George Hilsdon (in 1908) and Dixie Dean (in 1927) for a long time stood alone with a benchmark dozen in a single year before Kane also tallied 12 in England colours in 2019.
The Tottenham forward reached that mark again at home to Albania on Friday as he netted his fourth international hat-trick.
The 5-0 Wembley win meant England needed only a point at minnows San Marino to qualify for the 2022 World Cup, but Kane was keen to feature and add to his total.
"[Kane] is quick to let me know that he hasn't played in those games [against Andorra and San Marino]," manager Gareth Southgate said at the weekend.
In an otherwise experimental line-up on Monday, featuring Emile Smith Rowe from the start for the first time, Kane led the line and got on the scoresheet.
Kane netted the visitors' third from the penalty spot in the 27th minute after Harry Maguire's opener and a Filippo Fabbri own goal.
It was England's 45th goal of 2021, also extending a team record at the end of a year that began with a 5-0 home success against San Marino.
Lionel Scaloni has confirmed Lionel Messi will definitely play a part in Argentina's World Cup qualifier against Brazil.
The rival nations meet for the first time since this year's Copa America final, which Argentina won 1-0, when they face off in San Juan on Tuesday.
Both teams have identical records since that final, each winning five of their six qualifiers. A clash between the pair in Sao Paulo in September was suspended due to coronavirus restrictions relating to Argentina's England-based players.
Already-qualified Brazil sit top of the CONMEBOL standings on 34 points, six clear of Scaloni's team, who defeated Uruguay on Friday.
Given the 12-point gap between Argentina and fifth-placed Colombia, who occupy the play-off spot, a win would all but guarantee their place in Qatar next year. Dropped points for two of Chile, versus Ecuador, Colombia, against Paraguay, and Uruguay, in Bolivia, would make the picture clearer still.
Messi, whose selection in Argentina's squad "did not make sense" – according to Paris Saint-Germain sporting director Leonardo – due to the 34-year-old's recent injury issues, came on as a 76th-minute substitute in the win over Uruguay.
Scaloni explained he had used Messi sparingly in order to keep him in top condition for Tuesday's clash with Brazil, and the coach confirmed in his pre-match news conference the former Barcelona superstar would certainly play, albeit he did not reveal if he would start.
"It is confirmed that Messi will play tomorrow," Scaloni told reporters on Monday.
On the challenge his team face, Scaloni said: "This Brazilian team is one of the most direct in recent times.
"They have already qualified for the World Cup, and we know how difficult this game is going to be.
"You have to always play the same, it is not worth it for me that a player of mine plays in one way against Venezuela and another against Brazil. Football is always the same regardless of the rival.
"I don't think the rest of the rivals in the qualifiers are less than Brazil. They are all very difficult games.
"There are always things to correct. Our goal is that the players do not relax, that they know that there are things to improve."
While Messi will play, Argentina may be without Paulo Dybala, who was taken off at half-time against Uruguay.
"Paulo came with a blow and at half-time of the game we decided to take him out, it was not worth risking it. Now we are waiting to see what [injury] he has," Scaloni added.
Brazil head coach Tite said the Selecao are pursuing excellence after booking their ticket to the 2022 World Cup in Qatar.
Lucas Paqueta's second-half strike secured a 1-0 win over Colombia on Thursday and Brazil's Qatar 2022 qualification with five games to spare.
Paqueta broke the deadlock 18 minutes from time in Sao Paulo, where he linked up with Neymar to guide Brazil to their 12th match without defeat in the CONMEBOL section of qualifying.
Brazil have now won their last 11 home games in World Cup qualifying – the longest winning streak of any team in CONMEBOL history.
Despite Brazil's World Cup berth already certain, Tite and the five-time world champions are refusing to rest on their laurels ahead of Tuesday's showdown against bitter rivals Argentina.
"Solidity, having creation, having a goal and winning," Tite told reporters. "That is excellence. Creation and scoring, defensive solidity and triumphs. That is what moves us.
"We have to get as close to that. Tomorrow [Friday] we are going to fraternise a little to celebrate the moment."
Tite added: "My greatest joy is sharing the joy. It is priceless when I look at the technical commission, at the people who work in the selection day by day. It is the way, the dignity with which we do our work."
Since taking charge in 2016, former Corinthians boss Tite has overseen 50 wins from 67 matches, with 12 draws and five defeats to go with 2019 Copa America glory.
"The only thing that moves me is doing a whole cycle, something that was not done at the last opportunity," Tite said, in reference to being appointed during Brazil's 2018 World Cup qualifying campaign before losing in the quarter-finals in Russia. "That's what moved me.
"I didn't volunteer for the selection, my manager didn't go honking in anyone's ear, I worked to get there. I took it halfway through a process, we went all the way, you know the story, I was invited back later for a whole process. Just like I did at Gremio, Corinthians, Caxias.
"Then I thought, I thought, man, maybe my professional trajectory will allow me to do an entire period. That's what moves me."
Paqueta has proved to be an influential member of Tite's Brazil since leaving Serie A giants Milan for Ligue 1's Lyon, where he has rediscovered his best form since the 2020 transfer.
Half of Paqueta's goals for Brazil (three of six) have been assisted by star team-mate Neymar.
"The qualification is the result of work that we have been building back there," Paqueta said. "Our goal was to qualify Brazil for the World Cup, and thank God we managed to do that today."
"I have to adapt to my roles, and that gives me a little more confidence to be fighting for my space," said Paqueta.
"No matter where I play, I hope to do my best. I have to think one step at a time to conquer my space and fulfil my dream of playing the World Cup."
Brazil qualified for the 2022 World Cup after Lucas Paqueta's second-half strike secured a 1-0 victory over Colombia.
Tite's Brazil knew a win on Thursday would book their spot at Qatar 2022 and the Selecao claimed the result they needed in hard-fought fashion on home soil.
Paqueta and Neymar combined for the decisive goal in the 72nd minute as CONMEBOL World Cup qualifying leaders Brazil stayed unbeaten through 12 rounds.
Brazil entered the contest having never lost a game against Colombia in all their previous 13 meetings in CONMEBOL World Cup qualifying (W6 D7). However, the Selecao had only won one of their last six games in this fixture.
It was a cagey start in Sao Paulo, where Brazil star Neymar was fortunate to escape punishment after getting into the face of referee Roberto Tobar.
The first half came to life during the closing stages as both teams had chances to open the scoring – Brazil finally got in behind Colombia and Danilo's cross deflected onto the post nine minutes before half-time.
Colombia star Luis Diaz then almost curled a stunning long-range effort into the back of the net three minutes later but it flashed just wide of the post, while Brazil's Marquinhos saw his header narrowly miss the far corner of the net on the stroke of half-time.
Like the opening 45 minutes, there was not much separating the two teams until Paqueta popped up to put Brazil ahead.
After Colombia failed to clear the ball properly, Brazil capitalised with 18 minutes remaining – Neymar playing a one-touch pass through to Paqueta, who managed to find a way past David Ospina in instinctive fashion.
What does it mean? Brazil maintain World Cup streak
Brazil have never missed the World Cup since the inaugural tournament in 1930 and the five-time champions extended that run thanks to Thursday's win. The South American powerhouse have gone five games without defeat since losing the Copa America final to bitter rivals Argentina in July.
Paqueta continues to star
After a difficult end to his Milan career, Paqueta has returned to form with Lyon in Ligue 1 and it has translated onto the international stage. The 24-year-old has scored four goals for Brazil this year. Half the goals scored by Paqueta for Brazil (three of six) have been assisted by Neymar.
Toothless Colombia
Colombia cannot buy a goal at the moment. La Tricolor have gone four matches without a goal following three consecutive 0-0 draws in qualifying. Colombia last found the back of the net in September's 3-1 win over Chile.
What's next?
Brazil will be back in action against Argentina on Tuesday, while fifth-placed Colombia host Paraguay on the same day.
Brazil head coach Tite said the Selecao were interested in Xavi joining their coaching staff before the Barcelona great returned to Camp Nou as head coach.
Xavi has been tasked with restoring the fortunes of embattled LaLiga giants Barca following his appointment as Ronald Koeman's successor on Saturday.
The 41-year-old spent 17 trophy-laden seasons at Barcelona before moving to Al-Sadd in 2015, eventually taking charge four years later.
After returning to Catalonia, Xavi revealed he turned down the opportunity to join Tite's Brazil ahead of the 2022 World Cup in Qatar.
As Brazil – six points clear atop the standings – prepare for Thursday's CONMEBOL World Cup qualifier against Colombia, Tite addressed the country's interest.
"I don't have too much information on Xavi to do a deeper analysis," Tite told reporters. "I know him from inside the pitch. And some information from the press that is superficial. I don't know him with the depth I have with my colleagues that I spend every day with. We have to be careful to talk about it.
"What I can say to you is that they talked to me about it. Rogerio Caboclo talked to me about that possibility. And he said that he would talk to Xavi. And I said yes because he could bring, as an assistant manager, the baggage of what he experienced inside the football field.
"Plus the experience he had outside it. As a captain, the conduct he had as a leader, and I could see it even from far away. He could bring his leadership, correction, knowledge, ideas.
"From that moment, what happened I don't know. Rogerio [Caboclo] told you about everything. But, yes, this was talked about. And right afterwards, they talked about Muricy [Ramalho]. And, yes, they talked about it. Yes, he was requested. And this is the second stage because Muricy is the one now."
Brazil are unbeaten through 11 World Cup qualifiers on the road to Qatar 2022, though the focus has been on Gabriel Jesus leading into the Colombia clash.
Jesus has not scored for the Selecao since the 2019 Copa America final against Peru, but Tite backed the Manchester City forward.
"Gabriel is an attacker," Tite said. "He is either nine or seven. Either he is on the side, as a wing, aggressive. Or he is the one infiltrating. From the depth pass. He has both characteristics. He has this history in the national team.
"Go back in time. When I took over in the game against the Equator, he was that player, he did a sequel. Then, he played on the side with [Roberto] Firmino and [Philippe] Coutinho inside. We didn't have Neymar. He has this versatility. He is a player who has the physical and technical virtues to perform one or another function. Sometimes, scoring a goal is from the opportunities you have.
"It reminds me of Edmar, a player I used to play with. I always thought that there are phases that the ball hits, hits, and I score. And there are some moments when I am in the right place, I follow the move, but the ball doesn't come. He will appear. In the last match, it appeared. And it had, in the great defences from the Uruguayan goalkeeper [Fernando] Muslera, two or three accurate finishes.
"That is what I want from an attacker. That is what the specific work has been given and what Gabriel Jesus can give."
Lionel Messi linking up with the Argentina squad while not fully fit "does not make sense", according to Paris Saint-Germain sporting director Leonardo.
The 34-year-old has endured an injury-plagued start to his PSG career since arriving on a shock free transfer three months ago after leaving Barcelona.
After sitting out last week's draw with RB Leipzig and win over Bordeaux with knee and hamstring injuries, Messi has now featured in just eight of PSG's 18 matches this season.
Despite his niggling injury issues in recent months, Messi has been included in Argentina's squad for their World Cup qualifiers against Uruguay and Brazil over the next eight days.
PSG boss Mauricio Pochettino said on Friday he is happy for his compatriot to play for La Albiceleste as it will give him an opportunity to build up his fitness.
However, Leonardo is not pleased with Argentina's decision to call up the forward and has urged world football governing body FIFA to get involved.
"We do not agree to release a player for national team selection who, for us, is not in physical condition or who is in the rehabilitation phase," he is quoted as saying by Le Parisien.
"It does not make sense, and this type of situation is worthy of a ruling from FIFA."
Messi has played just 325 minutes of Ligue 1 action for PSG, compared to 450 minutes for Argentina across their qualifying fixtures in September and October, not including the suspended match with Brazil.
The six-time Ballon d'Or winner has registered three goals in his first eight appearances for the French giants but has yet to score or assist in the league.
He has had 15 shots without finding the net in Ligue 1, failing to score from an expected goals value of 1.9.
Only Clermont midfielder Jim Allevinah (16) and Troyes forward Renaud Ripart (19) have had more shots without scoring in the French top flight this term.
Indeed, Messi has netted more times for Argentina in 2021-22 than he has for PSG, with four goals in five appearances.
James Rodriguez has been named in Colombia's squad for the first time in 12 months.
The former Real Madrid playmaker, who left Everton to join Qatari side Al-Rayyan in September, won the Golden Boot at the 2014 World Cup and had been a mainstay in Colombia's side since.
However, with injuries plaguing his time at Goodison Park, restricting him to 26 appearances in all competitions, James was not selected for this year's Copa America squad.
James did not take the news well, disputing the claim made by Colombia's coaching staff that he was not fit enough to be relied upon.
However, coach Reinaldo Rueda still took a hard-line approach and, with James not featuring at all for Everton under Rafael Benitez this season prior to his switch to Qatar, the 30-year-old was left out for World Cup qualifiers in September and October.
Colombia went unbeaten across those six matches, though they won just once. After scoring his first goal for Al-Rayyan in a 4-2 win over Al Sailiya towards the end of October, James has earned a recall for this month's games against Brazil and Paraguay. His last appearance for his country was in a 6-1 defeat to Ecuador in November 2020.
Though injuries did limit his game time, James was a creative fulcrum for Everton last term, creating 54 chances, placing him second in the squad behind Gylfi Sigurdsson (60).
James led the way for Everton with chances created from open play (38) and when it came to crafting big chances (14).
Per 90 minutes played, James forged 0.56 big chances in the Premier League, putting him just below Jack Grealish and Bruno Fernandes (0.58), ranking sixth in the competition among those who played 20 or more matches.
He finished the season with six goals and eight assists and when he was fit and available, James proved his quality for Carlo Ancelotti's team.
However, he has had a stuttering start to life in Qatar. After taking time to get up to full speed, he made his debut in disappointing fashion, with Laurent Blanc's side going down 3-0 to Al Duhail.
Following his goal against Al Sailiya, James was then sent off for dissent in his third appearance for Al-Rayyan, having reacted angrily to a decision going against him.
James subsequently posted a photo to his official Instagram account, showing evidence of facial injuries sustained during the match.
"After the blow I suffered in the game I am already a little better," James wrote. "As you can see, my nose and jaw suffered a bit in the blow.
"The rib took the worst part but nothing to worry about. All of this is part of our job. A few more days and I'll be training again."
Vinicius Junior has been left out of Brazil's squad for November's double-header of World Cup qualifiers, despite impressing for Real Madrid with his recent form.
The 21-year-old has seven goals and three assists in 13 appearances for Madrid this season, including an incredible solo strike in last week's 5-0 Champions League win over Shakhtar Donetsk.
Vinicius' 10 direct goal involvements is the most of any Brazilian player from Europe's top five leagues, but he is not part of Tite's plans for the games with Colombia and Argentina.
Tite has instead recalled Barcelona playmaker Philippe Coutinho, who has one goal and zero assists across 10 outings in all competitions this season.
The most recent of Coutinho's 63 caps for his country came against Peru in October 2020.
Leeds United winger Raphinha and Ajax prodigy Antony are also part of the Selecao's 23-man group.
Fabinho is one of three Liverpool players to have been called, along with Roberto Firmino and Alisson, despite Jurgen Klopp saying on Friday he is "concerned" about a knee injury that will keep the midfielder out for a third game running this weekend.
Brazil have won 10 and drawn one of their opening 11 CONMEBOL qualifiers and lead the way at the top of the standings, with their place at Qatar 2022 potentially being confirmed next month.
Brazil squad: Alisson (Liverpool), Ederson (Manchester City), Gabriel Chapeco (Gremio); Danilo (Juventus), Emerson Royal (Tottenham), Alex Sandro (Juventus), Renan Lodi (Atletico Madrid), Eder Militao (Real Madrid), Lucas Verissimo (Benfica), Marquinhos (Paris Saint-Germain), Thiago Silva (Chelsea); Casemiro (Real Madrid), Fabinho (Liverpool), Fred (Manchester United), Gerson (Marseille), Lucas Paqueta (Lyon), Philippe Coutinho (Barcelona); Antony (Ajax), Roberto Firmino (Liverpool), Gabriel Jesus (Manchester City), Matheus Cunha (Atletico Madrid), Neymar (Paris Saint-Germain), Raphinha (Leeds United).
Raphinha declared it would be difficult to top the euphoria he felt after scoring twice in Brazil's 4-1 win over Uruguay in World Cup qualifying.
The Leeds United forward made his first start for the Selecao one to remember, netting the second and third goals of a clinical victory.
Neymar and Gabriel Barbosa also got on the scoresheet in Manaus, with Uruguay's reply coming from Luis Suarez.
Raphinha said: "Tonight will be hard to beat, it will be difficult to forget tonight, it never had to end.
"I'll go back and be focused on what made me get here, the good work in Leeds, I'll do my job well to come back other times.
"I don't think there's any way to explain the happiness I'm feeling, this match with the goals and the victory couldn't have been more striking for me."
Quoted in Globo, Raphinha added: "I'm making my childhood dream come true, not only to wear the national team's shirt, but also to represent the national team. Being able to help with goals is very gratifying."
Raphinha has a close family association to Brazil great Ronaldinho and was asked what he thought the former Barcelona and Milan star would have made of his impressive display.
"[He would] just congratulate me for the match, not only him but other people," said Raphinha. "The most important thing is that I'm managing to represent the community I came from, my family and friends.
"I'm from Restinga, from Porto Alegre. It is where [former Brazil international] Tinga came from and where there is a lot of lost talent, thank God I'm managing to represent the community."
Raphinha became the first Leeds United player to score for Brazil, and the 24-year-old admitted it helped to have Paris Saint-Germain star Neymar as a team-mate, to guide him through such a game.
"Playing with Ney is very easy. I'm a big fan," Raphinha said. "I'm very inspired by him, in his way of playing, in his way of attacking his opponent. I watch many videos of him. To be playing with him is a dream come true."
Argentina captain Lionel Messi hit out at the referee, despite the in-form Copa America champions' 1-0 win against Peru in World Cup qualifying.
Lautaro Martinez's header two minutes before half-time settled Thursday's contest in Buenos Aires, where La Albiceleste extended their unbeaten streak to 25 matches across all competitions.
Peru wasted a chance to salvage a point when Yoshimar Yotun's penalty cannoned off the crossbar with 25 minutes remaining.
Messi reacted to Argentina remaining undefeated on the road to Qatar 2022 through 11 CONMEBOL fixtures, though it remains to be seen what he was referring to when mentioning the referee after Martinez had also gone down inside the area in the first half.
"Difficult match, difficult to play. A lot of wind, they were playing deep, leaving little space for us," Messi wrote via Instagram.
"The referee always does this when he referee's us, as if he does it on purpose. But well, three important points and we're close to our objective."
Martinez scored his 17th international goal and the Inter star is Argentina's top scorer in the Lionel Scaloni era, two ahead of Messi.
"The play against Uruguay was more fluid, there was more space. It got complicated for us a little but we always tried to have a solution and today, we knew how to find that," Martinez said.
"Every time we go out on the pitch, we try to give our all because this shirt deserves respect and responsibility. All of this is exciting, my family saw me play again after a long time. Today, they're here again. I hope that the people have enjoyed the win."
Argentina head coach Scaloni became the second coach in the history of the national team to go 25 games unbeaten in all competitions, after Alfio Basile.
"Today we felt a bit tired. Playing a triple date in South America is wearisome," added Scaloni. "We took it forward and got the three points, which is what we wanted.
"It was a very important game and there was tension for that. I do not think that Argentina was satisfied with the result. Peru plays well, it is a very difficult opponent. Beyond the penalty play, I think the game was controlled."
Brazil returned to winning ways and continued on their path to Qatar 2022 as Neymar and Raphinha dazzled in a 4-1 World Cup qualifying win over Uruguay on Thursday.
The Selecao, whose perfect qualifying record ended with Sunday's 0-0 draw in Colombia, raced to a two-goal lead within 18 minutes against a ragged Uruguay side via strikes from Neymar and Raphinha, making his first international start.
Raphinha doubled his account in the 58th minute as Brazil dominated La Celeste, with Uruguay goalkeeper Fernando Muslera prevented the score from being uglier in Manaus.
Luis Suarez's 77th minute free-kick meant Brazil, who had gone six qualifiers without conceding a goal and nine in home World Cup qualifying games, have conceded twice in their past three before Gabriel 'Gabigol' Barbosa's rounded out the scoring four minutes from time.
Neymar netted in the 10th minute, chesting down Fred's lofted ball into the box, the superstar forward getting around Muslera and drilling home from a sharp angle past Sebastian Coates on the line.
Raphinha doubled Brazil's advantage, firing in after Neymar's shot deflected off Diego Godin and Muslera into his path to become the first Leeds United player to score for the South American giants.
Brazil should have had a third in the 34th minute when Neymar and Raphinha both took a touch too many inside the box, failing to shoot.
Muslera kept Uruguay in the game after the interval, denying Manchester City forward Gabriel Jesus twice in quick succession, along with Raphinha.
Edinson Cavani, who started alongside Uruguay's all-time leading scorer Suarez, had a goal disallowed for a clear offside in the 56th minute before Brazil added a third.
Raphinha grabbed his second, capping off a swift counter-attack by firing in off the post from Neymar's release approaching the hour.
Muslera saved well to thwart substitute Barbosa twice, before Suarez rifled in a free-kick into the bottom corner for a consolation goal – his 65th international strike.
Barbosa got his goal after VAR consultation, heading in from Neymar's cross to make it two goals in his last three international appearances.
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