Pep Guardiola noticeably bristled when asked in his pre-match broadcast interview whether Manchester City would ever have a better opportunity to break their Anfield hoodoo.
Not since 2003 had City claimed all three points at this ground, but this time they arrived on a 13-game winning streak to face opponents who have not looked themselves of late.
Still, their manager did not wish to tempt fate ahead of his side running out at a stadium that has been far from a happy hunting ground for him.
Not only had City never won here under his stewardship, they had been regularly dismantled across meetings in the Premier League and Champions League.
And it was fear of a repeat that no doubt accounted for a cautious start from the visitors that did not reflect the form book.
When the first real chance of note arrived late in the first half, it came for City from the penalty spot, but Ilkay Gundogan could only blast the ball into the Kop from 12 yards.
Since the start of last season, the Blues have only scored nine out of their 17 penalties – a 53 per cent conversion rate – and this latest miss must have had Guardiola fearing it would be another forgettable visit to Merseyside.
But, as has been the case across a season that started in less-than-ideal fashion for the visitors, both team and player grew from that moment forth.
As such, it was no surprise to see Gundogan on hand to smash the ball home from close range with the first of three shots across the 90 minutes following the restart.
And, though a rare error from Ruben Dias – a figure who has had a transformative effect on City's defence this term – allowed Mohamed Salah to level things shortly after, the idea that it might inspire the hosts on to victory looked fanciful.
So it proved, with Gundogan restoring the lead after Phil Foden showed lovely feet in the aftermath of a poor Alisson Becker kick before Raheem Sterling capitalised on another questionable moment from the Brazilian goalkeeper.
The scoreline then got the gloss it deserved as Foden smashed in powerfully to underline his new-found status as a key man in a refreshed City side which now looks destined to be win the league.
Guardiola and his squad spent last season fending off the critics as Liverpool marched off into the distance to clinch the title in record time.
But, having added Dias and found new heroes in the likes of Gundogan and Foden, it looks like they who will cruise to silverware this time around.
Perhaps Jurgen Klopp can cling to that idea as he reflects on a poor performance that got the result it deserved and ended any hopes of his team taking part in a title challenge this term rather than a scrap for a top-four finish.
Having gone 1,369 days and 68 games without a Premier League defeat at Anfield, Liverpool have now lost three on the bounce at home for the first time since 1963.
Injuries no doubt account for that historic run in some way, evident as they were in the Reds once again naming two midfielders at centre-back.
Yet waiting until deadline day to sign the two defenders they desperately needed looked particularly ill-advised when Klopp revealed ahead of kick-off that neither was considered ready to feature in this game.
And the German will surely have been concerned by the fact that September signing Thiago Alcantara in no way showed himself to be capable of picking up the midfield slack as he put in an unimpressive showing.
In fairness, a lack of both fight and quality was not just a midfield issue for Liverpool, it has spread throughout the team during a run of results that has wrecked their season.
The only hope for the Reds this campaign is that the imminent return of Diogo Jota and the opportunity to restore Fabinho and Jordan Henderson to the centre of the park can help fend off potential challengers for a top-four spot.
Should that happen, Klopp will believe his side is capable of following City in immediately bouncing back into title contention next term with the help of a few tweaks.
If not, then Europa League football and a far trickier rebuild job surely awaits.