Dan Evans produced a stunning victory over Novak Djokovic at the Monte Carlo Masters, revealing the world number one had irritated him before the match even began.

A 6-4 7-5 victory for 33rd-ranked Evans in his first career clash with Djokovic carried the Briton through to his first Masters 1000 quarter-final and inflicted a first defeat of 2021 on his opponent.

The seeds of the upset were planted before the players hit the court, Evans later revealed, with the 30-year-old having been irked at having to wait for Djokovic in the locker room.

Top seed Djokovic was playing his first tournament since winning the Australian Open in February, for his 18th grand slam title, and he found it tough against a player who has previously enjoyed little success on clay.

"I thought I did a good job to get out of my service games. He had so many break points but didn't take them, so I was a little lucky there," Evans told Amazon Prime.

"I ran around the first second serve I got, to tell him I'm not going to just stand back and rally, I'm going to try to hit his second serve a little, and I got a few doubles out there."

Djokovic served four double faults, with Evans setting the tone for the match by surging 3-0 ahead early in the opening set.

"He kept me waiting at the start of the match in the changing rooms a little bit, so it was a little annoying," Evans said. "I was ready to go from that, so that got me a little extra fired up."

Rather than being intimidated by the presence of Djokovic on the other side of the net, Evans indicated he treated the Serbian like just another opponent, there to be beaten.

"That's why we roll the balls out, it's one against one and we've got to see who wins," Evans said.

"He gave me some cheap ones today which he never normally does, so I was a little lucky there, but I'm just really happy with coming through."

Evans' win was hailed by former British number one Tim Henman, who said: "He played fantastic tennis. In difficult conditions, he was the one that really dealt with it so well.

"Those first three games where he got up a double break, that probably changed his mindset. It increased his belief and Djokovic was frustrated, but in so many critical moments it was Evans who came up with the great tennis.

"It's an unbelievable achievement. Evans has won so few matches on clay so to beat the world number one, it's an amazing win."

Shelby Rogers booked her spot in the MUSC Health Women's Open quarter-finals, but fellow seeds Ajla Tomljanovic and Lauren Davis crashed out.

Following her third-round appearance at the Volvo Car Open, Charleston native Rogers moved through to the quarters of her second hometown tournament in as many weeks after easing past qualifier Claire Liu 6-2 6-2.

"I think I was due for a couple of tame matches," said third seed Rogers, who lost to world number one Ash Barty at last week's Volvo Car Open. "I've had quite a few mental battles over the last couple of months, so it's been nice to just take care of business in straight sets, get in and get out."

Next up for Rogers at the WTA 250 event is in-form Montenegrin opponent Danka Kovinic, who upstaged seventh seed Davis 6-1 1-6 6-3 on Wednesday.

Australian sixth seed Tomljanovic was swept aside by teenager Clara Tauson 6-1 6-4, while Nao Hibino beat Francesca Di Lorenzo 6-4 6-3.

Rafael Nadal's bid to win a 12th Monte Carlo Masters title got off to an emphatic start as the Spaniard swept Federico Delbonis aside after Novak Djokovic had also booked his passage to the third round.

Nadal, 34, has won the competition more times than anyone else in its history and looked in good shape as he returned to the court for the first time since losing to Stefano Tsitsipas in the Australian Open quarter-finals on February 17.

He needed just 81 minutes to get past the Argentinian qualifier 6-1 6-2 as he improved his record in the tournament to 72-5, breaking Delbonis' serve five times and only dropping his own once.

He is not getting carried away, however, with Grigor Dimitrov likely to provide a sterner test in the next round after beating Jeremy Chardy 7-6 (7-3) 6-4.

"It was solid match, I think. Of course, a very positive result. He's a good player on clay. [It was a] positive start for me," Nadal said in his post-match interview.

"I think I just really played a solid match. Nothing unbelievable, but nothing wrong. Just a solid match, a positive start. I think I did what I had to do."

On Dimitrov, Nadal added: "We've had some great matches. In Melbourne, of course... we played another great match in Beijing, another one in Shanghai. He's a good friend, a good guy, and a great player. It's going to be a tough test in my second round.

"It's going to be his third. I need to be ready for it. I hope to be ready for it. I am just excited to play a tough match very early in the tournament."

A little earlier in the day, world number one Djokovic was in a similarly unforgiving mood as he overcame the potentially tricky obstacle of Jannik Sinner, the Serbian and two-time Monte Carlo champion winning 6-4 6-2.

Like Nadal, Djokovic was back in action for the first time since the Australian Open – which he won – and appeared fresh as he gave the promising young Italian something of a lesson in game management, reaching 10 matches unbeaten at the start of a season for the sixth time.

"It feels great [to be back and] also playing in Monaco, where I reside," Djokovic said. "I have used this club as a training base for almost 15 years, so it feels like playing at home."

Despite the rather commanding nature of his win, Djokovic was keen to pay tribute to the 19-year-old Sinner, adding: "It was a very good encounter. I thought it was a great first match [and] a big challenge for me. Jannik is in form. He played the final [in] Miami and has been playing well. I just hung in there today and managed to find the right shots and the right game at the right time.

"He has got a lot of talent and he has proven that he is the future of our sport. Actually, he is already the present of our sport. He played a final [in an] ATP Masters 1000 [tournament] already. He is making big strides in professional tennis."

Dan Evans awaits Djokovic after an impressive 6-4 6-1 win over Miami champion Hubert Hurkacz, while Alexander Zverez and Andrey Rublev – the fifth and sixth seeds – moved into the next round with respective straight-set victories over Lorenzo Sonego and Salvatore Caruso.

There were mixed fortunes for the other two top-10 seeds in action on Wednesday, as Pablo Carreno-Busta defeated Karen Khachanov 6-2 6-3, but Diego Schwartzman was sent packing by Casper Ruud, the Norwegian winning 6-3 6-3.

Top seed Ons Jabeur advanced to the last 16 at the MUSC Health Women's Open, while Magda Linette was a casualty on Tuesday.

Jabeur – who reached the semi-finals of the Volvo Car Open – made a winning start at the WTA 250 event after toppling Stefanie Vogele 6-4 6-1.

The Tunisian won 88.9 per cent of her first serves to set up a clash with qualifier Alycia Parks – the latter eased past fellow American Grace Min 6-1 6-4.

However, second seed Linette crashed out at the hands of in-form Colombian Maria Camila Osorio Serrano.

Osorio Serrano, who claimed her maiden singles title at the Copa Colsanitas in Bogota last week, upstaged Linette 6-3 4-6 7-5.

Elsewhere, 15-year-old wildcard Linda Fruhvirtova – in just her second WTA main-draw appearance – progressed 6-2 6-7 (7-9) 4-4 after fourth seed Alize Cornet retired in the final set.

Novak Djokovic will tackle teenage rising star Jannik Sinner for the first time in a tantalising clash of tennis generations on Wednesday at the Monte Carlo Masters.

World number one Djokovic is returning to action this week, having taken time away from the tour since banking an 18th grand slam title by winning the Australian Open in February.

He received a first-round bye, but waiting for him in the last 32 is Sinner, who on Tuesday saw off 2017 Monte Carlo runner-up Albert Ramos-Vinolas 6-3 6-4, again illustrating the 19-year-old Italian's great potential.

World number 22 Sinner is the only teenager ranked inside the top 80 in the men's game and is coming off his first run to a Masters final, at the Miami Open.

The switch from hard courts to clay is one that Sinner is having to deal with, and seeing off a specialist on the surface in round one represents an impressive start, although facing two-time former champion Djokovic will be a step up.

"It's always good for me to see what I can do on clay," Sinner said, quoted on the ATP website. "Obviously, I am not in the best form on clay now for the first week.

"But I think today was a solid match from my side. It was not easy. He's not giving [away] one point, so you have to stay there the whole match. I think I played a good match from my side."

Greek fourth seed Stefanos Tsitsipas reached the last 16 with a 6-3 6-4 win over Russian Aslan Karatsev, but there was disappointment at the same stage for Italian eighth seed Matteo Berrettini, beaten 7-5 6-3 by Spain's Alejandro Davidovich Fokina. Those were the only second-round matches of the day.

Surprise Miami champion Hubert Hurkacz made a winning start, battling to a 6-3 3-6 6-3 first-round success against Italian qualifier Thomas Fabbiano to reach round two.

Roberto Bautista Agut, Grigor Dimitrov, Pablo Carreno Busta and Fabio Fognini each booked places in round two thanks to straight-sets wins.

Qualifier Federico Delbonis was a 7-5 6-1 victor over France's Adrian Mannarino, meaning the Argentinian faces the ultimate test in clay-court tennis next, a tussle with Rafael Nadal, the 11-time former champion in Monte Carlo.

Nadal has won all four of their previous matches, and their fifth encounter will immediately follow the Djokovic-Sinner match on Wednesday.

World number two Daniil Medvedev has pulled out of the Monte Carlo Masters after returning a positive coronavirus test.

The Russian, who was given a bye for the first round, went into isolation after returning a positive test on Monday.

"It's a big disappointment not to play in Monte Carlo," he said in a statement. "My focus is now on recovery and I look forward to getting back out on Tour as soon and as safely as possible."

Medvedev, who lost the Australian Open final to Novak Djokovic in January, had been practising with 11-time Monte Carlo champion Rafael Nadal on Monday.

The 25-year-old last played at the Miami Open at the end of March, where he lost in the quarter-finals to Roberto Bautista Agut.

Third seed Shelby Rogers eased into the second round of the MUSC Women's Health Open while fifth seed Misaki Doi retired in a three-hour epic on Monday in Charleston.

World number 46 Rogers, who reached the last 16 at last week's Volvo Car Open in Charleston, proved too good for fellow American Caty McNally winning 6-0 6-1 in just over an hour.

Doi's match with countrywoman Nao Hibino lasted much longer, extending to three hours and nine minutes with the latter progressing in a walkover 7-5 5-7 6-6. Doi succumbed to cramps in the third set tiebreaker.

Seventh seed Lauren Davis defeated Coco Vandeweghe 7-6 (7-3) 6-4 in their All American battle while Australian sixth seed Ajla Tomljanovic cruised past Renata Zarazua 6-1 6-1 in the final match of the first day.

Eighth seed Madison Brengle also progressed in three sets past Natalia Vikhlyantseva and unseeded Dane Clara Tauson won 6-3 6-3 over Liudmila Samsonova.

Rain curtailed much of Monday's schedule at the Monte Carlo Masters but it could not prevent Aslan Karatsev from continuing his hugely impressive start to the season.

Karatsev, a surprise Australian Open semi-finalist and a champion in Dubai last month, overcame Lorenzo Musetti, the Italian teenager who was a semi-finalist in Acapulco in March, in straight sets after a four-hour rain delay.

He went into that interruption with a 4-3 lead in the first set and duly polished off the next two games on his return to the court.

The Russian sent down 23 winners as he completed a 6-3 6-4 win in 88 minutes, his last a cross-court backhand that set up a second-round meeting with Stefanos Tsitsipas.

"It was a really tough match [for] my first match of the season on clay [with] tough weather conditions," said Karatsev.

"We started in the morning [and] I started pretty well, I broke him and then the court was getting heavy, the ball was heavy.

"It is tough to play against him. [He is] really fit, [he] runs a lot and gives everything back, so you have to build the point by yourself and close the point by yourself."

There were mixed fortunes for Australians Alex de Minaur and John Millman in Monaco.

De Minaur went down to a surprise straight-sets defeat to Alejandro Davidovich Fokina but Millman broke Ugo Humbert four times in a 6-3 6-3 win.

Next for Millman is either Felix Auger-Aliassime or Cristian Garin, whose first-round contest was among those unable to finish because of the inclement weather on the Cote d'Azur.

Tommy Paul also progressed to the next round, with five matches on court when play was cancelled for the day.

Veronika Kudermetova became the first winner of the Charleston Open since Serena Williams to triumph without dropping a set all week.

The 23-year-old Russian crushed the hopes of Montenegrin rival Danka Kovinic in Sunday's final, landing her maiden WTA Tour title with a 6-4 6-2 victory.

It meant Kudermetova sealed a perfect tournament, winning all six of her matches without being taken to a deciding set, just as superstar and 23-time grand slam champion Williams managed in 2012.

World number 38 Kudermetova said, quoted on the WTA website: "All the matches were really tough. It's really tough matches for nerves, and the tennis part, but I'm really proud of myself that I can take the first title. I'm really happy.

"It means a lot. It shows me that I can play really well, that I can beat good players, and if I play like this and keep working, I think I can be in the top 10 or higher."

The Copa Colsanitas title went to Colombian 19-year-old Maria Camila Osorio Serrano, a former US Open junior champion who entered the tournament on a wildcard but came through the field to also grab a first senior singles title.

She sank the trophy prospects of Slovenian fifth seed Tamara Zidansek, with the world number 180 recording a 5-7 6-3 6-4 victory, describing her success as "unreal".

David Goffin made an encouraging start to the Monte Carlo Masters as he beat Marin Cilic, though Jordan Thompson found things much harder against Benoit Paire.

World number 14 Goffin had lost his previous three matches heading to Monaco, but the Belgian delivered a sharp performance on Sunday, winning 6-4 3-6 6-0.

Open Sud de France champion Goffin did not start well, and had to come from 3-0 down in the first set, but Cilic made 52 unforced errors to help his opponent progress.

"It’s a good win. [This is my] first tournament on clay [in 2021]. Starting with a victory is good," said 2017 Monte Carlo semi-finalist Goffin, quoted on the ATP website.

"I did what I needed to do to win that match. I was playing better and better. In the first and second set, I had problems with the returns. In the third set, I was more consistent. It was a good match."

Goffin will face Marco Cecchinato or Dominik Koepfer in the second round, where he has been joined by Australian Jordan Thompson.

Thompson, the world number 62, needed three hours and two tie-breaks to beat Paire 6-4 6-7 (3-7) 7-6 (7-5), as the Frenchman's dismal string of results in 2021 continued.

Paire has now won just one of 10 matches this calendar year, while Thompson registered a fifth win of the season.

Pablo Carreno Busta won his first home ATP Tour title at the Andalucia Open on Sunday, while Lorenzo Sonego triumphed in Cagliari.

Hunting a fifth Tour title, top-seed Carreno Busta needed three sets to overcome compatriot Jaume Munar 6-1 2-6 6-4 in Marbella.

It is his 200th tour-level win, though it took him two hours and 21 minutes to claim his maiden Spanish title, and his first win since 2019.

Carreno Busta certainly had to work hard for it, with Munar having battled to 4-4 in the decider.

Yet a seventh break point of the ninth game was taken by Carreno Busta, whose powerful backhand return forced his 23-year-old opponent into an error.

Meanwhile, Sonego became the first Italian since Filippo Volandri in October 2006 to win an ATP Tour title on home soil as he overcame Laslo Djere in the Sardegna Open. 

Serbian Djere was on a nine-match winning streak in Italy, but Sonego – who won the doubles title on Saturday – succeeded 2-6 7-6 (7-5) 6-4.

Sonego is the first player since Feliciano Lopez at the 2019 Queen's Club Championships to win both the doubles and singles titles, and the first Italian to do so since Matteo Berrettini at the 2018 Swiss Open Gstaad.

It represents a second tour-level triumph for world number 34 Sonego, who previously won the 2019 Antalya Open.

There will be no dream first WTA Tour final for Paula Badosa at the Charleston Open after she was defeated in the last four by Veronika Kudermetova.

Badosa claimed the biggest win of her career so far in the quarter-finals when she knocked out world number one Ash Barty.

But the 23-year-old, twice beaten in the semis at WTA 250-level events in the past year, came up short against 15th seed Kudermetova.

The Russian was clinical, taking four of her six break point opportunities in a straightforward 6-3 6-3 success.

Kudermetova had previously knocked out Sloane Stephens but will now be favourite against Danka Kovinic.

The underdog's straight-sets defeat of Ons Jabeur in the last four should ensure there is no complacency from Kudermetova.

In Bogota, 19-year-old wildcard Maria Camila Osorio Serrano will play for the title after swatting aside qualifier Harmony Tan 6-1 6-2.

The former top-ranked junior will have to negotiate fifth seed Tamara Zidansek, however, after she defeated Viktoriya Tomova 6-3 7-5.

Top seed Pablo Carreno Busta and fellow Spaniard Jaume Munar will meet in the Andalucia Open final on Sunday. 

Carreno Busta was pushed all the way by Albert Ramos-Vinolas in a pulsating semi-final, ultimately coming through 6-1 3-6 7-6 (7-5). 

"It was so close. I don't know what happened in the second set," Carreno said. "At the beginning of the match, I was very focussed on my game and being aggressive. 

"After that, Albert, of course, started to push [back] more and [I] started to lose my level a little bit. 

"I just kept fighting all the time, and I want to thank everyone [in the crowd] for their support. This is what we missed last year, the crowd. It's very important to play these kinds of very close matches with a crowd like this."

He will take on Munar after the 23-year-old edged past Carlos Alcaraz 7-6 (7-4) 6-4. 

Munar, who reached a final on the ATP Challenger Tour last week, said: "I feel happy and excited. I've been working a lot during the last [few] months. 

"It's a gift for me to be here in a final, and especially in Marbella which is one of my favourite places. I feel excited."

Elsewhere, Lorenzo Sonego is aiming to become the first Italian to win an ATP Tour clay-court title on home soil for 15 years when he takes on Laslo Djere in the final of the Sardegna Open on Sunday. 

Sonego, 25, overcame American Taylor Fritz 6-4 5-7 6-1 to give himself the opportunity to add to his Antalya Open title from 2019. 

Standing in his way is Serbian Djere, who cruised past Nikoloz Basilashvili 6-2 6-0 in just 52 minutes. 

Djere was in control from the outset and from 3-2 in the first set went on to win nine straight games, helping him to his third ATP Tour final.

World number one Ash Barty has been knocked out of the Charleston Open after a straight-sets loss to unseeded Spaniard Paula Badosa in Friday's quarter-finals.

Badosa won 6-4 6-3 over the favoured Australian in one hour, 16 minutes to book a spot in the last four on the green clay and a meeting with 15th seed Veronika Kudermetova.

Kudermetova beat 2017 US Open winner Sloane Stephens 6-3 6-4 in her first win over a grand slam winner.

Former French Open junior champion Badosa, who beat fifth seed Belinda Bencic in the second round, claimed her second career victory over a top-20 player against Barty.

Barty may have hit 34 to 19 winners but she also made twice as many unforced errors, 24 to 12.

The Spaniard broke Barty's serve five times while she sent down seven aces and saved 12 of 14 break points.

"I was quite nervous today but I think I served very well and I think that was the key for the match," Badosa said in her on-court interview.

"It was a tough match but I was there until the last moment and I managed to win."

World number 71 Badosa becomes the lowest-ranked player to beat Barty since September 2019.

The Australian had won eight matches in a row after last week's triumph at the Miami Open.

Unseeded Montenegrin Danka Kovinic came from a set down to topple 11th seed Yulia Putintseva 6-7 (2-7) 7-5 6-1.

Kovinic, who knocked out Petra Kvitova in the third round, will play 12th seed Ons Jabeur in the semi-finals after she overcame Coco Gauff 6-3 6-3.

Meanwhile, at the Copa Colsanitas in Bogota, fifth Tamara Zidansek beat Italy's Sara Errani 6-3 6-4 to claim a spot in the semi-finals.

Viktoriya Tomova outlasted qualifier Nuria Parrizas-Diaz 5-7 6-2 6-4 in almost two and a half hours, while Harmony Tan and local wildcard Maria Camila Osorio Serrano also won.

Top seed Pablo Carreno Busta led a clean sweep for home players to head up an all-Spanish semi-final slate at the Andalucia Open, where teenage sensation Carlos Alcaraz made history.

Carreno Busta demolished seventh seed Soonwoo Kwon 6-4 6-0, while Casper Ruud was stunned in straight sets by wildcard Alcaraz.

The 17-year-old backed up his victory over the veteran Feliciano Lopez in style, becoming the youngest ATP Tour semi-finalist since Alexander Zverev at Hamburg in 2014 with a 6-2 6-4 win.

Albert Ramos-Vinolas will face Carreno Busta after beating Norbert Gombos 6-7 (4-7) 7-5 6-4, while Alcarez is next on the agenda for compatriot Jaume Munar, who was taken the distance by Ilya Ivashka having overcome second seed Fabio Fognini on Thursday.

Taylor Fritz continued his solid form this season with a straight sets victory over Aljaz Bedene to reach the semi-finals of Sardegna Open.

Fritz is playing as the US number one for the first time in Cagliari this week and he made light work of Bedene, prevailing 6-3 6-4 to book a showdown with third seed Lorenzo Sonego, who beat Yannick Hanfmann 3-6 7-6 (8-6) 6-3 despite being 3-5 down in the second.

Seeded second and ranked 30 in the world, Fitz improved his 2021 record to 11-5 and will look to avenge a defeat in his only other meeting with Sonego on clay, when he lost at Roland Garros last year.

Lorenzo Musetti thrilled as he saved four match points to sink top seed Dan Evans on Thursday but bowed out after another epic, losing to Serbia's Laslo Djere 6-4 4-6 6-2 in two hours and 21 minutes.

Djere, who beat sixth seen John Millman en route to the quarter-finals, will face Nikoloz Basilashvili after the battle between seeds four and five ended 7-5 4-6 6-3 in the Georgian's favour.