Lyston, who earlier this season claimed both the SEC and NCAA Indoor 60m titles, produced her first sub-11 time to finish in a close second behind Favour Ofili of Tiger Olympians who won in 10.85.
McKenzie Long of Ole Miss was third in 10.89.
Interestingly, this was Lyston's first 100m race since the Class One final at the 2022 ISSA/GraceKennedy Boys and Girls Championships.
Elsewhere, LSU’s Jahiem Stern ran 13.43 for third in the men’s 110m hurdles behind the Texas A&M pair Jaqualon Scott (13.34) and Connor Schulman (13.42).
Mississippi State’s Tyrese Reid ran a personal best 1:45.76 for second in the men’s 800m won by Texas A&M’s Sam Whitmarsh in 1:44.46.
Marcus Dropik of Ole Miss ran 1:47.82 in third.
In the field, Kentucky’s Luke Brown produced 16.40m to take the win in the men’s triple jump ahead of Ole Miss’s Iangelo Atkinstall-Daley (15.25m) and Georgia’s Zavien Wolfe (14.84m).
Pinnock, who was second last year to then teammate Carey McLeod, secured his first indoor title with a leap of 8.28m at the Randal Tyson Track Center in Arkansas.
The World Championships silver medallist, Pinnock, stamped his class and led from the second round after a foul in the first round.
His teammate Nia Robinson was second in the women’s long jump with 6.44m. Robinson also recovered well after she fouled her opening attempt.
Meanwhile, Brianna Lyston is among a number of Jamaicans down to contest finals on Saturday. The Louisiana State University (LSU) representative is down to contest the women’s 60m final, after she clocked 7.12 seconds to win her heat on Friday.
Rosealee Cooper of Mississippi State will enter the women's 60m hurdles with as the sixth fastest qualifiers, as she clocked 8.21s for third in her heat.
Nickisha Pryce of Arkansas will line up in the women’s 200m and 400m finals, after she clocked personal best times of 22.94 and 50.90, when she finished tops in the heats. She is one of five Razorback athlete in the 400m final.
Jevaughn Powell also displayed good early season form with a personal best 45.35-clocking to lead qualifiers to the final of the men’s 400m.
Meanwhile, Tyrese Reid of Mississippi State and Kimar Farquharson of Texas A&M, both booked their spots in the men’s 800m final, after placing first and second in their respective heats in 1:50.50 and 1:50.95 respectively.
