Lille have now beaten a second Madrid team in consecutive matchdays after also stunning holders Real Madrid 1-0 earlier in October.
Atletico took the lead in the eighth minute with Julian Alvarez intercepting a weak back-pass from Lille defender Ousmane Toure and slotting in for the lead.
There was more bad news for Lille when they had to take off injured midfielder Remy Cabella in the 16th minute, bringing in Edon Zhegrova, but they avoided further pain as Alexander Sorloth wasted three golden scoring opportunities in the first half.
The visitors punished Atleti by leveling in the 61st minute as Zhegrova whipped in a superb left-footed shot into the top far corner.
Lille then scored again to seal their comeback courtesy of a 74th-minute penalty by David, who had also scored the winner against Real.
The Canadian then added another goal with a deflected effort in the 89th to lift Lille to six points. Atletico, meanwhile, are on three with just one win from their three games so far.
Data Debrief: Lille put another Madrid side to the sword
Three weeks on from defeating Real Madrid in one of the most famous results in their history, Lille followed it up with three more points against Atletico.
In doing so, they are just the third team in Champions League history to beat those two sides in a single edition of the competition, along with Chelsea (2020/21) and Manchester City (2021/22).
David was the hero after his 65th-minute introduction, netting his fifth and sixth goals in this season's competition - at least twice as many as any other Lille player.
Lille have now beaten a second Madrid team in consecutive matchdays after also stunning holders Real Madrid 1-0 earlier in October.
Atletico took the lead in the eighth minute with Julian Alvarez intercepting a weak back-pass from Lille defender Ousmane Toure and slotting in for the lead.
There was more bad news for Lille when they had to take off injured midfielder Remy Cabella in the 16th minute, bringing in Edon Zhegrova, but they avoided further pain as Alexander Sorloth wasted three golden scoring opportunities in the first half.
The visitors punished Atleti by leveling in the 61st minute as Zhegrova whipped in a superb left-footed shot into the top far corner.
Lille then scored again to seal their comeback courtesy of a 74th-minute penalty by David, who had also scored the winner against Real.
The Canadian then added another goal with a deflected effort in the 89th to lift Lille to six points. Atletico, meanwhile, are on three with just one win from their three games so far.
Data Debrief: Lille put another Madrid side to the sword
Three weeks on from defeating Real Madrid in one of the most famous results in their history, Lille followed it up with three more points against Atletico.
In doing so, they are just the third team in Champions League history to beat those two sides in a single edition of the competition, along with Chelsea (2020/21) and Manchester City (2021/22).
David was the hero after his 65th-minute introduction, netting his fifth and sixth goals in this season's competition - at least twice as many as any other Lille player.
Mukau opened the scoring for Lille a minute before the break from a rebound after his initial shot was blocked, before Bologna struck through Jhon Lucumi in the 63rd minute.
That marked the Serie A side's first goal in the competition this campaign, though the home celebrations were cut short soon after.
Mukau scored his second just three minutes later before Bologna were unable to find another goal as their goalkeeper Lukasz Skorupski pulled off several fine saves to keep them in the game.
Lille's win moved them on to 10 points in the standings, while Bologna remain on one point after slumping to their third successive defeat.
Data Debrief: Lovely Lille flying
Outside of the knockout stages, Lille have lost just one of their last nine matches in the Champions League (W6 D2), losing 2-0 against Sporting CP on MD1 this season.
Bologna, meanwhile, have lost their last four in this competition and are the first Italian side to suffer as many defeats in a row in a single campaign.
The Serie A club, at least, avoided becoming just the second side to fail to score in their first five games in Champions League history, with Galatasaray the only to do so during the 1993-94 season.
Mendy has enjoyed another strong campaign, lifting the Club World Cup with Thomas Tuchel's team after starring in his nation's first major trophy success at the Africa Cup of Nations.
He kept four clean sheets and was named the tournament's best goalkeeper as Senegal lifted the trophy.
But with the London outfit facing a crucial week on two fronts, hosting Lille in the Champions League last 16 on Tuesday before facing Liverpool in Sunday's EFL Cup final, the 29-year-old says he is simply taking each game as it comes without any time to celebrate just yet.
"A lot of good things have happened in the last weeks," Mendy said ahead of Chelsea's first-leg clash with Lille. "I am very happy and proud of my success with the national team and Chelsea.
"I don't have time to celebrate, because we have a lot of big games in the coming weeks, so I am just focused on the next game. I will have time to celebrate at the end of the season.
"It's an important week but like I said, when you play for Chelsea you play for this kind of week, with finals and big games.
"We just [have to] focus on ourselves and what we have done well this season. We don't need to do something new, just rely on our work and our game."
Mendy, who has kept nine clean sheets in 21 league appearances for Chelsea in the Premier League this season, was also keen to praise teammate Kepa Arrizabalaga, who deputised ably when he travelled to Africa.
"My relationship with Kepa is good since I came here, we have a good relationship on and off the pitch," he said.
"When you play for Chelsea, you have competition in every position, so you have to give your best and play at your highest level to be in the team at the weekend."
Mendy also warned of the challenge posed by Lille ahead of the Ligue 1 holders' trip to London, as Chelsea try to retain their Champions League title.
He added: "When it's the Champions League and this stage of the competition, there are no easy draws.
"Lille are a very good team. They've struggled a bit more this season in the league [sitting 11th in Ligue 1 after 25 games] but it's always difficult to be reigning champions.
"They will give everything to make it hard for us and get a result. It's up to us to be wary of that and play our best football."
Chelsea are the first Champions League holders to progress to the knockout stages without winning their group since Real Madrid in 2017-18, but the Spanish side did go on to retain their title that season.
The midfielder had not made a competitive appearance since starting for Saint-Etienne in a defeat to Lyon on March 1, 2020.
Cabaye posted on Twitter: "It is with great emotion that after more than 17 years of passionate love for football, with emotions greater than any other, memories that will remain forever and unforgettable human and sporting encounters, I announce the end of my professional football career.
"If this decision may seem obvious, logical and inevitable to some, having spent 35 years in the world of football, it remains very difficult to take and to accept because my love for football is immense."
Cabaye debuted with Lille in 2005 and won a Ligue 1 and Coupe de France double in his final season with the club in 2010-11.
His performances over his final two campaigns with Lille, in which he scored 18 goals, provided 18 assists and created 140 chances across 90 games in all competitions, earned international recognition and a move to the Premier League with Newcastle United.
Cabaye quickly found his feet in England, scoring five goals and delivering six assists in his debut season as Newcastle fell just short of Champions League qualification.
His form attracted the attention of Arsenal, but Cabaye failed to force through a move in August 2013 and instead enjoyed one of the most productive spells of his career as he scored seven times and laid on a pair of assists in 20 games before departing for Paris Saint-Germain in January 2014.
Two further Ligue 1 triumphs followed, along with success in the Coupe de France and twice in the Coupe de la Ligue, but he failed to establish himself as a regular starter in Paris.
Just 30 of his 57 PSG appearances came from the start and he soon left for Crystal Palace, spending a further three years back in the Premier League before ending his career with Al-Nasr and finally Saint-Etienne.
Cabaye played for his country on 48 occasions, scoring four times.
His first international goal came against Ukraine at Euro 2012 and he was a regular again at the World Cup two years later. France's home European Championship in 2016, where they reached the final, saw Cabaye appear only twice and once as a starter.
Greenwood converted from 12 yards with just a minute of normal time remaining, moving Marseille up to second in the table and ahead of Monaco on goal difference.
The spot-kick was awarded for a handball from full-back Christian Mawissa as Marseille ended a three-game winless run against Monaco in the league.
Valentin Rongier's poor pass in the first half had earlier allowed Aleksandr Golovin to counter-attack and open the scoring with just his second Ligue 1 goal of the campaign.
Luis Henrique subsequently levelled before the hour, capitalising on some fine work from Neal Maupay, before Greenwood snatched victory for Roberto De Zerbi's side.
At the other end of the table, bottom side Montpellier salvaged a 2-2 draw with fourth-placed Lille thanks to Arnaud Nordin's last-gasp leveller in an ill-tempered clash.
Jonathan David had earlier scored a penalty in either half for the visitors, with Issiaga Sylla on target for Montpellier on the stroke of half-time to level after the Lille forward's first spot-kick.
Montpellier head coach Jean-Louis Gasset was sent off late on before Tanguy Coulibaly and Mitchel Bakker were both dismissed in a chaotic ending.
Coulibaly prompted the altercation by kicking the ball against Lille head coach Bruno Genesio, with Bakker and the Montpellier man taking the punishment for the clash that subsequently followed.
Far less drama ensued in Lyon's routine 4-1 victory over Nice as Alexandre Lacazette's hat-trick helped his side move into fifth place.
Sofiane Diop managed an equaliser for sixth-placed Nice after Lacazette's opener, only for the Lyon striker to put the visitors to the sword along with a goal from midfielder Jordan Veretout.
Sunday marked the seventh time Lacazette has scored three or more goals in a Ligue 1 game, more than any other Lyon player in the competition's history.
He also scored his 149th, 150th and 151st Ligue 1 goals. In the 21st century, only Kylian Mbappe (191) and Wissam Ben Yedder (161) have scored more in the top-flight.
The midfielder announced his retirement from the French national team last month after a stellar career saw him help them win the 2018 World Cup and finish as runners-up in 2022.
He amassed 137 caps over 10 years for Les Bleus, scoring 44 goals in that time, making him the country's fourth-highest scorer, while he also provided the most assists of any France player (30) since records began in 1966.
Despite Griezmann's pivotal role in the French team, the captain's armband was given to striker Kylian Mbappe ahead of him. Mbappe was booed during Real Madrid's shock 1-0 Champions League defeat by Lille earlier this month for opting not to play during the international break.
Atletico host French side Lille in the Champions League on Wednesday, following a humiliating 4-0 loss at Benfica in their last such match, and a 2-1 home win against RB Leipzig in their opener.
"I believe Antoine has given all his talent, his game, and leadership to France," Simeone told a news conference.
"He has won titles, developed a playing style that has progressed [the French team], and gave it all for his country until the day he retired as a standout player.
"The same has happened with us, and he is an extremely important player for us. He won't have these national games that usually add significant strain to his legs after so much playing time, and we hope we can continue to enjoy all the potential he has."
Atletico have scored just twice in the Champions League this season from 25 shots, despite bolstering their attack with forwards Alexander Sorloth, Julian Alvarez and Conor Gallagher in the close season.
"Julian is improving every day, settling into the team and the new city," Simeone said of the former Manchester City player, who has scored three goals in 12 appearances for Atleti.
"He's starting to show all the unique qualities he possesses. I have no doubt that he will make a difference."
Simeone will be without defender Robin Le Normand, who suffered a traumatic brain injury during their 1-1 draw in the Madrid derby last month, as well as midfielders Marcos Llorente, Pablo Barrios and defender Clement Lenglet.
Atletico Madrid have decided not to sell tickets to some of their supporters for their next five away games in all competitions after sanctions from UEFA and the Spanish Football Federation (RFEF). This includes their next Champions League fixtures at Paris Saint-Germain and Sparta Prague.
The prize, presented by Italian newspaper Tuttosport and won by Joao Felix last year, is given to the best player aged 21 or under from a top-tier league in Europe.
Haaland is a leading contender for the accolade after scoring 44 goals across all competitions in 2019-20 – 16 of those coming in 18 appearances after a mid-season move from Salzburg to Borussia Dortmund.
Among all Bundesliga players last season to have scored at least 10 goals, only Robert Lewandowski (81.2) had a better minutes-per-goal record than Haaland (81.7).
His Dortmund team-mate Sancho finished the 2019-20 league campaign with 17 goals and 16 assists, making him the first player since Opta began detailed data collection (2004-05) to register at least 15 in both categories in the same Bundesliga campaign.
The England international's prolific campaign saw him become the youngest player (20 years, two months and six days old) in the history of Germany's top flight to reach 30 career goals.
Despite their impressive numbers, Haaland and Sancho face stiff competition from Fati, who became the third-youngest player (16 years, 304 days old) to find the net in LaLiga history and the youngest of all time in the Champions League (17 years, 40 days).
He finished the season with eight goals in all competitions and has continued his rise this term, netting three times in as many LaLiga games and becoming the youngest player to score for Spain.
Alphonso Davies will also be in contention after establishing himself as one of the top left-backs in the game during Bayern Munich's treble-winning season.
The full 20-man shortlist:
Mitchel Bakker (Paris Saint-Germain), Eduardo Camavinga (Rennes), Jonathan David (Lille), Alphonso Davies (Bayern Munich), Sergino Dest (Barcelona), Fabio Silva (Wolves), Ansu Fati (Barcelona), Phil Foden (Manchester City), Ryan Gravenberch (Ajax), Mason Greenwood (Manchester United), Erling Haaland (Borussia Dortmund), Callum Hudson-Odoi (Chelsea), Dejan Kulusevski (Juventus), Rodrygo (Real Madrid), Bukayo Saka (Arsenal), Jadon Sancho (Borussia Dortmund), Dominik Szoboszlai (Salzburg), Sandro Tonali (Milan), Ferran Torres (Manchester City), Vinicius Junior (Real Madrid).
Jonathan David's first-half penalty - after Eduardo Camavinga handled from Edon Zhegrova's free-kick - ended Madrid's 14-match unbeaten streak in this competition, while condemning them to a first reverse overall in 36 games.
Genesio also had Lucas Chevalier to thank after the Lille goalkeeper made a string of superb saves to keep Carlo Ancelotti's side at bay, including a wonderful instinctive stop to thwart Antonio Rudiger right at the death.
Indeed, Madrid simply had no answer to their stubborn hosts, despite the introduction of a fit-again Kylian Mbappe during the second half.
And Genesio saluted his players for their efforts in delivering a memorable result.
"What this team did is incredible," he said. "We try to put things in place, but you need the players to believe in the plan for this kind of upset to happen.
"You have to do everything perfectly, you need a keeper who makes the decisive saves, a striker who scores, and a bit of luck.
"We played a very good first half, we played together. It's a great night for everyone.
"We saw that Real like to cut inside, so we put intensity in that sector - even if we had to abandon possession sometimes.
"Then, it was all about pressing when it mattered. Everything worked perfectly, it was an ideal scenario - even if we suffered a lot in the last 25 to 30 minutes, but Lucas made the saves we needed."
The Canada international is into his fifth season with the Ligue 1 side but is due to become a free agent at the end of the current campaign.
Lille have attempted to persuade David with a new deal, though he looks set to depart Stade Pierre-Mauroy in 2025 – potentially as early as January if a club is prepared to pay a transfer fee.
However, while the 24-year-old is seemingly open to a move to Barcelona, he suggested he would prefer to wait until the end of the campaign before taking the next step in his career.
"Going to a club midseason is never easy," he told The Athletic. "It's not like the beginning of a season where you have a pre-season, you get to know your team-mates, you have time to gel.
"In January, things are very hectic. It's about right now. It's tougher."
"[Barcelona] was always the team I grew up supporting. When you grow up supporting a team, it's your dream to play for them.
"Some people might say, 'Oh, he's staying at Lille, this is a downgrade, he's not getting better'. But for me, there's always opportunities to get better."
David has scored 13 goals in 19 games for Lille in all competitions this season, including goals against heavyweight sides Real Madrid, Atletico Madrid and Juventus in the Champions League.
Including penalties, eight of those goals have been scored via his stronger right boot, four with his left and one with his head – an area the forward accepts he can still improve.
"Aerially, I can get better," he said. "Getting that header on target and scoring.
"I can get in good positions and win headers but the finishing touch, I'm still missing. With my back to goal, I can also get better."
David is averaging a goal every 112 minutes across all competitions this season, which compares to one every 139 minutes last season and 131 in 2022-23.
However, he still has some way to go to match the 18 goals scored in 27 league games for former club Gent in 2019-20.
"Things are good right now because I'm scoring goals," David said.
"But is this the best I've played in my life? Probably not. For me, it was my second year in Belgium. That was the season of my life."
Juve face a tough task against a side who have already upset Real Madrid and Atletico Madrid in this season's competition.
This will be the first ever meeting between these teams.
However, Juve have lost three of their last four Champions League matches against French opponents (W1), including both against Paris Saint-Germain in the 2022-23 campaign. and Motta warned against any complacency.
"All matches are important. We, as Juventus, always want to win. The most important thing is always trying to improve," Motta told reporters on Monday.
"Lille are very confident, and we want to face them in optimal condition. We aim to give more than our maximum.
"There are no favourites in a match. It's a beautiful game, in a beautiful stadium, and we hope the pitch will be in good condition tomorrow. We can only talk tomorrow about who played better."
Motta will have midfielder Douglas Luiz from injury, but is still without a glut of players.
"He's [Luiz] one more player who can help the team. We’ll be missing Arek [Arkadiusz Milik], Gleison [Bremer] and [Nicolas Gonzalez]."
Lille boss Bruno Genesio knows Juve will present a stern test for his team, despite their shock wins over the Madrid clubs this term.
"Every Champions League match is different, but there is one essential parameter to get a result - commitment," he said.
"Like all Italian teams, Juventus are very well organised, very difficult to play against. Having already achieved two big results in this competition, we are going to give it our all again and we have our fans who will give us strength."
Jonathan David will be one of the standout Lille players Juve have to keep a close eye on.
The Canada international has scored six goals in his last eight Champions League appearances for Lille.
Lille have won all five games he has scored in but have not won any of the six games he has featured in without scoring (D2 L4).
The Lille midfielder was teed up by Burak Yilmaz before blasting in from long range on the stroke of half-time, with PSG unable to make their possession count from there on in.
The story of the final could have been different, however, had Abdou Diallo taken the best second-half opportunity, failing to convert a headed effort from inside the six-yard area with just Leo Jardim to beat.
After dethroning the capital side as Ligue 1 champions last campaign, Jocelyn Gourvennec's side have now collected the first piece of silverware of France's domestic season, with the showpiece event taking place in Israel this year.
Yilmaz's drilled free-kick seemed destined to open the scoring inside 10 minutes, though Keylor Navas' fingertip save pushed the effort wide of his left-hand post.
PSG, who were hampered by big-name absentees, including Kylian Mbappe and Neymar, dictated proceedings for the remainder of the first half, yet only Julian Draxler tested Jardim as he fizzed from range to force the goalkeeper into a smart save.
Yilmaz worked Navas once more on the counter, but it was Xeka who broke the deadlock as he powered in a right-footed effort from just outside the area.
Diallo should have restored parity with a close-range header but somehow managed to nod wide after Mauro Icardi had redirected the ball towards the left-back.
Icardi thought he had levelled things up with 15 minutes to go but his chipped finish was ruled out for offside, while Draxler volleyed inches wide moments later as PSG drew a blank.
Fifteen-time European champions Madrid had not tasted defeat since going down to Atletico Madrid in the Copa del Rey 36 games ago, while they were also unbeaten in their last 14 Champions League outings.
But Los Blancos were flat from the off in France and had a couple of warnings before David converted from the spot in first-half stoppage time, after Eduardo Camavina handled from Edon Zhegrova's free-kick.
Andriy Lunin, standing in for the injured Thibaut Courtois, had earlier clawed David's attempt onto the post, while Endrick called Lucas Chevalier into action at the other end after becoming the youngest player to start for Madrid in the Champions League, at the age of 18 years and 78 days.
Zhegrova went close to a second Lille goal after the break, before Carlo Ancelotti introduced the fit-again Kylian Mbappe from the bench in a bid to find a leveller.
However, Los Blancos were unable to salvage a point with Dani Carvajal heading wide and Chevalier making an instinctive save to deny Antonio Rudiger at the death.
The result sees Lille move level with Madrid in the competition's new-look league phase, on three points apiece after two matches.
Data Debrief: Lille halt imperious Madrid
Madrid entered Wednesday's game unbeaten in their last 14 Champions League outings, but they were kept out by a resolute Lille rearguard – though they also had Chevalier to thank as Los Blancos failed to score from chances worth 2.09 expected goals (xG).
This is Madrid's first Champions League loss since they were crushed 4-0 by Manchester City in the 2022-23 semi-finals, and their first in the group stages since October 2022 versus RB Leipzig (2-3).
Ancelotti's men started with a home victory against Stuttgart on matchday one, but they are now winless in three straight European away games, drawing two and losing one.
That is their longest such run since November 2016, when they endured a run of four without victory on their travels (three draws, one defeat).
Jonathan David had fired the French club ahead in the first half, before Dusan Vlahovic scored a second-half penalty to level things up and leave both sides on seven points after four matches.
Things didn't start well for the home side, with Teun Koopmeiners thinking he had scored the opener for Juventus only for it to be disallowed for offside.
David put Lille ahead just three minutes later with their first chance of note in the match. The Canadian turned home to convert from a slick counter-attacking move.
Goalkeeper Lucas Chevalier had to be on form to keep the home side ahead before half-time, sensationally saving a Vlahovic half-volley 10 minutes before the break. Koopmeiners, meanwhile, had another effort chalked off in the 42nd minute.
Juventus upped the pressure in the second half, with Chevalier also upping things and pulling off two impressive saves in quick succession.
But ultimately, the Lille resistance was broken by a Vlahovic penalty on the hour after Francisco Conceicao had been fouled by Benjamin Andre.
The result leaves Juventus 10th and Lille 12th in the Champions League table.
Data debrief: Lille looking good for qualification
After drawing 1-1, Lille are unbeaten in nine matches in all competitions and three matches in the Champions League.
The French side had beaten Atletico Madrid and Real Madrid in back-to-back European games.
They now have a seven-point buffer between themselves and the bottom eight in the league table.
Vitinha opened the scoring from the penalty spot before Bradley Barcola added another goal just three minutes later in the first half at Stade Pierre-Mauroy.
Barcola's fourth strike of the Ligue 1 season had PSG in control at 2-0 heading into the second period, though Edon Zhegrova reduced the arrears with 12 minutes remaining.
Randal Kolo Muani made sure of all three points, however, with the substitute climbing high to head home from Desire Doue's cross in stoppage time.
Luis Enrique's reigning champions remain top of the table on nine points, two ahead of a four-team chasing pack, while Lille are sixth with six.
Data Debrief: Brilliant Barcola frustrates Lille again
Zhegrova's late finish forced PSG into a nervier ending than expected, considering the visitors dominated almost 60% of the possession and accumulated 2.3 expected goals to Lille's 1.24.
Yet it was a familiar face who proved the thorn in the hosts' side once more, with Barcola netting in the first half for his fourth Ligue 1 goal involvement against Lille (two goals, two assists).
Only against Montpellier (six) has the France winger managed more goal involvements in his top-flight career, and Barcola will expect further domestic achievements this campaign having stepped up to replace Kylian Mbappe on the left.
Barcola's exploits, alongside the youthful midfield of Joao Neves, Vitinha and Warren Zaire-Emery, will be pivotal for Luis Enrique's side, too, this season – where they continue to succeed on the road.
PSG have now won their last seven Ligue 1 away matches, including the back end of last term, last managing more in the competition between January and April 2017 (eight).
The Icelandic midfielder had only been on the pitch a minute when he settled the five-goal thriller, while lifting Bruno Genesio's side into the Champions League's top eight.
Osame Sahraoui drilled the hosts in front on 37 minutes, while Mitchel Bakker rounded off a sweeping move to double the lead in first-half stoppage time.
However, Sturm Graz responded before the break as Otar Kiteishvili fired into the roof of the net, before Mika Biereth turned home William Boving's cross within two minutes of the restart.
But there was to be a final twist as, nine minutes from time, substitute Haraldsson found the top corner to seal another three points for Lille.
Data Debrief: Super sub Haraldsson the hero
Haraldsson's strike sealed successive Champions League home wins in the same season for the first time for Lille, who are now unbeaten in five games.
That is their longest such streak since at least 2004-05.
Scoring more than once in a Champions League home game for the first time in 15 attempts, Lille took their tally for the season to 10 - their most in a single campaign.
Haraldsson was the hero, scoring just 56 seconds after his introduction. That is the second-quickest substitute goal in this season's Champions League, after Brest’s Mathias Pereira Lage took just 47 seconds to net against Salzburg in October.
As for Sturm Graz, their winless streak away against French opposition stretches to six matches (losing five).
Former head coach Galtier steered Lille to a first Ligue 1 title in a decade before departing for Nice, with new boss Gourvennec masterminding a 1-0 win over Paris Saint-Germain in Sunday’s curtain-raiser for the new domestic season.
Xeka's first-half strike from long range was the difference between the teams, ending PSG's eight-year spell of dominance in the competition, while it also secured Lille's first ever triumph at the third attempt.
"When you play a trophy, what matters is the title," Gourvennec told the media after the game. "We suffered in the second half because there was a high technical quality in front of us.
"We went through a lot but the players are used to it. There were also moments like that last season, and we were able to stay strong.
"It is not easy to take over from Christophe [Galtier]. I say it very simply: I share this title with him because he has done a remarkable job with his staff. It's kind of his title.
"It's good to start on a positive note. There is collective strength in this team, and talent too. We found that tonight."
Pochettino's men were dethroned in Ligue 1 last term by Gourvennec's new side, who denied the former Tottenham boss a third domestic trophy at the French giants, with the hard-fought win an early psychological blow ahead of the new campaign.
However, Julian Draxler, who was denied by Lille goalkeeper Leo Jardim in the first half and volleyed wide in the second, insisted the result would not impact PSG's Ligue 1 preparations.
"It's hard to accept losing a final but we didn't play badly when we were missing players," the attacking midfielder said after the final loss. "It wasn't perfect, but in the second half we were the best team.
"Congratulations to Lille. We are sad and disappointed for our supporters, but we gave everything until the last minute. We'll be ready for Ligue 1."
PSG had a number of first-team regulars absent, including Kylian Mbappe and Neymar.
Gianluigi Donnarumma was also not involved, though fellow new recruit Achraf Hakimi started and Georginio Wijnaldum was introduced as a second-half substitute.
The result – a fifth win in their last six league games – moved them four points clear of second-place Paris Saint-Germain, although Mauricio Pochettino's side can restore the one-point deficit with victory over Rennes on Sunday.
Should the reigning Ligue 1 champions lose, Christophe Galtier's side can seal a first league triumph since the 2010-11 season against Saint-Etienne in their penultimate game of the campaign on May 16.
Burak Yilmaz got them on their way in the fourth minute, slotting home from the penalty spot after Jonathan Bamba had been fouled in the area by Seko Fofana.
Clement Michelin received a second yellow card for the hosts in the 35th minute, with Yilmaz scoring his second five minutes later courtesy of a stunning 25-yard strike into the top-left corner.
Jonathan David added a third on the hour mark as Lille cranked up the pressure on PSG, whose run of three straight league titles is in grave danger of coming to an end.
Madrid return to LaLiga action on the back of the 1-0 defeat to the French side, with Jonathan David's penalty enough to deny the holders a victory.
It also ended their 36-match unbeaten run in all competitions and was their first Champions League group-stage defeat since October 2022 against RB Leipzig.
Ancelotti's side have now failed to win their last two, having also conceded a late equaliser in a 1-1 draw with Atletico Madrid last weekend, but he is confident the team will be back to winning ways soon.
"[Villarreal] are doing really well. Saturday, it's an opportunity for us to reconnect, to get back to playing good football," Ancelotti told a press conference on Friday.
"[The mood] is fine, as always. [Wednesday's] defeat is an opportunity, if we take it and react well. We are self-critical. There are times when you have to reconnect and you need to do it quickly.
"Sometimes a good run makes you think you're invincible, but a defeat brings you back to reality. We are still not at our level, we have players who are not at their best.
"We are not far from where we want to be. There is a lack of defensive intensity and, offensively, a lack of ball circulation."
Coming off a remarkable 2023-24 season in which they won the LaLiga and Champions League double, Madrid are second in the Spanish top-flight standings on 18 points, three behind leaders Barcelona and one ahead of Villarreal.
Ancelotti expects to get Kylian Mbappe back into the starting team after the forward missed last weekend's derby against Atletico and came off the bench at Lille due to a hamstring injury, which led to France manager Didier Deschamps leaving his captain out of the squad for next week's Nations League matches against Israel and Belgium.
"He has had a problem that seems to have been solved. He has trained normally," Ancelotti said.
"I don't get involved in what national coaches do. Deschamps has decided not to call him. We need to get the ball to the strikers quicker and we lack defensive intensity."
Osimhen, who scored 13 Ligue 1 goals last season, joined the Partenopei at the end of July in a deal that could eventually be worth €54m.
While Lille moved quickly to bring in veteran Turkey forward Burak Yilmaz, a large chunk of the Osimhen fee was used to recruit Canada's David.
The 20-year-old has signed a five-year contract in Lille and will wear the number nine shirt, which previously belonged to Loic Remy, who is said to have failed a medical at Benevento in recent weeks.
David scored an impressive 37 goals in 83 games for Gent in all competitions, having made his debut in August 2018.
The American-born front man also has an outstanding strike rate at international level, netting 11 times in 12 senior matches for Canada.
"I'm really happy," David said. "I've been eagerly awaiting this day and it's a pleasure to be a Dogue.
"I know the project that has been put in place here by the president, [sporting director] Luis Campos and [head coach] Christophe Galtier. This is a very good team with great players.
"I want to play and to progress and I think that this is the perfect place."
