Mahomes' health is the dominant storyline for the Chiefs ahead of their clash with the Philadelphia Eagles at State Farm Stadium on Sunday.
He suffered a high ankle sprain in the Chiefs' Divisional round win over the Jacksonville Jaguars, an injury that forced him to come out of the game before returning in the second half.
Mahomes subsequently played through the injury in the AFC Championship Game with the Cincinnati Bengals, willing them to a thrilling 23-20 victory.
Speaking at Opening Night on Monday, Mahomes said his ankle is "definitely better", however Reid on Tuesday clarified that his star quarterback is still not at full strength.
"Yeah, so I wouldn't tell you he is 100 per cent," Reid said.
"But the training staff works with him endlessly. I guess it'd be a tribute to both of them for Pat coming back for more and for those guys cranking on him."
Despite his ankle issue, Mahomes has still performed at a very high level in the postseason.
Across his two playoff games, Mahomes has completed 69.9 per cent of his passes for 521 yards, four touchdowns and no interceptions.
Reid is used to seeing Mahomes producing magic on the field, but even he has been taken aback by what his signal-caller has produced while playing on one healthy ankle.
"So, Julie [Frymyer, Chiefs physical therapist] spent most of the time with him," Reid added. "We've got all the latest greatest stuff to use, technology-wise, so he's used it all and has been able to make these jumps here where he can actually function and play in a game, which is very remarkable."
Reid was an assistant coach for the Green Bay Packers in Super Bowl XXXI and has now twice celebrated success while in the top job in Kansas City.
His latest triumph, in Super Bowl LVII, came against the Philadelphia Eagles, a franchise he coached for 13 years.
Between his stints with the Eagles and the Chiefs, Reid has been a head coach for 24 years.
Now 64, he was asked during the Chiefs' Super Bowl celebrations if he might be ready to quit the sport, but his focus was on the party that lay ahead.
"No, I'm going to enjoy this one right here," Reid replied. "Let me tell you, this is unbelievable.
"Philadelphia, you did a great job, it was a great game. But how about those Chiefs?"
Reid had been introduced on the podium by Chiefs chairman Clark Hunt as "one of the best coaches in the history of the National Football League".
"We couldn't have done it without [him]," Hunt said, although Reid was keen to share the praise around.
In his FOX Sports interview, Reid said of the Chiefs' second-half rally in a 38-35 victory: "I'll give the credit to the big O-line and Pat Mahomes and all those guys around him. [Offensive coordinator] Eric Bieniemy was phenomenal also."
Of Mahomes, who has been playing with a high ankle sprain, Reid added: "He's the MVP. That's all that needs to be said, right? He's the MVP, and you saw it tonight."
The Chiefs trailed 24-14 to the Philadelphia Eagles at half-time at State Farm Stadium and appeared to be in some what desperate straits when Patrick Mahomes came up limping after a scramble late in the second quarter.
But Reid produced a masterful gameplan in the second half, tormenting the Eagles’ defense with a varied run-game approach and intelligent use of motion to give Mahomes easy completions.
Those easy completions propelled the Chiefs to a 38-35 win, sealed with a Harrison Butker field goal with eight seconds remaining after a drive on which a remarkable 26-yard scramble from Mahomes put Kansas City in position to complete the comeback.
Reid had faced questions about potential retirement prior to the game and was again asked on the podium as he collected the Vince Lombardi Trophy, saying simply that he was going to "enjoy this one".
He declared his intentions more definitively in his post-game press conference, indicating he will back for a run at a third Super Bowl with Kansas City.
The Chiefs faced a 12-point deficit before quarterback Mahomes fuelled a 33-29 come-from-behind victory against the Browns on Sunday.
Mahomes threw a pair of touchdowns in the fourth quarter for reigning AFC champions the Chiefs, including a 75-yard pass to Hill that helped close the gap.
He completed 27 of his 36 passes for 337 yards and three touchdowns as the former MVP made more NFL history.
The 25-year-old broke the record for most passing yards in NFL history through the first 50 games, while he also boasts the most passing touchdowns ever through the same amount of appearances.
"That's Patrick Mahomes being Patrick Mahomes," said Chiefs team-mate Hill. "There it is."
Chiefs head coach Reid added: "You love his attitude because he always feels like we're in it.
"He does such a great job with the guys around him. He's a great communicator during tough times on the sideline."
Mahomes led the Chiefs to their ninth win in the last 11 games in which they trailed by double-digit points.
"We think we can win no matter what the situation is," Mahomes said.
"Getting that play to Tyreek kind of got the crowd back into it," Mahomes continued. "When you're at Arrowhead [Stadium] and the crowd's rolling, it gets the defence going and it kind of translates to the offence."
