Italy's humiliating failure to qualify for the World Cup means "profound change" must follow the sorrow, according to Serie A president Lorenzo Casini.

A stunning 1-0 defeat to North Macedonia in Thursday's play-off semi-final in Palermo has left Italy knowing they will miss consecutive World Cups for the first time in their history.

The Azzurri will be absent at Qatar 2022, just as they played no part in Russia 2018, and there will be a process whereby some are likely to be held to account over such a dire outcome for the four-time winners.

Elation at triumphing at Euro 2020 has been replaced by suspicions that was a flicker of rude health amid serious worries over the health of the Italian game.

Casini said on Friday: "Failure to qualify for the final phase of the World Cup is a failure for the whole of Italian football, which must lead everyone to serious reflection and a profound change in our system.

"Right now I am only experiencing the great disappointment of all the fans. I am very sorry when I think of the girls and boys who are still waiting to see Italy at the World Cup and who must be able to continue growing in the blue dream.

"Serie A clubs and their players have always responded positively to the call of the national team and always will, also because it is about the sporting commitment that unites the country and should always make us overcome every allegiance and every division. The national team belongs to everyone."

Roberto Mancini was backed to stay on as head coach by Italian Football Federation (FIGC) president Gabriele Gravina in the immediate aftermath of Italy's defeat.

Gravina wanted the previous round of Serie A fixtures to be postponed to give Italy more time to prepare for the game, but his request was denied by the league. 

"I'm sorry the boys only met for one day to prepare for the game," Gravina said after Thursday's game. "It doesn't help, but I don't want to cause a controversy."

The FA Cup semi-final between Liverpool and Manchester City will take place at Wembley Stadium on Saturday, April 16, the Football Association has confirmed.

There are scheduled to be significant travel issues between the north of England and London that weekend, with no trains running from either Liverpool or Manchester and the capital.

The mayors of both cities wrote to the FA earlier this week requesting that the game be moved to a more convenient location for supporters of both teams, pointing out the rising cost of fuel as well as the fact the game is set to take place over a bank holiday weekend.

However, the FA announced on Friday that while the game between the top two teams in the Premier League will still be held at Wembley, they intend to provide 100 free charter buses from Anfield and the Etihad Stadium to the game and back.

In addition, English football's governing body has said it will work with National Highways to "ensure that the road networks are running as efficiently as possible".

A statement on the FA's website read: "We recognise the significant challenges that are being faced by some Liverpool and Manchester City supporters, with train services being severely limited due to essential engineering works being carried out over the bank holiday weekend by Network Rail on the West Coast Mainline.

"On Saturday 16 and Sunday 17 April there will be no trains running between London Euston and Scotland on the West Coast Mainline. All services on this route will be affected, including between London and the North West. These planned works will also make services operated by Chiltern Railways extremely busy.

"Therefore, the FA, Network Rail and Chiltern Railways strongly advise that Liverpool and Manchester City supporters affected should avoid travelling from the North West by train wherever possible and seek alternative travel arrangements."

The statement also said the provision of 100 free buses "will ensure that up to 5000 Liverpool and Manchester City supporters will be able to travel to Wembley Stadium free of charge for their semi-final tie. These bus schedules are subject to availability, must be pre-booked, and the clubs will provide more information in due course."

The game is scheduled to kick-off at 3.30pm, while the other semi-final between Chelsea and Crystal Palace will also take place at Wembley on Sunday, April 17, with a 4.30pm kick-off.

Kylian Mbappe is expected to join Real Madrid upon the conclusion of his Paris Saint-Germain contract.

The 2018 World Cup winner has opted not to extend his PSG deal.

Los Blancos have long circled for Mbappe's signature, having come close to signing him in the off-season.

TOP STORY - BARCELONA PLOT SWOOP FOR REAL TARGET MBAPPE

Barcelona are plotting a sensational move to snap up Mbappe ahead of rivals Madrid, reports L'Equipe.

The 23-year-old PSG winger has been heavily linked with a move to Madrid upon the conclusion of his contract at season's end.

However, the report claims Barcelona view him as a more financially shrewd option than Erling Haaland, who could cost them up to €300million.

ROUND-UP

- Barcelona have also joined the race to sign Leeds United's Brazil international Raphinha alongside Liverpool, Manchester City and Bayern Munich, according to the Mirror.

- Barcelona are also interested in Bayern forward Robert Lewandowski, claims SPORT. The same outlet have also linked the Blaugrana with Liverpool forward Mohamed Salah , who is yet to extend at Anfield beyond his existing deal, which expires in 2023.

- The Sun claims that Bruno Fernandes will have his salary doubled with a new Manchester United deal in the works. The contract is understood to be a five-year deal.

- Chelsea's Antonio Rudiger has been offered a deal by Juventus, reports Sky Sports.

Mexico and the United States shared the points in a tense 0-0 draw in Thursday's CONCACAF World Cup qualifier in Mexico City.

A victory for either side would have put them on the brink of qualification, but both will need to wait, with the result leaving United States and Mexico in second and third positions respectively with two matches remaining.

Costa Rica moved into fourth spot after their 1-0 win over CONCACAF leaders Canada - who missed out on sealing their spot for Qatar - with the Ticos now three points behind US and Mexico who are locked on 22 points.

In a game where Mexico had a lion's share of possession, it was the Americans creating the best of the chances, with Mexican goalkeeper Guillermo Ochoa looking spry at 36 years young.

Ochoa was called upon in the 14th minute to deny Yunus Musah, and again in the 36th minute to thwart Christian Pulisic to keep things deadlocked heading into half-time.

Pulisic had another chance just minutes into the second half, but his sharp chance was kept out by Ochoa as he finished the match with four saves. Hirving Lozano had a pair of chances for Mexico in the second half, but sent one over in the 57th minute, and one into the crossbar in the 80th minute.

US's final game away to Costa Rica on Wednesday is shaping up to have plenty on the line. The top three CONCACAF qualifiers will move on to the World Cup, while fourth-placed side will need to go through a play-off.

Brazil head coach Tite was emotional after his side's 4-0 win over Chile in World Cup qualifying on Thursday in what may his final game in charge on home soil.

Tite previously announced he would exit the role after the 2022 World Cup, having taken over in June.

During Tite's tenure Brazil won the 2019 Copa America, but were eliminated from the 2018 World Cup in the quarter-finals.

More recently, Tite guided Brazil to 2022 World Cup qualification in November with several games to spare, with Selecao currently unbeaten in their qualifying campaign with 13 wins and three draws.

Brazil are currently on a 10-game unbeaten run in all competitions, dating back to last year's Copa America final defeat to Argentina.

"It has many meanings, many situations," Tite said after the win over Chile about his final game as head coach on home soil.

"There are many and they are very particular. Many thanks to the fans who attended the Maracana today, thank you very much."

Tite may still lead Selecao in Brazil again with the postponed qualifier against Argentina yet to be re-scheduled although the match would be a dead rubber with both sides comfortably qualified, with appetite low for a re-match.

On the win over the Chileans, who appear destined to miss the 2022 World Cup, Tite praised his side's level of performance, without pinpointing individuals.

"Two aspects have swayed me: the players with the personality and confidence to come to the national team and repeat the performances of their clubs, this is difficult due to the expectation of wearing the national team's shirt," Tite said.

Brazil's next qualifier is away to Bolivia on Tuesday, where they will be without Neymar and Vinicius Junior after they picked up yellow cards against Chile forcing suspension.

Mexico and the United States shared the points in a tense 0-0 draw in Thursday's CONCACAF World Cup qualifier in Mexico City.

A victory for either side would have put them on the brink of qualification, but both will need to wait, with the result leaving United States and Mexico in second and third positions respectively with two matches remaining.

Costa Rica moved into fourth spot after their 1-0 win over CONCACAF leaders Canada - who missed out on sealing their spot for Qatar - with the Ticos now three points behind US and Mexico who are locked on 22 points.

In a game where Mexico had a lion's share of possession, it was the Americans creating the best of the chances, with Mexican goalkeeper Guillermo Ochoa looking spry at 36 years young.

Ochoa was called upon in the 14th minute to deny Yunus Musah, and again in the 36th minute to thwart Christian Pulisic to keep things deadlocked heading into half-time.

Pulisic had another chance just minutes into the second half, but his sharp chance was kept out by Ochoa as he finished the match with four saves. Hirving Lozano had a pair of chances for Mexico in the second half, but sent one over in the 57th minute, and one into the crossbar in the 80th minute.

US's final game away to Costa Rica on Wednesday is shaping up to have plenty on the line. The top three CONCACAF qualifiers will move on to the World Cup, while fourth-placed side will need to go through a play-off.

Gareth Bale described the criticism he has been the subject of as a Real Madrid player as "disgusting" after leading Wales into a World Cup play-off final.

Bale has played in just five of Madrid's 42 matches in all competitions this season, totalling 270 minutes on the field – the equivalent of three whole games.

Once the most expensive player in world football, the winger was absent for Madrid's most recent match, a painful 4-0 defeat to bitter rivals Barcelona.

However, Bale was back and back to his best when Wales came calling on Thursday.

The 32-year-old captained his country to a 2-1 win against Austria in their play-off semi-final, scoring two sublime goals – the first a breathtaking free-kick.

Bale appeared to play through the pain barrier in a brilliant display, eventually making way while holding his groin.

The former Tottenham man appeared to enjoy the celebrations, but his tone shifted slightly when asked if he had a message for his critics in Spain.

"No," he told Sky Sports. "I don't need to send a message, honestly. It's a waste of my time.

"It's disgusting, they should all be ashamed of themselves. I'm not fussed. End of."

Bale has come into form at a great time for Wales, scoring five goals in his past four international appearances – more than in his previous 28 games for his country (four).

In European qualifying for the 2022 World Cup, only five players have been involved in more goals than Bale's eight (five goals, three assists).

Wales will play either Scotland or Ukraine for a place in Qatar, with that decider at home, where Bale and Co. are unbeaten in 17 games in all competitions.

Ecuador qualified for the 2022 World Cup on Thursday despite a 3-1 defeat to Paraguay, benefiting from a victory for Uruguay that also sent the two-time champions to Qatar.

La Tri, who failed to make Russia 2018, knew they needed only a point to be sure of a top-four finish with a game to spare.

However, already-eliminated Paraguay were clinical in Ciudad del Este, three up before the hour mark through Robert Morales, a Piero Hincapie own goal and Miguel Almiron.

Ecuador threatened a dramatic fightback as Jordy Caicedo scored a late penalty and Blas Riveros was sent off, but ultimately their fate was decided in Montevideo.

The third-placed side joined Uruguay in advancing with both teams on 25 points, four ahead of fifth-placed Peru, who went down 1-0 to Giorgian De Arrascaeta's goal late in the first half.

Peru are still in control of their play-off fate, although both Colombia and Chile can catch them as Paraguay attempt to again play the role of spoilers in Tuesday's final match in Lima.

A spectacular first-half performance from Brazil's forward trio of Neymar, Vinicius Junior and Antony paved the way for a stylish 3-0 win against Chile.

Neymar scored his 71st international goal in his 117th cap for Brazil, while for Vinicius there was just a second goal in his 13th international appearance as the Selecao claimed a deserved 2-0 half-time lead, controlling 63 per cent of the possession.

To Chile's credit – with their World Cup qualification hopes just about alive – their second half ensured a competitive encounter with chances of their own, but Brazil were comfortable, having already booked their place in Qatar.

A hopeful long ball forward ended up with a second penalty for the hosts, with Philippe Coutinho getting his name on the scoresheet soon after his arrival into the match after Neymar delegated the duties. There was time for Richarlison to add a fourth, too.

Brazil almost made a superb start after Antony sliced his way into the box from the right wing 30 seconds after kick-off, but his shot on goal was tame and easily gathered by Claudio Bravo.

Bravo stood firm amid an early onslaught, crucially taking the ball off Neymar's toes after a sloppy first touch 19 minutes in, but his first half took a turn for the worse.

After Mauricio Isla brought down Neymar in the box for a clear penalty in the 42nd minute, which the felled forward converted, Bravo botched a clearance less than two minutes later to allow Antony to slip in Vinicius for Brazil's second.

Chile's Arturo Vidal thought he had pegged one back four minutes into the second half, but the VAR ruled it out for offside, before Brazil made sure of the points with a penalty scored by substitute Coutinho when Antony beat Bravo to the ball and was wiped out.

Richarlison – also introduced off the bench – put the icing on the cake in stoppage time, cutting in on his left foot and curling a finish across Bravo to make it four.

Blagoja Milevski felt North Macedonia "won Italian style against the Italians" after his side sensationally ended the European champions' bid to qualify for the 2022 World Cup.

Aleksandar Trajkovski's long-range stoppage-time strike secured a stunning upset for the underdogs in a World Cup qualifying semi-final at Renzo Barbera on Thursday.

Italy dominated the game in Palermo, but failed to find the back of the net from 32 shots and were made to pay for their lack of a cutting edge.

Trajkovski's brilliant finish was North Macedonia's second shot on target as they set up a showdown with Portugal at Estadio do Dragao next Tuesday for a place in the finals in Qatar.

North Macedonia head coach Milevski felt his team played Italy at their own game.

"We won Italian style against the Italians, a goal from just two shots," he said. 

"I'm very happy for this victory, I'm proud for these guys. All energy from tomorrow will be on Portugal.

"I am very happy for Trajkovski with his goal. The game was prepared in this way, we know that Italy are a great team with several champions but we played as we should.

"We know our strengths. Before the game I told the guys to have fun and they did just that."

North Macedonia have never played in a World Cup and will have to pull off another major surprise in Porto to beat a Portugal side that beat Turkey 3-1 on Thursday.

Cristiano Ronaldo's dip in goalscoring form is of no concern to Fernando Santos, who felt he was "tremendous" in Portugal's World Cup qualifying play-off semi-final success against Turkey. 

First-half efforts from Otavio and Diogo Jota put Portugal in control in Porto, but Burak Yilmaz pulled one back after the hour mark and had a chance to equalise from the penalty spot with five minutes remaining. 

However, Yilmaz missed the target from 12 yards and Matheus Nunes completed a 3-1 win for the hosts in stoppage time, with Ronaldo hitting the bar in the final act of the game. 

The Manchester United forward had five efforts on goal and hit the target with two of them. Diogo Jota (38), who played 20 minutes fewer than Ronaldo, was Portugal's only outfield starter with fewer touches than him (40).  

Ronaldo also failed to find the back of the net in Portugal's draw with the Republic of Ireland and the defeat to Serbia that cost Santos' men automatic qualification for Qatar. 

He has scored just four goals in his past 13 appearances in all competitions for club and country, but the Portugal boss is unconcerned by his displays. 

"Ronaldo is judged on the goals he scores, it's always that way," said Santos. 

"From my perspective, he played a tremendous game, bringing the group together, working and pressing with the intensity of the game. 

"He didn't score, but that doesn't invalidate what was an excellent performance for Ronaldo. He had several opportunities. He didn't convert them, but he opened up a lot of spaces for others and that's something to highlight."

Ronaldo is one of several veterans in the side that it has been suggested should be phased out by Santos to make way for a new generation, but the coach spoke out in defence of the more experienced options at his disposal. 

"The one that everyone is asking to be replaced is the only golden generation. I'm very sorry to say this, but it is the only one that has brought a trophy to Portugal," he said. 

"Now, if you ask me if Portuguese football has a bright future ahead of it, with high-quality players capable of responding at any time, I'd say yes. 

"Portugal have always had great players, but the golden generation is the one that won the gold." 

Jorginho admits his missed penalties earlier in the campaign will haunt him forever following Italy's failure to qualify for the 2022 World Cup.

The Azzurri were crowned Euro 2020 champions just eight months ago after beating England in the final on penalties.

However, Roberto Mancini's side will not be at the World Cup later this year after they were stunned 1-0 by North Macedonia in the playoff semi-finals.

Although the hosts dominated proceedings in Palermo, Aleksandar Trajkovski struck in stoppage time to give the visitors a shock victory.

Having drawn four of their last five games, Italy had to settle for a playoff place after finishing two points behind Switzerland in Group C.

Among them was a 1-1 stalemate with the Swiss, during which Jorginho missed two penalties that would have seen the Azzurri displace their opponents in top spot.

And the Chelsea midfielder revealed his sense of responsibility for his nation’s subsequent failure to qualify.

"It is difficult to explain what happened," he told RAI Sport. "It hurts so much. I'll be honest, I am still incredulous. 

"I don't think we lacked creativity, as we always dominated matches and created so many chances. Unfortunately, we were unable to finish them off.

"We played good football, we won the European Championship last summer, but unfortunately in the last few games, we made small errors and were unable to recover from them. They made the difference.

"It hurts when I think about [the missed penalties], because I do still think about it, and it will haunt me for the rest of my life.

"Stepping up there twice and not being able to help your team and your country is something that I will carry with me forever, and it weighs on me.

"People say we need to lift our heads and carry on, but it's tough."

Meanwhile, team-mate Marco Verratti acknowledged that the reigning European champions were made to pay after failing to turn their superiority into goals.

"It is difficult to understand. I think we dominated this match, and we should've won. We had to win," the Paris Saint-Germain midfielder added.

"This is football, it is fundamental to be clinical and ruthless. It's just so difficult to explain. It was a nightmare.

"Looking around the locker room, we had the players to challenge for the tournament itself, yet here we are talking about a disaster. It's so tough to go from hero to zero.

"We experienced special times together, and I will always be proud of my team-mates. 

"We have to ask ourselves questions now. There's some bad luck, but you also need to make your own luck."

Roberto Mancini has been backed to stay on as head coach by FIGC president Gabriele Gravina despite Italy’s failure to qualify for the 2022 World Cup. 

The Azzurri succumbed to a sensational 1-0 defeat to North Macedonia in a play-off semi-final in Palermo on Thursday, ending their hopes of securing a place in the tournament in Qatar this year. 

Having missed out on a spot at the 2018 World Cup in Russia, Italy will not feature in two successive editions of the competition for the first time in their history. 

However, with Mancini having led the team on a 37-game unbeaten run that included Euro 2020 glory and only ended last October, Gravina still believes he is the right man for the job. 

"I hope Mancini will continue with us. He has a commitment to the project," Gravina told Rai Sport. 

"I hope, like all the other Italians, that he will dispose of the waste from this elimination and remain at the helm to continue our work. I still have a lot of energy. 

"I'm sorry, I'm truly embittered for all our fans. The great joy of the previous summer remains, but also the great bitterness of this defeat. We didn't expect it. 

"The guys were splendid and will continue to be so. They gave our country an extraordinary dream just a few months ago. However, tonight's defeat makes us understand there is something we need to do."

Gravina wanted the previous round of Serie A fixtures be postponed to give Italy more time to prepare for the game but his request was denied by the league. 

"I'm sorry the boys only met for one day to prepare for the game. It doesn't help, but I don't want to cause a controversy," he added. 

Italy have failed to qualify for the 2022 World Cup following a shock 1-0 defeat by North Macedonia on Thursday.

For the first time in their history, the Azzurri will miss out on successive finals after Aleksandar Trajkovski struck a stoppage-time winner at Renzo Barbera.

Roberto Mancini's side triumphed at Euro 2020 just eight months ago, defeating England on penalties in the final to claim their second title.

But four years after their playoff defeat by Sweden denied them a place in Russia, they will be absent in Qatar after suffering their first ever loss on home soil in a World Cup qualifier.

It is fair to say it has been quite the journey from one World Cup qualifying failure to another.

Swede success

Despite finishing behind Spain in their qualifying group, Italy were heavy favourites to overcome Sweden in a two-legged playoff.

However, Jakob Johansson struck the only goal of the opening leg to set up a tense climax in Milan.

The Azzurri dominated their opponents, but the Swedes stood firm to deny them a place at the World Cup finals for the first time since 1958.

Euro 2020 glory

Failure to qualify for Russia culminated in the departure of Gian Piero Ventura, who was replaced in the hot-seat by Mancini.

Despite winning just one of his first six matches in charge, things eventually clicked into gear for the former Inter and Manchester City coach, who oversaw a perfect qualifying campaign for the delayed Euro 2020.

The Azzurri came flying out of the blocks; topping Group A with maximum points before seeing off Austria, Belgium and Spain, before holding their nerve to overcome England on penalties for a second European crown.

The record-breaking run

In fact, Italy did not look back after a 1-0 defeat by Portugal in the Nations League in September 2018.

The Azzurri subsequently embarked on a record-breaking 37-match unbeaten run across all competitions spanning three years.

The streak came to an end following a 2-1 defeat by Spain in the Nations League semi-finals last October.

North Macedonia mayhem

Despite going unbeaten in qualifying, four draws from their last five matches meant Italy had to settle for second place in Group C and another playoff berth.

Once again, the Azzurri were red-hot favourites to overcome North Macedonia, who are seeking their first appearance at the finals as an independent nation.

But despite 32 attempts on goal, the hosts were unable to make their superiority count in Palermo, and were punished right at the death as the visitors stunned the four-time world champions.

Gareth Bale scored a pair of stunning goals to secure a home World Cup play-off final for Wales against either Scotland or Ukraine.

Wales have not qualified for a World Cup since 1958 and surely will not get a better opportunity than ahead of Qatar 2022.

Rob Page's side hosted Austria in their play-off semi-final on Thursday and once again relied on Real Madrid superstar Bale to prove the difference in a 2-1 win.

He netted the opener with a sublime first-half free-kick, then doubled Wales' lead with another brilliant effort, placed high past the Austria goalkeeper.

Only a Ben Davies own goal – deflecting Marcel Sabitzer's shot beyond Wayne Hennessey – threatened to spoil the Welsh party, as they held on despite Bale's withdrawal in stoppage time with an apparent groin injury.

Bale will at least have time to recover from that issue before the final, as Russia's invasion of Ukraine saw the former banned from FIFA competitions and the latter allowed to postpone their semi against Scotland.

No date has yet been set for the Scotland tie, with Steve Clarke's men instead facing Poland – Russia's planned play-off opponents – in a friendly they drew 1-1 on Thursday.

Krzysztof Piatek's 94th-minute penalty rescued a draw for Poland, albeit that goal came earlier than Sweden's decisive strike against Czech Republic.

Sweden will be Poland's final opponents after Robin Quaison finished off a smart team move with 10 minutes remaining in extra time following a goalless draw – that 1-0 victory teeing up the trip to Chorzow on Tuesday.