France resume their bid to win a first Six Nations title since 2010 with a trip to face wounded England at Twickenham, and Wales should made it four wins out of four this weekend.
A coronavirus outbreak in the French camp led to their clash with Scotland being postponed, but they will be back in action against the Red Rose on Saturday a month after beating Ireland.
Wales shattered England's hopes of retaining the title with a 40-24 win at the Principality Stadium and will be expected to stay perfect when they face Italy in Rome, also on Saturday.
Scotland will look to reignite their title challenge when they face Ireland at Murrayfield on Sunday.
We use Opta data to preview the round-four encounters.
ITALY v WALES
FORM
Wales have won their last 15 Tests against Italy, and a 16th would represent their longest ever winning run against a single opponent in Test rugby (they won 15 in a row against France from 1908 to 1927).
A win over England secured Wales' fifth Triple Crown of the Six Nations era, They completed the Grand Slam in each of their previous four Triple Crown-winning campaigns since 2000 (2005, 2008, 2012, 2019).
Italy's losing run in the competition stands at 30 games and they have lost 19 in a row at home, stretching back to a defeat of Ireland eight years ago.
ONES TO WATCH
Azzurri fly-half Paolo Garbisi has made more kicks in play (29) and recorded more kicking metres (1,142m) than any other player in this year's Six Nations.
Josh Adams marked his first match of the tournament by scoring a controversial try against England and the Wales wing will fancy his chances of touching down again in Rome.
ENGLAND v FRANCE
FORM
England have won nine of their 10 home games against France in the Six Nations, including the last seven in a row. Their only defeat came in February 2005, going down 18-17.
France have won seven of their last eight games in the Six Nations and will look for a fourth consecutive victory in the competition this weekend.
Les Bleus have scored the opening try of the game in 15 of their most previous 18 matches in this tournament, including their last eight in a row.
ONES TO WATCH
Wing Anthony Watson will win his 50th cap for England. He has the best average gain per carry rate (10.1 metres) of anyone to make 10 or more carries in the 2021 Six Nations and has also made the most post-contact metres (141).
France lock Paul Willemse has not missed any of his 34 tackles in the Six Nations this year and has made the joint-second most dominant tackles with four, England's Tom Curry (5) the only player to have made more.
SCOTLAND v IRELAND
FORM
Ireland have lost just three of their last 19 games against Scotland in the Six Nations, winning all the rest. Each of the men in green's defeats came by a margin of five points or fewer.
Scotland have lost their last two Test matches at Murrayfield. They have not been beaten in more consecutive games at their traditional home venue since losing four on the bounce between November 2014 and March 2015.
Gregor Townsend's side are the only team to average fewer than 10 missed tackles (8.5) per game in the Six Nations in 2021 and as a result boast the best tackle success rate of 92 per cent.
ONES TO WATCH
Hamish Watson has been an influential performer for Scotland, winning three turnovers and getting through a huge amount of work in the back row.
Ireland back-row Tadhg Beirne has recorded the most ruck arrivals (117) in the tournament, hitting the most rucks of anyone in both attack (87) and defence (30).
Kane injury doubt for England Euro 2024 squad
Harry Kane may be a doubt for England’s Euro 2024 squad as he continues to struggle with a back problem.
Gareth Southgate is due to name his preliminary squad for Euro 2024 on Tuesday, ahead of upcoming friendlies against Bosnia and Herzegovina and Iceland.
The England captain missed the final two Bundesliga games of the season after going off towards the end of Bayern Munich’s Champions League semi-final second leg against Real Madrid.
Thomas Tuchel confirmed prior to their final match against Hoffenheim that Kane was back in England to undergo treatment.
When later asked again about the nature of the striker’s injury, Tuchel admitted that Kane had been struggling for a couple of weeks.
"In Madrid, it was borderline. We tried injections and treatments. The back has completely closed.
"It has gotten worse and kept breaking out in small, everyday movements. There's no chance he's even training."
Kane scored 36 league goals in his debut campaign for Bayern, though due to the injury, he finished five adrift of Robert Lewandowski’s single-season goal record of 41, set in 2019-20.
The final announcement of Southgate's 26-man squad will be revealed on June 7, ahead of the tournament opener against Serbia on June 16.
Howe taking plenty of positives despite frustrating Newcastle campaign
Eddie Howe was keen to look at the positives after Newcastle United secured seventh place in the Premier League on Sunday.
Alexander Isak and Bruno Guimaraes were among the goalscorers as Newcastle won 4-2 at Brentford to finish their Premier League campaign.
The victory ensured a seventh-place finish, and a Manchester City victory over Manchester United in next Saturday's FA Cup final will confirm Newcastle's place in next season's Europa Conference League.
While this season did not quite live up to the heroics of last term, which saw the Magpies finish in the Champions League spots, Howe still feels it has been a successful campaign.
"It summed up our season," Howe told BBC Sport. "We weren't totally secure at the back, but great credit to the players. They've done their job - now we wait and see.
"We anticipated after losing against Manchester United that our control of the [European] situation had gone. It's never a nice situation, but whatever happens, happens.
"We have issues to solve defensively. If we can do that, next season could be another season of really strong performances. This was a season that could have been better, but a good season overall.
"We're a really united club. I think we're still moving forward, so there's a lot to be positive about."
Postecoglou will not settle until Tottenham hit his 'lofty ambitions'
Ange Postecoglou warned Tottenham he will not settle until the club hits the "lofty ambitions" targeted in his mind.
Spurs were 3-0 victors over Sheffield United at Bramall Lane on Sunday, ending their Premier League season with a convincing win to finish fifth in the table.
Postecoglou voiced his frustrations after Tuesday's 2-0 defeat to Manchester City ended their hopes of Champions League football next term.
The Spurs head coach was far more relaxed after his side performed well in Sheffield, with Dejan Kulusevski twice on target, along with a goal for Pedro Porro against the relegated Blades.
Yet Postecoglou insisted his ambitions remain high as the Australian attempts to take Tottenham to the next level.
"Contrary to my general demeanour, I have loved every minute of it," former Celtic boss Postecoglou said of his first season in charge of Tottenham.
"It is a great challenge in the Premier League and taking over a big club that didn't have a great year last year. You understand it is not going to run smoothly, but I have enjoyed the whole season.
"I have got some lofty ambitions for the football club and until we reach that point I am not going to be smiling too much.
"As I said, all any manager wants is maximum effort and I have got that from everyone involved. I have enjoyed it and looking forward to pushing on from here."
Asked to summarise his first campaign in England's top league, Postecoglou continued: "It's been good, it's been eventful, it's had a bit of everything.
"I am obviously not delighted with the way we finished the season but in fairness to the players and staff we have been in the top five all season, in a year where there was a fair bit of upheaval.
"We finished eighth last year, player turnover, different football, different way of training, it is not easy to maintain a level when you are trying to do that.
"Even in our tough periods this year we have still been competitive for the most part."
Kulusevski scored his seventh and eighth Premier League goals of the season (36 outings), more than he managed in his first two league campaigns with Tottenham combined (seven across 48 games).
Only in the 2019-20 season with Parma has the Sweden winger scored more times in a league season (10 in Serie A), and Postecoglou hailed Kulusevski's returns.
He added: "I thought Deki was good. He's worked awfully hard this year without a lot of reward in the front third.
"We thought playing him through middle today would help us with his mobility and ability to run in behind. He did well.
"He always works hard but it's that sort of final third where we need him to get rewards and he got them today so he did well."
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