Wales go in search of a Triple Crown in a blockbuster battle against England, but France will not have an opportunity to make it three Six Nations wins out of three this weekend.
Wayne Pivac's Wales side are level on nine points with Les Bleus following victories over Ireland and Scotland, both of whom had a man sent off.
George North will become the youngest player in history to win 100 caps, but defending champions England will be determined to spoil the Wales centre's big occasion at the Principality Stadium on Saturday.
The Red Rose beat Italy 41-18 last time out, following a loss to Scotland at Twickenham.
Winless Ireland will be expected to defeat the Azzurri to get up and running in the opening match of round three at Stadio Olimpico.
Sunday's planned showdown between France and Scotland was postponed due to a COVID-19 outbreak in the French squad.
We preview the matches in Rome and Cardiff with help from Opta.
ITALY v IRELAND
FORM
Ireland have scored 45 tries across their last seven games against Italy in the Six Nations (6.4 per game), scoring eight or more tries in three of their last five clashes.
Italy have conceded a try-scoring bonus point in 17 of their 22 matches since those incentives were introduced to the Six Nations in 2017; only England (9) have picked up more bonus points in the championship than Ireland (8). The Azzurri are the only side yet to register one.
Ireland have lost their opening two games of a Six Nations campaign for the first time. The last time they lost their opening three matches was in 1998, when they were beaten in all four Five Nations clashes.
ONES TO WATCH
Sebastian Negri has made 96 metres and made 21 tackles combined in Italy's losses to France and England. Franco Smith will need another strong showing from the flanker.
Ireland back-row CJ Stander has made more carries (36) than any other player in the 2021 Six Nations. He has topped the final rankings for this category in three of the last four editions of the championship.
WALES v ENGLAND
FORM
England have won six of their last seven Six Nations matches against Wales, with the last six of those fixtures all decided by a single-figure margin.
Wales have won their opening two games of the tournament for a sixth time. On four of the previous five occasions when they have started with back-to-back victories, they have gone on to win a Grand Slam (2005, 2008, 2012, 2019, not in 2009).
This weekend's visitors are the only team to have never conceded more than two tries in a Six Nations game played in Wales. They have scored 19 tries in Wales during the Six Nations, no visiting team have scored more (Ireland also 19).
ONES TO WATCH
North will become only the sixth Wales player to win a century of caps. The 28-year-old will form a new pairing with Jonathan Davies and will be looking to bring up his hundred with an all-action display.
Elliot Daly will win his 50th cap for England and coach Eddie Jones will expect the full-back to repay the faith he has shown in him after a slow start to the tournament.
Kane injury doubt for England Euro 2024 squad
Harry Kane may be a doubt for England’s Euro 2024 squad as he continues to struggle with a back problem.
Gareth Southgate is due to name his preliminary squad for Euro 2024 on Tuesday, ahead of upcoming friendlies against Bosnia and Herzegovina and Iceland.
The England captain missed the final two Bundesliga games of the season after going off towards the end of Bayern Munich’s Champions League semi-final second leg against Real Madrid.
Thomas Tuchel confirmed prior to their final match against Hoffenheim that Kane was back in England to undergo treatment.
When later asked again about the nature of the striker’s injury, Tuchel admitted that Kane had been struggling for a couple of weeks.
"In Madrid, it was borderline. We tried injections and treatments. The back has completely closed.
"It has gotten worse and kept breaking out in small, everyday movements. There's no chance he's even training."
Kane scored 36 league goals in his debut campaign for Bayern, though due to the injury, he finished five adrift of Robert Lewandowski’s single-season goal record of 41, set in 2019-20.
The final announcement of Southgate's 26-man squad will be revealed on June 7, ahead of the tournament opener against Serbia on June 16.
Howe taking plenty of positives despite frustrating Newcastle campaign
Eddie Howe was keen to look at the positives after Newcastle United secured seventh place in the Premier League on Sunday.
Alexander Isak and Bruno Guimaraes were among the goalscorers as Newcastle won 4-2 at Brentford to finish their Premier League campaign.
The victory ensured a seventh-place finish, and a Manchester City victory over Manchester United in next Saturday's FA Cup final will confirm Newcastle's place in next season's Europa Conference League.
While this season did not quite live up to the heroics of last term, which saw the Magpies finish in the Champions League spots, Howe still feels it has been a successful campaign.
"It summed up our season," Howe told BBC Sport. "We weren't totally secure at the back, but great credit to the players. They've done their job - now we wait and see.
"We anticipated after losing against Manchester United that our control of the [European] situation had gone. It's never a nice situation, but whatever happens, happens.
"We have issues to solve defensively. If we can do that, next season could be another season of really strong performances. This was a season that could have been better, but a good season overall.
"We're a really united club. I think we're still moving forward, so there's a lot to be positive about."
Postecoglou will not settle until Tottenham hit his 'lofty ambitions'
Ange Postecoglou warned Tottenham he will not settle until the club hits the "lofty ambitions" targeted in his mind.
Spurs were 3-0 victors over Sheffield United at Bramall Lane on Sunday, ending their Premier League season with a convincing win to finish fifth in the table.
Postecoglou voiced his frustrations after Tuesday's 2-0 defeat to Manchester City ended their hopes of Champions League football next term.
The Spurs head coach was far more relaxed after his side performed well in Sheffield, with Dejan Kulusevski twice on target, along with a goal for Pedro Porro against the relegated Blades.
Yet Postecoglou insisted his ambitions remain high as the Australian attempts to take Tottenham to the next level.
"Contrary to my general demeanour, I have loved every minute of it," former Celtic boss Postecoglou said of his first season in charge of Tottenham.
"It is a great challenge in the Premier League and taking over a big club that didn't have a great year last year. You understand it is not going to run smoothly, but I have enjoyed the whole season.
"I have got some lofty ambitions for the football club and until we reach that point I am not going to be smiling too much.
"As I said, all any manager wants is maximum effort and I have got that from everyone involved. I have enjoyed it and looking forward to pushing on from here."
Asked to summarise his first campaign in England's top league, Postecoglou continued: "It's been good, it's been eventful, it's had a bit of everything.
"I am obviously not delighted with the way we finished the season but in fairness to the players and staff we have been in the top five all season, in a year where there was a fair bit of upheaval.
"We finished eighth last year, player turnover, different football, different way of training, it is not easy to maintain a level when you are trying to do that.
"Even in our tough periods this year we have still been competitive for the most part."
Kulusevski scored his seventh and eighth Premier League goals of the season (36 outings), more than he managed in his first two league campaigns with Tottenham combined (seven across 48 games).
Only in the 2019-20 season with Parma has the Sweden winger scored more times in a league season (10 in Serie A), and Postecoglou hailed Kulusevski's returns.
He added: "I thought Deki was good. He's worked awfully hard this year without a lot of reward in the front third.
"We thought playing him through middle today would help us with his mobility and ability to run in behind. He did well.
"He always works hard but it's that sort of final third where we need him to get rewards and he got them today so he did well."
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