Ireland will be without Jamison Gibson-Park, Cian Healy and Tadhg Furlong for a huge Six Nations clash with France on Saturday.
Scrum-half Gibson-Park and prop Healy were late withdrawals from an opening 34-10 win over Wales at the weekend due to hamstring injuries.
The duo will not be fit in time for a showdown with defending champions France at the Aviva Stadium, while prop Furlong also misses out due to a calf issue that sidelined him for the victory at the Principality Stadium.
Conor Murray will be expected to retain the number nine shirt after coming into the side to replace Gibson-Park.
Captain Johnny Sexton, who suffered a dead leg in Cardiff, will complete the HIA process on Monday, while Ronan Kelleher is due to return to training this week.
Scrum-half Caolin Blade and loosehead prop Michael Milne have been called up to the squad, while Roman Salanoa and Tom Stewart will remain with the group after being drafted in last week.
France started the defence of their title with a 29-24 win over Italy at Stadio Olimpico on Sunday.
Ireland shock Pakistan in T20I opener
Ireland shocked Pakistan with a five-wicket victory in the first T20I at Clontarf, with Andrew Balbirnie starring for the hosts.
Balbirnie plundered 77 from 55 balls, including 10 fours and two sixes, and his partnership of 76 with Harry Tector (36) edged Ireland closer to victory.
Curtis Campher (15*) and Gareth Delany (10*) saw them over the line to secure the win with one ball to spare.
Despite an early setback, Pakistan started strong, with Babar Azam hitting 57 and Saim Ayub adding 45.
However, Craig Young’s strong performance saw him take 2-27 as Ireland took control to limit the visitors in the later stages as Azam Khan and Shadab Khan both walked without getting any runs.
The sides will meet again at the Dublin venue on Sunday and Tuesday.
Data Debrief:
Ireland achieved their target of 183 against Pakistan successfully today, making it their highest run chase against a full-member side in men's T20Is.
Ireland's first win against Pakistan came at the 2007 World Cup and 17 years later they secured a first victory over them in T20 cricket.
Rees-Zammit relishing Mahomes advice as former rugby star eyes spot on Chiefs roster
Louis Rees-Zammit has likened Patrick Mahomes to an extra coach as he looks to make an impact in the NFL with the Kansas City Chiefs.
Rees-Zammit shocked rugby union fans in January when he announced he was turning his back on the sport to enter the NFL's International Player Pathway programme.
He was signed by two-time defending Super Bowl champions Kansas City in March and is now looking to earn a place on their roster for 2024, learning the role of running back at the Chiefs' rookie minicamp after attending another training camp alongside Mahomes.
Rees-Zammit has made sure to pick the brains of Mahomes, who has led the Chiefs to six straight AFC Championship games and won three Super Bowl rings since being drafted in 2017.
"It was amazing, all the quarterbacks and receivers were there, we were running routes, we were working in the gym", Rees-Zammit said of his experience at that camp in Texas.
"It was a great two weeks, I definitely learned a lot with Pat and the other boys."
Asked if Mahomes was acting like an extra coach, he said: "100 per cent.
"I'm new to the game so I'm trying to pick everyone's brains and try and pick up the sport as quick as possible because I want to be out there playing.
"The way I can do that is picking the brains of everyone that's currently here and trying to learn the game as quickly as possible."
Chiefs head coach Andy Reid has been impressed by Rees-Zammit's attitude, saying: "He's so diligent with everything and wants to be so good at everything. I appreciate that.
"I like the fact he's got shorter steps initially, that's a good thing as a running back. If you're a long strider in there you've got to really work on making it through those tight adjustments you have to make. He seems to have a nice feel."
Lucas Hernandez to miss Euro 2024 after PSG defender sustains knee injury
France have been dealt a blow ahead of Euro 2024 following confirmation that Paris Saint-Germain's Lucas Hernandez will miss the tournament.
Hernandez sustained a knee injury and had to be taken off in the 42nd minute of PSG's Champions League defeat to Borussia Dortmund on Wednesday.
And on Thursday, PSG announced Hernandez had sustained an anterior cruciate ligament (ACL) injury and will now need surgery.
"Lucas Hernandez suffered a torn anterior cruciate ligament in his left knee after coming off injured during the Champions League match," a statement read.
"An MRI scan carried out today confirmed the diagnosis made by the club's doctors on Wednesday evening.
"The player will undergo surgery in the next few days."
Hernandez suffered a similar injury during the last major international tournament, the 2022 World Cup, in which France finished as runners-up to Argentina.
The 28-year-old subsequently posted on his official Instagram account.
"When I signed with PSG, I made a promise that I would give my heart and soul to this team and this is what I have done ever since. Unfortunately, during last night's match I ended up with an injury," Hernandez said.
"I pushed myself back onto the field and tried to keep on fighting for our team, but it was not possible. My comeback will be stronger than ever before."
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