Joey Carbery and Robbie Henshaw have been omitted from Ireland's Six Nations squad but the uncapped Jamie Osborne has been included.
Carbery has been seen as the long-term successor to fly-half Johnny Sexton, who will retire after the Rugby World Cup in France this year.
There is no place for the Munster number 10 in Andy Farrell's 37-man Six Nations squad, though, as Ross Byrne and Jack Crowley were given the nod as back-ups to captain Sexton.
Centre Henshaw has endured an injury-hit season and is currently sidelined with a wrist problem, so he was overlooked by head coach Farrell.
Fellow centre Osborne, 21, is the only uncapped player in the squad as the top-ranked team in the world target a first Six Nations title in five years.
Ireland start the tournament with a trip to the Principality Stadium for Warren Gatland's first game since returning for a second spell as Wales head coach on February 4.
Farrell said: "The Six Nations is a huge competition for us and another opportunity for us to grow as a group. 2022 was a busy year as we got to work with a larger group of players as we continued to build our squad depth and competition for places.
"While there are a few players carrying knocks and others that have missed out on selection for the start of the tournament, they will have the opportunity to push their case playing for their provinces in the URC over the coming weeks as no doubt we will need to call upon the wider group as the tournament progresses."
Ireland squad:
Forwards: Ryan Baird, Finlay Bealham, Tadhg Beirne, Jack Conan, Gavin Coombes, Caelan Doris, Tadhg Furlong, Cian Healy, Iain Henderson, Rob Herring, Ronan Kelleher, Dave Kilcoyne, Joe McCarthy, Peter O'Mahony, Tom O'Toole, Andrew Porter, Cian Prendergast, James Ryan, Dan Sheehan, Josh van der Flier.
Backs: Bundee Aki, Ross Byrne, Craig Casey, Jack Crowley, Keith Earls, Jamison Gibson Park, Mack Hansen, Hugo Keenan, Jordan Larmour, James Lowe, Stuart McCloskey, Conor Murray, Jimmy O’Brien, Jamie Osborne, Garry Ringrose, Johnny Sexton (captain), Jacob Stockdale.
Ireland shock Pakistan in T20I opener
Ireland shocked Pakistan with a five-wicket victory in the first T20I at Clontarf, with Andrew Balbirnie starring for the hosts.
Balbirnie plundered 77 from 55 balls, including 10 fours and two sixes, and his partnership of 76 with Harry Tector (36) edged Ireland closer to victory.
Curtis Campher (15*) and Gareth Delany (10*) saw them over the line to secure the win with one ball to spare.
Despite an early setback, Pakistan started strong, with Babar Azam hitting 57 and Saim Ayub adding 45.
However, Craig Young’s strong performance saw him take 2-27 as Ireland took control to limit the visitors in the later stages as Azam Khan and Shadab Khan both walked without getting any runs.
The sides will meet again at the Dublin venue on Sunday and Tuesday.
Data Debrief:
Ireland achieved their target of 183 against Pakistan successfully today, making it their highest run chase against a full-member side in men's T20Is.
Ireland's first win against Pakistan came at the 2007 World Cup and 17 years later they secured a first victory over them in T20 cricket.
Rees-Zammit relishing Mahomes advice as former rugby star eyes spot on Chiefs roster
Louis Rees-Zammit has likened Patrick Mahomes to an extra coach as he looks to make an impact in the NFL with the Kansas City Chiefs.
Rees-Zammit shocked rugby union fans in January when he announced he was turning his back on the sport to enter the NFL's International Player Pathway programme.
He was signed by two-time defending Super Bowl champions Kansas City in March and is now looking to earn a place on their roster for 2024, learning the role of running back at the Chiefs' rookie minicamp after attending another training camp alongside Mahomes.
Rees-Zammit has made sure to pick the brains of Mahomes, who has led the Chiefs to six straight AFC Championship games and won three Super Bowl rings since being drafted in 2017.
"It was amazing, all the quarterbacks and receivers were there, we were running routes, we were working in the gym", Rees-Zammit said of his experience at that camp in Texas.
"It was a great two weeks, I definitely learned a lot with Pat and the other boys."
Asked if Mahomes was acting like an extra coach, he said: "100 per cent.
"I'm new to the game so I'm trying to pick everyone's brains and try and pick up the sport as quick as possible because I want to be out there playing.
"The way I can do that is picking the brains of everyone that's currently here and trying to learn the game as quickly as possible."
Chiefs head coach Andy Reid has been impressed by Rees-Zammit's attitude, saying: "He's so diligent with everything and wants to be so good at everything. I appreciate that.
"I like the fact he's got shorter steps initially, that's a good thing as a running back. If you're a long strider in there you've got to really work on making it through those tight adjustments you have to make. He seems to have a nice feel."
England and Saracens number eight Vunipola fined after arrest in Mallorca
England international Billy Vunipola has confirmed he has been fined after an incident which saw him arrested in Mallorca on Sunday, with his club Saracens set to launch an internal investigation.
On Monday, widespread reports claimed Vunipola had been tasered by Spanish police in the early hours of Sunday morning, with an altercation taking place after he left a club in Palma.
Saracens later confirmed they were aware of an incident and said they would deal with it internally.
The number eight, who was born in Australia but has represented England 75 times, later released a statement of his own via his club, denying that any violence took place and confirming the police investigation was now closed.
"I can confirm I was involved in an unfortunate misunderstanding when I was leaving a club in Mallorca on Sunday, which got out of hand," that statement read.
"Contrary to media reports, there was no violence, no fight and I did not threaten anybody at any stage, with bottles or chairs or anything else.
"I was charged with resisting the law and, following an 'express trial', I have paid a fine of €240. The Spanish police investigation is now closed, and I am flying back to the UK today.
"I will obviously cooperate with the Saracens internal process and unreservedly apologise for any inconvenience to all involved."
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