Youssoufa Moukoko will miss both legs of Borussia Dortmund's Champions League tie against Chelsea after he was ruled out for around six weeks with an ankle injury.
The 18-year-old was replaced by Sebastien Haller in the first half of in-form Dortmund's 2-0 Bundesliga win at Werder Bremen on Saturday.
Moukoko on Monday discovered he suffered a torn syndesmosis ligament and is expected to be sidelined until late next month.
Dortmund sporting director Sebastian Kehl said: "This is tough news for him and for us, especially in the current stretch. We kept our hopes up, but unfortunately he will be out some time."
The teenager will miss the first leg of Dortmund's round of 16 clash with Chelsea on Wednesday and the return fixture at Stamford Bridge on March 7.
A showdown with RB Leipzig is among the Bundesliga matches the Germany international will sit out.
Dortmund boss Edin Terzic will hope Moukoko will be available when his side travel to face leaders Bayern Munich on March 31, with a home game against second-placed Union Berlin to come a week later.
Terzic's men are three points behind Bayern in third place and have won six consecutive games since the season resumed.
Terzic slams Mainz showing after Dortmund suffer Champions League hangover
Edin Terzic warned Borussia Dortmund must swiftly forget about their Champions League heroics in Paris after a 3-0 humbling by Mainz on Saturday.
Lee Jae-Sung twice punished a sloppy Dortmund performance after Leandro Barreiro had opened the scoring for relegation-battling Mainz in their Bundesliga clash.
That abject performance came after BVB managed a 1-0 away victory against Paris Saint-Germain, progressing to the Champions League final after a 2-0 aggregate victory over Luis Enrique's side.
Dortmund head coach Terzic was far from impressed after defeat against Mainz left his side four points adrift of fourth-placed RB Leipzig in the German top flight.
"Let's let Paris be Paris and talk about last week and this week," Terzic told Sky Sport Germany.
"The starting position was similar to last week. Except now we were always late and outnumbered.
"It was a deserved defeat, especially because of the first half."
Marco Reus echoed Terzic's sentiment after Dortmund came crashing back down to earth following their European success.
"If you see the first half, it's deserved, even at the highest level," the Dortmund veteran added.
"We expect more from ourselves. There was still a lot at stake for Mainz.
"It was important for us to continue to gain self-confidence. That just was not good today. This is a pity."
Dortmund will hope to respond when they host Darmstadt next Saturday before their Champions League final against Real Madrid on June 1 at Wembley Stadium.
Al Hilal crowned Saudi Pro League champions after Al Hazm hammering
Al Hilal secured their fourth straight Saudi Pro League title after Aleksandar Mitrovic starred in Saturday's 4-1 thrashing of bottom side Al Hazm.
Faiz Selemani restored parity after Mitrovic's 15th-minute opener at Prince Faisal bin Fahd Stadium, only for Jorge Jesus' hosts to roar back and be crowned champions with three games remaining.
Ahmed Al Juwaid's own goal handed the initiative back to the dominant Al Hilal, who led 4-1 at the break after Mitrovic added another to his tally and Sergej Milinkovic-Savic was on target.
The second of Mitrovic's strikes took him to a team-leading 26 league goals this term as Al Hilal breezed to another title, moving an unassailable 12 points clear of Cristiano Ronaldo's Al Nassr.
Jesus' side are unbeaten through all 31 games this season after securing their record-extending 19th top-flight crown in history, while Al Hazm need to win their last three matches to have any chance of staying up.
Al Hazm's relegation rivals Al Tai boosted their chances of survival in Saturday's earlier clash after a 1-1 draw away against Al Raed.
Al Tai are just a point away from 15th-placed Abha Club in their bid for top-flight safety after Ibrahim Al Nakhli's strike was cancelled out by Al Raed's Mohammed Fouzair in the second half.
Al-Ittihad 0-5 Al-Ettifaq: Ekambi scores hat-trick in five-star display
Karl Toko Ekambi netted a hat-trick as Al-Ettifaq got back to winning ways in style with a 5-0 thrashing of Al-Ittihad in the Saudi Pro League on Friday.
He scored twice in four minutes at the end of the first half to send the visitors into the break 4-0 up before getting his third just 10 minutes after the break.
Seko Fofana had already given Steven Gerrard’s side the lead five minutes into the contest, while Moussa Dembele doubled their advantage from the penalty spot.
Al-Ittihad had the chances, but they could not find the back of the net, as they stayed fifth, but are now just six points above Al-Ettifaq.
Data Debrief: Clinical finishers
Al-Ettifaq had five shots on target against Al-Ittihad, scoring with all of them while creating an xG of 3.62.
With his hat-trick against Al-Ittihad, Ekambi has now scored 11 goals for the season, netting more than once for the first time since joining the club.
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