Premier League leaders Manchester City collected a routine victory over Brentford to further their advantage at the top.
That victory saw Pep Guardiola's side extend their lead at the summit to 12 points, with second-placed Liverpool due to host Leicester City on Thursday.
Tottenham fell to a late defeat against Southampton as Antonio Conte suffered his first home league loss as Spurs boss, while Aston Villa shared the spoils in a six-goal thriller with Leeds United.
And strugglers Norwich City picked up a valuable draw at home to Crystal Palace, with Dean Smith's side now a point behind 17th-placed Newcastle United as the relegation battle continues.
Here, Stats Perform unpacks the pick of the Opta data from the day's top-flight action.
Manchester City 2-0 Brentford: Citizens cruise to league double over Bees
Strikes either side of the interval from Kevin De Bruyne and Riyad Mahrez helped City to a 2-0 win over Brentford as the Citizens completed the league double over the Bees for the first time since 1936-37.
Mahrez opened the scoring as he netted in his seventh consecutive game across all competitions for City – only Lionel Messi (twice) and Sergio Aguero have previously achieved that feat under Pep Guardiola.
De Bruyne doubled the hosts' lead in the second half, the midfielder recording his 85th goal involvement (35G 50A) in his 96th top-flight appearance at the Etihad Stadium, where he has found the net five times in his last four games.
Brentford rarely troubled Ederson's goal and were caught offside 10 times in the match, the most by a Premier League team since January 2018 as City recorded their 100th clean sheet under Guardiola in the competition.
The Bees have now lost five consecutive league matches for the first time since December 2007, under Terry Butcher in League Two, and for the first time in the top flight since April 1947 (seven in a row).
Tottenham 2-3 Southampton: No home comforts for Conte
Southampton twice rallied from behind to earn a late 3-2 victory at Tottenham to end Conte's unbeaten start at home in the league as Spurs boss.
Jan Bednarek poked into his own net to give Spurs the lead, the centre-back now on a Premier League-high three own goals since the start of 2019-20. Similarly, Tottenham have benefited from the most own goals in the competition this season (three).
But Armando Broja soon levelled up. That was the Albania striker's sixth top-flight goal this term – only Kevin Davies (nine in 1997-98) managed more in the Premier League for Southampton while aged 20 or under.
Son Heung-min restored his side's advantage with his 12th strike against Southampton across all competitions, five more than he has registered against any other team for Spurs.
Saints fought back again, Mohamed Elyounoussi equalising before Che Adams sealed victory. Both finishes were set up by James Ward-Prowse, who assisted two goals in a single Premier League match for only the second time in 290 appearances.
Having equalised in the 79th minute, Southampton's victory was the latest they had been behind in a Premier League match that they would go on to win since March 2016 against Liverpool (equalised in 83rd minute).
Aston Villa 3-3 Leeds United: Whites continue away scoring run in Villa Park classic
Aston Villa, who had Ezri Konsa dismissed late on, shared the points with Leeds in a 3-3 thriller as Dan James, Jacob Ramsey and Philippe Coutinho dominated proceedings.
James scored his third and fourth Premier League goals this term, his best-ever tally in a season, though Marcelo Bielsa found his side 3-2 down at half-time.
Coutinho initially cancelled out James' opener as he became the sixth Villa player to score in each of his first two Premier League appearances at Villa Park, and the first since Carlton Cole in August 2004.
The Brazil international then teed up a Ramsey double as the midfielder became the youngest player to score more than one goal in a Premier League game for Villa (20y 257d) since Luka Moore got a hat-trick in February 2006 (19y 356d).
Diego Llorente restored parity in the second half as Leeds recorded three goals in consecutive Premier League away games for just the second time, and for the first time since March 1995, to earn a valuable point.
Norwich City 1-1 Crystal Palace: Zaha's penalty falter costs poor travelling Eagles
Norwich City raced out the blocks at Carrow Road but ultimately had to settle for a point after a 1-1 draw with Crystal Palace.
Teemu Pukki – who has scored 43 per cent of Norwich's top-flight this season (6/14), the highest such share of any player in the competition – netted the fastest goal in the Premier League this season as he finished after just 38 seconds.
Wilfried Zaha pegged Smith's team back with his 80th goal involvement in England's top division (53G 27A), 79 of which have been for the Eagles.
Michael Olise teed up the Ivory Coast international's second-half equaliser, his seventh goal involvement (3G 4A) across all competitions in 2022 – the most by any Premier League player.
Palace should have secured all three points but Zaha failed from the penalty spot for the first time, on his fifth attempt, meaning the Eagles have won just one of their last 13 away games in the league.
Walker: Man City driven on by creating history
Kyle Walker believes Manchester City were spurred on by creating history to a fourth straight Premier League title.
A Phil Foden double and a Rodri strike saw City beat West Ham 3-1 on Sunday as they claimed a fourth consecutive Premier League crown, finishing two points above Arsenal.
In doing so, City became the first team ever to win England's top division four times in a row, and Walker feels that was one of the key motivations behind the team finishing top of the Premier League pile yet again.
When asked if creating history had driven him and his team-mates on, Walker told Sky Sports: "I think so, I think so. We went out of the Champions League, got into the FA Cup final, but to do this, make it four in a row, it made it something special.
"It has been spoken about all year what we can achieve and the history we can make. But it is about the finer details. It was down to just one game and that game was West Ham United. We get past that then we make history, but more importantly we claim the Premier League again.
"It is a very, very tough league to win. I looked at the Italian league, German league, Spanish league, the winners are 10, 15 points clear. Fair play to Arsenal and Liverpool for what they have done throughout the season, making sure they push us right to the limit."
Walker turns 34 later this month but has shown little signs of slowing down, playing an integral role again this season on his way to a sixth Premier League title of his decorated career.
Walker still feels he is capable of playing at the top level, saying: "I feel young. I don't know if that is a good thing or a bad thing. I feel young, I feel great, I still have my pace.
"I come to training every day wanting to learn. Once that goes then it is probably time to pack up, but this group of lads keeps you on your toes. They keep on you to keep improving every day."
Walker has been City's captain this season, making his 300th appearance for the club in the title-securing win over West Ham.
The defender was keen to emphasise that it has been a collective effort this term, though, explaining: "I am the man at the front and I wear the armband, but I don't put myself above anyone else. We are a team.
"There are four captains including myself, and we all pull our weight. I am just the man they've picked to wear the armband which I am very grateful for. To be able to lift the trophy in this scenario, the four in a row, it is a dream come true."
Ancelotti focused on fitness and rhythm despite Villarreal comeback against Madrid
Carlo Ancelotti was unbothered by Real Madrid's failed attempt to defend a three-goal lead against Villarreal, instead focusing on avoiding injuries and keeping their rhythm.
A double from Arda Guler, as well as goals from Joselu and Lucas Vazquez, had Madrid in control at 4-1 up away to Villarreal on Sunday.
Yet Alexander Sorloth, who pulled a goal back earlier on, managed three goals in eight minutes to salvage a 4-4 draw for the hosts against the LaLiga champions.
Despite faltering to a late comeback, Ancelotti was more than pleased with his side's efforts, ahead of the upcoming Champions League final with Borussia Dortmund on June 1 at Wembley Stadium.
"The target was not the points because we don't need them, the target was to play a good game with rhythm, intensity, avoiding injuries. Everything went perfectly," he told a post-match press conference.
"I'm not worried ahead of the Champions League final, this was an open game.
"Maybe we conceded more goals than necessary but that's okay, it doesn't change anything about what the final has to be. In attack, we played well."
Villarreal are set to finish eighth in the LaLiga table, unable to be caught by any team below and incapable of reaching seventh-placed Real Betis.
Sorloth may end with an individual award, though, after scoring his league-leading 23rd goal of the season with the fourth of his quartet of strikes.
"It was a match with a lot of goals, the kind that the fans like," Villarreal forward Gerard Moreno, who provided three assists, told Movistar.
"I'll take the reaction in the second half. We will try to go to Europe next year.
"I hope Sorloth ends up top scorer. He's a fantastic teammate. He deserves it. We're going to try to help him. He's had an incredible season."
Zverev sees off Jarry to claim second Italian Open crown
Alexander Zverev claimed his second Italian Open title following a 6-4 7-5 victory over Nicolas Jarry in the final.
The German, who also triumphed in Rome seven years ago, captured his first silverware of the season - and sixth of his career in an ATP Masters event.
Having dropped just a single set on the way to his 11th Masters final, Zverev continued his impressive form by winning 95 per cent of his first-serve points (37 out of 39) and committing just eight unforced errors.
Jarry had enjoyed an impressive fortnight in Rome, defeating Stefanos Tsitsipas and Tommy Paul on the way to becoming the first Masters finalist from Chile since Fernando Gonzalez (also at the Italian Open) in 2007.
However, just two break points were enough to deny the 21st seed a fourth career ATP title, with Zverev eventually converting his fourth championship point to ensure a return to the winner's circle.
Data debrief
Zverev joins Rafael Nadal (10) and Novak Djokovic (six) as one of only three players since 2000 to win the Italian Open on multiple occasions.
Landing his second crown in Rome seven years after his first, it marks the longest gap in seasons between two men's singles titles at the event in the Open Era.
Meanwhile, Zverev became the most successful German male in ATP Masters events since the format's introduction in 1990, with his sixth such success seeing him eclipse Boris Becker's total of five.
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