A toothless attacking display from Inter saw them beaten 1-0 by Bologna on Sunday as Riccardo Orsolini scored to give the hosts all three points.
The Nerazzurri had four shots on target without scoring at Stadio Renato Dall'Ara as Napoli's charge towards a first Serie A title in more than two decades received yet another boost.
Musa Barrow saw an early goal disallowed for offside, though it would matter little as Orsolini fired home a 76th-minute winner to clinch victory and put another dent in Inter's already slim title hopes.
With an 18-point deficit to overturn, catching runaway leaders Napoli now looks a hugely improbable prospect for Inter and they may now have to focus on fending off the likes of Roma and Milan for second spot.
Bologna thought they were ahead after 12 minutes through a fine finish from Barrow, but a VAR review ruled the offside Nicolas Dominguez as having blocked Andre Onana's view.
The hosts continued to look the more threatening as Roberto Soriano hit the crossbar, though Lautaro Martinez should have done better when he sent a free header wide of the post.
Clear-cut chances for both teams continued to be few and far between as the game went into the break goalless, but Hakan Calhanoglu missed a golden opportunity shortly after the interval when he blazed over.
Soriano saw a shot blocked, before Edin Dzeko came off the bench to force a decent save out of Lukasz Skorupski.
The deadlock would be broken with 14 minutes to play, though, as Orsolini latched onto Jerdy Schouten's throughball before firing home his fourth goal in five matches to claim an impressive victory.
What does it mean? Drab Inter not matching Napoli's stunning form
The title race looks all but over as Napoli's closest challengers continue to falter while they march on, rattling off eight straight Serie A victories since they were beaten by Inter in early January.
The Nerazzurri looked a far cry from challengers here as they failed to score against Bologna for the first time in eight league meetings.
Inter accumulated just 1.01 xG (expected goals) to Bologna's 1.28 as Skorupski enjoyed a relatively comfortable 90 minutes between the sticks before watching Orsolini secure all three points for his team.
Orsolini the hero
In-form winger Orsolini has now been involved in six of Bologna's last seven Serie A goals as he fired them to a fifth victory in six league games.
The goal capped an impressive display from the 26-year-old, registering three shots and creating three chances as well as scoring the well-taken winner.
Ineffective Lukaku fires a blank
Romelu Lukaku managed just nine touches in the first half while also not creating any chances as he failed to provide much of a focal point for Inter.
Simone Inzaghi saw enough after 64 minutes, deciding to bring on former Manchester City striker Edin Dzeko with Lukaku unable to add to his two Serie A goals this season.
Key Opta Facts:
- Bologna have won four of their past five Serie A games (L1), three of these by just a one-goal margin.
- Inter have failed to score in two consecutive away games in Serie A for their first time since April 2018 (three).
- Orsolini has been involved in 10 goals in a Serie A season for the fourth time with Bologna (seven goals and three assists in the current campaign).
- Inter have not score a single goal with their last 40 shots fired on the road in Serie A.
- The Nerazzurri have conceded at least nine shots in a Serie A first half for only the second time this season, after doing so against Milan last September (13).
What's next?
Inter host Lecce in Serie A next Sunday, while Bologna travel to Torino the following day.
Borussia Dortmund 4-0 Darmstadt: Reus stars in farewell game
Marco Reus scored and assisted in his final Bundesliga game for Borussia Dortmund as they thrashed already-relegated Darmstadt 4-0.
The German teed up Ian Maatsen for the opener on the half-hour mark before scoring a stunning free-kick eight minutes later to put Dortmund in control.
Donyell Malen scored his 13th goal of the season to round things off after substitute Julian Brandt had latched onto Jadon Sancho's ball for a third.
Dortmund could have had more as Reus, Malen and Marcel Sabitzer struck the woodwork in either half, but it did not matter as Darmstadt struggled to show a threat.
Edin Terzic's side finished fifth in the final Champions League spot, while Darmstadt are relegated as the bottom club.
Data Debrief:
Reus has been directly involved in 251 goals in the Bundesliga (156G 95A in 391 games), making him just the third player to reach 250 goals and assists since his Bundesliga debut in August 2009, behind Thomas Müller 318 and Robert Lewandowski 367.
The German bids farewell to Signal Iduna Park having scored nine goals and assisting seven in all competitions this season, though he will be hoping to add to that tally in his final match for Dortmund - the Champions League final against Real Madrid on June 1.
Chelsea edge out Man City to claim fifth straight WSL title with thumping win at Old Trafford
Mayra Ramirez turned in a stellar performance to propel Chelsea to the WSL title in Emma Hayes' final match in charge as the Blues thrashed Manchester United 6-0.
Earlier in May, Hayes – who is ending a 12-year stint in charge of the Blues to become the United States coach – had all but given up on claiming a fifth straight WSL crown.
Yet Chelsea's 8-0 victory over Bristol City two weeks ago, combined with Manchester City's defeat to Arsenal, opened the door, and after beating Tottenham in midweek, the Blues knew a win, while maintaining their positive goal difference, would be enough.
And they made sure there was no room for error with an incredible first-half display inspired by Ramirez, who scored twice and set up goals for Johanna Rytting Kaneryd and Sjoeke Nusken at Old Trafford.
Melanie Leupolz got in on the act early in the second half as Chelsea's celebrations began in earnest, with Fran Kirby netting late on to complete the rout on her farewell appearance.
Ultimately, City – likely deflated by the news coming from Old Trafford – held up their end of the bargain, but shorn of top goalscorer Khadija Shaw, Gareth Taylor's team could only beat Aston Villa 2-1.
City were constantly chasing their title rivals, with Ramirez and Rytting Kaneryd putting Chelsea 2-0 up at United inside eight minutes.
Mary Fowler nudged City ahead at Villa Park, though when Taylor's team went in at the interval, they will have seen additional goals from record signing Ramirez and Nusken had all but sewn up the title for Chelsea already.
Leupolz has scored her first WSL goal in over two years to add further gloss for Chelsea when they came back out from the restart in Manchester, and City were then hit by a further blow when Rachel Daly equalised for Villa.
Lauren Hemp, who had assisted Fowler's opener, restored City's lead, though it was never going to be enough, with Kirby's farewell goal ensuring Chelsea finished with a goal difference of 53 compared to their rivals' 46.
Chelsea are now unbeaten across their last nine WSL games that have come on the final day of the season, while the Blues are now nine WSL matches without loss against United, having won eight of those fixtures.
Hoffenheim 4-2 Bayern Munich: Tuchel bows out on defeat thanks to Kramaric hat-trick
Bayern Munich squandered a two-goal lead to slump to a 4-2 loss at Hoffenheim courtesy of a second-half Andrej Kramaric hat-trick in Thomas Tuchel's final game.
Early goals from Mathys Tel and Alphonso Davies saw the injury-depleted Bavarians go 2-0 up by the sixth minute.
Hoffenheim, however, pulled a goal back through Germany international Maximilian Beier just two minutes later, with the hosts gradually taking some of the early pace out of the game.
Bayern's injury troubles were further compounded when they lost Aleksandar Pavlovic to injury in the 35th minute, and struggled to cope with Hoffenheim's threat in the second half.
Kramaric then delivered a stunning 19-minute hat-trick with the Bayern defence in ruins, ending a disappointing season in third place with 72 points.
Bayer Leverkusen finished in top spot on 90 points. VfB Stuttgart finished runners-up on 73 with a 4-0 demolition of Borussia Moenchengladbach, while Hoffenheim finished seventh, in the Europa Conference League place.
Data Debrief:
Thomas Muller made his 473rd Bundesliga appearance for Bayern on Saturday, drawing level with Sepp Maier as the club's record appearance maker in the competition.
Bayern failed to have a single shot on target in the second half, while Kramaric ran riot to subject Bayern to their worst league finish since 2011.
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