Brahim Diaz's first goal since October gave Milan a 1-0 victory over Tottenham in the first leg of their Champions League round of 16 tie.
Diaz had gone 12 games without a goal for the Serie A champions but stunned Spurs with an early header on Tuesday.
Tottenham saw plenty of the ball but were unable to come up with an equaliser on former Inter boss Antonio Conte's return to San Siro.
Milan had been without a win in seven matches before beating Torino last Friday, but Diaz gave them back-to-back victories and a slender advantage to take into the second leg at Tottenham Hotspur Stadium on March 8.
San Siro erupted when Diaz opened the scoring in the seventh minute, diving to nod in on the goal-line after Fraser Forster produced a brilliant double save to deny the Spaniard and Theo Hernandez.
Spurs responded well to that early blow, though did not create a clear-cut opportunity until Harry Kane rattled the crossbar just before the break, but an offside flag against Son Heung-Min meant the striker's effort would not have counted if it had found the back of the net.
There was concern for Milan when goalkeeper Ciprian Tatarusanu appeared to go over on his ankle before Eric Dier was shown a yellow card that will rule him out of the second leg.
Conte introduced Richarlison with 20 minutes to go before Charles De Ketelaere and Malick Thiaw wasted glorious chances to extend Milan's lead with headers from close range.
Tottenham applied some late pressure, but lacked the quality to salvage a draw and have work to do next month.
Inter Miami came from behind once more to beat CF Montreal 3-2 and go three points clear at the top of the Eastern Conference.
For the sixth match in a row, Miami found themselves behind when Bryce Duke slotted in the 22nd minute, and Jules-Anthony Vislant, who set up the opener, finished off a lovely team move 10 minutes later.
However, Miami displayed their fighting spirit again. Matias Rojas stepped up to a free-kick while Lionel Messi received treatment, curling a delightful strike into the top corner.
Shortly before the break, Luis Suarez turned the ball into an empty net while Benjamin Cremaschi completed the comeback in the 59th minute when he bundled it over the line after being picked out by Rojas.
Miami hold a three-point lead over Supporters’ Shield holders FC Cincinnati at the top of the East, with the Orange and Blue keeping pace with a 2-1 win over Columbus Crew.
Data Debrief: Comeback Kings
Miami have won 20 points from losing positions already in the MLS this season, more than any other team. It is the first time they have come from 2-0 down to win since a 3-2 victory over Charlotte in July 2022.
On a quiet day for Messi by his standards, Suarez stepped up with a crucial goal, netting his 11th of the season to equalise. The Uruguayan has now scored in each of his last three matches.
Pioli says speculation over his Milan future is part of the job
Milan coach Stefano Pioli said criticism and speculation are part of his job, as he still does not know if he will remain in the role for next season.
Milan snapped a six-match winless streak with an emphatic 5-1 win over Cagliari on Saturday, yet the pressure remains on the Italian coach, with the Rossoneri only aiming for second place in Serie A after city rivals Inter became champions.
"We are a big club, there are big expectations, so fierce criticism is to be expected, just as ebullient praise is expected when you win," Pioli told Sky Sports.
"That is part of the job, you have to accept it all, or you do a different profession.
"I try to help the team to overcome difficult moments and play as well as possible. Sometimes it worked, and sometimes I got things wrong."
A section of Milan fans have been holding protests at matches, demanding clarity from the management regarding the club's plans after two seasons without silverware.
The club ended their Europa League campaign in the quarter-finals last month, losing at Roma.
Pioli added: "I am really sad about this situation, as we were so proud to create that symbiosis with the fans, which passed on positivity, energy and confidence.
"I have not yet talked to the club. We have another two rounds to go, the season is not over yet.
"I hope everyone around Milan can rediscover that harmony, enthusiasm and energy that helped us to achieve things that perhaps nobody believed were possible."
Ancelotti excited by Guler potential after Madrid teenager's goal at Granada
Arda Guler was once again on target for Real Madrid against Granada and an excited Carlo Ancelotti believes Los Blancos can expect more to come from the teenager.
Chances to impress in a first-team environment have been limited for Guler, who chose Madrid over Barcelona to join from Fenerbahce last July, owing to the quality of Vinicius Junior and Rodrygo.
Yet the Turkey youngster has scored twice in his last three LaLiga starts, finding the net in Saturday's 4-0 thrashing of Granada after also striking against Real Sociedad on April 26.
"We still don't know what his potential is because he is very young," the Madrid head coach said of Guler.
"But he is showing incredible talent, he is very effective in front of goal and has speed.
"I don't know what his ceiling is, today it is difficult to say, but he has natural talent and he's doing very well."
Brahim Diaz has also had to settle for a backup role in the Spanish capital but scored twice in the hammering of Granada, as well as a goal for Fran Garcia.
Ancelotti heaped praise on his much-changed Madrid side as the newly-crowned LaLiga champions impressed after reaching the Champions League final in midweek with their win over Bayern Munich.
"Well… it's hard to say who surprised me the most," Ancelotti said after resting the likes of Jude Bellingham, Vinicius and Rodrygo in 10 changes for Saturday's victory.
"Among those who returned, Brahim earned an important role, but I don't want to forget Joselu or Fran Garcia, who arrived this year and did really well.
"Fran in the first period and the others, in terms of goals, were fundamental to having this level at this moment of the season."
Madrid host Alaves and Real Betis either side of a trip to Villarreal to end their league season, before the Champions League final with Borussia Dortmund on June 1 at Wembley Stadium.
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