Christian Eriksen will be out of action for up to three months due to the ankle injury he suffered in Saturday's FA Cup win over Reading, Manchester United have confirmed.
Eriksen was on the receiving end of a heavy tackle from Andy Carroll in the second half, with the Reading forward surprisingly avoiding a yellow card.
Carroll was later sent off for another two forceful challenges.
Eriksen walked away from the incident to play on briefly, but he was soon replaced and later spotted leaving Old Trafford on crutches, with a protective boot supporting his left ankle.
United boss Erik ten Hag offered little insight after the match, but following examinations the club believe it is serious enough to potentially rule him out until May.
A statement read: "Manchester United midfielder Christian Eriksen is expected to be out of action for an extended period because of an ankle injury sustained in our Emirates FA Cup victory over Reading on Saturday.
"While investigations are continuing, initial assessments indicate that Eriksen is likely to be out until late April or early May."
The absence of Eriksen will be a major blow to United and Ten Hag, as the Danish midfielder has been a key component of the side since his arrival on a free transfer in pre-season.
Bruno Fernandes (2,603) is the only outfield player to spend more minutes on the pitch than Eriksen (2,274) across all competitions for United this season.
It is a similar story in terms of chances created, with Eriksen's 53 bettered by only Fernandes' 81, highlighting the Dane's creative importance, particularly from set-pieces.
Eriksen ranks highest in the squad for assists (nine), however, three more than Fernandes.
If the 31-year-old does not play again until the start of May, he will have missed at least 18 matches in all competitions.
That total will increase if United progress in the FA Cup, Europa League and EFL Cup – they are just 90 minutes away from the final of the latter after winning 3-0 away to Nottingham Forest in last week's semi-final first leg.
The return game at Old Trafford on Wednesday will be the first match Eriksen misses.
The absence of Eriksen further stretches United's midfield options after Donny van de Beek was ruled out for the season at the start of January.
It leaves Fernandes, Fred, Casemiro and Scott McTominay as their only recognised senior midfielders, potentially requiring 17-year-old Kobbie Mainoo – who has made two cup appearances but is yet to make his Premier League bow – to step up unless they delve into the transfer market before the window closes on Tuesday.
Vardy eyes 100-point season after Leicester's title win
Jamie Vardy has challenged his Leicester City team-mates to reach 100 points after sealing the Championship title with one game to spare.
The Foxes were promoted back to the Premier League without kicking a ball after Leeds United’s 4-0 defeat to QPR on Friday, but they needed to win on Monday to earn top spot.
Enzo Maresca’s side cruised to a 3-0 victory over Preston through Vardy’s brace and Kasey McAteer’s header, moving them to 97 points.
With one last milestone in their reach, Vardy wants to make sure they end an already successful season on a high.
Speaking to Sky Sports, he said: “We can celebrate it tonight, but now we have another target which is 100 points.
“We are over the moon. It has gone by quick but it's a graft. Not many days off, I'll tell you that.
“The lads - they've given it all. Thoroughly deserved, and I'm glad we've had 5000 to come and celebrate with us. It's not like it's 20 minutes up the road."
After a run of just three victories from nine games in the league between mid-February and April, Leicester have now won each of their last three outings.
Maresca has praised his players for their hard work in what he labelled a “tough season”.
“Fantastic, it's been a fantastic season. The Championship is a tough season and very intense, but I'm very happy," said Maresca.
"Now it's time to enjoy the work of the season to bring this special club back to the Premier League. We deserve it.
“The last two days they have been fantastic. We got promoted, but it was difficult in game preparation. But we used all of today to prepare for the game, the morning and afternoon. It was good.”
Preston 0-3 Leicester City: Foxes seal Championship title in style
Leicester City cruised to a 3-0 win over Preston in the Championship on Monday to clinch the title with a game to spare.
Jamie Vardy was the star for the Foxes as he scored in both halves before Kasey McAteer made sure of the points with an unmarked header.
Abdul Fatawu had the chance to cap an already memorable night for the travelling fans but hit the post with his curler.
Preston slumped to a fourth consecutive defeat, while Leicester go into their final game against Blackburn Rovers with the knowledge that they will lift the trophy after the final whistle.
Data Debrief
Jamie Vardy has scored 18 goals this season (two in this game), more than any other Leicester player in the competition. He has also netted in his last three games, scoring four goals in total.
It was a dominant performance from the Foxes, who had 19 shots with 11 of those on target. At the other end, Preston only managed to test Jakub Stolarczyk once from their five attempts.
'I know my worth and I will show it' – Antony vows to silence Man Utd critics
Manchester United winger Antony has pledged to silence his critics after ending his long wait for a Premier League goal on Saturday, saying: "I know my worth and I will show it."
Antony has struggled since swapping Ajax for Old Trafford in an £86million ($108m) deal last year, only managing five goals and three assists in 52 Premier League appearances.
The Brazilian failed to net in his first 26 league games this season before ending his goal drought against Burnley on Saturday, though Zeki Amdouni's late penalty earned the Clarets a 1-1 draw.
Antony was also roundly criticised for taunting Coventry City's players in the aftermath of United's FA Cup semi-final win over the Sky Blues earlier this month, with the Red Devils inching through on penalties after surrendering a 3-0 lead in a 3-3 draw.
Having struggled to live up to expectations since arriving in England, he was asked by The Athletic whether his price tag had put him under additional pressure, but he says that is not the case.
"It doesn't really impact me because I know my worth," Antony said. "The money is the money and obviously everyone speaks about it, but no one would if the performances were at the top.
"It's just a way of working harder, knowing I can get better, I know my worth and I will show it. The critics are going to exist, and they make me want to work harder and prove it to myself first.
"I'm going to keep working, giving everything for the group because it's most important to have a good mentality and to be focused."
Saturday's draw officially ended United's hopes of a top-four finish, heightening speculation regarding the future of manager Erik ten Hag.
While Antony accepts United have not been good enough this season, he is hopeful they can end the campaign on a high with another FA Cup final against Manchester City to come.
"It's been a very tough year for me and the team, the results are not ones we expected," Antony added.
"I am someone who takes criticism very well and I want to work on it, and I think we all have to focus on finishing the season the best we can.
"We still have five games and we have to think game by game, get better and go into the final in the best way possible to win it."
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