Manchester City recovered from two goals down at half-time to defeat Tottenham 4-2 at the Etihad Stadium and close the gap on Premier League leaders Arsenal.
Spurs took advantage of some poor City defending – with Ederson in particular at fault – through goals from Dejan Kulusevski and Ederson Royal just before the interval.
But City's response was just as swift as they were level eight minutes into the second half thanks to Julian Alvarez and Erling Haaland, who ended his mini goal drought.
City survived a scare when Perisic hit the post, but Riyad Mahrez put them ahead and added another late on to move his side within five points of Arsenal, who have a game in hand.
Like he did in Spurs' 3-2 win here last year, Kulusevski opened the scoring after Rodri poked the ball into his path when put under pressure following Ederson's poor pass.
Emerson headed in a second for Spurs moments later after Kane won a tackle against Rodri and had an angled drive pushed back into danger by Ederson.
Guardiola opted against making any changes at the break, but his side's response was instant, with Alvarez firing home a loose ball after Riyad Mahrez's cross was not dealt with.
City, who left Kevin De Bruyne on the bench all match, were on level terms two minutes later through Haaland's close-range header after Mahrez headed the ball back across goal.
Ivan Perisic had a shot blocked right in front of goal by Rico Lewis, with the loose ball hitting the post, and that would prove a big moment as Mahrez completed the comeback.
Mahrez first fired a low, hard shot past Lloris at the Spurs keeper's near post, before capitalising on Clement Lenglet's poor touch to race in and double his tally at the death.
Rodri suggests Arsenal's mentality cost them Premier League title
Rodri has suggested Arsenal's mentality cost them the Premier League title, after Manchester City became the first team to win four straight English top-flight crowns.
City edged out Arsenal by two points on the final day of the season, their 3-1 win over West Ham ensuring the Gunners' comeback victory over Everton was immaterial.
Rodri scored the crucial third goal just before the hour mark to settle nerves at the Etihad Stadium, after Mohammed Kudus had drawn West Ham within one goal.
City finished the season with nine straight wins after playing out a 0-0 draw with Arsenal at the Etihad Stadium in late March, while the Gunners dropped three points in a 2-0 home defeat to Aston Villa in April.
Reflecting on that goalless draw, Rodri accused Arsenal of settling for a point and hinted a lack of bravery had cost them.
Asked by Optus Sport for the secret behind City's success, Rodri pointed to his head as he said: "To be honest, I think it's in here. It's the mentality.
"Arsenal, also they deserved [to win the league], they did an unbelievable season, but I think the difference was in here.
"When they came here, they faced us at the Etihad, I saw them and said, 'Ah, these guys, they don't want to beat us, they just want a draw.'
"That mentality… I don't think we would do it the same way. We caught them.
"At the end, if you give us one point, we will win the last seven, eight games even though it's so tough. So I think it comes down to mentality."
Rodri did not taste defeat in the Premier League throughout 2023-24, with all three of City's losses coming when the Spaniard was suspended.
He has now gone unbeaten through his last 50 Premier League matches, with only former Arsenal defender Sol Campbell enjoying a longer such streak (56 games between 2002 and 2004).
City's historic triumph means they have surpassed the achievements of Huddersfield Town (1923-1926), Arsenal (1932-35), Liverpool (1981-1984) and Manchester United (1998-2001 and 2006-2009), all of whom won three straight top-flight titles.
They could also become the first team to ever win back-to-back league and FA Cup doubles on Saturday, when they face Manchester United in the final of the latter competition at Wembley Stadium.
Howe taking plenty of positives despite frustrating Newcastle campaign
Eddie Howe was keen to look at the positives after Newcastle United secured seventh place in the Premier League on Sunday.
Alexander Isak and Bruno Guimaraes were among the goalscorers as Newcastle won 4-2 at Brentford to finish their Premier League campaign.
The victory ensured a seventh-place finish, and a Manchester City victory over Manchester United in next Saturday's FA Cup final will confirm Newcastle's place in next season's Europa Conference League.
While this season did not quite live up to the heroics of last term, which saw the Magpies finish in the Champions League spots, Howe still feels it has been a successful campaign.
"It summed up our season," Howe told BBC Sport. "We weren't totally secure at the back, but great credit to the players. They've done their job - now we wait and see.
"We anticipated after losing against Manchester United that our control of the [European] situation had gone. It's never a nice situation, but whatever happens, happens.
"We have issues to solve defensively. If we can do that, next season could be another season of really strong performances. This was a season that could have been better, but a good season overall.
"We're a really united club. I think we're still moving forward, so there's a lot to be positive about."
Postecoglou will not settle until Tottenham hit his 'lofty ambitions'
Ange Postecoglou warned Tottenham he will not settle until the club hits the "lofty ambitions" targeted in his mind.
Spurs were 3-0 victors over Sheffield United at Bramall Lane on Sunday, ending their Premier League season with a convincing win to finish fifth in the table.
Postecoglou voiced his frustrations after Tuesday's 2-0 defeat to Manchester City ended their hopes of Champions League football next term.
The Spurs head coach was far more relaxed after his side performed well in Sheffield, with Dejan Kulusevski twice on target, along with a goal for Pedro Porro against the relegated Blades.
Yet Postecoglou insisted his ambitions remain high as the Australian attempts to take Tottenham to the next level.
"Contrary to my general demeanour, I have loved every minute of it," former Celtic boss Postecoglou said of his first season in charge of Tottenham.
"It is a great challenge in the Premier League and taking over a big club that didn't have a great year last year. You understand it is not going to run smoothly, but I have enjoyed the whole season.
"I have got some lofty ambitions for the football club and until we reach that point I am not going to be smiling too much.
"As I said, all any manager wants is maximum effort and I have got that from everyone involved. I have enjoyed it and looking forward to pushing on from here."
Asked to summarise his first campaign in England's top league, Postecoglou continued: "It's been good, it's been eventful, it's had a bit of everything.
"I am obviously not delighted with the way we finished the season but in fairness to the players and staff we have been in the top five all season, in a year where there was a fair bit of upheaval.
"We finished eighth last year, player turnover, different football, different way of training, it is not easy to maintain a level when you are trying to do that.
"Even in our tough periods this year we have still been competitive for the most part."
Kulusevski scored his seventh and eighth Premier League goals of the season (36 outings), more than he managed in his first two league campaigns with Tottenham combined (seven across 48 games).
Only in the 2019-20 season with Parma has the Sweden winger scored more times in a league season (10 in Serie A), and Postecoglou hailed Kulusevski's returns.
He added: "I thought Deki was good. He's worked awfully hard this year without a lot of reward in the front third.
"We thought playing him through middle today would help us with his mobility and ability to run in behind. He did well.
"He always works hard but it's that sort of final third where we need him to get rewards and he got them today so he did well."
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