The only Champions League group with qualifying places still to play for on Tuesday is Group D, with all four teams in with a reasonable chance of progression.
Marseille host leaders Tottenham while Sporting CP take on Eintracht Frankfurt, with each team knowing a win will see them through and defeat will mean third our fourth spot.
It has been a sensational start to the season for Napoli, and they can complete a perfect Champions League group stage on Tuesday.
Luciano Spalletti's men travel to Liverpool looking for a sixth win in six Group A games, and will top the group as long as they avoid defeat by four or more at Anfield.
As the Champions League group stage prepares to draw to a close, Stats Perform takes a look at the Opta numbers behind these and the rest of Tuesday's clashes.
Marseille v Tottenham
Having lost six home matches in a row in the Champions League between March 2012 and November 2020, Marseille have since won two of their last three such matches (L1), including last time out against Sporting. They have not won consecutive home games in the competition since the 2010-11 campaign when they beat MSK Zilina and Chelsea.
Despite currently sitting bottom of Group D, Marseille can still top the standings if results go their way. Only once in 10 previous campaigns have the Ligue 1 side finished top of their Champions League group, which was in 1992-93 when they went on to lift the trophy.
Spurs have failed to win any of their last four away matches in the Champions League. Should they fail to win here, it will be their longest run of games without a win away from home in the competition.
Antonio Conte will be concerned that Tottenham have failed to score in any of their last three away matches in the Champions League; the last English side to go on a longer run without a goal away from home in the competition was Manchester United between October 2004 and November 2005 (five games – a record for an English club).
Sporting CP v Eintracht Frankfurt
In what is their first ever Champions League campaign, Eintracht Frankfurt can still win their group if results go their way. The only German club to win their first group participation in the competition was Kaiserslautern in 1998-99, while the last Bundesliga side to progress to the knockout rounds at the first attempt was Stuttgart in 2003-04.
Sporting are looking to progress to the knockout stages in consecutive Champions League campaigns, having been eliminated during the group stage in seven of their previous eight participations (progressing in 2008-09).
Eintracht's Mario Gotze has recorded an assist in each of his past two appearances in the Champions League; only once before has he set up a goal in three consecutive games in the competition – between November 2012 and March 2013 for Borussia Dortmund.
Sporting have been shown three red cards so far this season in the Champions League – the last team to have more players sent off in a single group stage was Anderlecht in 2013-14 (four).
Liverpool v Napoli
This will be the eighth meeting between Liverpool and Napoli in European competition, with the Italian side (three) edging the Reds (two) in terms of victories so far (two draws). After their 4-1 win in this season's reverse fixture, Napoli could beat Liverpool in consecutive games for the first time.
The Italian side have travelled to face the Reds on three previous occasions in European competition, but are yet to win at Anfield (D1 L2) – losing 3-1 in the Europa League in November 2010 and 1-0 in the Champions League in December 2018, before a 1-1 draw in November 2019, also in the Champions League.
This will be Jurgen Klopp's 100th match as a manager in the Champions League, across spells with Borussia Dortmund and Liverpool. He will become the first German coach to take charge of a century of games in the competition.
Napoli have scored more goals than any other team through the first five matchdays in this season's group stage (20). The only team to score more during a single group stage in the previous four campaigns has been Bayern Munich (twice, 24 in 2019-20 and 22 in 2021-22).
Bayern Munich v Inter
Speaking of which, Bayern and Inter have met on eight previous occasions in European competition, with the German side winning half of those meetings (W4 D1 L3). Indeed, they are unbeaten in the three matches in the Champions League that have taken place in the group stage (W2 D1).
Inter are themselves unbeaten in their previous three away games at Bayern (W2 D1). This makes them the team to have faced the Bavarians away from home on the most occasions without ever losing in European competition.
Bayern have won each of their last 12 group-stage matches in the Champions League, and are looking to become the first side in history to win all six group games in consecutive campaigns. They would also become the first side to do so on three separate occasions, having also achieved perfection in 2019-20.
Inter are unbeaten in three away games in the Champions League, and could go four games without defeat away from home in the competition for the first time since December 2003 to February 2005 (five games).
Bayern have scored in 42 of their last 43 home matches in the Champions League, netting 136 goals across this spell at an average of 3.2 per game. They have scored in each of their last 21 in a row since being held by Sevilla in April 2018.
Other fixtures:
Viktoria Plzen v Barcelona
3 - Viktoria Plzen have lost all three of their previous games against Barcelona in the Champions League, scoring just one goal and conceding 11 times in return.
3 - Barcelona have lost each of their last three away matches in the Champions League, and could lose four in a row for the first time since a run between November 1994 and October 1997.
Rangers v Ajax
5 - Rangers have lost all five of their games in the Champions League this season. No Scottish side have ever been beaten six times within a single campaign in the European Cup/Champions League.
4 - Ajax have lost each of their previous four games in the Champions League; they have not lost five in a row in the competition since September 2004 under Ronald Koeman.
Bayer Leverkusen v Club Brugge
18 - Leverkusen forward Patrik Schick has played 18 times in the Champions League without scoring a goal. His three goals in major European competition have all been scored in the Europa League, where he averages a goal every 138 minutes.
1 - Club Brugge have already qualified for the knockout stage, and could finish top of their group for the very first time in a single edition of the tournament.
Porto v Atletico Madrid
3 - Porto goalkeeper Diogo Costa has saved three of the four penalties he has faced in the Champions League this season. This is already the most ever by a goalkeeper in a single season on record in the competition (since 2003-04).
4 - Atletico are winless in their last four Champions League games (D2 L2). They last had a longer run without a victory in the competition between December 2008 and December 2009, when they went nine games without one prior to head coach Diego Simeone's arrival.
Postecoglou rues missed chances against City as Son squanders decisive opportunity
Ange Postecoglou was left to rue missed chances as Tottenham's Champions League hopes were ended after Tuesday's 2-0 defeat to Manchester City.
Spurs needed three points to take the Premier League's top-four race to the final day but were undone by Pep Guardiola's side, who moved within touching distance of another top-flight title.
Erling Haaland's routine tap-in from Kevin De Bruyne's brilliance after 51 minutes proved a cruel blow before the City striker's stoppage-time penalty sealed a decisive three points.
It could have been a different story, though, if Stefan Ortega – on as a second-half substitute for Ederson – did not deny Heung-min Son's gilt-edged chance following Manuel Akanji's error.
The City goalkeeper denied the onrushing Spurs forward when one-on-one with the visitors 1-0 up, and Postecoglou acknowledged his side failed to seize their opportunities.
"We lost the game so it was a missed chance for three points," the frustrated Tottenham manager told Sky Sports.
"We had the opportunities and we had to punish them. It was a tight game and in the big moments we were not able to capitalise and they were.
"I thought we were in the game the whole time, even at 1-0 we had a great chance to go level.
"In the second half we were chasing the game so they got a little more space but I thought we were well in it up until that point [the second goal]."
Spurs' loss proved Aston Villa's gain as Unai Emery's side qualified for the Champions League for the first time in their history, ending a 41-year absence after last featuring in the European Cup in 1982-83.
Postecoglou found it hard to seek the immediate positives, having watched Tottenham fall short and inadvertently damage rivals Arsenal's title hopes in the process.
"We lost the game so I am disappointed," the Australian added, before responding to whether any pride could be taken.
"Not right now because we have lost. We will assess the season, still one more game to go, one more game against Sheffield United and we need to make sure we win.
"I think wherever you finish is a fair reflection of where you are at."
Tottenham will finish outside the top four for the fourth time in the last five seasons, after finishing in the Champions League spots in Mauricio Pochettino’s final four full campaigns in charge (2015-16 to 2018-19).
Postecoglou acknowledged there is still work to do to catch up with England's perennial champions City.
Asked how his side measure up to Guardiola's men, he said: Nothing earth-shattering that I didn't know before the game. We still have some work to do. We need to do some work to catch up."
Real Madrid 5-0 Alaves: Vinicius double continues LaLiga champions party
Vinicius Junior scored twice as newly-crowned LaLiga champions Real Madrid thrashed visitors Alaves 5-0 on Tuesday, after the hosts had paraded the trophy in front of the home fans before the game.
Jude Bellingham and Vinicius scored a goal each inside 30 minutes before Federico Valverde put Los Blancos 3-0 up at the break, unleashing an unstoppable shot into the roof of the net in first-half stoppage time.
Vinicius added one more in the 70th minute from a precise cross by Bellingham that the Brazilian fired into the top corner, and substitute Arda Guler completed the scoring with a low finish.
Carlo Ancelotti's side travel to Villarreal on Sunday before hosting Real Betis on May 25 ahead of their Champions League final against Borussia Dortmund on June 1.
Having thrashed Granada 4-0 on Saturday and Cadiz 3-0, either side of their Champions League semi-final victory over Bayern, Real are firing on all fronts heading into the Wembley Stadium showpiece.
Meanwhile, Alavez remain 11th in the table heading into their next game against Getafe at home on Saturday.
Data Debrief: Madrid capitalise on opportunities
Madrid found the back of the net five times from just 2.47 expected goals (xG), suggesting Los Blancos' finishing quality was far greater than Alaves' 1.28 xG.
Ancelotti's side have now kept 20 clean sheets in 36 LaLiga games this campaign, their most in a single season in the competition's history (19 in the 1986-87, 1987-88 and 2019-20 seasons).
'One more game, and we can change history' – Rodri knows Man City have one more step to take
Manchester City know they cannot let complacency set in as they aim to make Premier League history, so says Rodri.
City beat Tottenham 2-0 on Tuesday, taking a huge stride towards winning an unprecedented fourth straight Premier League title.
Erling Haaland scored twice, with his second – a calmly taken spot-kick in stoppage time – came after a string of fine stops from Stefan Ortega.
City's stand-in goalkeeper replaced the injured Ederson just after the hour mark, and twice denied Dejan Kulusevski before making an exceptional save to prevent Son Heung-min scoring in a one-v-one.
With one game left, City are two points above Arsenal, and Rodri knows the job must now be done against West Ham on Sunday.
"It's unbelievable. For us, it gives us the chance to fight again in the last game," he told Sky Sports.
"We know it's one more game, but you saw the character of the team, of course it wasn't our best performance, but we came here to win – that's what we do. It's the mentality of these guys, the substitutions, Stefan saved us, Jeremy was unbelievable, every player that came in was exceptional.
"This is football. We have the best striker in the world and today he made the difference, but today, Stefan was simply incredible. We were 1-0 up and he made three outstanding saves. I have no words. We want to make history again, but we have one more to come.
"We have the experience from against Aston Villa [in 2022]. We know it's not done. We know it's going to be tough, but if we do it, we can change history."
Kyle Walker echoed the sentiment.
"We know it's not done, but we've taken it down to the last game, in front of our fans," he said. "You have to take each game as it comes."
City are now unbeaten in 22 consecutive Premier League games (W18 D4), including all 18 in 2024 (W15 D3); however, the last two teams to make as long an unbeaten start to a calendar year have failed to go on to win the title in that same year (Liverpool in 2022 – second and Chelsea in 2008 – second).
Pep Guardiola's team will sit top of the Premier League table heading into the final day of the season for the sixth time in the last seven seasons, having gone on to win the title in each of those previous campaigns.
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